ATE197306T1 - Inhibitoren mit zweifacher wirkung, die 1,2- diazepin enthalten - Google Patents

Inhibitoren mit zweifacher wirkung, die 1,2- diazepin enthalten

Info

Publication number
ATE197306T1
ATE197306T1 AT96108439T AT96108439T ATE197306T1 AT E197306 T1 ATE197306 T1 AT E197306T1 AT 96108439 T AT96108439 T AT 96108439T AT 96108439 T AT96108439 T AT 96108439T AT E197306 T1 ATE197306 T1 AT E197306T1
Authority
AT
Austria
Prior art keywords
diazepine
dual action
inhibitors containing
action inhibitors
chem
Prior art date
Application number
AT96108439T
Other languages
English (en)
Inventor
Denis E Ryono
Chong-Qing Sun
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of ATE197306T1 publication Critical patent/ATE197306T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT96108439T 1995-06-07 1996-05-28 Inhibitoren mit zweifacher wirkung, die 1,2- diazepin enthalten ATE197306T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US47404195A 1995-06-07 1995-06-07

Publications (1)

Publication Number Publication Date
ATE197306T1 true ATE197306T1 (de) 2000-11-15

Family

ID=23881962

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96108439T ATE197306T1 (de) 1995-06-07 1996-05-28 Inhibitoren mit zweifacher wirkung, die 1,2- diazepin enthalten

Country Status (11)

Country Link
US (1) US5635504A (de)
EP (1) EP0747392B1 (de)
JP (1) JPH08337527A (de)
AT (1) ATE197306T1 (de)
AU (1) AU696673B2 (de)
CA (1) CA2178355A1 (de)
DE (1) DE69610792T2 (de)
DK (1) DK0747392T3 (de)
ES (1) ES2151977T3 (de)
GR (1) GR3035239T3 (de)
PT (1) PT747392E (de)

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US5587375A (en) * 1995-02-17 1996-12-24 Bristol-Myers Squibb Company Azepinone compounds useful in the inhibition of ACE and NEP
US5877313A (en) 1995-05-17 1999-03-02 Bristol-Myers Squibb Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
DE19750002A1 (de) * 1997-11-12 1999-05-20 Solvay Pharm Gmbh Phosphonsäure-substituierte Benzazepinon-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US6340752B1 (en) 1998-01-06 2002-01-22 Bristol-Myers Squibb Co. Deprotection and recrystallization processes
WO1999046248A1 (en) * 1998-03-09 1999-09-16 Vertex Pharmaceuticals Incorporated 1,2-diazepane derivatives as interleukin-1beta converting enzyme inhibitors
WO2001055074A1 (en) 2000-01-25 2001-08-02 Kaneka Corporation Process for producing optically active carboxylic acid substituted in 2-position
ES2227069T3 (es) * 2000-03-30 2005-04-01 Ajinomoto Co., Inc. Metodo de produccion de un derivado de acido acetiltiocarboxilico aromatico.
WO2001081300A1 (fr) * 2000-04-21 2001-11-01 Kaneka Corporation Procede de cristallisation d'acide 2-acetylthio-3-phenylpropionique
NL1015714C2 (nl) * 2000-07-14 2002-01-15 Dsm Nv Werkwijze voor het kristalliseren van enantiomeer verrijkt 2-acetylthio-3-fenylpropaanzuur.
JP4718534B2 (ja) * 2007-11-09 2011-07-06 カルピス株式会社 Ｆｉｓｃｈｅｒ比低下抑制剤
CN102575275A (zh) 2009-09-01 2012-07-11 Lz治疗公司 用于提取和纯化神经节苷脂的方法
CA2772877A1 (en) * 2009-09-01 2011-03-10 Lz Therapeutics, Inc. Treatment of glaucoma and other retinopathies with gangliosides
US8877815B2 (en) 2010-11-16 2014-11-04 Novartis Ag Substituted carbamoylcycloalkyl acetic acid derivatives as NEP
ES2634387T3 (es) 2012-01-20 2017-09-27 Garnet Biotherapeutics, Inc Métodos de producción de gangliósidos
CN102805751B (zh) * 2012-08-27 2014-07-02 澳门科技大学 治疗心脑血管疾病的药物组合物及其制备方法
WO2019040109A1 (en) 2017-08-21 2019-02-28 Celgene Corporation PROCESSES FOR THE PREPARATION OF (S) -TERT-BUTYL 4,5-DIAMINO-5-OXOPENTANOATE
CN109111371B (zh) * 2018-09-27 2021-08-06 江西万里药业有限公司 一种肼基乙酸乙酯盐酸盐的制备方法

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Also Published As

Publication number Publication date
US5635504A (en) 1997-06-03
DE69610792T2 (de) 2001-06-13
PT747392E (pt) 2001-02-28
ES2151977T3 (es) 2001-01-16
JPH08337527A (ja) 1996-12-24
DE69610792D1 (de) 2000-12-07
AU5476096A (en) 1996-12-19
DK0747392T3 (da) 2001-01-29
AU696673B2 (en) 1998-09-17
CA2178355A1 (en) 1996-12-08
EP0747392A1 (de) 1996-12-11
EP0747392B1 (de) 2000-11-02
GR3035239T3 (en) 2001-04-30

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee