ATE195432T1 - Iodierte paramagnetische chelaten, und deren verwendung als kontrastmittel - Google Patents

Iodierte paramagnetische chelaten, und deren verwendung als kontrastmittel

Info

Publication number
ATE195432T1
ATE195432T1 AT94918782T AT94918782T ATE195432T1 AT E195432 T1 ATE195432 T1 AT E195432T1 AT 94918782 T AT94918782 T AT 94918782T AT 94918782 T AT94918782 T AT 94918782T AT E195432 T1 ATE195432 T1 AT E195432T1
Authority
AT
Austria
Prior art keywords
pct
date
contrast agents
iodinated
rays
Prior art date
Application number
AT94918782T
Other languages
English (en)
Inventor
Fulvio Uggeri
Pier Lucio Anelli
Franco Fedeli
Marcella Murru
Haen Christoph De
Original Assignee
Bracco Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI931155A external-priority patent/IT1270974B/it
Priority claimed from IT001274 external-priority patent/IT1264610B1/it
Application filed by Bracco Spa filed Critical Bracco Spa
Application granted granted Critical
Publication of ATE195432T1 publication Critical patent/ATE195432T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Steroid Compounds (AREA)
AT94918782T 1993-06-02 1994-05-25 Iodierte paramagnetische chelaten, und deren verwendung als kontrastmittel ATE195432T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI931155A IT1270974B (it) 1993-06-02 1993-06-02 Chelati paramagnetici iodurati
IT001274 IT1264610B1 (it) 1993-06-15 1993-06-15 Chelati paramagnetici iodurati
PCT/EP1994/001677 WO1994027644A1 (en) 1993-06-02 1994-05-25 Iodinated paramagnetic chelates, and their use as contrast agents

Publications (1)

Publication Number Publication Date
ATE195432T1 true ATE195432T1 (de) 2000-09-15

Family

ID=26330998

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94918782T ATE195432T1 (de) 1993-06-02 1994-05-25 Iodierte paramagnetische chelaten, und deren verwendung als kontrastmittel

Country Status (9)

Country Link
US (1) US5660814A (de)
EP (1) EP0703790B1 (de)
JP (1) JPH08510458A (de)
AT (1) ATE195432T1 (de)
AU (1) AU6996594A (de)
DE (1) DE69425572T2 (de)
IL (1) IL109852A0 (de)
IS (1) IS4172A (de)
WO (1) WO1994027644A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4302287A1 (de) * 1993-01-25 1994-07-28 Schering Ag Derivatisierte DTPA-Komplexe, diese Verbindungen enthaltende pharmazeutische Mittel, ihre Verwendung und Verfahren zu deren Herstellung
US5672335A (en) * 1994-11-30 1997-09-30 Schering Aktiengesellschaft Use of metal complexes as liver and gallbladder X-ray diagnostic agents
TW319763B (de) * 1995-02-01 1997-11-11 Epix Medical Inc
FR2736051B3 (fr) * 1995-06-29 1997-09-26 Guerbet Sa Complexes metalliques de polyaminoacides, leur procede de preparation et leur utilisation en imagerie diagnostique
US5834456A (en) * 1996-02-23 1998-11-10 The Dow Chemical Company Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents
JP2002528521A (ja) * 1998-10-29 2002-09-03 ザ ゼネラル ホスピタル コーポレーション 放射線濃密性組成物
ES2581781T3 (es) * 2002-09-24 2016-09-07 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Método por imágenes para administración mejorada por convección de agentes terapéuticos
ITMI20022411A1 (it) * 2002-11-14 2004-05-15 Bracco Imaging Spa Agenti per la diagnosi e la terapia di tumori che espongono sulla superficie delle cellule proteine alterate.
US7208140B2 (en) 2003-02-19 2007-04-24 Schering Aktiengesellschaft Trimeric macrocyclic substituted benzene derivatives
DE10307759B3 (de) * 2003-02-19 2004-11-18 Schering Ag Trimere makrocyclisch substituierte Benzolderivate, deren Herstellung und Verwendung als Kontrastmittel sowie diese enthaltende pharmazeutische Mittel
DE102004023093B3 (de) * 2004-05-05 2006-03-02 Schering Ag Trimere makrocyclisch substituierte Halogen-Benzolderivate
DE102004026103A1 (de) * 2004-05-25 2005-12-22 Schering Ag Trimere makrocyclisch substituierte Aminoisophthalsäure-Halogen-Benzolderivate
KR100695744B1 (ko) * 2005-05-03 2007-03-19 한국원자력연구소 디티피에이(ｄｔｐａ) 유도체 및 이들을 이용한 금속 착화물, 이들을 포함하는 방사선원 및 조영제
EP1762563A1 (de) * 2005-09-13 2007-03-14 BRACCO IMAGING S.p.A. Verfahren zur Herstellung von Kontrastmitteln
US20100121188A1 (en) * 2006-10-10 2010-05-13 Sandhu Gurpreet S Reducing contrast agent-induced toxicity
NO20073382L (no) * 2007-06-29 2008-12-30 Ge Healthcare As Contrast Agents
DE102007058220A1 (de) 2007-12-03 2009-06-04 Bayer Schering Pharma Aktiengesellschaft Dimere macrocyclisch substituierte Benzolderivate
GB0808086D0 (en) * 2008-05-02 2008-06-11 Iti Scotland Ltd Magnetic proteins for in vivo imaging
KR101638851B1 (ko) * 2014-06-13 2016-07-12 경북대학교 산학협력단 신규한 삼요오드화 화합물, 이의 제조방법 및 이를 포함하는 x-선 조영제
EP3101012A1 (de) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft Neue gadoliniumchelat-verbindung zur verwendung in der magnetresonanzbildgebung
ES2814555T3 (es) 2016-11-28 2021-03-29 Bayer Pharma AG Compuestos de quelato de gadolinio con alta relaxividad para usar en la obtención de imágenes por resonancia magnética
KR102934987B1 (ko) 2018-11-23 2026-03-09 바이엘 악티엔게젤샤프트 조영 매체의 제형 및 그의 제조 방법
EP4015509A1 (de) 2020-12-18 2022-06-22 Justesa Imagen S.A.U Organometallische verbindungen und ihre verwendung als multimodale kontrastmedien zur bilddiagnose

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1213029B (it) * 1986-01-30 1989-12-07 Bracco Ind Chimica Spa Chelati di ioni metallici paramagnetici.
GB8916781D0 (en) * 1989-07-21 1989-09-06 Nycomed As Compositions
US5324503A (en) * 1992-02-06 1994-06-28 Mallinckrodt Medical, Inc. Iodo-phenylated chelates for x-ray contrast
US5525328A (en) * 1994-06-24 1996-06-11 Nanosystems L.L.C. Nanoparticulate diagnostic diatrizoxy ester X-ray contrast agents for blood pool and lymphatic system imaging

Also Published As

Publication number Publication date
JPH08510458A (ja) 1996-11-05
DE69425572T2 (de) 2001-04-26
US5660814A (en) 1997-08-26
IL109852A0 (en) 1994-10-07
AU6996594A (en) 1994-12-20
DE69425572D1 (de) 2000-09-21
IS4172A (is) 1994-12-03
WO1994027644A1 (en) 1994-12-08
EP0703790A1 (de) 1996-04-03
EP0703790B1 (de) 2000-08-16

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties