ATE195930T1 - Verfahren zur trennung der chiralen säuren mittels 1-aminoindan-olen - Google Patents

Verfahren zur trennung der chiralen säuren mittels 1-aminoindan-olen

Info

Publication number: ATE195930T1
Authority: AT; Austria
Prior art keywords: disclosed; chiral; aminoindanolen; chiral acids; separating chiral
Prior art date: 1995-05-18

Application number

AT96914630T

Other languages

English (en)

Inventor

Eikeren Paul Van

Conville Francis X Mc

Jorge Lopez

Original Assignee

Sepracor Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-05-18

Filing date

1996-05-15

Publication date

2000-09-15

1996-05-15 Application filed by Sepracor Inc filed Critical Sepracor Inc

2000-09-15 Application granted granted Critical

2000-09-15 Publication of ATE195930T1 publication Critical patent/ATE195930T1/de

Links

239000002253 acid Substances 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 3
150000007513 acids Chemical class 0.000 title 1
150000003839 salts Chemical class 0.000 abstract 4
LOPKSXMQWBYUOI-UHFFFAOYSA-N 1-amino-2,3-dihydro-1h-inden-2-ol Chemical compound C1=CC=C2C(N)C(O)CC2=C1 LOPKSXMQWBYUOI-UHFFFAOYSA-N 0.000 abstract 1
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
150000001735 carboxylic acids Chemical class 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
SYTBZMRGLBWNTM-UHFFFAOYSA-N flurbiprofen Chemical compound FC1=CC(C(C(O)=O)C)=CC=C1C1=CC=CC=C1 SYTBZMRGLBWNTM-UHFFFAOYSA-N 0.000 abstract 1
229960002390 flurbiprofen Drugs 0.000 abstract 1
238000001640 fractional crystallisation Methods 0.000 abstract 1
229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 abstract 1
229960000991 ketoprofen Drugs 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
239000011707 mineral Substances 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000002243 precursor Substances 0.000 abstract 1
238000000926 separation method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/487—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B57/00—Separation of optically-active compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Oil, Petroleum & Natural Gas (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT96914630T 1995-05-18 1996-05-15 Verfahren zur trennung der chiralen säuren mittels 1-aminoindan-olen ATE195930T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/446,255 US5677469A (en)	1995-05-18	1995-05-18	Process for resolving chiral acids with 1-aminoindan-2-ols
PCT/US1996/006901 WO1996036584A1 (en)	1995-05-18	1996-05-15	Process for resolving chiral acids with 1-aminoindan-2-ols

Publications (1)

Publication Number	Publication Date
ATE195930T1 true ATE195930T1 (de)	2000-09-15

Family

ID=23771917

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96914630T ATE195930T1 (de)	1995-05-18	1996-05-15	Verfahren zur trennung der chiralen säuren mittels 1-aminoindan-olen

Country Status (12)

Country	Link
US (1)	US5677469A (de)
EP (1)	EP0828702B1 (de)
JP (1)	JPH11511742A (de)
AT (1)	ATE195930T1 (de)
AU (1)	AU700193B2 (de)
CA (1)	CA2221375A1 (de)
DE (1)	DE69610089T2 (de)
DK (1)	DK0828702T3 (de)
ES (1)	ES2152024T3 (de)
GR (1)	GR3034975T3 (de)
PT (1)	PT828702E (de)
WO (1)	WO1996036584A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6013830A (en) *	1998-03-30	2000-01-11	Sepracor Inc.	Asymmetric grignard synthesis with cyclic 1,2 aminoalcohols
EP1029846A1 (de) *	1999-02-17	2000-08-23	Sekhsaria Chemicals Ltd.	Racematspaltung von Alpha-Arylpropionsäuren
US6479702B1 (en)	2000-09-06	2002-11-12	Daicel Chemical Industries, Ltd.	3-amino-1-indanole, method of synthesizing the same and method of optical resolution
US20030027867A1 (en) *	2001-06-29	2003-02-06	Myriad Genetics, Incorporated	Use of R-NSAID compounds for anti-HIV treatment
ATE319668T1 (de) *	2003-04-09	2006-03-15	Servier Lab	Verfahren zur synthese von (2s)-indolin-2- carbonsäure, und verwendung in der synthese von perindopril
NZ597109A (en)	2007-03-29	2013-01-25	Daiichi Sankyo Co Ltd	Tablet composition having favorable dissolution property useful as an anticoagulant
BRPI0922434A2 (pt) *	2008-12-12	2015-12-15	Daiichi Sankyo Co Ltd	processo para produzir ácido carboxílico opticamente ativo
SI2371830T1 (sl)	2008-12-17	2014-01-31	Daiichi Sankyo Company, Limited	Postopek za pridobivanje diaminskih derivatov
EP2383272A4 (de)	2009-01-13	2012-07-25	Daiichi Sankyo Co Ltd	Aktiver blutgerinnungsfaktor-hemmer
WO2010104078A1 (ja)	2009-03-10	2010-09-16	第一三共株式会社	ジアミン誘導体の製造方法
WO2010104106A1 (ja)	2009-03-13	2010-09-16	第一三共株式会社	光学活性なジアミン誘導体の製造方法
MY155256A (en)	2009-06-18	2015-09-30	Daiichi Sankyo Co Ltd	Pharmaceutical composition having improved solubility
JP5390014B2 (ja)	2010-03-19	2014-01-15	第一三共株式会社	抗凝固剤の溶出改善方法
CN102791719B (zh)	2010-03-19	2015-07-29	第一三共株式会社	二胺衍生物的晶体及其制备方法
WO2011146873A1 (en)	2010-05-21	2011-11-24	Miller Brewing International, Inc.	Preparation of hop acids and their derivatives
CA2804262C (en)	2010-07-02	2016-04-05	Daiichi Sankyo Company, Limited	Process for preparation of optically active diamine derivative salt
WO2013021343A1 (en) *	2011-08-05	2013-02-14	Ranbaxy Laboratories Limited	Process for the optical resolution of () -3- (2 -benzyloxy- 5 - bromophenyl) - 3 - phenylpropionic
ES2673182T3 (es)	2011-08-10	2018-06-20	Daiichi Sankyo Company, Limited	Composición farmacéutica que contiene un derivado de diamina

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH641432A5 (de) *	1978-07-19	1984-02-29	Syntex Pharma Int	Verfahren zur aufspaltung von racemischer 6-methoxy-alpha-methyl-2-naphthalinessigsaeure in die optischen antipoden.
CA2023954C (en) *	1989-10-17	1999-05-04	Hiroyuki Nohira	Process for the optical resolution of 2-(3-benzoyl) phenylpropionic acid
US5015764A (en) *	1990-06-18	1991-05-14	Ethyl Corporation	Preparation of optically active aliphatic carboxylic acids
CA2052892A1 (en) *	1990-10-11	1992-04-12	Suresh K. Balani	Inhibitors of hiv protease
DE69206306T2 (de) *	1991-04-08	1996-06-13	Sumitomo Chemical Co	Optisch aktive Sekundär-Aminverbindung, Verfahren zur Herstellung einer optisch aktiven Sekundär-Aminverbindung und Verfahren zur Herstellung optisch aktiver Carbonsäure durch die Verwendung dieser Verbindung.
US5162576A (en) *	1991-04-15	1992-11-10	Ethyl Corporation	Resolution of ketoprofen
US5599985A (en) *	1993-09-14	1997-02-04	Sepracor, Inc.	Optically pure 1-amido-2-indanols

1995
- 1995-05-18 US US08/446,255 patent/US5677469A/en not_active Expired - Lifetime
1996
- 1996-05-15 AU AU57932/96A patent/AU700193B2/en not_active Ceased
- 1996-05-15 CA CA002221375A patent/CA2221375A1/en not_active Abandoned
- 1996-05-15 DE DE69610089T patent/DE69610089T2/de not_active Expired - Fee Related
- 1996-05-15 EP EP96914630A patent/EP0828702B1/de not_active Expired - Lifetime
- 1996-05-15 DK DK96914630T patent/DK0828702T3/da active
- 1996-05-15 ES ES96914630T patent/ES2152024T3/es not_active Expired - Lifetime
- 1996-05-15 WO PCT/US1996/006901 patent/WO1996036584A1/en not_active Ceased
- 1996-05-15 AT AT96914630T patent/ATE195930T1/de not_active IP Right Cessation
- 1996-05-15 PT PT96914630T patent/PT828702E/pt unknown
- 1996-05-15 JP JP8534990A patent/JPH11511742A/ja active Pending
2000
- 2000-11-24 GR GR20000402597T patent/GR3034975T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0828702A1 (de)	1998-03-18
DE69610089D1 (de)	2000-10-05
DE69610089T2 (de)	2001-05-03
JPH11511742A (ja)	1999-10-12
WO1996036584A1 (en)	1996-11-21
DK0828702T3 (da)	2001-01-02
AU5793296A (en)	1996-11-29
ES2152024T3 (es)	2001-01-16
US5677469A (en)	1997-10-14
CA2221375A1 (en)	1996-11-21
GR3034975T3 (en)	2001-02-28
PT828702E (pt)	2001-01-31
AU700193B2 (en)	1998-12-24
EP0828702B1 (de)	2000-08-30

Similar Documents

Publication	Publication Date	Title
ATE195930T1 (de)	2000-09-15	Verfahren zur trennung der chiralen säuren mittels 1-aminoindan-olen
US5015764A (en)	1991-05-14	Preparation of optically active aliphatic carboxylic acids
ATE151740T1 (de)	1997-05-15	Verfahren zur herstellung von im wesentlichen enantiomeren der phenylpropionsäuren
CA1266248C (en)	1990-02-27	METHOD AND APPARATUS FOR THE RESOLUTION OF STEREOISOMERES IN MULTI-PHASE AND EXTRACTIVE MEMBRANE REACTORS
ATE44953T1 (de)	1989-08-15	Verfahren zur racematspaltung bicyclischer imino- alpha-carbonsaeureester.
DE69623900D1 (de)	2002-10-31	Verfahren zur Herstellung von enantiomerisch reinen Imidazol-Verbindungen
PL334838A1 (en)	2000-03-27	Method of separating salts of rithalinic acid
DE69404306D1 (de)	1997-08-21	Verfahren zur herstellung und optischen auflösung von 2-phenyl-3-aminopiperidine
ATE167677T1 (de)	1998-07-15	Verfahren zur reinigung von roher clavulansäure
RU94046047A (ru)	1996-09-27	Производные аминоуксусной кислоты в виде рацемата или d- и l-энантиомеров и их фармацевтически приемлемые соли, способ получения d- и l-энантиомеров производных аминоуксусной кислоты или их фармацевтически приемлемых солей и промежуточные d- и l-энантиомеры аминоуксусной кислоты в виде цинхонидиновой соли
JP2009108079A (ja)	2009-05-21	エナンチオマーに富むｎ−アシルアゼチジン−２−カルボン酸の製造方法
ATE118476T1 (de)	1995-03-15	Verfahren zur herstellung von l-carnitin aus d,l- carnitinnitrilsalzen.
FR2450246B1 (fr)	1983-10-07	Procede de separation des isomeres optiques du 1-(o-methoxy-phenoxy)-3-isopropyl-amino-propane-2-ol et compositions pharmaceutiques contenant l'antipode levogyre, utile notamment comme agent b-bloquant
DE68914703D1 (de)	1994-05-26	Verfahren zur kontinuierlichen biotechnologischen Herstellung des optischen Isomeres S(+) der 2-(6-Methoxy-2-naphthyl)propionsäure.
DE68923883D1 (de)	1995-09-21	Verfahren zur herstellung optisch aktiver glycidat-ester.
ES2127278T3 (es)	1999-04-16	Preparados de acidos 2-aril-propionicos y procedimiento para su produccion.
DE69424065D1 (de)	2000-05-25	Verfahren zur herstellung von zwischenprodukten, die für die herstellung von retroviral-protease hemmenden verbindungen verwendbar sind
ATE30910T1 (de)	1987-12-15	Verfahren zur optischen trennung einer enantiomer-mischung von trans-3-((4-methoxyphenoxy)-methyl)1-methyl-4-phenyl-piperidin.
ATE423091T1 (de)	2009-03-15	Verfahren zur synthese von l-y- methylenglutaminsäure und analoga
JPH0632787A (ja)	1994-02-08	プロピオン酸誘導体の製造法
ATE144982T1 (de)	1996-11-15	Verfahren zur enantiomerentrennung von 5-hetaryl- 1,3,4-thiadiazinon
ATE157663T1 (de)	1997-09-15	6-piperazinyl-1h-pyrazolo(3,4-b)pyridin-3- carbonsäuren, ihre ester, amide und verwandte verbindungen, ein verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
ATE108172T1 (de)	1994-07-15	Verfahren zur umsetzung der r(-)(benzoyl-3 phenyl)-2 propionsäure zum isomer s(+).
EP0204481A3 (de)	1987-09-16	Verfahren zur Herstellung von optisch wirksamem Threo-3-(3,4-methylendioxyphenol)-serin
ATE161290T1 (de)	1998-01-15	Verfahren zur trennung von 1,2- isopropylidenglycerinbenzoylester-enantiomeren

Legal Events

Date	Code	Title	Description
2001-02-15	UEP	Publication of translation of european patent specification
2003-02-15	REN	Ceased due to non-payment of the annual fee