ATE195808T1 - Neue konjugate und testverfahren für die gleichzeitige bestimmung von multiplen liganden - Google Patents

Neue konjugate und testverfahren für die gleichzeitige bestimmung von multiplen liganden

Info

Publication number
ATE195808T1
ATE195808T1 AT92911465T AT92911465T ATE195808T1 AT E195808 T1 ATE195808 T1 AT E195808T1 AT 92911465 T AT92911465 T AT 92911465T AT 92911465 T AT92911465 T AT 92911465T AT E195808 T1 ATE195808 T1 AT E195808T1
Authority
AT
Austria
Prior art keywords
binding
test methods
simultaneous determination
multiple ligands
binding domains
Prior art date
Application number
AT92911465T
Other languages
English (en)
Inventor
Gunars Edwin Valkirs
Original Assignee
Biosite Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biosite Diagnostics Inc filed Critical Biosite Diagnostics Inc
Application granted granted Critical
Publication of ATE195808T1 publication Critical patent/ATE195808T1/de

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306Solid-phase reaction mechanisms
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
AT92911465T 1991-04-12 1992-04-07 Neue konjugate und testverfahren für die gleichzeitige bestimmung von multiplen liganden ATE195808T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68508491A 1991-04-12 1991-04-12
PCT/US1992/002839 WO1992018866A1 (en) 1991-04-10 1992-04-07 Novel conjugates and assays for simultaneous detection of multiple ligands

Publications (1)

Publication Number Publication Date
ATE195808T1 true ATE195808T1 (de) 2000-09-15

Family

ID=24750715

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92911465T ATE195808T1 (de) 1991-04-12 1992-04-07 Neue konjugate und testverfahren für die gleichzeitige bestimmung von multiplen liganden

Country Status (11)

Country Link
US (1) US5851776A (de)
EP (1) EP0579767B1 (de)
JP (1) JP3290988B2 (de)
AT (1) ATE195808T1 (de)
AU (1) AU1911592A (de)
CA (1) CA2107899A1 (de)
DE (1) DE69231382T2 (de)
ES (1) ES2150915T3 (de)
FI (1) FI934438A7 (de)
NO (1) NO933582L (de)
WO (1) WO1992018866A1 (de)

Families Citing this family (197)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2132342A1 (en) * 1992-04-06 1993-10-14 Kenneth F. Buechler Novel opiate derivatives and protein and polypeptide opiate derivative conjugates and labels
US5470997A (en) * 1992-04-06 1995-11-28 Biosite Diagnostics Incorporated Amphetamine derivatives and protein and polypeptide amphetamine derivative conjugates and labels
CA2096495C (en) * 1992-06-16 2002-07-09 Kathy Palmer Ordonez Dual analyte immunoassay
US6037455A (en) * 1992-11-09 2000-03-14 Biosite Diagnostics Incorporated Propoxyphene derivatives and protein and polypeptide propoxyphene derivative conjugates and labels
US5804452A (en) * 1995-04-27 1998-09-08 Quidel Corporation One step urine creatinine assays
US5965375A (en) * 1997-04-04 1999-10-12 Biosite Diagnostics Diagnostic tests and kits for Clostridium difficile
DE19859912C2 (de) * 1998-12-23 2001-06-21 Aventis Res & Tech Gmbh & Co Testsystem zur Erkennung verschiedener Marker, seine Herstellung sowie Verwendung
EP1294749A2 (de) * 2000-03-09 2003-03-26 Heska Corporation Rekombinanten antigenen zur bestimmung des immun-zustandes eines tieres
US20020110843A1 (en) * 2000-05-12 2002-08-15 Dumas David P. Compositions and methods for epitope mapping
US7981420B2 (en) 2000-12-22 2011-07-19 Max-Planck-Gesellschaft Zur Foederung Der Wissenschaften E.V. Therapeutic use of antibodies directed against repulsive guidance molecule (RGM)
US20030219734A1 (en) * 2001-04-13 2003-11-27 Biosite Incorporated Polypeptides related to natriuretic peptides and methods of their identification and use
US20030199000A1 (en) * 2001-08-20 2003-10-23 Valkirs Gunars E. Diagnostic markers of stroke and cerebral injury and methods of use thereof
US7524635B2 (en) * 2003-04-17 2009-04-28 Biosite Incorporated Methods and compositions for measuring natriuretic peptides and uses thereof
US7632647B2 (en) 2001-04-13 2009-12-15 Biosite Incorporated Use of B-type natriuretic peptide as a prognostic indicator in acute coronary syndromes
US20040253637A1 (en) * 2001-04-13 2004-12-16 Biosite Incorporated Markers for differential diagnosis and methods of use thereof
US20040126767A1 (en) * 2002-12-27 2004-07-01 Biosite Incorporated Method and system for disease detection using marker combinations
US7713705B2 (en) * 2002-12-24 2010-05-11 Biosite, Inc. Markers for differential diagnosis and methods of use thereof
US20040121350A1 (en) * 2002-12-24 2004-06-24 Biosite Incorporated System and method for identifying a panel of indicators
US20040203083A1 (en) * 2001-04-13 2004-10-14 Biosite, Inc. Use of thrombus precursor protein and monocyte chemoattractant protein as diagnostic and prognostic indicators in vascular diseases
EP1322957B1 (de) * 2001-05-04 2009-08-12 Biosite Incorporated Diagnostische marker für akute herzerkrankungen und verfahren des gebrauchs
DE10125258A1 (de) 2001-05-23 2003-01-09 November Ag Molekulare Medizin Verfahren zur Bestimmung des Bindeverhaltens von an Ziel-Molekülen spezifisch bindenden Liganden
DE60233949D1 (de) * 2001-08-20 2009-11-19 Biosite Inc Diagnostische marker für schlaganfall und hirntrauma sowie verfahren zur verwendung davon
US6780602B2 (en) * 2001-11-01 2004-08-24 Microbiosystems, Limited Partnership Taxonomic identification of pathogenic microorganisms and their toxic proteins
US7459127B2 (en) 2002-02-26 2008-12-02 Siemens Healthcare Diagnostics Inc. Method and apparatus for precise transfer and manipulation of fluids by centrifugal and/or capillary forces
US7094354B2 (en) 2002-12-19 2006-08-22 Bayer Healthcare Llc Method and apparatus for separation of particles in a microfluidic device
US7125711B2 (en) 2002-12-19 2006-10-24 Bayer Healthcare Llc Method and apparatus for splitting of specimens into multiple channels of a microfluidic device
US7341838B2 (en) 2003-04-17 2008-03-11 Biosite Incorporated Polypeptides related to natriuretic peptides and methods of their identification and use
US7435381B2 (en) 2003-05-29 2008-10-14 Siemens Healthcare Diagnostics Inc. Packaging of microfluidic devices
US20040265171A1 (en) * 2003-06-27 2004-12-30 Pugia Michael J. Method for uniform application of fluid into a reactive reagent area
US7347617B2 (en) 2003-08-19 2008-03-25 Siemens Healthcare Diagnostics Inc. Mixing in microfluidic devices
US20050164238A1 (en) * 2003-09-29 2005-07-28 Biosite, Inc. Methods and compositions for the diagnosis of sepsis
US20050130243A1 (en) * 2003-12-15 2005-06-16 Zheng Yi F. Assay for entactogens
US6991911B2 (en) * 2003-12-15 2006-01-31 Dade Behring Inc. Assay for entactogens
US7022492B2 (en) * 2003-12-15 2006-04-04 Dade Behring Inc. Ecstasy haptens and immunogens
US7115383B2 (en) * 2004-03-22 2006-10-03 Dade Behring Inc. Assays for amphetamine and methamphetamine
US7037669B2 (en) * 2004-03-22 2006-05-02 Dade Behring Inc. Assays for amphetamine and methamphetamine using stereospecific reagents
WO2006031583A2 (en) * 2004-09-09 2006-03-23 Biosite Incorporated Methods and compositions for measuring canine bnp and uses thereof
US20080050832A1 (en) * 2004-12-23 2008-02-28 Buechler Kenneth F Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes
WO2006078813A2 (en) * 2005-01-21 2006-07-27 Biosite Incorporated Arginine analogs, and methods for their synthesis and use
US7939342B2 (en) * 2005-03-30 2011-05-10 Kimberly-Clark Worldwide, Inc. Diagnostic test kits employing an internal calibration system
EP1715341B1 (de) * 2005-04-04 2008-02-27 Micronas Holding GmbH Verfahren und Vorrichtung zum Bestimmen der Konzentrationen von mindestens zwei Liganden
US20070087453A1 (en) * 2005-10-19 2007-04-19 Council Of Scientific And Industrial Research Immuno conjugate and process for preparation thereof
WO2007028070A2 (en) * 2005-08-30 2007-03-08 Biosite, Inc. Use of soluble flt-1 and its fragments in cardiovascular conditions
EP1928905B1 (de) 2005-09-30 2015-04-15 AbbVie Deutschland GmbH & Co KG Bindungsdomänen von proteinen der repulsive guidance molecule (rgm) proteinfamilie und funktionale fragmente davon sowie deren verwendung
WO2007103568A2 (en) * 2006-03-09 2007-09-13 Biosite, Inc. Methods and compositions for the diagnosis of diseases of the aorta
EP1845377A1 (de) 2006-04-10 2007-10-17 Micronas GmbH Verfahren und Vorrichtung zum Bestimmen der Konzentrationen von Liganden
US20080118924A1 (en) * 2006-05-26 2008-05-22 Buechler Kenneth F Use of natriuretic peptides as diagnostic and prognostic indicators in vascular diseases
GB0611116D0 (en) 2006-06-06 2006-07-19 Oxford Genome Sciences Uk Ltd Proteins
ATE528411T1 (de) 2006-06-07 2011-10-15 Otago Innovation Ltd Diagnoseverfahren und -marker
EP2049902A4 (de) * 2006-07-28 2010-09-01 Biosite Inc Vorrichtung und verfahren zur durchführung von rezeptorbindungstests mithilfe magnetischer partikel
WO2008030122A1 (en) 2006-09-07 2008-03-13 University Of Otago Biomarkers
DE502006005987D1 (de) * 2006-10-20 2010-03-11 Micronas Holding Gmbh Verfahren und Vorrichtung zum Bestimmen der Konzentrationen von Liganden
WO2008060607A2 (en) 2006-11-14 2008-05-22 Biosite Incorporated Methods and compositions for monitoring and risk prediction in cardiorenal syndrome
EP2095106B1 (de) * 2006-11-14 2013-03-20 Alere San Diego, Inc. Verfahren und zusammensetzungen zur diagnose und prognose von nierenarterienstenose
US8221995B2 (en) * 2007-03-23 2012-07-17 Seok-Won Lee Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes
US20090004755A1 (en) * 2007-03-23 2009-01-01 Biosite, Incorporated Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes
US7947465B2 (en) * 2007-08-20 2011-05-24 Bio-Rad Laboratories, Inc. Simultaneous assay for determining drugs
US20090053832A1 (en) * 2007-08-20 2009-02-26 Link William F Simultaneous assay for determining drugs
US8962803B2 (en) 2008-02-29 2015-02-24 AbbVie Deutschland GmbH & Co. KG Antibodies against the RGM A protein and uses thereof
JP2011516038A (ja) 2008-03-12 2011-05-26 オタゴ イノベーション リミテッド バイオマーカー
AU2009224113B2 (en) * 2008-03-12 2013-02-21 Otago Innovation Limited Biomarkers
NZ610356A (en) 2008-08-28 2015-03-27 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CA2735590A1 (en) 2008-08-29 2010-03-04 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
NZ607703A (en) 2008-10-21 2014-09-26 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
WO2010048347A2 (en) 2008-10-21 2010-04-29 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CN102264230B (zh) 2008-11-10 2014-12-10 阿斯图特医药公司 用于诊断和预后肾损伤和肾衰竭的方法和组合物
MX2011005379A (es) 2008-11-22 2011-06-09 Astute Medical Inc Metodos y composiciones para diagnosis y prognosis de lesion renal y falla renal.
US20100204055A1 (en) * 2008-12-05 2010-08-12 Bonner-Ferraby Phoebe W Autoantibody detection systems and methods
EP2394166B1 (de) 2009-02-06 2016-07-13 Astute Medical, Inc. Verfahren zur diagnose und prognose von nierenläsion und niereninsuffizienz
EP2393934A4 (de) 2009-02-06 2012-08-29 Astute Medical Inc Diagnose und prognose von nierenläsion und niereninsuffizienz
WO2011006119A2 (en) 2009-07-09 2011-01-13 The Scripps Research Institute Gene expression profiles associated with chronic allograft nephropathy
CA2770393A1 (en) 2009-08-07 2011-02-10 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CA2770382A1 (en) 2009-08-07 2011-02-10 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
NZ598712A (en) 2009-08-28 2014-05-30 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EA201290106A1 (ru) 2009-09-18 2012-12-28 Астьют Медикал, Инк. Способы и композиции для диагностики и прогнозирования повреждения почек и почечной недостаточности
NZ630277A (en) 2009-09-21 2015-02-27 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP2496942B1 (de) 2009-11-07 2017-03-22 Astute Medical, Inc. Verfahren und zusammensetzungen zur diagnose und prognose von nierenverletzungen und niereninsuffizienz
CA2779905A1 (en) 2009-11-07 2011-05-12 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
MX2012006560A (es) 2009-12-08 2012-10-05 Abbott Gmbh & Co Kg Anticuerpos monoclonales contra la proteina rgm a para utilizarse en el tratamiento de degeneracion de capa de fibra de nervio retinal.
JP5763098B2 (ja) 2009-12-20 2015-08-12 アスチュート メディカル,インコーポレイテッド 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物
PT2666872T (pt) 2010-02-05 2016-07-08 Astute Medical Inc Processos e composições para o diagnóstico e o prognóstico de lesões renais e de insuficiência renal
AU2011213685B2 (en) 2010-02-05 2014-10-30 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP2531622B1 (de) 2010-02-05 2016-04-06 Astute Medical, Inc. Verfahren und zusammensetzungen zur diagnose und prognose von nierenverletzungen und niereninsuffizienz
EP3070474A3 (de) 2010-02-26 2016-12-07 Astute Medical, Inc. Verfahren und zusammensetzungen zur diagnose und prognose von nierenläsion und niereninsuffizienz
WO2011129382A1 (en) 2010-04-16 2011-10-20 Abbott Japan Co. Ltd. Methods and reagents for diagnosing rheumatoid arthritis
IN2012MN02812A (de) 2010-06-23 2015-05-22 Astute Medical Inc
EP2899545B1 (de) 2010-06-23 2018-08-22 Astute Medical, Inc. Verfahren zur diagnose und prognose von nierenläsion und niereninsuffizienz
NZ605698A (en) 2010-06-23 2015-03-27 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
DK2596010T3 (en) 2010-07-19 2017-07-31 Otago Innovation Ltd SIGNAL biomarkers
EA201390294A1 (ru) 2010-09-24 2013-09-30 Астьют Медикал, Инк. Способы и композиции для оценки повреждения почек с применением гиалуроновой кислоты
US10557856B2 (en) 2010-09-24 2020-02-11 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Biomarkers of renal injury
CA2811438A1 (en) 2010-10-07 2012-04-12 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CN103370619B (zh) 2010-11-29 2016-01-20 美艾利尔圣地亚哥有限公司 诊断或风险预测心力衰竭的方法和试剂
CA2824434A1 (en) 2011-01-08 2012-07-12 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP2668497B1 (de) 2011-01-26 2020-03-25 University of Pittsburgh - Of the Commonwealth System of Higher Education Urinbiomarker zur vorhersage der erholung nach einer akuten nierenverletzung: proteomik
EP2668499A4 (de) 2011-01-29 2015-05-27 Astute Medical Inc Verfahren und zusammensetzungen zur diagnose und prognose von nierenverletzungen und niereninsuffizienz
CN103874923B (zh) 2011-08-26 2016-09-14 阿斯图特医药公司 用于肾损伤和肾衰竭的诊断及预后的方法和组合物
EP3282257A1 (de) 2011-11-22 2018-02-14 Astute Medical, Inc. Verfahren und zusammensetzungen zur diagnose und prognose von nierenläsion und niereninsuffizienz
ES2734494T3 (es) 2011-12-08 2019-12-10 Astute Medical Inc Métodos y usos para el diagnóstico de una lesión renal y de una insuficiencia renal
CA2855570A1 (en) 2011-12-14 2013-06-20 AbbVie Deutschland GmbH & Co. KG Composition and method for the diagnosis and treatment of iron-related disorders
CA3204283A1 (en) 2011-12-14 2013-06-20 AbbVie Deutschland GmbH & Co. KG Composition and method for the diagnosis and treatment of iron-related disorders
EP3369746A1 (de) 2012-01-27 2018-09-05 AbbVie Deutschland GmbH & Co KG Zusammensetzung und verfahren zur diagnose und behandlung von krankheiten im zusammenhang mit neuritenabbau
EP2820419B1 (de) 2012-02-27 2020-12-09 Astute Medical, Inc. Verfahren und zusammensetzungen zur diagnose und prognose von nierenläsion und niereninsuffizienz
AU2013231230A1 (en) 2012-03-13 2014-08-07 AbbVie Deutschland GmbH & Co. KG Method for selecting or identifying a subject for V1B antagonist therapy
US10114028B2 (en) 2012-03-20 2018-10-30 Upstream Medical Technologies Limited Biomarkers for pneumonia and acute decompensated heart failure
EP2834638B1 (de) 2012-04-02 2020-02-12 Astute Medical, Inc. Verfahren zur diagnose und prognose von sepsis
WO2013163345A1 (en) 2012-04-24 2013-10-31 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of stroke or other cerebral injury
WO2014018464A1 (en) 2012-07-23 2014-01-30 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of sepsis
WO2014028339A1 (en) 2012-08-11 2014-02-20 Astute Medical, Inc. Evaluating renal injury using hyaluronic acid
TR201807542T4 (tr) 2013-01-17 2018-06-21 Astute Medical Inc Böbrek hasarı ve böbrek yetmezliği teşhisi ve prognozuna yönelik metotlar ve bileşimler.
CN105916860A (zh) 2013-03-14 2016-08-31 美艾利尔圣地亚哥公司 6-单乙酰吗啡类似物的合成和使用方法
US9469686B2 (en) 2013-03-15 2016-10-18 Abbott Laboratories Anti-GP73 monoclonal antibodies and methods of obtaining the same
CN105556305A (zh) 2013-06-05 2016-05-04 阿斯图特医药公司 用于肾损伤和肾衰竭的诊断及预后的方法和组合物
US10183988B2 (en) 2013-06-07 2019-01-22 Duke University Anti-Complement factor H antibodies
EP3617234A1 (de) 2013-08-07 2020-03-04 Astute Medical, Inc. Tests auf timp2 mit verbesserter leistung bei biologischen proben
EP4736949A2 (de) 2013-08-23 2026-05-06 Reata Pharmaceuticals Holdings, LLC Verfahren zur behandlung und vorbeugung einer endothelfehlfunktion unter verwendung von bardoxolonmethyl oder analogen davon
WO2015031626A1 (en) 2013-08-28 2015-03-05 Abbvie Inc. Soluble cmet assay
WO2015179773A1 (en) 2014-05-22 2015-11-26 The Scripps Research Institute Tissue molecular signatures of kidney transplant rejections
EP3047270A4 (de) 2013-09-20 2017-07-19 Astute Medical, Inc. Verfahren und zusammensetzungen zur diagnose und prognose von appendizitis und differenzierung von ursachen für bauchschmerzen
US9822172B2 (en) 2013-11-06 2017-11-21 Astute Medical, Inc. Assays for IGFBP7 having improved performance in biological samples
US10300108B2 (en) 2013-12-03 2019-05-28 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP3090067B1 (de) 2013-12-30 2020-07-22 The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. Genomische neuanordnungen im zusammenhang mit prostatakrebs und verfahren zur verwendung davon
AU2015263998A1 (en) 2014-05-22 2016-12-08 Northwestern University Gene expression profiles associated with sub-clinical kidney transplant rejection
US10443100B2 (en) 2014-05-22 2019-10-15 The Scripps Research Institute Gene expression profiles associated with sub-clinical kidney transplant rejection
EP3146076A4 (de) 2014-05-22 2018-05-09 The Scripps Research Institute Mit subklinischer nierentransplantatabstossung assoziierte genexpressionsprofile
US11104951B2 (en) 2014-05-22 2021-08-31 The Scripps Research Institute Molecular signatures for distinguishing liver transplant rejections or injuries
GB2528657B (en) * 2014-07-24 2019-03-13 Intelligent Fingerprinting Ltd Sample analysing device
CN107003301B (zh) 2014-10-20 2019-11-01 阿斯图特医药公司 用于诊断和预后肾损伤和肾衰竭的方法和组合物
US10473671B2 (en) 2014-12-18 2019-11-12 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US11243202B2 (en) 2015-04-09 2022-02-08 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
HK1249467A1 (zh) 2015-05-12 2018-11-02 阿斯图特医药公司 用於肾损伤和肾衰竭的诊断和预後的方法和组合物
CN107709993A (zh) 2015-06-11 2018-02-16 阿斯图特医药公司 用于肾损伤和肾衰竭的诊断和预后的方法和组合物
US20180224466A1 (en) 2015-06-17 2018-08-09 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of appendicitis and differentiation of causes of abdominal pain
AU2016291558A1 (en) 2015-07-10 2018-02-08 West Virginia University Markers of stroke and stroke severity
EP3359558B1 (de) 2015-10-06 2023-12-13 Bio-Rad Laboratories, Inc. Immunoassays für borrelia und materialien dafür
CA3024622A1 (en) 2016-05-18 2017-11-23 Alere San Diego, Inc. 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine analogs and methods for their synthesis and use
EP3465201A4 (de) 2016-06-06 2020-08-26 Astute Medical, Inc. Verwaltung von akuter nierenverletzung mit insulinähnlichem wachstumsfaktorbindendem protein 7 und gewebehemmer der metalloproteinase 2
NL2017267B1 (en) 2016-07-29 2018-02-01 Aduro Biotech Holdings Europe B V Anti-pd-1 antibodies
CN110383068A (zh) 2016-10-03 2019-10-25 雅培实验室 评估患者样品中uch-l1状态的改进方法
WO2018067730A1 (en) 2016-10-04 2018-04-12 University Of Maryland, Baltimore Methods of treating sepsis using anti-sepsis lipid a (asla) based therapeutics
CN110198718B (zh) 2016-11-08 2023-01-10 里亚塔医药控股有限责任公司 使用甲基巴多索隆或其类似物治疗阿尔波特综合征的方法
JP2020504157A (ja) 2017-01-12 2020-02-06 アスチュート メディカル,インコーポレイテッド C−cモチーフケモカインリガンド14の測定に基づく腎損傷および腎不全の評価および処置のための方法および組成物
EP3593134A1 (de) 2017-03-09 2020-01-15 Cleara Biotech B.V. Biomarker für zellalterung
CA3261113A1 (en) 2017-03-23 2025-10-27 Abbott Laboratories Methods for aiding in the diagnosis and determination of the extent of traumatic brain injury in a human subject using the early biomarker ubiquitin carboxy-terminal hydrolase l1
WO2018191531A1 (en) 2017-04-15 2018-10-18 Abbott Laboratories Methods for aiding in the hyperacute diagnosis and determination of traumatic brain injury in a human subject using early biomarkers
ES3053676T3 (en) 2017-04-28 2026-01-23 Abbott Lab Methods for aiding in the hyperacute diagnosis and determination of traumatic brain injury using early biomarkers on at least two samples from the same human subject
US10865238B1 (en) 2017-05-05 2020-12-15 Duke University Complement factor H antibodies
WO2018208684A1 (en) 2017-05-07 2018-11-15 Astute Medical, Inc. Use of insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinase 2 in the management of renal replacement therapy
US10866251B2 (en) 2017-05-25 2020-12-15 Abbott Laboratories Methods for aiding in the determination of whether to perform imaging on a human subject who has sustained or may have sustained an injury to the head using early biomarkers
JP7269182B2 (ja) 2017-05-30 2023-05-08 アボット・ラボラトリーズ 心臓トロポニンi及び早期バイオマーカーを使用する、ヒト対象における軽度外傷性脳損傷を診断及び査定する一助となるための方法
US11169159B2 (en) 2017-07-03 2021-11-09 Abbott Laboratories Methods for measuring ubiquitin carboxy-terminal hydrolase L1 levels in blood
EP3721233A2 (de) 2017-12-09 2020-10-14 Abbott Laboratories Verfahren zur unterstützung bei der diagnose und bewertung eines patienten, der eine orthopädische verletzung erlitten hat und der eine verletzung des kopfes wie eine leichte traumatische hirnverletzung (tbi) hat oder möglicherweise erlitten hat, unter verwendung eines glialen fibrillären sauren proteins (gfap) und/oder einer ubiquitin-carboxy-terminalen hydrolase l1 (uch-l1)
JP7379165B2 (ja) 2017-12-09 2023-11-14 アボット・ラボラトリーズ Gfapとuch-l1との組合せを使用する、ヒト対象における外傷性脳損傷を診断及び査定する一助となるための方法
US11891439B2 (en) 2017-12-28 2024-02-06 Astute Medical, Inc. Antibodies and assays for CCL14
CN111699391A (zh) 2017-12-29 2020-09-22 雅培实验室 用于诊断和评估创伤性脑损伤的新型生物标志物和方法
EP3759213B1 (de) 2018-03-02 2026-04-29 Quantumcyte, Inc. Verfahren, zusammensetzungen und vorrichtungen zur isolierung und expressionsanalyse von interessierenden regionen aus einem gewebe
WO2019213619A1 (en) 2018-05-04 2019-11-07 Abbott Laboratories Hbv diagnostic, prognostic, and therapeutic methods and products
WO2020051231A1 (en) 2018-09-04 2020-03-12 H. Lee Moffitt Cancer Center & Research Institute Inc. Use of delta-tocotrienol for treating cancer
US12061200B2 (en) 2018-12-28 2024-08-13 Abbott Laboratories Direct detection of single molecules on microparticles
WO2020144535A1 (en) 2019-01-08 2020-07-16 Aduro Biotech Holdings, Europe B.V. Methods and compositions for treatment of multiple myeloma
EP3931573A1 (de) 2019-03-01 2022-01-05 Abbott Laboratories Verfahren zur vorhersage von schwerwiegenden kardiovaskulären ereignissen bei patienten mit koronararterienerkrankung
US12582726B1 (en) 2019-04-05 2026-03-24 Earli Inc. Synthetic cancer-specific promoters
JP2022527629A (ja) 2019-04-05 2022-06-02 アーリー・インコーポレイテッド 合成バイオマーカーのための改良された方法及び組成物
EP4136459A1 (de) 2020-04-13 2023-02-22 Abbott Laboratories Verfahren, komplexe und kits zum nachweis oder zur bestimmung einer menge eines ss-coronavirus-antikörpers in einer probe
BR112022022599A2 (pt) 2020-05-09 2023-03-21 Reata Pharmaceuticals Holdings Llc Métodos de tratamento de covid-19 usando bardoxolona metil ou análogos da mesma
KR20230012539A (ko) 2020-05-13 2023-01-26 디스크 메디슨, 인크. 골수섬유증을 치료하기 위한 항-헤모주벨린 (hjv) 항체
EP4158352A1 (de) 2020-06-01 2023-04-05 Loop Diagnostics, S.L. Verfahren und kit zum frühen nachweis von sepsis
CA3188349A1 (en) 2020-08-04 2022-02-10 A. Scott Muerhoff Improved methods and kits for detecting sars-cov-2 protein in a sample
US11988671B2 (en) 2020-08-04 2024-05-21 Abbott Rapid Diagnostics International Unlimited Company Assays for detecting SARS-CoV-2
US20220170948A1 (en) 2020-12-01 2022-06-02 Abbott Laboratories Use of one or more biomarkers to determine traumatic brain injury (tbi) in a human subject having received a head computerized tomography scan that is negative for a tbi
WO2023102384A1 (en) 2021-11-30 2023-06-08 Abbott Laboratories Use of one or more biomarkers to determine traumatic brain injury (tbi) in a subject having received a head computerized tomography scan that is negative for a tbi
AU2021397631A1 (en) 2020-12-11 2023-07-20 Reata Pharmaceuticals Holdings, LLC Synthetic triterpenoids for use in therapy
EP4271998A1 (de) 2020-12-30 2023-11-08 Abbott Laboratories Verfahren zur bestimmung des sars-cov-2-antigens und anti-sars-cov-2-antikörpers in einer probe
US20220381796A1 (en) 2021-05-18 2022-12-01 Abbott Laboratories Methods of evaluating brain injury in a pediatric subject
WO2022266034A1 (en) 2021-06-14 2022-12-22 Abbott Laboratories Methods of diagnosing or aiding in diagnosis of brain injury caused by acoustic energy, electromagnetic energy, an over pressurization wave, and/or blast wind
EP4392783A1 (de) 2021-08-27 2024-07-03 Abbott Laboratories Verfahren zum nachweis von immunoglobulin g, subklassen 4 (igg4) in einer biologischen probe
CN118715440A (zh) 2021-08-31 2024-09-27 雅培实验室 诊断脑损伤的方法和系统
JP2024534849A (ja) 2021-08-31 2024-09-26 アボット・ラボラトリーズ 脳の損傷を診断する方法及びシステム
JP2024538608A (ja) 2021-09-30 2024-10-23 アボット・ラボラトリーズ 脳の損傷を診断する方法及びシステム
EP4448179A1 (de) 2021-12-17 2024-10-23 Abbott Laboratories Systeme und verfahren zur bestimmung von uch-l1, gfap und anderen biomarkern in blutproben
JP2025503207A (ja) 2022-01-27 2025-01-30 サノフィ・パスツール 修飾されたVero細胞、及びウイルス産生にこれを使用する方法
WO2023150652A1 (en) 2022-02-04 2023-08-10 Abbott Laboratories Lateral flow methods, assays, and devices for detecting the presence or measuring the amount of ubiquitin carboxy-terminal hydrolase l1 and/or glial fibrillary acidic protein in a sample
KR20250018169A (ko) 2022-04-29 2025-02-04 브로드윙 바이오 엘엘씨 이중특이적 항체 및 안구 질환의 치료 방법
US20250296996A1 (en) 2022-04-29 2025-09-25 Broadwing Bio, Inc. Angiopoietin-related protein 7-specific antibodies and uses thereof
EP4514844A1 (de) 2022-04-29 2025-03-05 Broadwing Bio LLC Komplementfaktor-h-verwandte 4-spezifische antikörper und verwendungen davon
EP4587840A1 (de) 2022-09-15 2025-07-23 Abbott Laboratories Hbv-diagnostische, prognostische und therapeutische verfahren und produkte
JP2025532597A (ja) 2022-09-15 2025-10-01 アボット・ラボラトリーズ 軽度及び超軽度の外傷性脳損傷を区別するためのバイオマーカー及び方法
EP4658687A1 (de) 2023-01-31 2025-12-10 University of Rochester Immuncheckpoint-blockadetherapie zur behandlung von staphylococcus-aureus-infektionen
WO2024211475A1 (en) 2023-04-04 2024-10-10 Abbott Laboratories Use of biomarkers to determine whether a subject has sustained, may have sustained or is suspected of sustaining a subacute acquired brain injury (abi)
EP4713682A1 (de) 2023-04-28 2026-03-25 Abbott Point of Care Inc. Verbesserte tests, kartuschen und kits zum nachweis von biomarkern, einschliesslich biomarkern für hirnverletzungen
WO2024227154A1 (en) 2023-04-28 2024-10-31 Broadwing Bio Llc Complement component 3 (c3)-specific antibodies and uses thereof
WO2024231728A2 (en) 2023-05-05 2024-11-14 Bio-Rad Abd Serotec Gmbh Spycatcher analogs and uses thereof
US12122842B1 (en) 2023-09-27 2024-10-22 R&D Systems, Inc. Human CD30-specific binding proteins and uses thereof
WO2025111147A1 (en) 2023-11-21 2025-05-30 Abbott Laboratories Two-dimensional matrix droplet array
WO2026024666A1 (en) 2024-07-22 2026-01-29 Abbott Laboratories Systems and methods for digital detection assays
WO2026024668A1 (en) 2024-07-22 2026-01-29 Abbott Laboratories Method of determining a volume of a liquid in a sample
WO2026024677A1 (en) 2024-07-22 2026-01-29 Abbott Laboratories Method for determining the plasma volume of a blood sample and method for determining the dilution of plasma

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444878A (en) * 1981-12-21 1984-04-24 Boston Biomedical Research Institute, Inc. Bispecific antibody determinants
US4506009A (en) * 1982-03-30 1985-03-19 University Of California Heterogeneous immunoassay method
NL8501219A (nl) * 1985-04-29 1986-11-17 Stichting Vrienden Van De Stic Immunologisch complex, de bereiding en toepassing daarvan.
US4803170A (en) * 1985-05-09 1989-02-07 Ultra Diagnostics Corporation Competitive immunoassay method, device and test kit
US4853335A (en) * 1987-09-28 1989-08-01 Olsen Duane A Colloidal gold particle concentration immunoassay
US5028535A (en) * 1989-01-10 1991-07-02 Biosite Diagnostics, Inc. Threshold ligand-receptor assay

Also Published As

Publication number Publication date
DE69231382T2 (de) 2001-01-25
WO1992018866A1 (en) 1992-10-29
NO933582L (no) 1993-12-10
EP0579767A4 (de) 1995-05-17
FI934438A0 (fi) 1993-10-08
NO933582D0 (no) 1993-10-07
CA2107899A1 (en) 1992-10-11
FI934438L (fi) 1993-11-04
US5851776A (en) 1998-12-22
EP0579767B1 (de) 2000-08-23
JP3290988B2 (ja) 2002-06-10
DE69231382D1 (de) 2000-09-28
FI934438A7 (fi) 1993-11-04
JPH06507021A (ja) 1994-08-04
ES2150915T3 (es) 2000-12-16
AU1911592A (en) 1992-11-17
EP0579767A1 (de) 1994-01-26

Similar Documents

Publication Publication Date Title
ATE195808T1 (de) Neue konjugate und testverfahren für die gleichzeitige bestimmung von multiplen liganden
KR970074793A (ko) 올리고머화된 수용체를 사용한 결정 방법
ATE221997T1 (de) Immunoassays zum nachweis von antiphospholipid- antikörpern
DE69421582D1 (de) Verfahren für nicht-kompetitive Bindungsassays
EP0465266A1 (de) Immunoassay mit komplementärem sichtbaren Signal
DE68921650D1 (de) Immunoassays.
CA2007532A1 (en) Threshold ligand-receptor assay
DE69022286D1 (de) Reagenzien, Verfahren und Testsätze zum Nachweis von Amphetaminen durch einen Fluoreszenz-Polarisations-Immunoassay.
ATE22730T1 (de) Chromatographisches enzym-immunoverfahren.
SE7702464L (sv) Reagens till anvendning vid immunkemiska bestemningsmetoder
DK0930365T3 (da) Bindingsdomæner i Serrate-protein
ATE228247T1 (de) Testreagentien und testvorrichtungen
DE68926779D1 (de) Zusammensetzung und Methoden zur Bestimmung der Anwesenheit von Amphetaminen in einer Probe, die in Verdacht steht, Amphetamine und/oder Metamphetamine zu enthalten
ATE297554T1 (de) Verfahren zur besserung der wiederfindung troponin i und t
ES2141086T3 (es) Anticuerpos contra los ligando-analogos y su uso en los dosificados ligando-receptores.
KR900002075A (ko) 특이적으로 결합가능한 물질의 정량 방법 및 시약
ATE343597T1 (de) Diagnostisches assay für typ-2-heparin induzierte thrombocytopenie
DE69032489D1 (de) Ligand/antiligandteste für anklebende proteine
DE69018968D1 (de) BLUTGERINNUNGSFAKTOR BETA XIIa MONOKLONALE ANTIKÖRPER UND IMMUNANALYSE.
JPS63142267A (ja) 試料からの分析物を測定する方法および試験担体
KR930702680A (ko) 증폭된 불균질 화학발광 면역 검정법
ES2115750T3 (es) Ensayo de captura de proteinas de union.
DE68919294D1 (de) Bestätigender Nachweis für Chlamydia trachomatis.
DE69909312D1 (de) Methoden zur identifizierung von "hot-spot" resten bindender proteine und kleine verbindungen die an diese binden
CA2021658A1 (en) Multiplex immunoassay system

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties