ATE357526T1 - Modifizierte hcv peptid-impfstoffe - Google Patents

Modifizierte hcv peptid-impfstoffe

Info

Publication number: ATE357526T1
Authority: AT; Austria
Prior art keywords: subject; amino acid; core polypeptide; hcv core; seq
Prior art date: 1998-08-21

Application number

AT99945074T

Other languages

English (en)

Inventor

Jay A Berzofsky

Pablo Sarobe

Stephen M Feinstone

Marian E Major

Original Assignee

Us Gov Health & Human Serv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-08-21

Filing date

1999-08-17

Publication date

2007-04-15

1999-08-17 Application filed by Us Gov Health & Human Serv filed Critical Us Gov Health & Human Serv

2007-04-15 Application granted granted Critical

2007-04-15 Publication of ATE357526T1 publication Critical patent/ATE357526T1/de

Links

229940023041 peptide vaccine Drugs 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 7
102000004196 processed proteins & peptides Human genes 0.000 abstract 6
150000001413 amino acids Chemical group 0.000 abstract 5
229920001184 polypeptide Polymers 0.000 abstract 5
108700039791 Hepatitis C virus nucleocapsid Proteins 0.000 abstract 4
102000039446 nucleic acids Human genes 0.000 abstract 3
108020004707 nucleic acids Proteins 0.000 abstract 3
150000007523 nucleic acids Chemical class 0.000 abstract 3
239000013598 vector Substances 0.000 abstract 2
FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 1
239000012634 fragment Substances 0.000 abstract 1
230000028993 immune response Effects 0.000 abstract 1
208000015181 infectious disease Diseases 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
238000006467 substitution reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
- A61K2039/55527—Interleukins
- A61K2039/55538—IL-12
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24141—Use of virus, viral particle or viral elements as a vector
- C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Virology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Mycology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Microbiology (AREA)
Immunology (AREA)
Veterinary Medicine (AREA)
Organic Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Communicable Diseases (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT99945074T 1998-08-21 1999-08-17 Modifizierte hcv peptid-impfstoffe ATE357526T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US9744698P	1998-08-21	1998-08-21

Publications (1)

Publication Number	Publication Date
ATE357526T1 true ATE357526T1 (de)	2007-04-15

Family

ID=22263394

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99945074T ATE357526T1 (de)	1998-08-21	1999-08-17	Modifizierte hcv peptid-impfstoffe

Country Status (6)

Country	Link
US (3)	US6685944B1 (de)
EP (1)	EP1105496B1 (de)
AT (1)	ATE357526T1 (de)
AU (1)	AU5776799A (de)
DE (1)	DE69935599T2 (de)
WO (1)	WO2000011186A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT408721B (de) *	1999-10-01	2002-02-25	Cistem Biotechnologies Gmbh	Pharmazeutische zusammensetzung enthaltend ein antigen
JP2005533855A (ja)	2002-07-24	2005-11-10	インターツェル・アクチェンゲゼルシャフト	病原性ウイルスからの別のリーディングフレームによりコードされる抗原
EP1537418A2 (de)	2002-09-13	2005-06-08	Intercell AG	Verfahren zur isolierung von hepatitis c virus peptiden
AU2004224746B2 (en)	2003-03-24	2009-04-23	Valneva Austria Gmbh	Improved vaccines
CA2530062A1 (en)	2003-07-11	2005-01-20	Intercell Ag	Hcv vaccines
US7785875B2 (en)	2004-07-03	2010-08-31	Mogam Biotechnology Research Institute	Polynucleotide encoding HCV epitopes which can bind to various HLA supertypes, immunogenic composition comprising same and method of inducing an HCV-specific immune response using same
CN1976946A (zh) *	2004-07-03	2007-06-06	财团法人牧岩生命工学研究所	诱导抗hcv有效ctl应答的超型表位、其编码寡核苷酸及其应用
WO2006134280A2 (fr) *	2005-06-17	2006-12-21	Transgene	Sequences nucleotidiques mutees du virus de l'hepatite c
FR2887260A1 (fr) *	2005-06-17	2006-12-22	Centre Nat Rech Scient	Sequences nucleotidiques mutees du virus de l'hepatite c
WO2011001897A1 (ja) *	2009-06-30	2011-01-06	明治製菓株式会社	難治性のｃ型慢性肝炎の治療のための薬剤及び方法
JP7068323B2 (ja) *	2017-02-02	2022-05-16	エフ．ホフマン－ラロシュアーゲー	少なくとも２種のペグ化された分析物特異的結合剤を使用する免疫アッセイ

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2197170T3 (es) *	1993-11-04	2004-01-01	Innogenetics N.V.	Epitopos de celulas t humanas inmunologicamente dominantes del virus de la hepatitis c.
US5709995A (en) *	1994-03-17	1998-01-20	The Scripps Research Institute	Hepatitis C virus-derived peptides capable of inducing cytotoxic T lymphocyte responses
DE69517521T2 (de) *	1994-04-08	2001-03-08	The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Rockville	Peptid aus dem inneren des hepatitis-c-virus brauchbar für die stimulation cytotoxischer t-lymphocyten und die diagnose des hcv-kontaktes
GB9513261D0 (en) *	1995-06-29	1995-09-06	Smithkline Beecham Biolog	Vaccines
DE69723434T2 (de)	1996-04-26	2004-05-19	Rijksuniversiteit Te Leiden	Verfahren zur selektion und produktion von t-zell-peptide epitope und vakzine mit diese epitope
US7390619B1 (en) *	1998-02-11	2008-06-24	Maxygen, Inc.	Optimization of immunomodulatory properties of genetic vaccines

1999
- 1999-08-17 AU AU57767/99A patent/AU5776799A/en not_active Abandoned
- 1999-08-17 US US09/763,260 patent/US6685944B1/en not_active Expired - Fee Related
- 1999-08-17 DE DE69935599T patent/DE69935599T2/de not_active Expired - Lifetime
- 1999-08-17 EP EP99945074A patent/EP1105496B1/de not_active Expired - Lifetime
- 1999-08-17 AT AT99945074T patent/ATE357526T1/de active
- 1999-08-17 WO PCT/US1999/018674 patent/WO2000011186A1/en not_active Ceased
2004
- 2004-02-02 US US10/770,117 patent/US7074410B2/en not_active Expired - Fee Related
2006
- 2006-05-05 US US11/429,670 patent/US7341726B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU5776799A (en)	2000-03-14
US20050129705A1 (en)	2005-06-16
US6685944B1 (en)	2004-02-03
DE69935599D1 (de)	2007-05-03
US20060275322A1 (en)	2006-12-07
US7074410B2 (en)	2006-07-11
US7341726B2 (en)	2008-03-11
WO2000011186A9 (en)	2002-08-22
DE69935599T2 (de)	2007-11-29
WO2000011186A1 (en)	2000-03-02
EP1105496A1 (de)	2001-06-13
EP1105496B1 (de)	2007-03-21

Legal Events

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2007-12-15

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