ATE195723T1 - Succinamid-derivate und ihre verwendung als metalloproteinaseinhibitoren - Google Patents

Succinamid-derivate und ihre verwendung als metalloproteinaseinhibitoren

Info

Publication number: ATE195723T1
Authority: AT; Austria
Prior art keywords: pct; date oct; sec; metalloproteinase inhibitors; group
Prior art date: 1995-04-18

Application number

AT96910138T

Other languages

English (en)

Inventor

Raymond Paul Beckett

Andrew Miller

Zoe Marie Spavold

Mark Whittaker

Original Assignee

British Biotech Pharm

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-04-18

Filing date

1996-04-18

Publication date

2000-09-15

1996-04-18 Application filed by British Biotech Pharm filed Critical British Biotech Pharm

2000-09-15 Application granted granted Critical

2000-09-15 Publication of ATE195723T1 publication Critical patent/ATE195723T1/de

Links

SNCZNSNPXMPCGN-UHFFFAOYSA-N butanediamide Chemical class NC(=O)CCC(N)=O SNCZNSNPXMPCGN-UHFFFAOYSA-N 0.000 title 1
239000003475 metalloproteinase inhibitor Substances 0.000 title 1
101000627872 Homo sapiens 72 kDa type IV collagenase Proteins 0.000 abstract 1
101001013150 Homo sapiens Interstitial collagenase Proteins 0.000 abstract 1
102000004318 Matrilysin Human genes 0.000 abstract 1
108090000855 Matrilysin Proteins 0.000 abstract 1
102000000424 Matrix Metalloproteinase 2 Human genes 0.000 abstract 1
108010016160 Matrix Metalloproteinase 3 Proteins 0.000 abstract 1
229940124639 Selective inhibitor Drugs 0.000 abstract 1
102100030416 Stromelysin-1 Human genes 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Ophthalmology & Optometry (AREA)
Pain & Pain Management (AREA)
Immunology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Peptides Or Proteins (AREA)
Lubricants (AREA)
Enzymes And Modification Thereof (AREA)

AT96910138T 1995-04-18 1996-04-18 Succinamid-derivate und ihre verwendung als metalloproteinaseinhibitoren ATE195723T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9507799.6A GB9507799D0 (en)	1995-04-18	1995-04-18	Metalloproteinase inhibitors
PCT/GB1996/000965 WO1996033165A1 (en)	1995-04-18	1996-04-18	Derivatives of succinamide and their use as metalloproteinase inhibitor

Publications (1)

Publication Number	Publication Date
ATE195723T1 true ATE195723T1 (de)	2000-09-15

Family

ID=10773096

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT96910138T ATE195723T1 (de)	1995-04-18	1996-04-18	Succinamid-derivate und ihre verwendung als metalloproteinaseinhibitoren
AT96910104T ATE198319T1 (de)	1995-04-18	1996-04-18	Succinamid-derivate und ihre verwendung als metallproteinase-inhibitoren

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT96910104T ATE198319T1 (de)	1995-04-18	1996-04-18	Succinamid-derivate und ihre verwendung als metallproteinase-inhibitoren

Country Status (9)

Country	Link
US (2)	US5840939A (de)
EP (2)	EP0821666B1 (de)
JP (2)	JPH11503748A (de)
AT (2)	ATE195723T1 (de)
AU (1)	AU5343696A (de)
DE (2)	DE69611360T2 (de)
ES (2)	ES2150116T3 (de)
GB (1)	GB9507799D0 (de)
WO (2)	WO1996033161A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6548084B2 (en)	1995-07-20	2003-04-15	Smithkline Beecham Plc	Controlled release compositions
WO1997031892A1 (fr) *	1996-03-01	1997-09-04	Sankyo Company, Limited	Derives d'acide hydroxamique
US5840974A (en) *	1996-12-04	1998-11-24	Britisch Biotech Pharmaceuticals, Ltd.	Metalloproteinase inhibitors
US5985911A (en) *	1997-01-07	1999-11-16	Abbott Laboratories	C-terminal ketone inhibitors of matrix metalloproteinases and TNFα secretion
US5952320A (en) *	1997-01-07	1999-09-14	Abbott Laboratories	Macrocyclic inhibitors of matrix metalloproteinases and TNFα secretion
ZA9818B (en) *	1997-01-07	1998-07-02	Abbott Lab	C-terminal ketone inhibitors of matrix metalloproteinases and tnf alpha secretion
BR9813719A (pt) *	1998-01-09	2000-10-17	Pfizer	Agentes terapêuticos
GB9810464D0 (en)	1998-05-16	1998-07-15	British Biotech Pharm	Hydroxamic acid derivatives
GB9813451D0 (en) *	1998-06-22	1998-08-19	Smithkline Beecham Plc	Novel compounds
NZ525513A (en)	1998-08-07	2004-09-24	Pont Pharmaceuticals Du	Succinoylamino lactams as inhibitors of Abeta protein production
HRP990246A2 (en)	1998-08-07	2000-06-30	Du Pont Pharm Co	Succinoylamino benzodiazepines as inhibitors of a beta protein production
US6288261B1 (en)	1998-12-18	2001-09-11	Abbott Laboratories	Inhibitors of matrix metalloproteinases
WO2000038618A2 (en)	1998-12-24	2000-07-06	Du Pont Pharmaceuticals Company	SUCCINOYLAMINO BENZODIAZEPINES AS INHIBITORS OF Aβ PROTEIN PRODUCTION
US6297337B1 (en)	1999-05-19	2001-10-02	Pmd Holdings Corp.	Bioadhesive polymer compositions
US6960576B2 (en)	1999-09-13	2005-11-01	Bristol-Myers Squibb Pharma Company	Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production
US6503902B2 (en)	1999-09-13	2003-01-07	Bristol-Myers Squibb Pharma Company	Hydroxyalkanoylaminolactams and related structures as inhibitors of a β protein production
EP1222176A1 (de)	1999-10-08	2002-07-17	Bristol-Myers Squibb Pharma Company	Amino-laktam-sulfonamide als inhibitoren der bildung von a-beta-protein
US6797820B2 (en) *	1999-12-17	2004-09-28	Vicuron Pharmaceuticals Inc.	Succinate compounds, compositions and methods of use and preparation
CA2395862A1 (en)	2000-02-17	2001-08-23	Hong Liu	Succinoylamino carbocycles and heterocycles as inhibitors of a.beta. protein production
US6803383B2 (en) *	2000-03-27	2004-10-12	The Scripps Research Institute	Inhibition of angiogenesis and tumor growth
US6495540B2 (en)	2000-03-28	2002-12-17	Bristol - Myers Squibb Pharma Company	Lactams as inhibitors of A-β protein production
CN1436175A (zh)	2000-04-03	2003-08-13	布里斯托尔-迈尔斯斯奎布药品公司	作为Aβ－蛋白生产抑制剂的环状内酰胺
EP1268434A1 (de)	2000-04-03	2003-01-02	Bristol-Myers Squibb Pharma Company	Zyklische lactame als a-beta proteinproduktionsinhibitoren
WO2001077086A1 (en)	2000-04-11	2001-10-18	Dupont Pharmaceuticals Company	SUBSTITUTED LACTAMS AS INHIBITORS OF Aβ PROTEIN PRODUCTION
AR028606A1 (es) *	2000-05-24	2003-05-14	Smithkline Beecham Corp	Nuevos inhibidores de mmp-2/mmp-9
CN1386118A (zh)	2000-06-01	2002-12-18	布里斯托尔-迈尔斯斯奎布药品公司	作为Aβ蛋白产生抑制剂的被环状琥珀酸酯取代的内酰胺类化合物
WO2002028829A2 (en) *	2000-09-25	2002-04-11	Questcor Pharmaceuticals, Inc.	Peptide deformylase inhibitors
US20050112261A1 (en) *	2003-11-21	2005-05-26	Davis Robert J.	Churros and method for making same
KR101155335B1 (ko) *	2005-01-07	2012-06-11	엘지전자 주식회사	이동통신 단말기의 멀티미디어 메시지 동작방법
AU2007287645B2 (en)	2006-08-21	2012-11-08	F. Hoffmann-La Roche Ag	DI-aromatic substituted amides as inhibitors for GlyT1

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2058797A1 (en) *	1991-02-01	1992-08-02	Michael John Broadhurst	Amino acid derivatives
AU666727B2 (en) *	1992-06-25	1996-02-22	F. Hoffmann-La Roche Ag	Hydroxamic acid derivatives
GB9215665D0 (en) *	1992-07-23	1992-09-09	British Bio Technology	Compounds
GB9223904D0 (en) *	1992-11-13	1993-01-06	British Bio Technology	Inhibition of cytokine production
AU671724B2 (en) *	1993-03-16	1996-09-05	British Biotech Pharmaceuticals Limited	Hydroxamic acid derivatives as metalloproteinase inhibitors
EP0712390B1 (de) *	1993-08-02	1998-12-09	Celltech Therapeutics Limited	Succinamid-derivate, verfahren zu ihrer herstellung und ihre verwendung als gelatinase- und collagenase- inhibitoren
PT822186E (pt) *	1994-01-20	2000-08-31	British Biotech Pharm	L-tert-leucina-2-piridilamida

1995
- 1995-04-18 GB GBGB9507799.6A patent/GB9507799D0/en active Pending
1996
- 1996-04-18 ES ES96910138T patent/ES2150116T3/es not_active Expired - Lifetime
- 1996-04-18 AT AT96910138T patent/ATE195723T1/de not_active IP Right Cessation
- 1996-04-18 JP JP8531572A patent/JPH11503748A/ja active Pending
- 1996-04-18 EP EP96910104A patent/EP0821666B1/de not_active Expired - Lifetime
- 1996-04-18 ES ES96910104T patent/ES2153959T3/es not_active Expired - Lifetime
- 1996-04-18 JP JP8531557A patent/JPH11503746A/ja active Pending
- 1996-04-18 WO PCT/GB1996/000930 patent/WO1996033161A1/en not_active Ceased
- 1996-04-18 EP EP96910138A patent/EP0821668B1/de not_active Expired - Lifetime
- 1996-04-18 AU AU53436/96A patent/AU5343696A/en not_active Abandoned
- 1996-04-18 DE DE69611360T patent/DE69611360T2/de not_active Expired - Fee Related
- 1996-04-18 DE DE69609957T patent/DE69609957T2/de not_active Expired - Fee Related
- 1996-04-18 AT AT96910104T patent/ATE198319T1/de not_active IP Right Cessation
- 1996-04-18 US US08/930,619 patent/US5840939A/en not_active Expired - Fee Related
- 1996-04-18 US US08/930,620 patent/US5908851A/en not_active Expired - Fee Related
- 1996-04-18 WO PCT/GB1996/000965 patent/WO1996033165A1/en not_active Ceased

Also Published As

Publication number	Publication date
DE69609957D1 (de)	2000-09-28
WO1996033161A1 (en)	1996-10-24
WO1996033165A1 (en)	1996-10-24
ATE198319T1 (de)	2001-01-15
EP0821668B1 (de)	2000-08-23
US5908851A (en)	1999-06-01
EP0821668A1 (de)	1998-02-04
ES2150116T3 (es)	2000-11-16
ES2153959T3 (es)	2001-03-16
DE69609957T2 (de)	2001-03-01
JPH11503748A (ja)	1999-03-30
EP0821666B1 (de)	2000-12-27
DE69611360D1 (de)	2001-02-01
EP0821666A1 (de)	1998-02-04
US5840939A (en)	1998-11-24
GB9507799D0 (en)	1995-05-31
DE69611360T2 (de)	2001-06-13
JPH11503746A (ja)	1999-03-30
AU5343696A (en)	1996-11-07

Legal Events

Date	Code	Title	Description
2001-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE195723T1 (de)	2000-09-15	Succinamid-derivate und ihre verwendung als metalloproteinaseinhibitoren
ATE326448T1 (de)	2006-06-15	Arylpiperazin-derivate und ihre verwendung als metalloproteinase hemmende wirkstoffe (mmp)
ATE164837T1 (de)	1998-04-15	Acetamidderivate und ihre verwendung als modifizierungsmittel des verhaltens der verdauung
FI971412A0 (fi)	1997-04-04	Peptididyyliyhdisteet ja niiden terapeuttinen käyttö metalloproteaasien estäjinä
ATE204857T1 (de)	2001-09-15	Meta-substituierte phenylenderivate und ihre verwendung als alphavbeta3 intergrin-antagonisten oder inhibitoren
PT100606A (pt)	1993-08-31	Derivados fluoroalcoxibenzilamino de heterociclos contendo azoto
ATE188472T1 (de)	2000-01-15	4-arylmethyloxymethyl piperidine als tachykinin antagonisten
TR200200381T2 (tr)	2002-05-21	Pirimidin-2,4,6-Trion Metalloproteinaz İnhibitorler.
DE69835430D1 (de)	2006-09-14	Sulfonamidderivate, ihre herstellung und verwendung
TR199802344A2 (xx)	1999-06-21	�kame edilmi� imidazolidin t�revleri
EP1318811A4 (de)	2004-07-14	Cyclopentylmodulatoren der chemokin-rezeptor-aktivität
DK0677046T3 (da)	1997-09-01	Piperazinderivater som 5-HT-antagonister.
DE69433984D1 (de)	2004-10-14	Arylpiperazinderivate von indol als liganden der rezeptoren 5 ht1-like, 5 ht1b und 5 ht1d
DE69924292D1 (de)	2005-04-21	Pyrazol verbindungen und ihre verwendung
NO944892D0 (no)	1994-12-16	N-substituerte 3-azabicyklo (3.2.0) hepatanderivater som neuroleptika osv.
MX9303605A (es)	1993-12-01	Derivados de azabicicloheptano n-substituidas, su obtencion y uso.
DK0720598T3 (da)	1999-06-21	Phenoxyphenylcyclopentenyl-hydroxyurinstoffer
ATE145206T1 (de)	1996-11-15	Oxindol 1-(n-(alkoxycarbonyl)>carboxamide und 1- (n-carboxamido>carboxamide als antiinflammatorische wirkstoffe
ATE158301T1 (de)	1997-10-15	4-aza-pregnan-5-alpha-reductase isozym 1 inhibitoren
ATE214692T1 (de)	2002-04-15	Metalloproteinase-inhibitoren
ATE189886T1 (de)	2000-03-15	Synthese von carbonsäurederivaten
EP1325918A4 (de)	2004-03-10	Herzmuskelzellen-apoptose hemmstoffe und behandlung/vorbeugung von herzkrankheiten
ATE177098T1 (de)	1999-03-15	Mercaptoacetylamid disulfidderivate als enkephalinase und ace inhibitoren
ATE196134T1 (de)	2000-09-15	Substituierte chinolinderivate, und ihre verwendung als inhibitoren der magensekretion
DK0687257T3 (da)	1997-08-18	4-amino-2-(hetero)aryl-butanamider anvendelige som 5HT1A-antagonister