ATE195346T1 - Rekombinante dna moleküle die aminopeptidase enzyme kodieren und ihre anwendung für die herstellung von impfstoffen gegen helminth infektionen - Google Patents

Rekombinante dna moleküle die aminopeptidase enzyme kodieren und ihre anwendung für die herstellung von impfstoffen gegen helminth infektionen

Info

Publication number
ATE195346T1
ATE195346T1 AT93910164T AT93910164T ATE195346T1 AT E195346 T1 ATE195346 T1 AT E195346T1 AT 93910164 T AT93910164 T AT 93910164T AT 93910164 T AT93910164 T AT 93910164T AT E195346 T1 ATE195346 T1 AT E195346T1
Authority
AT
Austria
Prior art keywords
enzymes
aminoopeptidase
production
application
recombinant dna
Prior art date
Application number
AT93910164T
Other languages
English (en)
Inventor
Margaret Graham
Trevor Stanley Smith
Edward Albert Munn
David Patrick Knox
Joanna Jane Oliver
Susan Elizabeth Newton
Original Assignee
Babraham Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Babraham Inst filed Critical Babraham Inst
Application granted granted Critical
Publication of ATE195346T1 publication Critical patent/ATE195346T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0003—Invertebrate antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43536—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms
    • C07K14/4354—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms from nematodes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT93910164T 1992-05-08 1993-05-07 Rekombinante dna moleküle die aminopeptidase enzyme kodieren und ihre anwendung für die herstellung von impfstoffen gegen helminth infektionen ATE195346T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929209993A GB9209993D0 (en) 1992-05-08 1992-05-08 Vaccines
PCT/GB1993/000943 WO1993023542A1 (en) 1992-05-08 1993-05-07 Recombinant dna molecules encoding aminopeptidase enzymes and their use in the preparation of vaccines against helminth infections

Publications (1)

Publication Number Publication Date
ATE195346T1 true ATE195346T1 (de) 2000-08-15

Family

ID=10715227

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93910164T ATE195346T1 (de) 1992-05-08 1993-05-07 Rekombinante dna moleküle die aminopeptidase enzyme kodieren und ihre anwendung für die herstellung von impfstoffen gegen helminth infektionen

Country Status (25)

Country Link
US (4) US6066503A (de)
EP (1) EP0640133B1 (de)
JP (1) JPH07508879A (de)
CN (1) CN1053699C (de)
AT (1) ATE195346T1 (de)
AU (1) AU677582B2 (de)
BG (1) BG62700B1 (de)
CA (1) CA2134326A1 (de)
CZ (1) CZ274494A3 (de)
DE (1) DE69329195T2 (de)
DK (1) DK0640133T3 (de)
ES (1) ES2151506T3 (de)
FI (1) FI945221A0 (de)
GB (1) GB9209993D0 (de)
GR (1) GR3034766T3 (de)
HU (1) HU218041B (de)
NO (1) NO944245L (de)
NZ (1) NZ252221A (de)
PL (1) PL175900B1 (de)
PT (1) PT640133E (de)
RO (1) RO117709B1 (de)
RU (1) RU2140986C1 (de)
SK (1) SK132394A3 (de)
WO (1) WO1993023542A1 (de)
ZA (1) ZA933216B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6099843A (en) * 1991-02-12 2000-08-08 Heska Corporation Parasitic helminth PLA2 proteins
US5972645A (en) * 1991-12-13 1999-10-26 Heska Corporation Flea serine protease nucleic acid molecules
US6150125A (en) * 1991-12-13 2000-11-21 Heska Corporation Flea protease proteins and uses thereof
US6146870A (en) * 1991-12-13 2000-11-14 Heska Corporation Flea protease proteins
US6156556A (en) * 1991-12-13 2000-12-05 Heska Corporation Flea protease proteins, nucleic acid molecules, and uses thereof
US6121035A (en) * 1991-12-13 2000-09-19 Heska Corporation Flea aminopeptidase proteins and uses thereof
US6210920B1 (en) 1991-12-13 2001-04-03 Heska Corporation Flea protease proteins, nucleic acid molecules, and uses thereof
GB9209993D0 (en) * 1992-05-08 1992-06-24 Munn Edward A Vaccines
GB9302302D0 (en) * 1993-02-05 1993-03-24 Pitman Moore Inc Process
GB9303681D0 (en) * 1993-02-24 1993-04-14 Pitman Moore Inc Vaccines
GB9322702D0 (en) 1993-11-03 1993-12-22 Agricultural & Food Res Vaccines
BR9305075A (pt) * 1993-12-16 1995-08-08 Fundacao Oswaldo Cruz Antígeno para conferir imunidade protetora contra infecções helmínticas em humanos e animais,e processo de vacinação para aplicação na imunoprofilaxia de doenças helmintológicas de interesse veterinário e médico
US6214579B1 (en) 1994-10-18 2001-04-10 Heska Corporation Flea leucine aminopeptidase nucleic acid molecules and uses thereof
US6204010B1 (en) 1995-06-07 2001-03-20 Heska Corporation Flea protease proteins, nucleic acid molecules, and uses thereof
US6139840A (en) * 1995-10-18 2000-10-31 Heska Corporation Methods of eliciting an antibody response using flea protease proteins and homologs thereof
IL120704A0 (en) * 1996-04-24 1998-04-05 Heska Corp Flea protease proteins nucleic acid molecules and uses thereof
RU2423525C2 (ru) * 2001-02-23 2011-07-10 ДСМ Ай Пи ЭССЕТС Б.В. Новые гены, кодирующие новые протеолитические ферменты
US20040006204A1 (en) 2002-04-02 2004-01-08 Miriam Tendler Synthetic active peptide fragments
US7951557B2 (en) 2003-04-27 2011-05-31 Protalix Ltd. Human lysosomal proteins from plant cell culture
ES2660667T3 (es) 2007-05-07 2018-03-23 Protalix Ltd. Biorreactor desechable a gran escala
US20080294361A1 (en) * 2007-05-24 2008-11-27 Popp Shane M Intelligent execution system for the monitoring and execution of vaccine manufacturing
ES2325243B1 (es) 2008-02-27 2011-05-04 Universidad De Granada Antigeno recombinante.
US9052304B2 (en) 2009-03-13 2015-06-09 Terrasep, Llc Methods and apparatus for centrifugal liquid chromatography
CN112961848B (zh) * 2021-02-24 2022-09-09 中国海洋大学 一种新型氨肽酶及其可溶性表达方法
CN119391673B (zh) * 2024-10-21 2025-09-26 新镁(上海)生物技术有限公司 α-L-岩藻糖苷酶突变体及其应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2183662B (en) 1985-04-01 1989-01-25 Celltech Ltd Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same
GB8601597D0 (en) 1986-01-23 1986-02-26 Wilson R H Nucleotide sequences
GB8619293D0 (en) * 1986-08-07 1986-09-17 Munn E A Anthelmintic agents
US4879213A (en) * 1986-12-05 1989-11-07 Scripps Clinic And Research Foundation Synthetic polypeptides and antibodies related to Epstein-Barr virus early antigen-diffuse
GB8717430D0 (en) 1987-07-23 1987-08-26 Celltech Ltd Recombinant dna product
GB8809129D0 (en) 1988-04-18 1988-05-18 Celltech Ltd Recombinant dna methods vectors and host cells
JPH03503054A (ja) * 1988-09-26 1991-07-11 バイオテクノロジー・オーストラリア・プロプライエタリー・リミテッド ワクチン
GB8906156D0 (en) * 1989-03-17 1989-05-04 Munn Edward A Production and use of anthelmintic agents and protective immunogens
NL9001832A (nl) * 1990-08-16 1992-03-16 Rijksuniversiteit Specifieke sequenties van dna van een nematode die toegepast kunnen worden bij de diagnostiek van infektie met de nematode.
US5795768A (en) * 1991-02-12 1998-08-18 Heska Corporation Filariid nematode cysteine protease proteins, nucleic acid molecules and uses thereof
GB9209993D0 (en) * 1992-05-08 1992-06-24 Munn Edward A Vaccines
GB9302302D0 (en) * 1993-02-05 1993-03-24 Pitman Moore Inc Process

Also Published As

Publication number Publication date
AU677582B2 (en) 1997-05-01
PL175900B1 (pl) 1999-03-31
US20080145379A1 (en) 2008-06-19
WO1993023542A1 (en) 1993-11-25
ES2151506T3 (es) 2001-01-01
BG62700B1 (bg) 2000-05-31
PT640133E (pt) 2000-12-29
RU94046017A (ru) 1997-03-20
CA2134326A1 (en) 1993-11-25
AU4077593A (en) 1993-12-13
ZA933216B (en) 1994-06-14
FI945221L (fi) 1994-11-07
SK132394A3 (en) 1995-07-11
RO117709B1 (ro) 2002-06-28
EP0640133B1 (de) 2000-08-09
CZ274494A3 (en) 1995-08-16
HUT71847A (en) 1996-02-28
NO944245D0 (no) 1994-11-07
BG99246A (bg) 1995-07-28
FI945221A7 (fi) 1994-11-07
DK0640133T3 (da) 2000-12-18
CN1053699C (zh) 2000-06-21
RU2140986C1 (ru) 1999-11-10
JPH07508879A (ja) 1995-10-05
HU218041B (hu) 2000-05-28
DE69329195D1 (de) 2000-09-14
NZ252221A (en) 1996-12-20
CN1084563A (zh) 1994-03-30
FI945221A0 (fi) 1994-11-07
EP0640133A1 (de) 1995-03-01
NO944245L (no) 1995-01-06
US6066503A (en) 2000-05-23
US20030078398A1 (en) 2003-04-24
GR3034766T3 (en) 2001-02-28
GB9209993D0 (en) 1992-06-24
US6534638B1 (en) 2003-03-18
DE69329195T2 (de) 2001-04-05

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