ATE196288T1 - N-(3-amino-2-hydroxybutyl)sulfonamid-derivate as hiv-protease-inhibitoren - Google Patents

N-(3-amino-2-hydroxybutyl)sulfonamid-derivate as hiv-protease-inhibitoren

Info

Publication number: ATE196288T1
Authority: AT; Austria
Prior art keywords: hiv protease; protease inhibitors; hydroxybutyl; amino; sulfonamide derivatives
Prior art date: 1994-05-23

Application number

AT95921534T

Other languages

English (en)

Inventor

Vincent J Kalish

Original Assignee

Agouron Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-05-23

Filing date

1995-05-23

Publication date

2000-09-15

1995-05-23 Application filed by Agouron Pharma filed Critical Agouron Pharma

2000-09-15 Application granted granted Critical

2000-09-15 Publication of ATE196288T1 publication Critical patent/ATE196288T1/de

Links

239000004030 hiv protease inhibitor Substances 0.000 title abstract 2
ZPKCQPKSOUTTID-UHFFFAOYSA-N CC(N)C(O)CNS(=O)=O Chemical class CC(N)C(O)CNS(=O)=O ZPKCQPKSOUTTID-UHFFFAOYSA-N 0.000 title 1
241000725303 Human immunodeficiency virus Species 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
208000030507 AIDS Diseases 0.000 abstract 1
108010010369 HIV Protease Proteins 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
239000003443 antiviral agent Substances 0.000 abstract 1
230000004071 biological effect Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000010076 replication Effects 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/46—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms
- C07C323/49—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms to sulfur atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Virology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Bioinformatics & Cheminformatics (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Thiazole And Isothizaole Compounds (AREA)
Pyridine Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT95921534T 1994-05-23 1995-05-23 N-(3-amino-2-hydroxybutyl)sulfonamid-derivate as hiv-protease-inhibitoren ATE196288T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/247,983 US5527829A (en)	1994-05-23	1994-05-23	HIV protease inhibitors
PCT/US1995/006866 WO1995032185A1 (en)	1994-05-23	1995-05-23	N-(3-amino-2-hydroxybutyl)sulphonamide derivatives as hiv protease inhibitors

Publications (1)

Publication Number	Publication Date
ATE196288T1 true ATE196288T1 (de)	2000-09-15

Family

ID=22937168

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95921534T ATE196288T1 (de)	1994-05-23	1995-05-23	N-(3-amino-2-hydroxybutyl)sulfonamid-derivate as hiv-protease-inhibitoren

Country Status (12)

Country	Link
US (1)	US5527829A (de)
EP (1)	EP0763017B1 (de)
JP (2)	JP3732858B2 (de)
AT (1)	ATE196288T1 (de)
AU (1)	AU2658695A (de)
CA (1)	CA2190472A1 (de)
DE (1)	DE69518840T2 (de)
DK (1)	DK0763017T3 (de)
ES (1)	ES2151600T3 (de)
GR (1)	GR3035014T3 (de)
PT (1)	PT763017E (de)
WO (1)	WO1995032185A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6878728B1 (en)	1999-06-11	2005-04-12	Vertex Pharmaceutical Incorporated	Inhibitors of aspartyl protease
US20040122000A1 (en)	1981-01-07	2004-06-24	Vertex Pharmaceuticals Incorporated.	Inhibitors of aspartyl protease
US5484926A (en) *	1993-10-07	1996-01-16	Agouron Pharmaceuticals, Inc.	HIV protease inhibitors
MY126358A (en) *	1996-03-22	2006-09-29	Glaxo Group Ltd	Compositions comprising vx478 and a water soluble tocopherol derivative such as vitamin e-tpgs
US5962725A (en)	1996-09-05	1999-10-05	Agouron Pharmaceuticals, Inc.	Intermediate compounds useful for making HIV protease inhibitors such as nelfinavir
US5925759A (en)	1996-09-05	1999-07-20	Agouron Pharmaceuticals, Inc.	Methods of making HIV-protease inhibitors and intermediates for making HIV-protease inhibitors
US5705647A (en) *	1996-09-05	1998-01-06	Agouron Pharmaceuticals, Inc.	Intermediates for making HIV-protease inhibitors
US6001851A (en) *	1997-03-13	1999-12-14	Agouron Pharmaceuticals, Inc.	HIV protease inhibitors
DE19730602A1 (de) *	1997-07-17	1999-01-21	Clariant Gmbh	3-Acetoxy-2-methylbenzoesäurechlorid und ein Verfahren zu seiner Herstellung
US6084107A (en) *	1997-09-05	2000-07-04	Agouron Pharmaceuticals, Inc.	Intermediates for making HIV-protease inhibitors
US6436989B1 (en)	1997-12-24	2002-08-20	Vertex Pharmaceuticals, Incorporated	Prodrugs of aspartyl protease inhibitors
PT1086076E (pt)	1998-06-19	2005-05-31	Vertex Pharma	Inibidores de sulfonamida de aspartil protease
TNSN00027A1 (fr)	1999-02-12	2005-11-10	Vertex Pharma	Inhibiteurs de l'aspartyle protease
US6403799B1 (en)	1999-10-21	2002-06-11	Agouron Pharmaceuticals, Inc.	Methods for the preparation of intermediates in the synthesis of HIV-protease inhibitors
US6506786B2 (en)	2001-02-13	2003-01-14	Pharmacor Inc.	HIV protease inhibitors based on amino acid derivatives
DE10226219A1 (de) *	2002-06-13	2004-01-08	Bayer Ag	Verfahren zur Herstellung von 3-Acyloxy-2-methylbenzoesäuren
US7388008B2 (en) *	2004-08-02	2008-06-17	Ambrilia Biopharma Inc.	Lysine based compounds
WO2006114001A1 (en) *	2005-04-27	2006-11-02	Ambrilia Biopharma Inc.	Method for improving pharmacokinetics of protease inhibitors and protease inhibitor precursors
ES2452718T3 (es) *	2005-11-30	2014-04-02	Taimed Biologics, Inc.	Profármacos a base de lisina de inhibidores de la aspartil proteasa y procesos para su preparación
CA2664118A1 (en) *	2006-09-21	2008-07-03	Ambrilia Biopharma Inc.	Protease inhibitors

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5142056A (en) *	1989-05-23	1992-08-25	Abbott Laboratories	Retroviral protease inhibiting compounds
DE3023855A1 (de) *	1980-06-25	1982-01-14	Bayer Ag, 5090 Leverkusen	Reaktivfarbstoffe, verfahren zu ihrer herstellung und ihre verwendung zum faerben und bedrucken hydroxylgruppenhaltiger oder stickstoffhaltiger fasermaterialien
IL89900A0 (en) *	1988-04-12	1989-12-15	Merck & Co Inc	Hiv protease inhibitors useful for the treatment of aids and pharmaceutical compositions containing them
CA1340588C (en) *	1988-06-13	1999-06-08	Balraj Krishan Handa	Amino acid derivatives
IL91307A0 (en) *	1988-08-24	1990-03-19	Merck & Co Inc	Hiv protease inhibitors and pharmaceutical compositions for the treatment of aids containing them
EP0361341A3 (de) *	1988-09-28	1991-07-03	Miles Inc.	Therapeutika für AIDS auf der Basis von HIV-Protease-Inhibitoren
US5063208A (en) *	1989-07-26	1991-11-05	Abbott Laboratories	Peptidyl aminodiol renin inhibitors
WO1991008221A1 (en) *	1989-12-04	1991-06-13	Wisconsin Alumni Research Foundation	Peptide inhibitors of hiv protease
GB8927915D0 (en) *	1989-12-11	1990-02-14	Hoffmann La Roche	Novel alcohols
GB8927913D0 (en) *	1989-12-11	1990-02-14	Hoffmann La Roche	Amino acid derivatives
CA2056911C (en) *	1990-12-11	1998-09-22	Yuuichi Nagano	Hiv protease inhibitors
CA2060844A1 (en) *	1991-02-08	1992-08-09	Yabe Yuichiro	Beta-amino-alpha-hydroxycarboxylic acids and their use
US5235039A (en) *	1991-06-10	1993-08-10	Eli Lilly And Company	Substrates for hiv protease
CN1071930A (zh) *	1991-07-10	1993-05-12	伊莱利利公司	用作治疗艾滋病的人免疫缺陷病毒蛋白酶的抑制剂
DE4126482A1 (de) *	1991-08-10	1993-02-11	Bayer Ag	(alpha)-trifluormethyl-substituierte, gesaettigt-bicyclische amine und verfahren zu deren herstellung
US5516784A (en) *	1991-08-13	1996-05-14	Schering Corporation	Anti-HIV (AIDS) agents
EP0534511A1 (de) *	1991-08-16	1993-03-31	Merck & Co. Inc.	HIV-Protease-Hemmer zur Behandlung von AIDS
US5256783A (en) *	1991-09-18	1993-10-26	Hoffmann-La Roche Inc.	Method for producing 2-isoquinoline compounds
WO1993008184A1 (en) *	1991-10-23	1993-04-29	Merck & Co., Inc.	Hiv protease inhibitors
ZA929869B (en) *	1991-12-20	1994-06-20	Syntex Inc	Hiv protease inhibitors
DE69300043T2 (de) *	1992-03-13	1995-05-24	Bio Mega Boehringer Ingelheim	Substituierte Pipecoline-Säurederivate als HIV-Protease-Hemmer.
EP1148050A1 (de) *	1992-05-21	2001-10-24	Monsanto Company	Retrovirale Proteaseinhibitoren
ES2123065T3 (es) *	1992-08-25	1999-01-01	Searle & Co	Hidroxietilamino-sulfonamidas utiles como inhibidores de proteasas retroviricas.
DE69311810T2 (de) *	1992-08-25	1997-11-27	Monsanto Co	N-(alkanoylamino-2-hydroxypropyl)-sulfonamide verwendbar als retrovirale proteaseninhibitoren
IS2334B (is) *	1992-09-08	2008-02-15	Vertex Pharmaceuticals Inc., (A Massachusetts Corporation)	Aspartyl próteasi hemjari af nýjum flokki súlfonamíða

1994
- 1994-05-23 US US08/247,983 patent/US5527829A/en not_active Expired - Fee Related
1995
- 1995-05-23 AU AU26586/95A patent/AU2658695A/en not_active Abandoned
- 1995-05-23 EP EP95921534A patent/EP0763017B1/de not_active Expired - Lifetime
- 1995-05-23 WO PCT/US1995/006866 patent/WO1995032185A1/en not_active Ceased
- 1995-05-23 ES ES95921534T patent/ES2151600T3/es not_active Expired - Lifetime
- 1995-05-23 PT PT95921534T patent/PT763017E/pt unknown
- 1995-05-23 DE DE69518840T patent/DE69518840T2/de not_active Expired - Fee Related
- 1995-05-23 CA CA002190472A patent/CA2190472A1/en not_active Abandoned
- 1995-05-23 JP JP53056295A patent/JP3732858B2/ja not_active Expired - Fee Related
- 1995-05-23 DK DK95921534T patent/DK0763017T3/da active
- 1995-05-23 AT AT95921534T patent/ATE196288T1/de not_active IP Right Cessation
2000
- 2000-12-06 GR GR20000402705T patent/GR3035014T3/el not_active IP Right Cessation
2005
- 2005-07-26 JP JP2005216300A patent/JP2006022106A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
DK0763017T3 (da)	2001-01-08
JP3732858B2 (ja)	2006-01-11
GR3035014T3 (en)	2001-03-30
ES2151600T3 (es)	2001-01-01
DE69518840D1 (en)	2000-10-19
JPH10501796A (ja)	1998-02-17
DE69518840T2 (de)	2001-01-11
EP0763017A1 (de)	1997-03-19
JP2006022106A (ja)	2006-01-26
WO1995032185A1 (en)	1995-11-30
EP0763017B1 (de)	2000-09-13
CA2190472A1 (en)	1995-11-30
AU2658695A (en)	1995-12-18
US5527829A (en)	1996-06-18
PT763017E (pt)	2001-01-31

Legal Events

Date	Code	Title	Description
2007-02-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
MY138860A (en)	2009-08-28	Hiv protease inhibitors.
ATE196288T1 (de)	2000-09-15	N-(3-amino-2-hydroxybutyl)sulfonamid-derivate as hiv-protease-inhibitoren
EA199800943A1 (ru)	1999-04-29	Производные мочевины и их применение в качестве ингибиторов инозин-5`-монофосфат- дегидрогеназы
MX9603909A (es)	1997-03-29	Derivados de sulfonamida como inhibidores de proteasa aspartilo.
BR0009485A (pt)	2002-02-05	Método e composições para evitar ou reduzir infecção por hiv pelo uso de inibidores para leucina aminopeptidase
EA199700331A1 (ru)	1998-04-30	Тгф-содержащие сульфонамидные ингибиторы аспартил-протеазы
AP2003002915A0 (en)	2003-12-31	HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis.
FI962022A0 (fi)	1996-05-13	5,6-dihydropyronijohdannaiset proteaasi-inhibiittoreina ja antiviraalisina aineina
FI962021A0 (fi)	1996-05-13	5,6-dihydropyronijohdannaiset proteaasi-inhibiittoreina ja antiviraalisina aineina
ATE179164T1 (de)	1999-05-15	Hiv-proteaseinhibitoren
DE69828522D1 (de)	2005-02-10	Antithrombotische mittel
MY117535A (en)	2004-07-31	Hiv protease inhibitors
IT1318424B1 (it)	2003-08-25	Composti con attivita' anti-hiv.
EE9900188A (et)	1999-12-15	HIV proteaasi inhibiitoritena kasulikud 1-(3-aminoindasool-5-üül)-3-fenüülmetüül-tsüklilised uuread
TH14264B (th)	2003-02-21	ตัวยับยั้ง hiv โพรทิเอส