DK0763017T3 - N-(3-amino-2-hydroxybutyl)sulfonamidderivater som HIV-proteaseinhibitorer - Google Patents

N-(3-amino-2-hydroxybutyl)sulfonamidderivater som HIV-proteaseinhibitorer

Info

Publication number: DK0763017T3
Authority: DK; Denmark
Prior art keywords: hiv protease; protease inhibitors; hydroxybutyl; amino; sulfonamide derivatives
Prior art date: 1994-05-23

Application number

DK95921534T

Other languages

English (en)

Inventor

Vincent J Kalish

Original Assignee

Agouron Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-05-23

Filing date

1995-05-23

Publication date

2001-01-08

1995-05-23 Application filed by Agouron Pharma filed Critical Agouron Pharma

2001-01-08 Application granted granted Critical

2001-01-08 Publication of DK0763017T3 publication Critical patent/DK0763017T3/da

Links

239000004030 hiv protease inhibitor Substances 0.000 title abstract 2
ZPKCQPKSOUTTID-UHFFFAOYSA-N CC(N)C(O)CNS(=O)=O Chemical class CC(N)C(O)CNS(=O)=O ZPKCQPKSOUTTID-UHFFFAOYSA-N 0.000 title 1
241000725303 Human immunodeficiency virus Species 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
208000030507 AIDS Diseases 0.000 abstract 1
108010010369 HIV Protease Proteins 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
239000003443 antiviral agent Substances 0.000 abstract 1
230000004071 biological effect Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000010076 replication Effects 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/46—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms
- C07C323/49—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms to sulfur atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Virology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Molecular Biology (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Thiazole And Isothizaole Compounds (AREA)
Pyridine Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK95921534T 1994-05-23 1995-05-23 N-(3-amino-2-hydroxybutyl)sulfonamidderivater som HIV-proteaseinhibitorer DK0763017T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/247,983 US5527829A (en)	1994-05-23	1994-05-23	HIV protease inhibitors
PCT/US1995/006866 WO1995032185A1 (en)	1994-05-23	1995-05-23	N-(3-amino-2-hydroxybutyl)sulphonamide derivatives as hiv protease inhibitors

Publications (1)

Publication Number	Publication Date
DK0763017T3 true DK0763017T3 (da)	2001-01-08

Family

ID=22937168

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95921534T DK0763017T3 (da)	1994-05-23	1995-05-23	N-(3-amino-2-hydroxybutyl)sulfonamidderivater som HIV-proteaseinhibitorer

Country Status (12)

Country	Link
US (1)	US5527829A (da)
EP (1)	EP0763017B1 (da)
JP (2)	JP3732858B2 (da)
AT (1)	ATE196288T1 (da)
AU (1)	AU2658695A (da)
CA (1)	CA2190472A1 (da)
DE (1)	DE69518840T2 (da)
DK (1)	DK0763017T3 (da)
ES (1)	ES2151600T3 (da)
GR (1)	GR3035014T3 (da)
PT (1)	PT763017E (da)
WO (1)	WO1995032185A1 (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20040122000A1 (en)	1981-01-07	2004-06-24	Vertex Pharmaceuticals Incorporated.	Inhibitors of aspartyl protease
US6878728B1 (en)	1999-06-11	2005-04-12	Vertex Pharmaceutical Incorporated	Inhibitors of aspartyl protease
US5484926A (en)	1993-10-07	1996-01-16	Agouron Pharmaceuticals, Inc.	HIV protease inhibitors
MY126358A (en) *	1996-03-22	2006-09-29	Glaxo Group Ltd	Compositions comprising vx478 and a water soluble tocopherol derivative such as vitamin e-tpgs
US5925759A (en)	1996-09-05	1999-07-20	Agouron Pharmaceuticals, Inc.	Methods of making HIV-protease inhibitors and intermediates for making HIV-protease inhibitors
US5962725A (en)	1996-09-05	1999-10-05	Agouron Pharmaceuticals, Inc.	Intermediate compounds useful for making HIV protease inhibitors such as nelfinavir
US5705647A (en) *	1996-09-05	1998-01-06	Agouron Pharmaceuticals, Inc.	Intermediates for making HIV-protease inhibitors
US6001851A (en) *	1997-03-13	1999-12-14	Agouron Pharmaceuticals, Inc.	HIV protease inhibitors
DE19730602A1 (de) *	1997-07-17	1999-01-21	Clariant Gmbh	3-Acetoxy-2-methylbenzoesäurechlorid und ein Verfahren zu seiner Herstellung
US6084107A (en) *	1997-09-05	2000-07-04	Agouron Pharmaceuticals, Inc.	Intermediates for making HIV-protease inhibitors
US6436989B1 (en)	1997-12-24	2002-08-20	Vertex Pharmaceuticals, Incorporated	Prodrugs of aspartyl protease inhibitors
BR9912169A (pt)	1998-06-19	2001-04-10	Vertex Pharma	Inibidores de sulfonamida de protease de aspartil
TWI260322B (en)	1999-02-12	2006-08-21	Vertex Pharma	Inhibitors of aspartyl protease
US6403799B1 (en)	1999-10-21	2002-06-11	Agouron Pharmaceuticals, Inc.	Methods for the preparation of intermediates in the synthesis of HIV-protease inhibitors
US6506786B2 (en)	2001-02-13	2003-01-14	Pharmacor Inc.	HIV protease inhibitors based on amino acid derivatives
DE10226219A1 (de) *	2002-06-13	2004-01-08	Bayer Ag	Verfahren zur Herstellung von 3-Acyloxy-2-methylbenzoesäuren
US7388008B2 (en) *	2004-08-02	2008-06-17	Ambrilia Biopharma Inc.	Lysine based compounds
ES2539527T3 (es) *	2005-04-27	2015-07-01	Taimed Biologics, Inc.	Método para mejorar la farmacocinética de los inhibidores de las proteasas y de los precursores de los inhibidores de las proteasas
CN101405293B (zh) *	2005-11-30	2013-03-13	中裕新药股份有限公司	天冬氨酰基蛋白酶抑制剂基于赖氨酸的前体药物及其制备方法
US8410300B2 (en) *	2006-09-21	2013-04-02	Taimed Biologics, Inc.	Protease inhibitors

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5142056A (en) *	1989-05-23	1992-08-25	Abbott Laboratories	Retroviral protease inhibiting compounds
DE3023855A1 (de) *	1980-06-25	1982-01-14	Bayer Ag, 5090 Leverkusen	Reaktivfarbstoffe, verfahren zu ihrer herstellung und ihre verwendung zum faerben und bedrucken hydroxylgruppenhaltiger oder stickstoffhaltiger fasermaterialien
IL89900A0 (en) *	1988-04-12	1989-12-15	Merck & Co Inc	Hiv protease inhibitors useful for the treatment of aids and pharmaceutical compositions containing them
CA1340588C (en) *	1988-06-13	1999-06-08	Balraj Krishan Handa	Amino acid derivatives
IL91307A0 (en) *	1988-08-24	1990-03-19	Merck & Co Inc	Hiv protease inhibitors and pharmaceutical compositions for the treatment of aids containing them
EP0361341A3 (en) *	1988-09-28	1991-07-03	Miles Inc.	Therapeutics for aids based on inhibitors of hiv protease
US5063208A (en) *	1989-07-26	1991-11-05	Abbott Laboratories	Peptidyl aminodiol renin inhibitors
WO1991008221A1 (en) *	1989-12-04	1991-06-13	Wisconsin Alumni Research Foundation	Peptide inhibitors of hiv protease
GB8927915D0 (en) *	1989-12-11	1990-02-14	Hoffmann La Roche	Novel alcohols
GB8927913D0 (en) *	1989-12-11	1990-02-14	Hoffmann La Roche	Amino acid derivatives
CA2056911C (en) *	1990-12-11	1998-09-22	Yuuichi Nagano	Hiv protease inhibitors
ZA92913B (en) *	1991-02-08	1993-05-06	Sankyo Co	New beta-amino-alpha hydroxycarboxylic acids and ttheir use
US5235039A (en) *	1991-06-10	1993-08-10	Eli Lilly And Company	Substrates for hiv protease
CN1071930A (zh) *	1991-07-10	1993-05-12	伊莱利利公司	用作治疗艾滋病的人免疫缺陷病毒蛋白酶的抑制剂
DE4126482A1 (de) *	1991-08-10	1993-02-11	Bayer Ag	(alpha)-trifluormethyl-substituierte, gesaettigt-bicyclische amine und verfahren zu deren herstellung
US5516784A (en) *	1991-08-13	1996-05-14	Schering Corporation	Anti-HIV (AIDS) agents
EP0534511A1 (en) *	1991-08-16	1993-03-31	Merck & Co. Inc.	HIV protease inhibitors useful for the treatment of aids
US5256783A (en) *	1991-09-18	1993-10-26	Hoffmann-La Roche Inc.	Method for producing 2-isoquinoline compounds
WO1993008184A1 (en) *	1991-10-23	1993-04-29	Merck & Co., Inc.	Hiv protease inhibitors
WO1993013066A1 (en) *	1991-12-20	1993-07-08	Syntex (U.S.A.) Inc.	Cyclic amides of 3-amino-2-hydroxy-carboxylic acids as hiv-protease inhibitors
EP0560268B1 (en) *	1992-03-13	1995-01-04	Bio-Mega/Boehringer Ingelheim Research Inc.	Substituted pipecolinic acid derivatives as HIV protease inhibitors
AU667376B2 (en) *	1992-05-21	1996-03-21	Monsanto Company	Retroviral protease inhibitors
WO1994004491A1 (en) *	1992-08-25	1994-03-03	G.D. Searle & Co.	N-(alkanoylamino-2-hydroxypropyl)-sulfonamides useful as retroviral protease inhibitors
ATE218541T1 (de) *	1992-08-25	2002-06-15	Searle & Co	Hydroxyethylaminosulfonamide verwendbar als inhibitoren retroviraler proteasen
IS2334B (is) *	1992-09-08	2008-02-15	Vertex Pharmaceuticals Inc., (A Massachusetts Corporation)	Aspartyl próteasi hemjari af nýjum flokki súlfonamíða

1994
- 1994-05-23 US US08/247,983 patent/US5527829A/en not_active Expired - Fee Related
1995
- 1995-05-23 AU AU26586/95A patent/AU2658695A/en not_active Abandoned
- 1995-05-23 CA CA002190472A patent/CA2190472A1/en not_active Abandoned
- 1995-05-23 DK DK95921534T patent/DK0763017T3/da active
- 1995-05-23 DE DE69518840T patent/DE69518840T2/de not_active Expired - Fee Related
- 1995-05-23 EP EP95921534A patent/EP0763017B1/en not_active Expired - Lifetime
- 1995-05-23 AT AT95921534T patent/ATE196288T1/de not_active IP Right Cessation
- 1995-05-23 ES ES95921534T patent/ES2151600T3/es not_active Expired - Lifetime
- 1995-05-23 PT PT95921534T patent/PT763017E/pt unknown
- 1995-05-23 JP JP53056295A patent/JP3732858B2/ja not_active Expired - Fee Related
- 1995-05-23 WO PCT/US1995/006866 patent/WO1995032185A1/en not_active Ceased
2000
- 2000-12-06 GR GR20000402705T patent/GR3035014T3/el not_active IP Right Cessation
2005
- 2005-07-26 JP JP2005216300A patent/JP2006022106A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
DE69518840D1 (en)	2000-10-19
JP2006022106A (ja)	2006-01-26
JP3732858B2 (ja)	2006-01-11
CA2190472A1 (en)	1995-11-30
GR3035014T3 (en)	2001-03-30
PT763017E (pt)	2001-01-31
US5527829A (en)	1996-06-18
WO1995032185A1 (en)	1995-11-30
EP0763017B1 (en)	2000-09-13
ES2151600T3 (es)	2001-01-01
AU2658695A (en)	1995-12-18
EP0763017A1 (en)	1997-03-19
ATE196288T1 (de)	2000-09-15
DE69518840T2 (de)	2001-01-11
JPH10501796A (ja)	1998-02-17

Publication	Publication Date	Title
EP1340744A3 (en)	2003-12-03	Hiv protease inhibitors
DK0763017T3 (da)	2001-01-08	N-(3-amino-2-hydroxybutyl)sulfonamidderivater som HIV-proteaseinhibitorer
BR0009485A (pt)	2002-02-05	Método e composições para evitar ou reduzir infecção por hiv pelo uso de inibidores para leucina aminopeptidase
MX9603909A (es)	1997-03-29	Derivados de sulfonamida como inhibidores de proteasa aspartilo.
EA199700331A1 (ru)	1998-04-30	Тгф-содержащие сульфонамидные ингибиторы аспартил-протеазы
AP9600827A0 (en)	1997-10-17	Oxygenated-heterocycle containing sulfonamide inhibitors of aspartyl protease.
DK1142887T3 (da)	2004-06-21	5,6-Dihydropyronderivater som proteaseinhibitorer og antivirale midler
FI962021A0 (fi)	1996-05-13	5,6-dihydropyronijohdannaiset proteaasi-inhibiittoreina ja antiviraalisina aineina
ATE179164T1 (de)	1999-05-15	Hiv-proteaseinhibitoren
ATE253359T1 (de)	2003-11-15	Antithrombotische mittel
ATE286395T1 (de)	2005-01-15	Antithrombotische mittel
MY117535A (en)	2004-07-31	Hiv protease inhibitors
IT1318424B1 (it)	2003-08-25	Composti con attivita' anti-hiv.
EE9900188A (et)	1999-12-15	HIV proteaasi inhibiitoritena kasulikud 1-(3-aminoindasool-5-üül)-3-fenüülmetüül-tsüklilised uuread
NO20001846L (no)	2000-04-10	Nye farmasøytisk aktive forbindelser, deres fremstilling og anvendelse som ECE-inhibitorer
TH14264B (th)	2003-02-21	ตัวยับยั้ง hiv โพรทิเอส
MX9708055A (es)	1998-01-31	Inhibidores de aspartil proteasa consistentes en sulfonamida que contiene heterociclo oxigenado.