ATE196364T1 - Reagenzien und verfahren für die quantifizierung von imipramin oder desimipramin in biologischen flüssigkeiten - Google Patents

Reagenzien und verfahren für die quantifizierung von imipramin oder desimipramin in biologischen flüssigkeiten

Info

Publication number: ATE196364T1
Authority: AT; Austria
Prior art keywords: imipramine; desipramine; reagents; quantification; methods
Prior art date: 1991-07-31

Application number

AT92917086T

Other languages

English (en)

Inventor

Maciej Adamczyk

Donald Johnson

Charles A Harrington

Original Assignee

Abbott Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-07-31

Filing date

1992-07-29

Publication date

2000-09-15

1992-07-29 Application filed by Abbott Lab filed Critical Abbott Lab

2000-09-15 Application granted granted Critical

2000-09-15 Publication of ATE196364T1 publication Critical patent/ATE196364T1/de

Links

HCYAFALTSJYZDH-UHFFFAOYSA-N Desimpramine Chemical compound C1CC2=CC=CC=C2N(CCCNC)C2=CC=CC=C21 HCYAFALTSJYZDH-UHFFFAOYSA-N 0.000 title abstract 6
229960004801 imipramine Drugs 0.000 title abstract 6
BCGWQEUPMDMJNV-UHFFFAOYSA-N imipramine Chemical compound C1CC2=CC=CC=C2N(CCCN(C)C)C2=CC=CC=C21 BCGWQEUPMDMJNV-UHFFFAOYSA-N 0.000 title abstract 6
229960003914 desipramine Drugs 0.000 title abstract 5
239000003153 chemical reaction reagent Substances 0.000 title abstract 3
238000011002 quantification Methods 0.000 title abstract 2
239000007788 liquid Substances 0.000 title 1
238000000034 method Methods 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 2
239000012876 carrier material Substances 0.000 abstract 2
GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 abstract 2
125000005842 heteroatom Chemical group 0.000 abstract 2
238000003018 immunoassay Methods 0.000 abstract 2
230000002163 immunogen Effects 0.000 abstract 2
125000005647 linker group Chemical group 0.000 abstract 2
230000015572 biosynthetic process Effects 0.000 abstract 1
238000005259 measurement Methods 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
- C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
- C07D223/28—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a single bond between positions 10 and 11
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/9466—Antidepressants
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/815—Test for named compound or class of compounds
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/807—Hapten conjugated with peptide or protein

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Molecular Biology (AREA)
Urology & Nephrology (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Organic Chemistry (AREA)
Microbiology (AREA)
Cell Biology (AREA)
Food Science & Technology (AREA)
Medicinal Chemistry (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Biotechnology (AREA)
Psychiatry (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Pain & Pain Management (AREA)
Peptides Or Proteins (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Luminescent Compositions (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)
Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

AT92917086T 1991-07-31 1992-07-29 Reagenzien und verfahren für die quantifizierung von imipramin oder desimipramin in biologischen flüssigkeiten ATE196364T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US73901291A	1991-07-31	1991-07-31
US07/916,161 US5340750A (en)	1991-07-31	1992-07-24	Reagents and methods for the quantification of imipramine or desipramine in biological fluids
PCT/US1992/006303 WO1993003371A1 (en)	1991-07-31	1992-07-29	Reagents and methods for the quantification of imipramine or desipramine in biological fluids

Publications (1)

Publication Number	Publication Date
ATE196364T1 true ATE196364T1 (de)	2000-09-15

Family

ID=27113468

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92917086T ATE196364T1 (de)	1991-07-31	1992-07-29	Reagenzien und verfahren für die quantifizierung von imipramin oder desimipramin in biologischen flüssigkeiten

Country Status (9)

Country	Link
US (2)	US5340750A (de)
EP (1)	EP0641439B1 (de)
JP (1)	JP3285577B2 (de)
AT (1)	ATE196364T1 (de)
AU (1)	AU2424792A (de)
CA (1)	CA2110916C (de)
DE (1)	DE69231448T2 (de)
ES (1)	ES2151491T3 (de)
WO (1)	WO1993003371A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1298693B1 (it) *	1996-04-24	2000-01-12	Hoffmann La Roche	Derivati della fluoresceina 4'-metil sostituiti
US6368814B1 (en) *	2000-12-22	2002-04-09	Roche Diagnostics Corporation	Tricyclic antidepressant derivatives and immunoassay
CN101726530B (zh) *	2009-12-30	2013-01-02	中国科学院长春应用化学研究所	一种分离检测手性三甲丙咪嗪的方法
CN101799423B (zh) *	2010-03-15	2012-06-27	中国科学院长春应用化学研究所	一种分离检测丙咪嗪和三甲丙咪嗪的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4223013A (en) *	1978-12-29	1980-09-16	Syva Company	Amitriptyline conjugates to antigenic proteins and enzymes
US4275160A (en) *	1979-07-06	1981-06-23	Syva Company	Imipramine derivatives and poly(amino acid) conjugates
US4420568A (en) *	1980-07-30	1983-12-13	Abbott Laboratories	Fluorescent polarization immunoassay utilizing substituted triazinylaminofluoresceins
US4495281A (en) *	1982-10-21	1985-01-22	Miles Laboratories, Inc.	Tricyclic antidepressant drug immunogens, antibodies, labeled conjugates, and related derivatives
US4772697A (en)	1983-08-01	1988-09-20	Syntex (U.S.A.) Inc.	Tricylic antidepressant conjugates to antigens and enzymes
US4629691A (en) *	1983-08-01	1986-12-16	Syntex (U.S.A.) Inc.	Tricyclic antidepressant conjugates with antigens and enzymes
US4551275A (en) *	1984-03-23	1985-11-05	Syntex (U.S.A.) Inc.	Desmethylimipramine derivatives and poly(amino acid) conjugates
EP0226730B1 (de) *	1985-10-15	1994-03-02	Abbott Laboratories	Verbindungen und Immunoassay für tricyclische Antidepressiva
US5413911A (en)	1990-12-14	1995-05-09	Abbott Laboratories	Determination of tricyclic antidepressant drugs in the presence of interfering substances
US5407835A (en) *	1991-07-31	1995-04-18	Abbott Laboratories	Reagents and methods for the quantification of amitriptyline or nortriptyline in biological fluids

1992
- 1992-07-24 US US07/916,161 patent/US5340750A/en not_active Expired - Lifetime
- 1992-07-29 ES ES92917086T patent/ES2151491T3/es not_active Expired - Lifetime
- 1992-07-29 CA CA002110916A patent/CA2110916C/en not_active Expired - Fee Related
- 1992-07-29 EP EP92917086A patent/EP0641439B1/de not_active Expired - Lifetime
- 1992-07-29 DE DE69231448T patent/DE69231448T2/de not_active Expired - Fee Related
- 1992-07-29 JP JP50371393A patent/JP3285577B2/ja not_active Expired - Fee Related
- 1992-07-29 AU AU24247/92A patent/AU2424792A/en not_active Abandoned
- 1992-07-29 WO PCT/US1992/006303 patent/WO1993003371A1/en not_active Ceased
- 1992-07-29 AT AT92917086T patent/ATE196364T1/de not_active IP Right Cessation
1994
- 1994-08-05 US US08/286,731 patent/US5578500A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JPH06509581A (ja)	1994-10-27
CA2110916A1 (en)	1993-02-18
JP3285577B2 (ja)	2002-05-27
DE69231448D1 (de)	2000-10-19
DE69231448T2 (de)	2001-04-12
CA2110916C (en)	1997-02-25
AU2424792A (en)	1993-03-02
ES2151491T3 (es)	2001-01-01
EP0641439A1 (de)	1995-03-08
WO1993003371A1 (en)	1993-02-18
EP0641439B1 (de)	2000-09-13
US5340750A (en)	1994-08-23
EP0641439A4 (de)	1996-08-28
US5578500A (en)	1996-11-26

Legal Events

Date	Code	Title	Description
2001-04-15	UEP	Publication of translation of european patent specification
2006-04-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69030829T2 (de)	1998-01-15	Reagenzien zum Nachweis von Drogen
DE68911633T2 (de)	1994-04-07	Verfahren zur Bestimmung von Peroxidase-Aktivität unter Verwendung von Chemilumineszenz.
US5101015A (en)	1992-03-31	Reagents for an amphetamine-class fluorescence polarization immunoassay
DE69214942T2 (de)	1997-03-27	Verfahren für spezifische bindungsassays unter verwendung eines freisetzbaren liganden
US4476229A (en)	1984-10-09	Substituted carboxyfluoresceins
EP0647849A3 (de)	1996-05-15	Nachweis der Anwesenheit von Analyten in einer Probe.
DE69231559D1 (de)	2000-12-14	Reagenzien und verfahren zur quantifizierung des totalgehaltes an doxepinen in biologischen flüssigkeiten
US4255329A (en)	1981-03-10	Double receptor fluorescent immunoassay
KR910020438A (ko)	1991-12-20	다수염소화된 비페닐을 검출하기 위한 시약 및 방법
US4886744A (en)	1989-12-12	Fluorescent conjugates and biological diagnostic assay system
DE58907232D1 (de)	1994-04-21	Neue Digoxigenin-Derivate und ihre Verwendung.
GB2111476A (en)	1983-07-06	Substituted carboxy- fluoresceins and their use in fluorescence polarization immunoassay
ATE74663T1 (de)	1992-04-15	Quadratfarbstoffkonjugat, dessen herstellungsverfahren und dessen verwendung bei testverfahren sowie testsaetze.
DE69609108D1 (de)	2000-08-10	Verbesserte Immunoessayreagenzien zum Nachweis von Kannabinoiden
ATE257155T1 (de)	2004-01-15	Reagenzien für einen lysergsäurediethylamid- immuntest
ATE196364T1 (de)	2000-09-15	Reagenzien und verfahren für die quantifizierung von imipramin oder desimipramin in biologischen flüssigkeiten
DE69231443D1 (de)	2000-10-19	Reagenzien und verfahren zur quantitativen bestimmung von amitriptylin oder nortriptylin in biologischen flüssigkeiten
KR930703290A (ko)	1993-11-29	코티닌 면역검정용 합텐, 트레이서, 면역원 및 항체
US5248791A (en)	1993-09-28	Reagents, methods and kits for an amphetamine-class fluorescence polarization immunoassay
EP0747699A1 (de)	1996-12-11	Entstörungsreagenz für die Bestimmung eines Analyten mit einem lumineszenzfähigen Metallkomplex
Diamandis et al.	1992	Quantitative Western blot analysis and spot immunodetection using time-resolved fluorometry
FR2518096A1 (fr)	1983-06-17	Procede et reactifs de determination immunologique par polarisation de fluorescence
ATE285075T1 (de)	2005-01-15	Detektion und quantifikation von vancomycin in den biologischen flüssigkeiten
WO1997024621A3 (en)	1997-08-14	Reagents for measuring lead levels via the quantification of porphobilinogen
ATE34752T1 (de)	1988-06-15	Mit tritium radioaktiv markierte estradienderivate, verfahren zu ihrer herstellung, zwischenprodukte zu ihrer herstellung und ihre anwendung zum studium und zur bestimmung von steroiden in biologischen fluessigkeiten.