ATE195128T1 - Steroidnitrit/nitratesterderivate und ihre verwendung als entzündungshemmende medikamente - Google Patents

Steroidnitrit/nitratesterderivate und ihre verwendung als entzündungshemmende medikamente

Info

Publication number
ATE195128T1
ATE195128T1 AT96943559T AT96943559T ATE195128T1 AT E195128 T1 ATE195128 T1 AT E195128T1 AT 96943559 T AT96943559 T AT 96943559T AT 96943559 T AT96943559 T AT 96943559T AT E195128 T1 ATE195128 T1 AT E195128T1
Authority
AT
Austria
Prior art keywords
derivatives
nitratester
inflammatory medications
steroid
nitrite
Prior art date
Application number
AT96943559T
Other languages
English (en)
Inventor
Foe S Tjoeng
Mark G Currie
Mark E Zupec
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Application granted granted Critical
Publication of ATE195128T1 publication Critical patent/ATE195128T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
AT96943559T 1995-12-08 1996-12-06 Steroidnitrit/nitratesterderivate und ihre verwendung als entzündungshemmende medikamente ATE195128T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/569,812 US5707984A (en) 1995-12-08 1995-12-08 Steroid nitrite/nitrate ester derivatives useful as anti-inflammatory drugs
PCT/US1996/019219 WO1997021721A1 (en) 1995-12-08 1996-12-06 Novel steroid nitrite/nitrate ester derivatives useful as anti-inflammatory drugs

Publications (1)

Publication Number Publication Date
ATE195128T1 true ATE195128T1 (de) 2000-08-15

Family

ID=24276970

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96943559T ATE195128T1 (de) 1995-12-08 1996-12-06 Steroidnitrit/nitratesterderivate und ihre verwendung als entzündungshemmende medikamente

Country Status (12)

Country Link
US (1) US5707984A (de)
EP (1) EP0873351B1 (de)
JP (1) JP2000501732A (de)
AT (1) ATE195128T1 (de)
AU (1) AU1277297A (de)
CA (1) CA2239910A1 (de)
DE (1) DE69609632T2 (de)
DK (1) DK0873351T3 (de)
ES (1) ES2150152T3 (de)
GR (1) GR3034337T3 (de)
PT (1) PT873351E (de)
WO (1) WO1997021721A1 (de)

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US5824669A (en) * 1996-03-22 1998-10-20 Nitromed, Inc. Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
AU4093799A (en) 1998-05-22 1999-12-13 Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and therapies based thereon
IT1311922B1 (it) * 1999-04-13 2002-03-20 Nicox Sa Composti farmaceutici.
US6765019B1 (en) 1999-05-06 2004-07-20 University Of Kentucky Research Foundation Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids
US6777399B2 (en) * 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6759398B2 (en) 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
SI1775305T1 (sl) * 2000-08-05 2015-01-30 Glaxo Group Limited S-fluorometil ester 6alfa,9alfa-difluoro-17alfa-((2-furanilkarboksil)oksi)- 11beta-hidroksi-16alfa-metil-3-okso-androst-1,4-dien-17-karbotiojske kisline kot protivnetno sredstvo
US6858593B2 (en) * 2000-08-05 2005-02-22 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6858596B2 (en) * 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
US6777400B2 (en) * 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6787532B2 (en) * 2000-08-05 2004-09-07 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivatives
GB0019172D0 (en) * 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
US6750210B2 (en) * 2000-08-05 2004-06-15 Smithkline Beecham Corporation Formulation containing novel anti-inflammatory androstane derivative
UA77656C2 (en) * 2001-04-07 2007-01-15 Glaxo Group Ltd S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
KR100831534B1 (ko) * 2001-04-30 2008-05-22 글락소 그룹 리미티드 17.알파 위치에 시클릭 에스테르기를 지닌 항염증성의안드로스탄의 17.베타.-카르보티오에이트 에스테르 유도체
ES2307751T3 (es) * 2001-06-12 2008-12-01 Glaxo Group Limited Nuevos esteres heterociclicos centi-inflamatorios 17 alfa de derivados 17 beta de carbotioato de androstano.
AU2002322720B2 (en) 2001-07-25 2008-11-13 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
US20050175545A1 (en) * 2002-02-04 2005-08-11 Keith Biggadike Formulation for inhalation comprising a glucocorticoid and a beta 2-adrenoreceptor agonist
GB0202635D0 (en) * 2002-02-05 2002-03-20 Glaxo Wellcome Mfg Pte Ltd Formulation containing novel anti-inflammatory androstane derivative
EP1336602A1 (de) * 2002-02-13 2003-08-20 Giovanni Scaramuzzino Nitrat-Prodrugs zur Freisetzung von Stickstoffmonoxid in kontrollierter und selektiver Weise sowie deren Verwendung zur Prävention und Behandlung inflammatorischer, ischämischer und proliferativer Erkrankungen
GB2389530B (en) * 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
EP1562975A2 (de) * 2002-10-25 2005-08-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Steroide welche gruppen zur nachahmung von superoxidase dismutase sowie stickoxid donorgruppen beinhalten und ihre verwendung in der darstellung von medikamenten
GB0507165D0 (en) * 2005-04-08 2005-05-18 Glaxo Group Ltd Novel crystalline pharmaceutical product
CA2789262C (en) 2005-04-28 2016-10-04 Proteus Digital Health, Inc. Pharma-informatics system
EP1945240B1 (de) 2005-09-16 2016-12-28 Raptor Pharmaceutical Inc Zusammensetzungen mit rezeptor-assoziierten protein (rap) varianten, die für cr-haltige proteine spezifisch sind und ihre verwendungen
GB0615108D0 (en) * 2006-07-28 2006-09-06 Glaxo Group Ltd Novel formulations
TR201908314T4 (tr) 2009-02-20 2019-06-21 2 Bbb Medicines B V Glutatyon bazlı ilaç dağıtım sistemi.
KR101909711B1 (ko) 2009-05-06 2018-12-19 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
US20120237617A1 (en) * 2009-06-18 2012-09-20 Theravasc Inc. Use of nitrite salts in treating tissue damage
CN105399792A (zh) * 2015-12-07 2016-03-16 西宁意格知识产权咨询服务有限公司 一种新的甾体类化合物及其制备方法和医药用途

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US3215713A (en) * 1960-04-04 1965-11-02 Schering Corp Steroid nitrite esters
US3298941A (en) * 1961-05-29 1967-01-17 Schering Corp Photochemical process for rearranging organic hypohalite and nitrite compounds
GB1082574A (en) * 1965-02-12 1967-09-06 Boots Pure Drug Co Ltd Steroid esters
US3639434A (en) * 1967-02-02 1972-02-01 Boots Pure Drug Co Ltd 17-acyloxysteroids and their manufacture
DE1643036B2 (de) * 1967-08-16 1976-04-15 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue 11 beta-halogensteroide, diese enthaltende arzneimittel sowie verfahren zu ihrer herstellung
HU164115B (de) * 1971-05-07 1973-12-28
HU163145B (de) * 1971-09-23 1973-06-28
DE2236115A1 (de) * 1972-07-20 1974-02-07 Schering Ag Verfahren zur herstellung von delta hoch 4.9(11).16 -3.20diketosteroiden
GB1446126A (en) * 1974-05-16 1976-08-18 Res Inst For Medicine Chemistr Photolytic preparation of diol mononitrates
WO1994003421A2 (en) * 1992-07-30 1994-02-17 Cal International Limited Esters and combinations of an organic nitrate and a salicylate

Also Published As

Publication number Publication date
US5707984A (en) 1998-01-13
CA2239910A1 (en) 1997-06-19
EP0873351A1 (de) 1998-10-28
DK0873351T3 (da) 2000-10-23
GR3034337T3 (en) 2000-12-29
ES2150152T3 (es) 2000-11-16
JP2000501732A (ja) 2000-02-15
WO1997021721A1 (en) 1997-06-19
DE69609632D1 (de) 2000-09-07
EP0873351B1 (de) 2000-08-02
AU1277297A (en) 1997-07-03
PT873351E (pt) 2001-01-31
DE69609632T2 (de) 2000-11-09

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Legal Events

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UEP Publication of translation of european patent specification
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