ATE197049T1 - Verfahren zur isolierung von carbacephem- zwischenprodukten - Google Patents

Verfahren zur isolierung von carbacephem- zwischenprodukten

Info

Publication number: ATE197049T1
Authority: AT; Austria
Prior art keywords: carbacephem; isolation; intermediate products; products; appropriiate
Prior art date: 1991-07-23

Application number

AT92306563T

Other languages

English (en)

Inventor

Christopher Wiliam Doecke

Jeffrey Neal Levy

Wayne Douglas Luke

Michael Alexander Staszak

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-07-23

Filing date

1992-07-17

Publication date

2000-11-15

1992-07-17 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2000-11-15 Application granted granted Critical

2000-11-15 Publication of ATE197049T1 publication Critical patent/ATE197049T1/de

Links

238000000034 method Methods 0.000 title abstract 3
JSVCEVCSANKFDY-SFYZADRCSA-N carbacephem Chemical compound C1CC(C)=C(C(O)=O)N2C(=O)[C@@H](NC(=O)C)[C@H]21 JSVCEVCSANKFDY-SFYZADRCSA-N 0.000 title 1
239000013067 intermediate product Substances 0.000 title 1
238000002955 isolation Methods 0.000 title 1
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
-1 beta -lactam compound Chemical class 0.000 abstract 2
BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 abstract 1
150000001350 alkyl halides Chemical class 0.000 abstract 1
230000003115 biocidal effect Effects 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
238000007865 diluting Methods 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
238000011031 large-scale manufacturing process Methods 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

AT92306563T 1991-07-23 1992-07-17 Verfahren zur isolierung von carbacephem- zwischenprodukten ATE197049T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/734,394 US5142038A (en)	1991-07-23	1991-07-23	Process of enantiomeric separation of carbacephem intermediates

Publications (1)

Publication Number	Publication Date
ATE197049T1 true ATE197049T1 (de)	2000-11-15

Family

ID=24951513

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92306563T ATE197049T1 (de)	1991-07-23	1992-07-17	Verfahren zur isolierung von carbacephem- zwischenprodukten

Country Status (10)

Country	Link
US (1)	US5142038A (de)
EP (1)	EP0524777B1 (de)
JP (1)	JP3133493B2 (de)
AT (1)	ATE197049T1 (de)
CA (1)	CA2074058A1 (de)
DE (1)	DE69231512T2 (de)
DK (1)	DK0524777T3 (de)
ES (1)	ES2151482T3 (de)
GR (1)	GR3035153T3 (de)
PT (1)	PT524777E (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU6049000A (en) *	1999-07-23	2001-02-13	Eli Lilly And Company	Enantioselective acylation of cis racemic azetidinones

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4708956A (en) *	1985-12-12	1987-11-24	Kyowa Hakko Kogyo Co., Ltd.	3-position halogenated cephalosporin analogs and pharmaceutical compositions
US4931556A (en) *	1988-10-17	1990-06-05	Eli Lilly And Company	Method of resolving cis 3-amino-4-(2-(2-furyl)eth-1-yl)-methoxycarbonylmethyl-azetidin-2-one and malic acid salts thereof
US4923983A (en) *	1989-07-31	1990-05-08	Eli Lilly And Company	Method of resolving cis 3-amino-4-[2-(2-furyl)eth-1-yl]-1-methoxycarbonylmethyl-azetidin-2-one

1991
- 1991-07-23 US US07/734,394 patent/US5142038A/en not_active Expired - Lifetime
1992
- 1992-07-16 CA CA002074058A patent/CA2074058A1/en not_active Abandoned
- 1992-07-17 JP JP04190543A patent/JP3133493B2/ja not_active Expired - Fee Related
- 1992-07-17 PT PT92306563T patent/PT524777E/pt unknown
- 1992-07-17 DE DE69231512T patent/DE69231512T2/de not_active Expired - Fee Related
- 1992-07-17 EP EP92306563A patent/EP0524777B1/de not_active Expired - Lifetime
- 1992-07-17 ES ES92306563T patent/ES2151482T3/es not_active Expired - Lifetime
- 1992-07-17 DK DK92306563T patent/DK0524777T3/da active
- 1992-07-17 AT AT92306563T patent/ATE197049T1/de not_active IP Right Cessation
2000
- 2000-12-27 GR GR20000402841T patent/GR3035153T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE69231512D1 (de)	2000-11-23
DE69231512T2 (de)	2001-05-17
GR3035153T3 (en)	2001-04-30
US5142038A (en)	1992-08-25
CA2074058A1 (en)	1993-01-24
JPH05202036A (ja)	1993-08-10
PT524777E (pt)	2001-03-30
ES2151482T3 (es)	2001-01-01
JP3133493B2 (ja)	2001-02-05
EP0524777B1 (de)	2000-10-18
DK0524777T3 (da)	2000-11-13
EP0524777A1 (de)	1993-01-27

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Legal Events

Date	Code	Title	Description
2001-03-15	UEP	Publication of translation of european patent specification
2006-04-15	REN	Ceased due to non-payment of the annual fee