ATE195953T1 - Peptide zur induktion von immunantwort durch zytotoxischen t lymphocyten gegen das virus von hepatitis c - Google Patents
Peptide zur induktion von immunantwort durch zytotoxischen t lymphocyten gegen das virus von hepatitis cInfo
- Publication number
- ATE195953T1 ATE195953T1 AT95914048T AT95914048T ATE195953T1 AT E195953 T1 ATE195953 T1 AT E195953T1 AT 95914048 T AT95914048 T AT 95914048T AT 95914048 T AT95914048 T AT 95914048T AT E195953 T1 ATE195953 T1 AT E195953T1
- Authority
- AT
- Austria
- Prior art keywords
- sub
- seq
- cytotoxic
- peptides
- virus
- Prior art date
Links
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 241000711549 Hepacivirus C Species 0.000 title 1
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 title 1
- 230000028993 immune response Effects 0.000 title 1
- 230000001939 inductive effect Effects 0.000 title 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 208000006454 hepatitis Diseases 0.000 abstract 1
- 231100000283 hepatitis Toxicity 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/214,650 US5709995A (en) | 1994-03-17 | 1994-03-17 | Hepatitis C virus-derived peptides capable of inducing cytotoxic T lymphocyte responses |
| PCT/US1995/003224 WO1995025122A1 (en) | 1994-03-17 | 1995-03-16 | Peptides for inducing cytotoxic t lymphocyte responses to hepatitis c virus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE195953T1 true ATE195953T1 (de) | 2000-09-15 |
Family
ID=22799919
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95914048T ATE195953T1 (de) | 1994-03-17 | 1995-03-16 | Peptide zur induktion von immunantwort durch zytotoxischen t lymphocyten gegen das virus von hepatitis c |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US5709995A (de) |
| EP (1) | EP0759937B2 (de) |
| JP (3) | JP3844494B2 (de) |
| AT (1) | ATE195953T1 (de) |
| CA (1) | CA2184890C (de) |
| DE (1) | DE69518642T3 (de) |
| WO (1) | WO1995025122A1 (de) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5804381A (en) * | 1996-10-03 | 1998-09-08 | Cornell Research Foundation | Isolated nucleic acid molecule encoding an esophageal cancer associated antigen, the antigen itself, and uses thereof |
| DE69433160T2 (de) | 1993-05-12 | 2004-07-08 | Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville | Konserviertes Motiv der Hepatitis C Virus E2/NS1 Region |
| PT992580E (pt) | 1993-11-04 | 2005-07-29 | Innogenetics Nv | Epitopos para celulas t humanas imunodominantes do virus da hepatite c |
| DE69617396T2 (de) * | 1995-01-16 | 2002-09-05 | Northern Sydney Area Health Service, St. Leonards | T-Zellen beeinflussende Peptide |
| US7019112B1 (en) | 1996-03-19 | 2006-03-28 | University Of Virginia Patent Foundation | Peptides recognized by melanoma-specific A1-, A2- and A3-restricted cytoxic lymphocytes, and uses therefor |
| AU712820B2 (en) * | 1996-03-19 | 1999-11-18 | University Of Virginia Patent Foundation | Peptides recognized by melanoma-specific A1-, A2- and A3-restricted cytotoxic lymphocytes, and uses therefor |
| EP1767542B1 (de) * | 1996-03-21 | 2016-05-11 | Epimmune Inc. | HLA-A2.1 bindende Peptide und deren Verwendung |
| DE69733352T2 (de) * | 1996-03-21 | 2006-04-27 | Epimmune, Inc., San Diego | Hla-a2.1 bindende peptide und deren verwendung |
| US6265215B1 (en) * | 1996-09-13 | 2001-07-24 | Ludwig Institute For Cancer Research | Isolated peptides which complex with HLA-Cw16 and uses thereof |
| US6413517B1 (en) * | 1997-01-23 | 2002-07-02 | Epimmune, Inc. | Identification of broadly reactive DR restricted epitopes |
| WO2000011186A1 (en) * | 1998-08-21 | 2000-03-02 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Modified hcv peptide vaccines |
| US7091324B2 (en) | 1998-11-05 | 2006-08-15 | Board Of Trustees Of Leland Stanford Junior University | Prevention and treatment of HCV infection employing antibodies directed against conformational epitopes |
| WO2001021189A1 (en) * | 1999-07-19 | 2001-03-29 | Epimmune Inc. | Inducing cellular immune responses to hepatitis c virus using peptide and nucleic acid compositions |
| US20090130135A1 (en) * | 1999-10-01 | 2009-05-21 | Michael Buschle | Hcv vaccines |
| EP1221968B1 (de) * | 1999-10-13 | 2010-01-13 | Novartis Vaccines and Diagnostics, Inc. | Verfahren zur erhaltung zellimmuneantworten gegen proteinen |
| CN101684146A (zh) * | 1999-11-24 | 2010-03-31 | 诺华疫苗和诊断公司 | 新颖的hcv非结构多肽 |
| US6986892B1 (en) | 1999-11-24 | 2006-01-17 | Chiron Corporation | Immunogenic Hepatitis C virus non-structural polypeptides |
| MXPA02007796A (es) * | 2000-02-21 | 2003-12-08 | Pharmexa As | Metodo novedoso para la disminucion de cuerpos amiloides. |
| US20030086938A1 (en) * | 2000-02-21 | 2003-05-08 | Jensen Martin Roland | Novel methods for down-regulation of amyloid |
| IL142802A (en) * | 2000-04-27 | 2015-01-29 | Enzo Therapeutics Inc | Use of one or more HBV antigens for the preparation of oral pharmaceutical preparations for the treatment of a person with active HBV infection or hepatocellular carcinoma |
| CA2409287A1 (en) * | 2000-06-02 | 2001-12-13 | Merck & Co., Inc. | Hepatitis c virus conjugates |
| US20030092145A1 (en) * | 2000-08-24 | 2003-05-15 | Vic Jira | Viral vaccine composition, process, and methods of use |
| US9974847B2 (en) * | 2000-08-24 | 2018-05-22 | Immunitor USA, Inc. | Treatment and prevention of tuberculosis |
| EP1343819A4 (de) * | 2000-09-01 | 2005-03-23 | Epimmune Inc | Hla-a2.1- bindungspeptide und ihre verwendung |
| EP1195381A1 (de) * | 2000-09-28 | 2002-04-10 | Immusystems GmbH | CD4+ T-Lymphozyten spezifische Hepatitis C Virus-Epitope |
| JP2004525109A (ja) | 2001-02-15 | 2004-08-19 | キング・ファーマシューティカルズ・インコーポレイティッド | 安定化された甲状腺ホルモン医薬組成物、及びその製法 |
| US7097837B2 (en) * | 2001-02-19 | 2006-08-29 | Pharmexa A/S | Synthetic vaccine agents |
| US7326536B2 (en) | 2001-05-03 | 2008-02-05 | Eli Lilly And Company | Agents for treatment of HCV and methods of use |
| US20030224011A1 (en) * | 2001-05-29 | 2003-12-04 | Conley Anthony J | Hepatitis c virus conjugates |
| US7101569B2 (en) | 2001-08-14 | 2006-09-05 | Franz G Andrew | Methods of administering levothyroxine pharmaceutical compositions |
| MY144532A (en) * | 2001-08-20 | 2011-09-30 | Lundbeck & Co As H | Novel method for down-regulation of amyloid |
| WO2004041842A2 (en) * | 2002-05-16 | 2004-05-21 | The General Hospital Corporation | Epitopes of hepatitis c virus |
| FR2839722A1 (fr) * | 2002-05-17 | 2003-11-21 | Bio Merieux | Nouvelles compositions peptidiques et leur utilisation notamment dans la preparation de compositions pharmaceutiques actives contre le virus de l'hepatite c |
| CA2484941A1 (en) | 2002-07-24 | 2004-02-05 | Intercell Ag | Antigens encoded by alternative reading frame from pathogenic viruses |
| WO2004024182A2 (en) | 2002-09-13 | 2004-03-25 | Intercell Ag | Method for isolating hepatitis c virus peptides |
| WO2004073641A2 (en) | 2003-02-18 | 2004-09-02 | Kevin Slawin | Induced activation in dendritic cells |
| ES2562456T3 (es) | 2003-03-24 | 2016-03-04 | Valneva Austria Gmbh | Uso de un adyuvante que induce una respuesta inmune Th1 para mejorar las respuestas inmunes |
| CA2530062A1 (en) * | 2003-07-11 | 2005-01-20 | Intercell Ag | Hcv vaccines |
| FR2862648B1 (fr) * | 2003-11-21 | 2006-02-03 | Biomerieux Sa | Nouveau peptide immunogene et nouveaux epitopes et utilisations notamment dans la preparation de compositions pharmaceutiques actives contre le virus de l 'hepatite c |
| CA2566506A1 (en) * | 2004-06-01 | 2005-12-15 | Innogenetics N.V. | Peptides for inducing a ctl and/or htl response to hepatitis c virus |
| AU2006247802A1 (en) * | 2005-05-11 | 2006-11-23 | The Trustees Of The University Of Pennsylvania | Methods for the rapid expansion of antigen specific T-cells |
| US7951384B2 (en) * | 2005-08-05 | 2011-05-31 | University Of Massachusetts | Virus-like particles as vaccines for paramyxovirus |
| US9216212B2 (en) | 2005-08-05 | 2015-12-22 | University Of Massachusetts | Virus-like particles as vaccines for paramyxovirus |
| AU2006311255A1 (en) * | 2005-11-10 | 2007-05-18 | The University Of Chicago | HCV-reactiveT cell receptors |
| JP5031827B2 (ja) | 2006-06-01 | 2012-09-26 | 程云 | 予防或いは肝損傷を治療するペプチッド |
| EP2465510B1 (de) | 2006-10-19 | 2018-11-28 | Baylor College Of Medicine | Verfahren und Zusammensetzungen zur Erzeugung einer Immunreaktion mittels CD40-Induktion sowie Strukturerkennungsrezeptoren und Adapter davon |
| CA2738031C (en) | 2008-09-22 | 2022-11-29 | Baylor College Of Medicine | Methods and compositions for generating an immune response by inducing cd40 and pattern recognition receptor adapters |
| US8580270B2 (en) | 2008-09-30 | 2013-11-12 | University Of Massachusetts | Respiratory synctial virus (RSV) sequences for protein expression and vaccines |
| WO2011015379A1 (en) * | 2009-08-05 | 2011-02-10 | Nexigen Gbmh | Human hcv-interacting proteins and methods of use |
| US9089520B2 (en) | 2010-05-21 | 2015-07-28 | Baylor College Of Medicine | Methods for inducing selective apoptosis |
| US20130183376A1 (en) | 2010-09-08 | 2013-07-18 | Saitama Medical University | Hepatitis c virus liposome vaccine |
| CN103282375B (zh) | 2010-12-02 | 2017-01-11 | 比奥诺尔免疫有限公司 | 肽支架设计 |
| AU2012204955B2 (en) | 2011-01-06 | 2016-10-06 | Bionor Immuno As | Monomeric and multimeric immunogenic peptides |
| WO2012145509A2 (en) | 2011-04-19 | 2012-10-26 | The Research Foundation Of State University Of New York | Adeno-associated-virus rep sequences, vectors, and viruses |
| CA2850291A1 (en) | 2011-09-29 | 2013-04-04 | Apo-T B.V. | Multi-specific binding molecules targeting aberrant cells |
| US10946104B2 (en) | 2012-01-13 | 2021-03-16 | Apo-Tb.V. | Aberrant cell-restricted immunoglobulins provided with a toxic moiety |
| MX2014014683A (es) | 2012-06-06 | 2015-02-24 | Bionor Immuno As | Peptidos derivados de proteinas virales para usarse como inmunogenos y reactivos de dosificacion. |
| WO2014003552A1 (en) * | 2012-06-26 | 2014-01-03 | Apo-T B.V. | Binding molecules targeting pathogens |
| US9434935B2 (en) | 2013-03-10 | 2016-09-06 | Bellicum Pharmaceuticals, Inc. | Modified caspase polypeptides and uses thereof |
| EP2968502B1 (de) | 2013-03-14 | 2020-08-26 | Bellicum Pharmaceuticals, Inc. | Verfahren zur steuerung einer t-zellen-proliferation |
| CA2912172A1 (en) | 2013-06-05 | 2014-12-11 | Bellicum Pharmaceuticals, Inc. | Methods for inducing partial apoptosis using caspase polypeptides |
| US10934346B2 (en) | 2014-02-14 | 2021-03-02 | Bellicum Pharmaceuticals, Inc. | Modified T cell comprising a polynucleotide encoding an inducible stimulating molecule comprising MyD88, CD40 and FKBP12 |
| CA2959168A1 (en) | 2014-09-02 | 2016-03-10 | Bellicum Pharmaceuticals, Inc. | Costimulation of chimeric antigen receptors by myd88 and cd40 polypeptides |
| EP3215522B1 (de) | 2014-11-03 | 2021-12-01 | Academisch Ziekenhuis Leiden H.O.D.N. Leids Universitair Medisch Centrum | Gegen bob1 gerichtete t-zell-rezeptoren und verwendungen davon |
| WO2016142783A2 (en) | 2015-03-10 | 2016-09-15 | Leiden University Medical Center | T-cell receptors directed against the preferentially expressed antigen of melanoma and uses thereof |
| EP3443123B1 (de) * | 2016-04-11 | 2021-08-11 | Board of Regents, The University of Texas System | Verfahren und zusammensetzungen zum nachweis der affinität einzelner t-zellrezeptoren und sequenz |
| AU2017332854B2 (en) | 2016-09-21 | 2024-11-14 | The Governors Of The University Of Alberta | Hepatitis C virus immunogenic compositions and methods of use thereof |
| WO2018208849A1 (en) | 2017-05-09 | 2018-11-15 | Bellicum Pharmaceuticals, Inc. | Methods to augment or alter signal transduction |
| CA3084190A1 (en) | 2017-12-08 | 2019-06-13 | Bellicum Pharmaceuticals, Inc. | Methods for enhancing and maintaining car-t cell efficacy |
| EP4259163A2 (de) * | 2020-12-09 | 2023-10-18 | Tevogen Bio Inc. | Virusspezifische t-zellen und verfahren zur behandlung und prävention von virusinfektionen |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5017558A (en) * | 1980-01-14 | 1991-05-21 | The Regents Of The University Of California | Synthetic vaccine peptide epitomes of hepatitis B surface antigen |
| US4803164A (en) * | 1981-08-31 | 1989-02-07 | Genentech, Inc. | Preparation of hepatitis b surface antigen in yeast |
| ZW18282A1 (en) * | 1981-08-31 | 1983-03-23 | Genentech Inc | Preparation of polypeptides in vertebrate cell culture |
| US4977092A (en) * | 1985-06-26 | 1990-12-11 | Amgen | Expression of exogenous polypeptides and polypeptide products including hepatitis B surface antigen in yeast cells |
| DK154394C (da) * | 1982-10-21 | 1989-04-24 | Apv Pasilac As | Fremgangsmaade til at foroege kapaciteten af anlaeg for membranfiltrering af maelk eller maelkeprodukter til foderstoffer eller vaekstmedier. |
| JPS59101426A (ja) * | 1982-11-29 | 1984-06-12 | Green Cross Corp:The | B型肝炎感染予防用ワクチンの製造方法 |
| US4625918A (en) * | 1983-07-29 | 1986-12-02 | Diesel Kiki Co., Ltd. | Fuel injection valve |
| US4847080A (en) * | 1984-03-07 | 1989-07-11 | New York Blood Center, Inc. | Pre-S gene coded peptide hepatitis B immunogens, vaccines, diagnostics, and synthetic lipide vesicle carriers |
| US4599231A (en) * | 1984-03-09 | 1986-07-08 | Scripps Clinic And Research Foundation | Synthetic hepatitis B virus vaccine including both T cell and B cell determinants |
| US4599230A (en) * | 1984-03-09 | 1986-07-08 | Scripps Clinic And Research Foundation | Synthetic hepatitis B virus vaccine including both T cell and B cell determinants |
| US4624918A (en) | 1984-07-09 | 1986-11-25 | Genentech, Inc. | Purification process for hepatitis surface antigen and product thereof |
| JPS6137738A (ja) * | 1984-07-31 | 1986-02-22 | Tetsuo Nakamura | B型肝炎ワクチン |
| US4690915A (en) * | 1985-08-08 | 1987-09-01 | The United States Of America As Represented By The Department Of Health And Human Services | Adoptive immunotherapy as a treatment modality in humans |
| US4882145A (en) * | 1986-12-09 | 1989-11-21 | Scripps Clinic And Research Foundation | T cell epitopes of the hepatitis B virus nucleocapsid protein |
| US5350671A (en) * | 1987-11-18 | 1994-09-27 | Chiron Corporation | HCV immunoassays employing C domain antigens |
| HU225068B1 (en) * | 1989-03-17 | 2006-05-29 | Chiron Corp | Process for producing diagnostics and vaccine of nanbh |
| US5372928A (en) * | 1989-09-15 | 1994-12-13 | Chiron Corporation | Hepatitis C virus isolates |
| IT1237764B (it) * | 1989-11-10 | 1993-06-17 | Eniricerche Spa | Peptidi sintetici utili come carriers universali per la preparazione di coniugati immunogenici e loro impiego per lo sviluppo di vaccini sintetici. |
| US5106726A (en) * | 1990-02-16 | 1992-04-21 | United Biomedical, Inc. | Synthetic peptides specific for the detection of antibodies to HCV |
| JPH0454197A (ja) * | 1990-06-19 | 1992-02-21 | Chemo Sero Therapeut Res Inst | C型肝炎ウイルス抗体検出用合成ペプチド抗原、その組成物およびその使用方法 |
| NZ238681A (en) * | 1990-06-25 | 1992-03-26 | Univ Osaka Res Found | Non-a, non-b hepatitis virus particles and their production |
| KR0185426B1 (ko) * | 1991-06-24 | 1999-04-01 | 로버트 피. 블랙버언 | 씨형 간염 바이러스 폴리펩티드 |
| US6419931B1 (en) | 1991-08-26 | 2002-07-16 | Epimmune Inc. | Compositions and methods for eliciting CTL immunity |
| KR100257941B1 (ko) | 1992-03-06 | 2000-06-01 | 휴버스윗 에이치. 밴 | 면역학적으로 중요한 에피토프에 상응하는 펩티드의 측정 방법 및 면역학적으로 중요한 에피토프에 상응하는 항체 또는 비오티닐화된 펩티드의 측정 방법에 상기 펩티드를 사용하는 방법, 상기 펩티드의 제조 방법 및 상기 펩티드를 함유하는 조성물 |
| US5980899A (en) | 1992-06-10 | 1999-11-09 | The United States Of America As Represented By The Department Of Health And Human Services | Identification of peptides that stimulate hepatitis C virus specific cytotoxic T cells |
| JP3908271B2 (ja) * | 1993-03-05 | 2007-04-25 | エピミューン,インコーポレイティド | Hla−a2.1結合ペプチドおよびそれらの使用 |
| PT992580E (pt) * | 1993-11-04 | 2005-07-29 | Innogenetics Nv | Epitopos para celulas t humanas imunodominantes do virus da hepatite c |
| JPH10503473A (ja) * | 1994-04-08 | 1998-03-31 | アメリカ合衆国 | 細胞傷害性tリンパ球刺激およびhcv曝露診断用c型肝炎ウイルスコアペプチド |
-
1994
- 1994-03-17 US US08/214,650 patent/US5709995A/en not_active Expired - Lifetime
-
1995
- 1995-03-16 CA CA2184890A patent/CA2184890C/en not_active Expired - Lifetime
- 1995-03-16 AT AT95914048T patent/ATE195953T1/de not_active IP Right Cessation
- 1995-03-16 WO PCT/US1995/003224 patent/WO1995025122A1/en not_active Ceased
- 1995-03-16 EP EP95914048A patent/EP0759937B2/de not_active Expired - Lifetime
- 1995-03-16 DE DE69518642T patent/DE69518642T3/de not_active Expired - Lifetime
- 1995-03-16 JP JP52415195A patent/JP3844494B2/ja not_active Expired - Lifetime
-
1997
- 1997-05-12 US US08/854,825 patent/US7220420B2/en not_active Expired - Fee Related
-
2005
- 2005-03-07 JP JP2005061923A patent/JP4394019B2/ja not_active Expired - Lifetime
-
2006
- 2006-06-07 JP JP2006158108A patent/JP4463786B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0759937B2 (de) | 2008-12-31 |
| JP3844494B2 (ja) | 2006-11-15 |
| DE69518642T2 (de) | 2001-05-03 |
| US5709995A (en) | 1998-01-20 |
| JPH09510455A (ja) | 1997-10-21 |
| JP4394019B2 (ja) | 2010-01-06 |
| WO1995025122A1 (en) | 1995-09-21 |
| EP0759937A1 (de) | 1997-03-05 |
| CA2184890A1 (en) | 1995-09-21 |
| CA2184890C (en) | 2011-05-24 |
| JP4463786B2 (ja) | 2010-05-19 |
| US7220420B2 (en) | 2007-05-22 |
| JP2006265264A (ja) | 2006-10-05 |
| DE69518642D1 (de) | 2000-10-05 |
| US20020115061A1 (en) | 2002-08-22 |
| EP0759937B1 (de) | 2000-08-30 |
| DE69518642T3 (de) | 2009-05-14 |
| JP2005247852A (ja) | 2005-09-15 |
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