ATE196734T1 - Zusammensetzungen von ergolinderivaten zur behandlung des glaukoms - Google Patents

Zusammensetzungen von ergolinderivaten zur behandlung des glaukoms

Info

Publication number: ATE196734T1
Authority: AT; Austria
Prior art keywords: glaucoma; compositions; treatment; ergoline derivatives; compounds
Prior art date: 1993-08-18

Application number

AT94925815T

Other languages

English (en)

Inventor

Santis Louis De Jr

Vemey L Sallee

Marsha A Mclaughlin

Manoj L Maniar

Original Assignee

Alcon Lab Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-08-18

Filing date

1994-08-10

Publication date

2000-10-15

1994-08-10 Application filed by Alcon Lab Inc filed Critical Alcon Lab Inc

2000-10-15 Application granted granted Critical

2000-10-15 Publication of ATE196734T1 publication Critical patent/ATE196734T1/de

Links

AWFDCTXCTHGORH-HGHGUNKESA-N 6-[4-[(6ar,9r,10ar)-5-bromo-7-methyl-6,6a,8,9,10,10a-hexahydro-4h-indolo[4,3-fg]quinoline-9-carbonyl]piperazin-1-yl]-1-methylpyridin-2-one Chemical group O=C([C@H]1CN([C@H]2[C@@H](C=3C=CC=C4NC(Br)=C(C=34)C2)C1)C)N(CC1)CCN1C1=CC=CC(=O)N1C AWFDCTXCTHGORH-HGHGUNKESA-N 0.000 title abstract 2
208000010412 Glaucoma Diseases 0.000 title 1
239000000203 mixture Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 4
230000004410 intraocular pressure Effects 0.000 abstract 2
KORNTPPJEAJQIU-KJXAQDMKSA-N Cabaser Chemical compound C1=CC([C@H]2C[C@H](CN(CC=C)[C@@H]2C2)C(=O)N(CCCN(C)C)C(=O)NCC)=C3C2=CNC3=C1 KORNTPPJEAJQIU-KJXAQDMKSA-N 0.000 abstract 1
229960004596 cabergoline Drugs 0.000 abstract 1
230000003291 dopaminomimetic effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Ophthalmology & Optometry (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT94925815T 1993-08-18 1994-08-10 Zusammensetzungen von ergolinderivaten zur behandlung des glaukoms ATE196734T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US10885993A	1993-08-18	1993-08-18
PCT/US1994/009052 WO1995005176A1 (en)	1993-08-18	1994-08-10	Use of ergoline derivatives for the treatment of glaucoma

Publications (1)

Publication Number	Publication Date
ATE196734T1 true ATE196734T1 (de)	2000-10-15

Family

ID=22324476

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94925815T ATE196734T1 (de)	1993-08-18	1994-08-10	Zusammensetzungen von ergolinderivaten zur behandlung des glaukoms

Country Status (9)

Country	Link
US (1)	US5705510A (de)
EP (1)	EP0664705B1 (de)
JP (1)	JPH08502759A (de)
AT (1)	ATE196734T1 (de)
AU (1)	AU680539B2 (de)
CA (1)	CA2146006C (de)
DE (1)	DE69426062T2 (de)
ES (1)	ES2152329T3 (de)
WO (1)	WO1995005176A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU3641897A (en) *	1996-07-17	1998-02-09	Conrad W Kamienski	Protected functionalized heterotelechelic polymers and processes for preparing the same
KR20060056417A (ko) *	1998-05-15	2006-05-24	파마시아 앤드 업존 캄파니 엘엘씨	프라미펙솔의 신규 용도
GB0007308D0 (en)	2000-03-24	2000-05-17	Pharmacia & Upjohn Spa	Process for preparing crystalline form \| of cabergoline
PE20030828A1 (es) *	2002-03-04	2003-11-04	Novartis Ag	Composicion oftalmica que comprende ascomicina
MXPA04008915A (es) *	2002-03-15	2005-06-20	Pharmacia Corp	Proceso para la preparacion de la forma cristalina 1 de la cabergolina.
US7939665B2 (en)	2007-05-04	2011-05-10	Apotex Pharmachem Inc.	Efficient process for the preparation of cabergoline and its intermediates
IN2012DN04858A (de) *	2009-12-23	2015-09-25	Map Pharmaceuticals Inc
KR20140042868A (ko)	2011-06-23	2014-04-07	맵 파마슈티컬스, 인코포레이티드	신규한 플루오로에르골린 유사체
SG10201509139QA (en)	2011-12-19	2015-12-30	Map Pharmaceuticals Inc	Novel iso-ergoline derivatives
CA2859175A1 (en)	2011-12-21	2013-06-27	Map Pharmaceuticals, Inc.	Novel neuromodulatory compounds
EP2664329A1 (de) *	2012-05-15	2013-11-20	F. Holzer GmbH	Ophthalmologisches Vehikelsystem
RU2014153672A (ru) *	2012-06-22	2016-08-10	Мап Фармасьютикалс, Инк.	Новые каберголиновые производные
US9012640B2 (en)	2012-06-22	2015-04-21	Map Pharmaceuticals, Inc.	Cabergoline derivatives

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4526892A (en) *	1981-03-03	1985-07-02	Farmitalia Carlo Erba, S.P.A.	Dimethylaminoalkyl-3-(ergoline-8'βcarbonyl)-ureas
GB2103603B (en) *	1981-08-11	1985-04-11	Erba Farmitalia	Ergoline derivatives
GR78151B (de) *	1982-04-05	1984-09-26	Alcon Lab Inc
SE8206744D0 (sv) *	1982-11-26	1982-11-26	Fluidcarbon International Ab	Preparat for kontrollerad avgivning av substanser
US4722933A (en) *	1985-12-20	1988-02-02	Nelson Research & Development Co.	Substituted 2-aminotetralins
US4501749A (en) *	1983-10-31	1985-02-26	Merck & Co., Inc.	Peripherally selective dopamine antagonists in the treatment of ocular hypertension
GB8501078D0 (en) *	1985-01-16	1985-02-20	Erba Farmitalia	Piperazin-1-yl-ergo-line derivatives
US4774243A (en) *	1985-12-24	1988-09-27	Merck & Co., Inc.	Dopamine agonists for treating elevated intraocular pressure
GB8608893D0 (en) *	1986-04-11	1986-05-14	Erba Farmitalia	D-nor-7-ergoline derivatives
ATE56944T1 (de) *	1986-07-28	1990-10-15	Whitby Research Inc	Substituierte 2-aminotetraline.
DE3868866D1 (de) *	1987-11-20	1992-04-09	Erba Carlo Spa	Ergolinderivate mit antiparkinsonwirkung.
US5110606A (en) *	1990-11-13	1992-05-05	Affinity Biotech, Inc.	Non-aqueous microemulsions for drug delivery

1994
- 1994-08-10 WO PCT/US1994/009052 patent/WO1995005176A1/en not_active Ceased
- 1994-08-10 AT AT94925815T patent/ATE196734T1/de not_active IP Right Cessation
- 1994-08-10 DE DE69426062T patent/DE69426062T2/de not_active Expired - Fee Related
- 1994-08-10 AU AU75605/94A patent/AU680539B2/en not_active Ceased
- 1994-08-10 JP JP7507063A patent/JPH08502759A/ja active Pending
- 1994-08-10 CA CA002146006A patent/CA2146006C/en not_active Expired - Fee Related
- 1994-08-10 EP EP94925815A patent/EP0664705B1/de not_active Expired - Lifetime
- 1994-08-10 ES ES94925815T patent/ES2152329T3/es not_active Expired - Lifetime
1995
- 1995-10-25 US US08/547,755 patent/US5705510A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JPH08502759A (ja)	1996-03-26
EP0664705B1 (de)	2000-10-04
DE69426062T2 (de)	2001-03-22
CA2146006A1 (en)	1995-02-23
US5705510A (en)	1998-01-06
EP0664705A1 (de)	1995-08-02
AU680539B2 (en)	1997-07-31
WO1995005176A1 (en)	1995-02-23
DE69426062D1 (de)	2000-11-09
CA2146006C (en)	2004-10-12
ES2152329T3 (es)	2001-02-01
AU7560594A (en)	1995-03-14

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Legal Events

Date	Code	Title	Description
2001-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties