ATE196140T1 - Substituierte benzylaminoquinuclidine als substanz p antagonisten - Google Patents

Substituierte benzylaminoquinuclidine als substanz p antagonisten

Info

Publication number: ATE196140T1
Authority: AT; Austria
Prior art keywords: carbon atoms; alkyl; hydrogen; disorders; substituted
Prior art date: 1992-10-21

Application number

AT93922754T

Other languages

English (en)

Inventor

Fumitaka Ito

Kunio Satake

Kaoru Shimada

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-10-21

Filing date

1993-09-30

Publication date

2000-09-15

1993-09-30 Application filed by Pfizer filed Critical Pfizer

2000-09-15 Application granted granted Critical

2000-09-15 Publication of ATE196140T1 publication Critical patent/ATE196140T1/de

Links

DTJXCCUWIKIZEX-UHFFFAOYSA-N n-benzyl-1-azabicyclo[2.2.2]octan-2-amine Chemical class C1C(CC2)CCN2C1NCC1=CC=CC=C1 DTJXCCUWIKIZEX-UHFFFAOYSA-N 0.000 title 1
239000003890 substance P antagonist Substances 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 9
125000000217 alkyl group Chemical group 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000003342 alkenyl group Chemical group 0.000 abstract 2
125000000304 alkynyl group Chemical group 0.000 abstract 2
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
208000015114 central nervous system disease Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
208000027866 inflammatory disease Diseases 0.000 abstract 1
125000004043 oxo group Chemical group O=* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000003107 substituted aryl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

AT93922754T 1992-10-21 1993-09-30 Substituierte benzylaminoquinuclidine als substanz p antagonisten ATE196140T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP4283135A JP2656699B2 (ja)	1992-10-21	1992-10-21	置換ベンジルアミノキヌクリジン
PCT/US1993/009168 WO1994008997A1 (en)	1992-10-21	1993-09-30	Substituted benzylaminoquinuclidines as substance p antagonists

Publications (1)

Publication Number	Publication Date
ATE196140T1 true ATE196140T1 (de)	2000-09-15

Family

ID=17661684

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93922754T ATE196140T1 (de)	1992-10-21	1993-09-30	Substituierte benzylaminoquinuclidine als substanz p antagonisten

Country Status (16)

Country	Link
EP (1)	EP0665844B1 (de)
JP (1)	JP2656699B2 (de)
AT (1)	ATE196140T1 (de)
AU (1)	AU5165393A (de)
CA (1)	CA2146259C (de)
DE (1)	DE69329386T2 (de)
DK (1)	DK0665844T3 (de)
ES (1)	ES2149215T3 (de)
FI (1)	FI114636B (de)
GR (1)	GR3034498T3 (de)
HU (1)	HUT65133A (de)
IL (1)	IL107292A0 (de)
MX (1)	MX9306527A (de)
PT (1)	PT665844E (de)
WO (1)	WO1994008997A1 (de)
ZA (1)	ZA937780B (de)

Families Citing this family (48)

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WO1996014845A1 (en) *	1994-11-10	1996-05-23	Pfizer Inc.	Nk-1 receptor antagonists for the treatment of eye disorders
FR2728166A1 (fr)	1994-12-19	1996-06-21	Oreal	Composition topique contenant un antagoniste de substance p
TW458774B (en)	1995-10-20	2001-10-11	Pfizer	Antiemetic pharmaceutical compositions
FR2741262B1 (fr)	1995-11-20	1999-03-05	Oreal	Utilisation d'un antagoniste de tnf-alpha pour le traitement des rougeurs cutanees d'origine neurogene
US7163949B1 (en)	1999-11-03	2007-01-16	Amr Technology, Inc.	4-phenyl substituted tetrahydroisoquinolines and use thereof
DK1246806T3 (da)	1999-11-03	2008-06-16	Amr Technology Inc	Aryl- og heteroarylsubstituerede tetrahydroisoquinoliner og anvendelse deraf til blokering af genoptagelse af norepinefrin, dopsmin og serotonin
MXPA03000275A (es)	2000-07-11	2004-12-13	Albany Molecular Res Inc	Nuevas tetrahidroisoquinolinas substituidas con 4-fenilo y su uso terapeutico.
US6861526B2 (en)	2002-10-16	2005-03-01	Pfizer Inc.	Process for the preparation of (S,S)-cis-2-benzhydryl-3-benzylaminoquinuclidine
UA91341C2 (ru)	2004-07-15	2010-07-26	Амр Текнолоджи, Інк.	Арил- и гетероарилзамещенные тетрагидроизохинолины и их применение для блокирования обратного захвата норэпинефрина, допамина и серотонина
ATE550019T1 (de)	2005-05-17	2012-04-15	Merck Sharp & Dohme	Cis-4-ä(4-chlorophenyl)sulfonylü-4-(2,5- difluorophenyl)cyclohexanepropansäure zur behandlug von krebs
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KR20080048502A (ko)	2005-09-29	2008-06-02	머크 앤드 캄파니 인코포레이티드	멜라노코르틴-4 수용체 조절제로서의 아실화스피로피페리딘 유도체
GB0603041D0 (en)	2006-02-15	2006-03-29	Angeletti P Ist Richerche Bio	Therapeutic compounds
AU2007300627B2 (en)	2006-09-22	2012-02-16	Merck Sharp & Dohme Corp.	Method of treatment using fatty acid synthesis inhibitors
US20110218176A1 (en)	2006-11-01	2011-09-08	Barbara Brooke Jennings-Spring	Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
BRPI0806245B1 (pt)	2007-01-10	2022-01-25	Msd Italia S.R.L.	Compostos de fórmula i e seus usos
AU2008233662B2 (en)	2007-04-02	2012-08-23	Msd K.K.	Indoledione derivative
WO2009002495A1 (en)	2007-06-27	2008-12-31	Merck & Co., Inc.	4-carboxybenzylamino derivatives as histone deacetylase inhibitors
US8598184B2 (en)	2008-03-03	2013-12-03	Tiger Pharmatech	Protein kinase inhibitors
US9156812B2 (en)	2008-06-04	2015-10-13	Bristol-Myers Squibb Company	Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
UA105182C2 (ru)	2008-07-03	2014-04-25	Ньюрексон, Інк.	Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
EP2413932A4 (de)	2009-04-01	2012-09-19	Merck Sharp & Dohme	Hemmer der akt-aktivität
CN102595902B (zh)	2009-05-12	2015-04-29	阿尔巴尼分子研究公司	7-([1,2,4]三唑并[1,5-a]吡啶-6-基)-4-(3,4-二氯苯基)-1,2,3,4-四氢异喹啉及其用途
ES2446971T3 (es)	2009-05-12	2014-03-11	Albany Molecular Research, Inc.	Tetrahidroisoquinolinas sustituidas con arilo, heteroarilo, y heterociclo y su uso
JP5739415B2 (ja)	2009-05-12	2015-06-24	ブリストル−マイヤーズスクウィブカンパニー	（Ｓ）−７−（［１，２，４］トリアゾロ［１，５−ａ］ピリジン−６−イル）−４−（３，４−ジクロロフェニル）−１，２，３，４−テトラヒドロイソキノリンの結晶形態およびその使用
CA2777043C (en)	2009-10-14	2015-12-15	Schering Corporation	Substituted piperidines that increase p53 activity and the uses thereof
EP2584903B1 (de)	2010-06-24	2018-10-24	Merck Sharp & Dohme Corp.	Neue heterozyklische verbindungen als erk-hemmer
CN103068980B (zh)	2010-08-02	2017-04-05	瑟纳治疗公司	使用短干扰核酸（siNA）的RNA干扰介导的联蛋白（钙粘蛋白关联蛋白质），β1（CTNNB1）基因表达的抑制
RU2745848C2 (ru)	2010-08-17	2021-04-01	Сирна Терапьютикс, Инк.	ОПОСРЕДУЕМОЕ РНК-ИНТЕРФЕРЕНЦИЕЙ ИНГИБИРОВАНИЕ ЭКСПРЕССИИ ГЕНОВ ВИРУСА ГЕПАТИТА B (HBV) С ПРИМЕНЕНИЕМ МАЛОЙ ИНТЕРФЕРИРУЮЩЕЙ НУКЛЕИНОВОЙ КИСЛОТЫ (миНК)
US8883801B2 (en)	2010-08-23	2014-11-11	Merck Sharp & Dohme Corp.	Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
EP2613782B1 (de)	2010-09-01	2016-11-02	Merck Sharp & Dohme Corp.	Indazolderivate als erk-hemmer
US9242981B2 (en)	2010-09-16	2016-01-26	Merck Sharp & Dohme Corp.	Fused pyrazole derivatives as novel ERK inhibitors
WO2012058210A1 (en)	2010-10-29	2012-05-03	Merck Sharp & Dohme Corp.	RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA)
WO2012087772A1 (en)	2010-12-21	2012-06-28	Schering Corporation	Indazole derivatives useful as erk inhibitors
WO2012143879A1 (en)	2011-04-21	2012-10-26	Piramal Healthcare Limited	A crystalline form of a salt of a morpholino sulfonyl indole derivative and a process for its preparation
EP2770987B1 (de)	2011-10-27	2018-04-04	Merck Sharp & Dohme Corp.	Neue verbindungen als erk-hemmer
EP3919620A1 (de)	2012-05-02	2021-12-08	Sirna Therapeutics, Inc.	Zusammensetzungen mit kurzer interferierender nukleinsäure (sina)
CA2882950A1 (en)	2012-09-28	2014-04-03	Merck Sharp & Dohme Corp.	Novel compounds that are erk inhibitors
SMT201700595T1 (it)	2012-11-28	2018-03-08	Merck Sharp & Dohme	Composizioni e metodi per trattare il cancro
WO2014100065A1 (en)	2012-12-20	2014-06-26	Merck Sharp & Dohme Corp.	Substituted imidazopyridines as hdm2 inhibitors
WO2014120748A1 (en)	2013-01-30	2014-08-07	Merck Sharp & Dohme Corp.	2,6,7,8 substituted purines as hdm2 inhibitors
WO2015034925A1 (en)	2013-09-03	2015-03-12	Moderna Therapeutics, Inc.	Circular polynucleotides
US10975084B2 (en)	2016-10-12	2021-04-13	Merck Sharp & Dohme Corp.	KDM5 inhibitors
EP3706742B1 (de)	2017-11-08	2023-03-15	Merck Sharp & Dohme LLC	Prmt5-inhibitoren
WO2019094312A1 (en)	2017-11-08	2019-05-16	Merck Sharp & Dohme Corp.	Prmt5 inhibitors
WO2020033282A1 (en)	2018-08-07	2020-02-13	Merck Sharp & Dohme Corp.	Prmt5 inhibitors
CA3108388A1 (en)	2018-08-07	2020-02-13	Merck Sharp & Dohme Corp.	Prmt5 inhibitors
EP3833667B1 (de)	2018-08-07	2024-03-13	Merck Sharp & Dohme LLC	Prmt5-inhibitoren

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MX18467A (es) *	1988-11-23	1993-07-01	Pfizer	Agentes terapeuticos de quinuclidinas
RU2092486C1 (ru) *	1991-05-22	1997-10-10	Пфайзер Инк.	Замещенные 3-аминохинуклидины

1992
- 1992-10-21 JP JP4283135A patent/JP2656699B2/ja not_active Expired - Fee Related
1993
- 1993-09-30 DK DK93922754T patent/DK0665844T3/da active
- 1993-09-30 EP EP93922754A patent/EP0665844B1/de not_active Expired - Lifetime
- 1993-09-30 DE DE69329386T patent/DE69329386T2/de not_active Expired - Fee Related
- 1993-09-30 AU AU51653/93A patent/AU5165393A/en not_active Abandoned
- 1993-09-30 PT PT93922754T patent/PT665844E/pt unknown
- 1993-09-30 AT AT93922754T patent/ATE196140T1/de not_active IP Right Cessation
- 1993-09-30 CA CA002146259A patent/CA2146259C/en not_active Expired - Fee Related
- 1993-09-30 WO PCT/US1993/009168 patent/WO1994008997A1/en not_active Ceased
- 1993-09-30 ES ES93922754T patent/ES2149215T3/es not_active Expired - Lifetime
- 1993-10-14 IL IL107292A patent/IL107292A0/xx not_active IP Right Cessation
- 1993-10-20 ZA ZA937780A patent/ZA937780B/xx unknown
- 1993-10-20 FI FI934626A patent/FI114636B/fi active IP Right Grant
- 1993-10-20 MX MX9306527A patent/MX9306527A/es unknown
- 1993-10-20 HU HU9302965A patent/HUT65133A/hu unknown
2000
- 2000-09-28 GR GR20000402187T patent/GR3034498T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
GR3034498T3 (en)	2000-12-29
HU9302965D0 (en)	1993-12-28
ES2149215T3 (es)	2000-11-01
ZA937780B (en)	1995-04-20
CA2146259A1 (en)	1994-04-28
PT665844E (pt)	2001-01-31
AU5165393A (en)	1994-05-09
HUT65133A (en)	1994-04-28
EP0665844B1 (de)	2000-09-06
DE69329386D1 (de)	2000-10-12
DK0665844T3 (da)	2000-10-16
DE69329386T2 (de)	2001-01-04
JPH06135963A (ja)	1994-05-17
FI114636B (fi)	2004-11-30
EP0665844A1 (de)	1995-08-09
WO1994008997A1 (en)	1994-04-28
IL107292A0 (en)	1994-01-25
FI934626A0 (fi)	1993-10-20
CA2146259C (en)	1998-04-07
FI934626L (fi)	1994-04-22
MX9306527A (es)	1994-07-29
JP2656699B2 (ja)	1997-09-24

Legal Events

Date	Code	Title	Description
2001-01-15	UEP	Publication of translation of european patent specification
2006-06-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69329386D1 (de)	2000-10-12	Substituierte benzylaminoquinuclidine als substanz p antagonisten
DE69923849D1 (de)	2005-03-31	Quinolin-2-on-derivate verwendbar als antikrebsmittel
DE69331190D1 (de)	2002-01-03	Überbrückte azabicyclische derivate als substanz p antagonisten
ES534624A0 (es)	1985-12-16	Un procedimiento para preparar un derivado de 1,8-naftiridina
GB8501192D0 (en)	1985-02-20	Therapeutic agents
MY104335A (en)	1994-03-31	4-aminophridine deravatives
ES2098023T3 (es)	1997-04-16	Compuestos de estructura guanidinica y composiciones farmaceuticas que los contienen.
DE69711920D1 (de)	2002-05-16	Neue histidinderivate, verfahren zu ihrer herstellung und ihre verwendung als mittel gegen freie radikale
DE69918046D1 (de)	2004-07-22	Neue basische Derivate von Benz(e)isoindol-1-onen und Pyrrolo(3,4-c)chinolin-1-onen mit 5-HT3-antagonistischer Aktivität, ihre Herstellung und ihre therapeutische Verwendung
HU913892D0 (en)	1992-02-28	Method for producing new alkyl-amino-alkyl-amine and -ether derivatives and pharmaceutical preparatives containing said compounds
SE7502243L (de)	1975-09-08
EP0626369A4 (de)	1994-08-29	Benzolsulfonamid derivate.
MX9702089A (es)	1997-06-28	Carboxamidas biciclicas como antagonistas de 5-ht1a.
ATE247662T1 (de)	2003-09-15	Indolocarbazolalkaloide aus einer marinen actinomycete
ES2023760A6 (es)	1992-02-01	Procedimiento para la preparacion de derivados benzotiazinicos.
IS5623A (is)	2000-09-11	Ný efnasambönd
TW353071B (en)	1999-02-21	Chromene compounds with neutroleptic activity, their preparation and pharmaceutical compositions
FR2695643B1 (fr)	1994-11-25	Dérivés d'uréido-acétamide, leur préparation et les médicaments les contenant.
ES8602825A1 (es)	1985-12-01	Un procedimiento para preparar un compuesto fosforoditioico