ATE196737T1 - Adjuvantien für impfstoffe gegen das respiratorische synzitialvirus - Google Patents

Adjuvantien für impfstoffe gegen das respiratorische synzitialvirus

Info

Publication number
ATE196737T1
ATE196737T1 AT94918109T AT94918109T ATE196737T1 AT E196737 T1 ATE196737 T1 AT E196737T1 AT 94918109 T AT94918109 T AT 94918109T AT 94918109 T AT94918109 T AT 94918109T AT E196737 T1 ATE196737 T1 AT E196737T1
Authority
AT
Austria
Prior art keywords
pct
adjuvants
vaccines against
against respiratory
respiratory syncitial
Prior art date
Application number
AT94918109T
Other languages
English (en)
Inventor
Gerald E Hancock
Dan J Speelman
Patrick J Frenchick
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22078872&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE196737(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of ATE196737T1 publication Critical patent/ATE196737T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
AT94918109T 1993-05-25 1994-05-24 Adjuvantien für impfstoffe gegen das respiratorische synzitialvirus ATE196737T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6785593A 1993-05-25 1993-05-25
PCT/US1994/005833 WO1994027636A1 (en) 1993-05-25 1994-05-24 Adjuvants for vaccines against respiratory syncytial virus

Publications (1)

Publication Number Publication Date
ATE196737T1 true ATE196737T1 (de) 2000-10-15

Family

ID=22078872

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94918109T ATE196737T1 (de) 1993-05-25 1994-05-24 Adjuvantien für impfstoffe gegen das respiratorische synzitialvirus

Country Status (15)

Country Link
US (1) US5723130A (de)
EP (1) EP0705109B2 (de)
JP (1) JP3734263B2 (de)
AT (1) ATE196737T1 (de)
AU (1) AU676340B2 (de)
CA (1) CA2163550A1 (de)
DE (1) DE69426077T3 (de)
DK (1) DK0705109T4 (de)
ES (1) ES2150493T5 (de)
FI (1) FI955667A7 (de)
GR (1) GR3034785T3 (de)
NO (1) NO954786L (de)
PT (1) PT705109E (de)
RU (1) RU2160119C2 (de)
WO (1) WO1994027636A1 (de)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9105992D0 (en) * 1991-03-21 1991-05-08 Smithkline Beecham Biolog Vaccine
GB9326253D0 (en) 1993-12-23 1994-02-23 Smithkline Beecham Biolog Vaccines
US6727230B1 (en) 1994-03-25 2004-04-27 Coley Pharmaceutical Group, Inc. Immune stimulation by phosphorothioate oligonucleotide analogs
JP3939752B2 (ja) * 1994-10-05 2007-07-04 バンダービルト ユニバーシティー パラミクソウイルスワクチン用アジュバントとしてのインターロイキン−１２
US6488934B1 (en) * 1995-02-25 2002-12-03 Smithkline Beecham Biologicals S.A. Hepatitis B vaccine
UA56132C2 (uk) * 1995-04-25 2003-05-15 Смітклайн Бічем Байолоджікалс С.А. Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини
US7035384B1 (en) * 1996-04-17 2006-04-25 Convergys Cmg Utah, Inc. Call processing system with call screening
US5867562A (en) * 1996-04-17 1999-02-02 Scherer; Gordon F. Call processing system with call screening
US20020136739A1 (en) * 1996-07-12 2002-09-26 Cates George A. Subunit respiratory syncytial virus preparation
WO1998002180A1 (en) * 1996-07-12 1998-01-22 Connaught Laboratories Limited Two-step immunization procedure against the pyramyxoviridae family of viruses using attenuated viral strains and subunit protein preparation
US6020182A (en) * 1996-07-12 2000-02-01 Connaught Laboratories Limited Subunit respiratory syncytial virus vaccine preparation
US6180398B1 (en) * 1996-07-12 2001-01-30 Virogeneitics Corporation Two-step immunization procedure against the pyramyxoviridae family of viruses using recombinant virus and subunit protein preparation
US6406705B1 (en) * 1997-03-10 2002-06-18 University Of Iowa Research Foundation Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
GB9706957D0 (en) 1997-04-05 1997-05-21 Smithkline Beecham Plc Formulation
US6699478B1 (en) * 1997-09-19 2004-03-02 Wyeth Holdings Corporation Enhanced immune response to attachment (G) protein of Respiratory Syncytial Virus
US20080050367A1 (en) 1998-04-07 2008-02-28 Guriq Basi Humanized antibodies that recognize beta amyloid peptide
TWI239847B (en) * 1997-12-02 2005-09-21 Elan Pharm Inc N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
US7790856B2 (en) * 1998-04-07 2010-09-07 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize beta amyloid peptide
US7964192B1 (en) 1997-12-02 2011-06-21 Janssen Alzheimer Immunotherapy Prevention and treatment of amyloidgenic disease
US6787523B1 (en) * 1997-12-02 2004-09-07 Neuralab Limited Prevention and treatment of amyloidogenic disease
US20050059802A1 (en) * 1998-04-07 2005-03-17 Neuralab Ltd Prevention and treatment of amyloidogenic disease
HK1039072A1 (zh) * 1998-05-07 2002-04-12 科里克萨有限公司 佐剂组合物及其使用方法
GB9820525D0 (en) 1998-09-21 1998-11-11 Allergy Therapeutics Ltd Formulation
AU750587B2 (en) * 1998-10-16 2002-07-25 Smithkline Beecham Biologicals (Sa) Adjuvant systems and vaccines
US7198920B1 (en) * 1999-01-29 2007-04-03 Corika Corporation HER-2/neu fusion proteins
GB9909077D0 (en) * 1999-04-20 1999-06-16 Smithkline Beecham Biolog Novel compositions
US6537557B1 (en) * 1999-03-26 2003-03-25 The United States Of America As Represented By The Secretary Of The Army Attenuated dengue-4 virus vaccine
AU779280B2 (en) * 1999-03-26 2005-01-13 Walter Reed Army Institute Of Research Multivalent dengue virus vaccine
CA2365411A1 (en) * 1999-03-26 2000-10-05 Walter Reed Army Institute Of Research Attenuated dengue-2 virus vaccine
US7611721B1 (en) 1999-05-13 2009-11-03 Wyeth Holdings Corporation Adjuvant combination formulations
GB0000891D0 (en) * 2000-01-14 2000-03-08 Allergy Therapeutics Ltd Formulation
CN1437481A (zh) * 2000-06-22 2003-08-20 美国氰胺公司 作为佐剂组合的qs－21和il－12
US7229623B1 (en) * 2000-08-03 2007-06-12 Corixa Corporation Her-2/neu fusion proteins
PE20020530A1 (es) * 2000-11-10 2002-06-18 Wyeth Corp Formulaciones de combinacion adyuvante
US7700751B2 (en) 2000-12-06 2010-04-20 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize β-amyloid peptide
RU2208786C1 (ru) * 2001-12-28 2003-07-20 Государственное образовательное учреждение высшего профессионального образования Санкт-Петербургская государственная педиатрическая медицинская академия Способ определения спонтанной клеточной цитотоксичности
DE10205373B4 (de) * 2002-02-09 2007-07-19 Aloys Wobben Brandschutz
MY139983A (en) * 2002-03-12 2009-11-30 Janssen Alzheimer Immunotherap Humanized antibodies that recognize beta amyloid peptide
MXPA05008156A (es) * 2003-02-01 2005-09-30 Neuralab Ltd Inmunizacion activa para generar anticuerpos para beta-a soluble.
US20060095001A1 (en) * 2004-10-29 2006-05-04 Transcutaneous Technologies Inc. Electrode and iontophoresis device
PE20061329A1 (es) * 2004-12-15 2006-12-08 Neuralab Ltd Anticuerpos ab humanizados para mejorar la cognicion
JP2006346368A (ja) * 2005-06-20 2006-12-28 Transcutaneous Technologies Inc イオントフォレーシス装置及びその製造方法
JP2007000342A (ja) * 2005-06-23 2007-01-11 Transcutaneous Technologies Inc 複数薬剤の投与量および投与時期を制御するイオントフォレーシス装置
US8386030B2 (en) * 2005-08-08 2013-02-26 Tti Ellebeau, Inc. Iontophoresis device
US8295922B2 (en) 2005-08-08 2012-10-23 Tti Ellebeau, Inc. Iontophoresis device
US20070088332A1 (en) * 2005-08-22 2007-04-19 Transcutaneous Technologies Inc. Iontophoresis device
JPWO2007023907A1 (ja) * 2005-08-24 2009-02-26 Ｔｔｉ・エルビュー株式会社 冷凍型イオントフォレーシス用電極構造体
US20070048362A1 (en) * 2005-08-29 2007-03-01 Transcutaneous Technologies Inc. General purpose electrolyte solution composition for iontophoresis
US20100030128A1 (en) * 2005-09-06 2010-02-04 Kazuma Mitsuguchi Iontophoresis device
US20070112294A1 (en) * 2005-09-14 2007-05-17 Transcutaneous Technologies Inc. Iontophoresis device
CN101252968A (zh) * 2005-09-15 2008-08-27 Tti优而美株式会社 棒式离子电渗疗装置
AU2006289888B2 (en) * 2005-09-16 2010-12-02 Tti Ellebeau, Inc. Catheter type iontophoresis apparatus
JPWO2007037324A1 (ja) * 2005-09-28 2009-04-09 Ｔｔｉ・エルビュー株式会社 乾燥型イオントフォレーシス用電極構造体
WO2007041323A1 (en) * 2005-09-30 2007-04-12 Tti Ellebeau, Inc. Iontophoretic delivery of vesicle-encapsulated active agents
RU2008117153A (ru) * 2005-09-30 2009-11-10 ТиТиАй ЭЛЛЕБО, ИНК. (JP) Аппарат для ионтофореза, доставляющий множество активных агентов к биологическим барьерам
US20070135754A1 (en) * 2005-09-30 2007-06-14 Hidero Akiyama Electrode assembly for iontophoresis for administering active agent enclosed in nanoparticle and iontophoresis device using the same
WO2007037475A1 (ja) * 2005-09-30 2007-04-05 Tti Ellebeau, Inc. 形状記憶セパレータを有するイオントフォレーシス用電極構造体およびそれを用いたイオントフォレーシス装置
EP1944057A4 (de) * 2005-09-30 2009-02-18 Tti Ellebeau Inc Iontophorese-gerät zur kontrolle der dosis und zeit der verabreichung eines schlafinduzierenden und analeptischen mittels
KR20080066712A (ko) * 2005-09-30 2008-07-16 티티아이 엘뷰 가부시키가이샤 관능화된 미세바늘 경피 약물 전달 시스템, 장치 및 방법
EP1928539A1 (de) * 2005-09-30 2008-06-11 Tti Ellebeau, Inc. Transdermale funktionalisierte mikronadel-arzneiabgabesysteme, vorrichtungen und verfahren
WO2007041115A1 (en) * 2005-09-30 2007-04-12 Tti Ellebeau Inc. Method and system to detect malfunctions in an iontophoresis device that delivers active agents to biological interfaces
EP1931417A2 (de) * 2005-09-30 2008-06-18 Transcutaneous Technologies Inc. Transdermale arzneiabgabesysteme, vorrichtungen und verfahren mit neuen pharmazeutischen vehikeln
US20070197955A1 (en) * 2005-10-12 2007-08-23 Transcutaneous Technologies Inc. Mucous membrane adhesion-type iontophoresis device
US20080033338A1 (en) * 2005-12-28 2008-02-07 Smith Gregory A Electroosmotic pump apparatus and method to deliver active agents to biological interfaces
WO2007079190A2 (en) * 2005-12-29 2007-07-12 Tti Ellebeau, Inc. Device and method for enhancing immune response by electrical stimulation
US8784810B2 (en) * 2006-04-18 2014-07-22 Janssen Alzheimer Immunotherapy Treatment of amyloidogenic diseases
WO2008030497A2 (en) * 2006-09-05 2008-03-13 Tti Ellebeau, Inc. Transdermal drug delivery systems, devices, and methods using inductive power supplies
BRPI0719353A2 (pt) 2006-12-01 2014-01-07 Titi Ellebeau Inc Sistemas, dispositivos e métodos para dispositivos de energização e/ou controle, por exemplo, dispositivos de distribuição transdérmicos
US8003097B2 (en) * 2007-04-18 2011-08-23 Janssen Alzheimer Immunotherapy Treatment of cerebral amyloid angiopathy
EP2146746A4 (de) * 2007-04-18 2011-03-23 Janssen Alzheimer Immunotherap Vorbeugung und behandlung von zerebraler amyloid-angiopathy
EP1997830A1 (de) * 2007-06-01 2008-12-03 AIMM Therapeutics B.V. RSV-spezifische Bindemoleküle und Mittel zu ihrer Herstellung
SI2182983T1 (sl) * 2007-07-27 2014-09-30 Janssen Alzheimer Immunotherapy Zdravljenje amiloidogenih bolezni s humaniziranimi protitelesi proti abeta
JO3076B1 (ar) * 2007-10-17 2017-03-15 Janssen Alzheimer Immunotherap نظم العلاج المناعي المعتمد على حالة apoe
KR101671452B1 (ko) * 2007-10-25 2016-11-17 트렐리스 바이오싸이언스 인코포레이티드 항ｒｓｖ ｇ 단백질 항체
US9067981B1 (en) 2008-10-30 2015-06-30 Janssen Sciences Ireland Uc Hybrid amyloid-beta antibodies
EP2440694A4 (de) * 2009-06-09 2012-12-19 Tti Ellebeau Inc Langlebige elektrode von hoher kapazität und herstellungsverfahren dafür
US8883717B2 (en) 2012-03-30 2014-11-11 Artificial Cell Technologies, Inc. Antigenic compositions and methods
US9433671B2 (en) 2012-03-30 2016-09-06 Artificial Cell Technologies, Inc. Anti-malaria compositions and methods
US10272160B2 (en) * 2015-04-16 2019-04-30 The Research Foundation For The State University Of New York Nanostructures comprising cobalt porphyrin-phospholipid conjugates and polyhistidine-tags
US9968665B2 (en) 2015-09-16 2018-05-15 Artificial Cell Technologies, Inc. Anti-malaria compositions and methods
US11043823B2 (en) * 2017-04-06 2021-06-22 Tesla, Inc. System and method for facilitating conditioning and testing of rechargeable battery cells
JP7783047B2 (ja) * 2018-08-07 2025-12-09 ウィスコンシン アルムニ リサーチ ファンデイション 組換えの生物学的に封じ込められたフィロウイルスワクチン
WO2020163804A1 (en) 2019-02-08 2020-08-13 Wisconsin Alumni Research Foundation (Warf) Humanized cell line
JP7627911B2 (ja) 2019-08-27 2025-02-07 ウィスコンシン アルムニ リサーチ ファンデイション 卵内複製のための安定化されたｈａを持つ組換えインフルエンザウイルス
EP4093415A1 (de) 2020-01-24 2022-11-30 Wisconsin Alumni Research Foundation (WARF) Rekombinante influenza-viren mit stabilisiertem na
US12290562B2 (en) 2020-03-25 2025-05-06 Wisconsin Alumni Research Foundation (Warf) Recombinant multivalent influenza viruses
US20220226465A1 (en) 2021-01-18 2022-07-21 ConserV Bioscience Coronavirus Immunogenic Compositions, Methods and Uses Thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1188985A (en) † 1980-07-01 1985-06-18 National Research Development Corporation Production of viral antigens
US5057540A (en) * 1987-05-29 1991-10-15 Cambridge Biotech Corporation Saponin adjuvant
US5194595A (en) * 1987-12-23 1993-03-16 The Upjohn Company Chimeric glycoproteins containing immunogenic segments of the glycoproteins of human respiratory syncytial virus
US4912094B1 (en) * 1988-06-29 1994-02-15 Ribi Immunochem Research Inc. Modified lipopolysaccharides and process of preparation
GB9105992D0 (en) * 1991-03-21 1991-05-08 Smithkline Beecham Biolog Vaccine
GB9120221D0 (en) † 1991-09-23 1991-11-06 Smithkline Beecham Biolog Novel compounds
RU2026345C1 (ru) * 1991-11-26 1995-01-09 Санкт-Петербургский научно-исследовательский институт эпидемиологии и микробиологии им.Пастера Штамм ротавируса человека для получения диагностических и профилактических сывороток
RU2031945C1 (ru) * 1992-09-08 1995-03-27 Петр Петрович Федченко Способ инактивации вируса спида
SG48309A1 (en) * 1993-03-23 1998-04-17 Smithkline Beecham Biolog Vaccine compositions containing 3-0 deacylated monophosphoryl lipid a

Also Published As

Publication number Publication date
JP3734263B2 (ja) 2006-01-11
ES2150493T5 (es) 2004-07-01
EP0705109A4 (de) 1998-09-02
FI955667A0 (fi) 1995-11-24
CA2163550A1 (en) 1994-12-08
AU676340B2 (en) 1997-03-06
AU6957194A (en) 1994-12-20
ES2150493T3 (es) 2000-12-01
DE69426077D1 (de) 2000-11-09
EP0705109B2 (de) 2004-01-02
WO1994027636A1 (en) 1994-12-08
PT705109E (pt) 2001-02-28
FI955667L (fi) 1996-01-12
DE69426077T3 (de) 2004-09-02
FI955667A7 (fi) 1996-01-12
DK0705109T4 (da) 2004-05-10
US5723130A (en) 1998-03-03
EP0705109B1 (de) 2000-10-04
GR3034785T3 (en) 2001-02-28
JPH08510749A (ja) 1996-11-12
DE69426077T2 (de) 2001-05-10
EP0705109A1 (de) 1996-04-10
NO954786L (no) 1996-01-23
DK0705109T3 (da) 2000-11-13
NO954786D0 (no) 1995-11-24
RU2160119C2 (ru) 2000-12-10

Similar Documents

Publication Publication Date Title
DE69426077D1 (de) Adjuvantien für impfstoffe gegen das respiratorische synzitialvirus
CA2181832A1 (en) Immunization by inoculation of dna transcription unit
GB2322801B (en) Vaccine compositions for intranasal administration comprising chitosan and use thereof
RU95122391A (ru) Адъюванты для вакцины против распираторно-синцитиального вируса
FI944676A0 (fi) Rokotteita, jotka sisältävät ionisoitumattomia pinta-aktiivisten aineiden vesikkeleitä
WO2002009746A3 (en) Vaccines comprising outer membrane vesciles from gram negative bacteria
DE60012711D1 (de) Adjuvanszusammensetzungen zur erhöhung der immunantwort auf polynukleotid-basierende impfstoffe
DE69840383D1 (de) Ctl epitope des epstein-barr virus
DK0745387T3 (da) Adjuvanser til virale vacciner
GB0123580D0 (en) Vaccine
NZ503039A (en) Recombinant porcine adenovirus vector
BR9814204A (pt) "obtenção de vacinas destinadas a prevenir os efeitos patogênicos associados a uma infecção retroviral"
PT1409692E (pt) Novos péptidos do derivados da proteína g do vírus respiratório sincicial (vrs) e sua utilização numa vacina
HU9601462D0 (en) Adjuvants for viral vaccines
NO20001421D0 (no) T-cellevaksinasjon for behandling av multippel sklerose
DK0626008T3 (da) Vaccine, der som en adjuvans indeholder acemannan
NO890565D0 (no) Forhindring og behandling av retroviral sykdom.
BR9909076A (pt) Vìrus atenuado do sarampo, recombinantemente gerado, isolado, vìrus do sarampo, vìrus sincicial respiratório humano (rsv), subgrupo b, atenuado, recombinantemente gerado, isolado, o rsv, subgrupo b, vacina processo para imunização de um indivìduo para induzir proteção contra vìrus do sarampo, processo para imunização de um indivìduo para induzir proteção contra o rsv, subgrupo b, composição, processo para produção de vìrus do sarampo infeccioso atenuado, processo para produção de rsv infeccioso atenuado subgrupo b
GB9018061D0 (en) Compositions for vaccines
NO20011075L (no) Peptidfragmenter av kolera-toksin eller enterotoksin som vaksineadjuvanser
EP0320034A3 (de) Synthetische Peptide, die immunologische Aktivität zeigen, benutzbar, um eine Impfung gegen Malaria vorzubereiten
FR2698271B1 (fr) Vaccin contre le virus de la leucémie bovine, nouveau peptide immunogène et kit de vaccination.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
UEP Publication of translation of european patent specification

Ref document number: 0705109

Country of ref document: EP

REN Ceased due to non-payment of the annual fee