ATE195948T1 - Endothelinantagonisten - Google Patents

Endothelinantagonisten

Info

Publication number: ATE195948T1
Authority: AT; Austria
Prior art keywords: endothelin antagonists; endothelin; arrythmias; endocrinological; preeclampsia
Prior art date: 1991-05-16

Application number

AT92923584T

Other languages

English (en)

Inventor

Wayne Livingston Cody

Patricia Depue

Annette Marian Doherty

Michael Douglas Taylor

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-05-16

Filing date

1992-04-24

Publication date

2000-09-15

1992-04-24 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

2000-09-15 Application granted granted Critical

2000-09-15 Publication of ATE195948T1 publication Critical patent/ATE195948T1/de

Links

102000002045 Endothelin Human genes 0.000 title abstract 2
108050009340 Endothelin Proteins 0.000 title abstract 2
239000005557 antagonist Substances 0.000 title abstract 2
ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title abstract 2
208000009304 Acute Kidney Injury Diseases 0.000 abstract 1
206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
206010014824 Endotoxic shock Diseases 0.000 abstract 1
206010019280 Heart failures Diseases 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
208000012902 Nervous system disease Diseases 0.000 abstract 1
208000025966 Neurological disease Diseases 0.000 abstract 1
208000033626 Renal failure acute Diseases 0.000 abstract 1
206010040070 Septic Shock Diseases 0.000 abstract 1
208000032851 Subarachnoid Hemorrhage Diseases 0.000 abstract 1
201000011040 acute kidney failure Diseases 0.000 abstract 1
208000012998 acute renal failure Diseases 0.000 abstract 1
206010003119 arrhythmia Diseases 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
206010012601 diabetes mellitus Diseases 0.000 abstract 1
230000002124 endocrine Effects 0.000 abstract 1
230000002503 metabolic effect Effects 0.000 abstract 1
208000010125 myocardial infarction Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
201000011461 pre-eclampsia Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57536—Endothelin, vasoactive intestinal contractor [VIC]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Endocrinology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Diabetes (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Hematology (AREA)
Obesity (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Biomedical Technology (AREA)
Reproductive Health (AREA)
Zoology (AREA)
Toxicology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Emergency Medicine (AREA)
Gastroenterology & Hepatology (AREA)
Pulmonology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Plant Substances (AREA)

AT92923584T 1991-05-16 1992-04-24 Endothelinantagonisten ATE195948T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US70127491A	1991-05-16	1991-05-16
US80974691A	1991-12-18	1991-12-18
PCT/US1992/003408 WO1992020706A1 (en)	1991-05-16	1992-04-24	Endothelin antagonists

Publications (1)

Publication Number	Publication Date
ATE195948T1 true ATE195948T1 (de)	2000-09-15

Family

ID=27106761

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92923584T ATE195948T1 (de)	1991-05-16	1992-04-24	Endothelinantagonisten

Country Status (11)

Country	Link
EP (1)	EP0584290B1 (de)
JP (1)	JP3294610B2 (de)
AT (1)	ATE195948T1 (de)
CA (1)	CA2108754A1 (de)
DE (1)	DE69231404T2 (de)
DK (1)	DK0584290T3 (de)
ES (1)	ES2151888T3 (de)
GR (1)	GR3034904T3 (de)
IE (1)	IE921572A1 (de)
MX (1)	MX9202191A (de)
WO (1)	WO1992020706A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5382569A (en) *	1991-05-16	1995-01-17	Warner-Lambert Company	Endotherlin antagonists
US5550110A (en) *	1992-04-22	1996-08-27	Warner-Lambert Company	Endothelin Antagonists II
WO1994003483A1 (en) *	1992-07-30	1994-02-17	Chiron Corporation	Endothelin receptor-binding compounds
US5352800A (en) *	1993-03-11	1994-10-04	Merck & Co., Inc.	Process for the production of a novel endothelin antagonist
US5420133A (en) *	1993-03-19	1995-05-30	Merck & Co., Inc.	Quinazolinones substituted with phenoxyphenylacetic acid derivatives
US5334598A (en) *	1993-03-19	1994-08-02	Merck & Co., Inc.	Six-membered ring fused imidazoles substituted with phenoxyphenylacetic acid derivatives
US5374638A (en) *	1993-03-19	1994-12-20	Merck & Co., Inc.	Six membered ring fused imidazoles substituted with phenoxyphenylacetic acid derivatives used to treat asthma
US5767310A (en) *	1993-03-19	1998-06-16	Merck & Co., Inc.	Phenoxyphenylacetic acid derivatives
US5401745A (en) *	1993-03-19	1995-03-28	Merck & Co., Inc.	Quinazolinones substituted with phenoxyphenylacetic acid derivatives
FI941826L (fi) *	1993-04-21	1994-10-22	Takeda Chemical Industries Ltd	Menetelmät ja koostumukset elimen hypofunktion ennaltaehkäisemiseksi ja/tai terapeuttiseksi hoitamiseksi
US5686478A (en) *	1993-07-20	1997-11-11	Merck & Co. Inc.	Endothelin antagonists
BR9407933A (pt) *	1993-11-01	1996-11-26	Japat Ltd	Antagonistas de receptores de endotelina
US5559135A (en) *	1994-09-14	1996-09-24	Merck & Co., Inc.	Endothelin antagonists bearing pyridyl amides
US5538991A (en) *	1994-09-14	1996-07-23	Merck & Co., Inc.	Endothelin antagonists bearing 5-membered heterocyclic amides
US5753628A (en) *	1995-06-07	1998-05-19	Centocor, Inc.	Peptide inhibitors of TNF containing predominantly D-amino acids
AUPO161196A0 (en) *	1996-08-13	1996-09-05	Commonwealth Scientific And Industrial Research Organisation	Novel compounds
LT3464336T (lt)	2016-06-01	2022-05-10	Athira Pharma, Inc.	Junginiai

1992
- 1992-04-24 EP EP92923584A patent/EP0584290B1/de not_active Expired - Lifetime
- 1992-04-24 ES ES92923584T patent/ES2151888T3/es not_active Expired - Lifetime
- 1992-04-24 WO PCT/US1992/003408 patent/WO1992020706A1/en not_active Ceased
- 1992-04-24 DE DE69231404T patent/DE69231404T2/de not_active Expired - Fee Related
- 1992-04-24 AT AT92923584T patent/ATE195948T1/de not_active IP Right Cessation
- 1992-04-24 DK DK92923584T patent/DK0584290T3/da active
- 1992-04-24 JP JP51032192A patent/JP3294610B2/ja not_active Expired - Fee Related
- 1992-04-24 CA CA002108754A patent/CA2108754A1/en not_active Abandoned
- 1992-05-12 MX MX9202191A patent/MX9202191A/es not_active IP Right Cessation
- 1992-07-01 IE IE157292A patent/IE921572A1/en not_active IP Right Cessation
2000
- 2000-11-24 GR GR20000402595T patent/GR3034904T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
CA2108754A1 (en)	1992-11-17
JPH06507626A (ja)	1994-09-01
ES2151888T3 (es)	2001-01-16
GR3034904T3 (en)	2001-02-28
DE69231404D1 (de)	2000-10-05
EP0584290A1 (de)	1994-03-02
DK0584290T3 (da)	2000-12-27
EP0584290B1 (de)	2000-08-30
JP3294610B2 (ja)	2002-06-24
MX9202191A (es)	1992-11-01
WO1992020706A1 (en)	1992-11-26
DE69231404T2 (de)	2001-02-08
IE921572A1 (en)	1992-11-18

Legal Events

Date	Code	Title	Description
2001-02-15	UEP	Publication of translation of european patent specification
2006-01-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE195948T1 (de)	2000-09-15	Endothelinantagonisten
MX9308191A (es)	1994-06-30	Antagonistas de endotelina.
EP0403158A3 (de)	1991-12-18	Imidazolyl-Alkensäuren
IL108944A0 (en)	1994-06-24	Phenoxyphenylacetic acid derivatives and pharmaceutical compositions containing them
LT2000123A (lt)	2001-07-25	Bifenilsulfonamidai kaip dvigubi angiotenzino ir endotelino receptorių antagonistai
EP0403159A3 (de)	1991-12-27	Imidazoalkensäure
CA2115170A1 (en)	1993-03-04	Imidazolyl-alkenoic acids
WO2001044239A3 (en)	2001-11-01	Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
SI1054887T1 (sl)	2006-08-31	Biciklicni pridinski in primidinski derivati kot receptorski antagonisti nevropeptida y
EP0437103A3 (de)	1991-07-24	Substituierte 5-(Alkyl)-carboxamid-Imidazole
AU2378988A (en)	1989-04-20	4-(N-3-pyridylmethyl)-amino-1,2,4-triazinones
CA2105867A1 (en)	1993-07-11	Novel imidazole derivatives, their preparation and therapeutic applications
CA2083401A1 (en)	1992-08-23	Identification of a novel human receptor tyrosine kinase gene
BG104819A (en)	2001-05-31	Substituted indolealkanoic acids
CA2080705A1 (en)	1993-04-25	Substituted pyrimidines
CA2175767A1 (en)	1996-11-06	Adhesion receptor antagonists
EE03564B1 (et)	2001-12-17	Bensotiasiindioksiidid kui endoteliini antagonistid
TR199700834T1 (xx)	1998-01-21	1-Aril-2-Akilamino ethan bile�ikleri ve bunlar�n n�rokinin olarak �zellikle n�rokinin 1 has�mlar� olarak kullan�mlar�.
WO1992020651A3 (en)	1993-02-18	N-(heteroaryl)-imidazolyl-alkenoic acids
DK0799221T3 (da)	2003-02-24	Quinazoliner som inhibitorer af endothelin converting enzym
NO944013L (no)	1994-10-21	Endothelin-antagonister II
NO20002154L (no)	2000-05-12	Nye heterocykliske substituerte alfa-hydroksykarboksylsyre- derivater
BG105618A (en)	2002-01-31	Beta-amido and beta-sulphonamide derivatives of carboxylic acids, method for preparation and application as endothelin-receptor antagonists
WO1991009016A3 (en)	1991-08-22	Halophenyl substituted heterocyclic derivatives
IT8322398V0 (it)	1983-07-19	Giunto per l'applicazione alle usuali cannucce per bibite, di oggetto decorativi, pubblicitari ed altro.