ATE178058T1 - Verfahren zur herstellung von gewissen biphenyltetrazolderivaten - Google Patents

Verfahren zur herstellung von gewissen biphenyltetrazolderivaten

Info

Publication number: ATE178058T1
Authority: AT; Austria
Prior art keywords: biphenyltetrazole; derivatives; producing certain; disclosed; producing
Prior art date: 1991-11-01

Application number

AT92309968T

Other languages

English (en)

Inventor

William V Murray

Ronald Russell

Original Assignee

Ortho Pharma Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-11-01

Filing date

1992-10-30

Publication date

1999-04-15

1992-10-30 Application filed by Ortho Pharma Corp filed Critical Ortho Pharma Corp

1999-04-15 Application granted granted Critical

1999-04-15 Publication of ATE178058T1 publication Critical patent/ATE178058T1/de

Links

238000004519 manufacturing process Methods 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
ZRFGTMYIGSTCSZ-UHFFFAOYSA-N 5-(2-fluorophenyl)-2h-tetrazole Chemical compound FC1=CC=CC=C1C1=NNN=N1 ZRFGTMYIGSTCSZ-UHFFFAOYSA-N 0.000 abstract 1
239000007818 Grignard reagent Substances 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
150000004795 grignard reagents Chemical class 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT92309968T 1991-11-01 1992-10-30 Verfahren zur herstellung von gewissen biphenyltetrazolderivaten ATE178058T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/786,666 US5252753A (en)	1991-11-01	1991-11-01	Process for the preparation of certain substituted biphenyl tetrazoles and compounds thereof

Publications (1)

Publication Number	Publication Date
ATE178058T1 true ATE178058T1 (de)	1999-04-15

Family

ID=25139265

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92309968T ATE178058T1 (de)	1991-11-01	1992-10-30	Verfahren zur herstellung von gewissen biphenyltetrazolderivaten

Country Status (11)

Country	Link
US (1)	US5252753A (de)
EP (1)	EP0540356B1 (de)
JP (1)	JP3145813B2 (de)
AT (1)	ATE178058T1 (de)
AU (1)	AU651014B2 (de)
CA (1)	CA2081847A1 (de)
DE (1)	DE69228727T2 (de)
DK (1)	DK0540356T3 (de)
ES (1)	ES2130161T3 (de)
GR (1)	GR3030330T3 (de)
SG (1)	SG47012A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE914572A1 (en) *	1991-01-17	1992-07-29	Zeneca Ltd	Chemical process
US5616599A (en) *	1991-02-21	1997-04-01	Sankyo Company, Limited	Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use
RU2109736C1 (ru) *	1992-12-17	1998-04-27	Санкио Компани Лимитед	Производные бифенила и способ их получения
ATE203526T1 (de) *	1994-10-27	2001-08-15	Novartis Erfind Verwalt Gmbh	Verfahren zur herstellung tetrazole
FR2753705B1 (fr) *	1996-09-20	1999-08-06		Procede pour la preparation de derives de 4-methyl-biphenyle
JPWO2002083127A1 (ja) *	2001-04-09	2004-09-30	宮田　敏男	蛋白修飾物生成抑制組成物
EP1571150A1 (de) *	2004-03-02	2005-09-07	Aventis Pharma Deutschland GmbH	Prozess zur Herstellung von Tryptase Hemmstoffen
KR20090102883A (ko) *	2004-09-02	2009-09-30	테바 파마슈티컬 인더스트리즈 리미티드	올메살탄 메독소밀의 정제
JP4511550B2 (ja) *	2004-09-02	2010-07-28	テバファーマシューティカルインダストリーズリミティド	オルメサルタンメドキソミルの調製法
US20070054948A1 (en) *	2004-09-02	2007-03-08	Lilach Hedvati	Purification of olmesartan medoxomil
EP1749828A1 (de)	2005-08-04	2007-02-07	Farmaprojects S.L.	Verfahren zur Herstellung eines Angiotensin-II-Antagonisten
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
MX354786B (es)	2007-06-04	2018-03-21	Synergy Pharmaceuticals Inc	Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
ES2522968T3 (es)	2008-06-04	2014-11-19	Synergy Pharmaceuticals Inc.	Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
AU2009270833B2 (en)	2008-07-16	2015-02-19	Bausch Health Ireland Limited	Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
US20130196971A1 (en) *	2010-09-17	2013-08-01	Christopher Joseph Aquino	Fatty acid synthase inhibitors
AU2014235209B2 (en)	2013-03-15	2018-06-14	Bausch Health Ireland Limited	Guanylate cyclase receptor agonists combined with other drugs
AU2014235215A1 (en)	2013-03-15	2015-10-01	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase and their uses
BR112015030326A2 (pt)	2013-06-05	2017-08-29	Synergy Pharmaceuticals Inc	Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1334092C (en) *	1986-07-11	1995-01-24	David John Carini	Angiotensin ii receptor blocking imidazoles
US4820843A (en) *	1987-05-22	1989-04-11	E. I. Du Pont De Nemours And Company	Tetrazole intermediates to antihypertensive compounds
EP0412594B1 (de) *	1989-07-28	1996-01-03	Merck & Co. Inc.	Substituierte Triazolinone, Triazolinthione und Triazolinimine als Angiotensin II-Antagonisten
DE122007000050I1 (de) *	1990-02-19	2007-11-08	Novartis Ag	Acylverbindungen
US5039814A (en) *	1990-05-02	1991-08-13	Merck & Co., Inc.	Ortho-lithiation process for the synthesis of 2-substituted 1-(tetrazol-5-yl)benzenes
CA2051705A1 (en)	1990-06-19	1991-12-20	Kiyoaki Katano	Pyridine derivatives having angiotensin ii antagonism
IE914572A1 (en) *	1991-01-17	1992-07-29	Zeneca Ltd	Chemical process

1991
- 1991-11-01 US US07/786,666 patent/US5252753A/en not_active Expired - Lifetime
1992
- 1992-10-28 AU AU27404/92A patent/AU651014B2/en not_active Ceased
- 1992-10-30 EP EP92309968A patent/EP0540356B1/de not_active Expired - Lifetime
- 1992-10-30 CA CA002081847A patent/CA2081847A1/en not_active Abandoned
- 1992-10-30 DE DE69228727T patent/DE69228727T2/de not_active Expired - Fee Related
- 1992-10-30 JP JP31565792A patent/JP3145813B2/ja not_active Expired - Fee Related
- 1992-10-30 AT AT92309968T patent/ATE178058T1/de not_active IP Right Cessation
- 1992-10-30 DK DK92309968T patent/DK0540356T3/da active
- 1992-10-30 SG SG1996001913A patent/SG47012A1/en unknown
- 1992-10-30 ES ES92309968T patent/ES2130161T3/es not_active Expired - Lifetime
1999
- 1999-05-27 GR GR990401417T patent/GR3030330T3/el unknown

Also Published As

Publication number	Publication date
EP0540356A3 (en)	1993-08-25
JPH05279350A (ja)	1993-10-26
EP0540356A2 (de)	1993-05-05
ES2130161T3 (es)	1999-07-01
EP0540356B1 (de)	1999-03-24
GR3030330T3 (en)	1999-09-30
SG47012A1 (en)	1998-03-20
US5252753A (en)	1993-10-12
CA2081847A1 (en)	1993-05-02
DE69228727T2 (de)	1999-08-19
DK0540356T3 (da)	1999-10-11
JP3145813B2 (ja)	2001-03-12
AU2740492A (en)	1993-05-06
AU651014B2 (en)	1994-07-07
DE69228727D1 (de)	1999-04-29

Legal Events

Date	Code	Title	Description
1999-11-15	UEP	Publication of translation of european patent specification
2008-07-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE178058T1 (de)	1999-04-15	Verfahren zur herstellung von gewissen biphenyltetrazolderivaten
DE69210347D1 (de)	1996-06-05	Verfahren zur Herstellung von Zwischenprodukten zur Verwendung in der Herstellung von Alkoxyiminoacetamide
ATE289608T1 (de)	2005-03-15	Herstellung von camptothecinderivaten durch intramolekulare cyclisierung
ATE207884T1 (de)	2001-11-15	Verfahren zur herstellung von aminobenzol- derivaten
ATE157647T1 (de)	1997-09-15	Verfahren zur herstellung von alpha- ketoamidderivaten
ATE127809T1 (de)	1995-09-15	Verfahren zur herstellung von verbindungen zur behandlung der gutartigen prostatahypertrophie.
ATE531702T1 (de)	2011-11-15	Verfahren zur herstellung von epoxytriazolderivat und zwischenprodukten dafür
ATE96464T1 (de)	1993-11-15	Verfahren zur herstellung von thiolen.
ATE221876T1 (de)	2002-08-15	Verfahren zur herstellung von zyklischen verbindungen
ATE272061T1 (de)	2004-08-15	Friedel-craft verfahren zur herstellung von thioxanthonen
DE69521012D1 (de)	2001-06-28	Verfahren zur Herstellung von 1-(4,5-Dihydro)2-thiazolyl-3-Azetidinthiolderivaten
DE69632919D1 (de)	2004-08-19	Verfahren zur herstellung von 2-chlor-5-chloromethyl-thiazol
DE60335865D1 (de)	2011-03-10	Verfahren zur herstellung von cilostazol
DE60116201D1 (de)	2006-02-02	Verfahren zur Herstellung von Cephalosporin-Verbindungen und Zwischenprodukte für die Synthese dieser Verbindungen
ATE157971T1 (de)	1997-09-15	Verfahren zur herstellung von aminotriazin- derivaten
ATE159246T1 (de)	1997-11-15	Verfahren zur herstellung von (s)-vinyl- und (s)- allenyl-gaba
ATE311382T1 (de)	2005-12-15	Verfahren zur herstellung von 2-carbamoyl- pyridinen
ATE189453T1 (de)	2000-02-15	Verfahren zur herstellung von 2-cyanobiphenyl- verbindungen
ATE177737T1 (de)	1999-04-15	Verfahren zur herstellung von 5-arylhydantoin
ATE127784T1 (de)	1995-09-15	Verfahren und zwischenprodukte für die herstellung von 2-hydroxy-3-sulfido-3- phenylpropansäuren.
ATE116288T1 (de)	1995-01-15	Verfahren zur herstellung von sulfonylisocyanaten.
DE69418802D1 (de)	1999-07-08	Verfahren zur Herstellung von N-Alkylacetamiden
ATE248841T1 (de)	2003-09-15	Verfahren zur herstellung von penicilling- phenylester
DE69615570D1 (de)	2001-10-31	Verfahren zur herstellung von carbamoylmethylharnstoff-derivaten
DE69611136D1 (de)	2001-01-11	Verfahren zur Herstellung von optisch aktivem (S)-(-)- und (R)-(+)- Deoxyspergualin und Zwischenprodukte dafür