ES2127397T3 - Sulfonamidas y sus derivados que modulan la actividad de la endotelina. - Google Patents

Sulfonamidas y sus derivados que modulan la actividad de la endotelina.

Info

Publication number
ES2127397T3
ES2127397T3 ES94918081T ES94918081T ES2127397T3 ES 2127397 T3 ES2127397 T3 ES 2127397T3 ES 94918081 T ES94918081 T ES 94918081T ES 94918081 T ES94918081 T ES 94918081T ES 2127397 T3 ES2127397 T3 ES 2127397T3
Authority
ES
Spain
Prior art keywords
activity
endotheline
sulfonamides
modulate
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94918081T
Other languages
English (en)
Inventor
Ming Fai Chan
Bore Gowda Raju
Adam Kois
Erik Joel Verner
Chengde Wu
Rosario Silvestre Castillo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Encysive Pharmaceuticals Inc
Original Assignee
Texas Biotechnology Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/142,159 external-priority patent/US5464853A/en
Priority claimed from US08/142,552 external-priority patent/US5514691A/en
Application filed by Texas Biotechnology Corp filed Critical Texas Biotechnology Corp
Application granted granted Critical
Publication of ES2127397T3 publication Critical patent/ES2127397T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms
    • C07D261/16—Benzene-sulfonamido isoxazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE PRESENTAN SULFONAMIDAS Y METODOS DE USAR ESTAS SULFONAMIDAS PARA INHIBIR LA UNION DE UN PEPTIDO DE ENDOTELINA A UN RECEPTOR DE LA ENDOTELINA MEDIANTE EL CONTACTO DEL RECEPTOR CON LA SULFONAMIDA. TAMBIEN SE PRESENTAN METODOS PARA EL TRATAMIENTO DE ENFERMEDADES INTERMEDIADAS POR LA ENDOTELINA MEDIANTE LA ADMINISTRACION DE CANTIDADES EFECTIVAS DE UNA O MAS DE ESTAS SULFONAMIDAS O PRODROGAS DE LAS MISMAS QUE INHIBEN O INCREMENTAN LA ACTIVIDAD DE LA ENDOTELINA. LAS SULFONAMIDAS TIENEN LA FORMULA (I) EN LA CUAL AR{SUP, 1} ES 3- O 5- ISOXAZOILO Y AR{SUP, 2} SE SELECCIONA ENTRE ALQUILO, INCLUYENDO ANALOGOS DEL MISMO DE CADENAS RECTA Y RAMIFICADA, DE ANILLOS AROMATICOS, DE ANILLOS AROMATICOS FUNDIDOS Y DE ANILLOS HETEROCICLICOS, INCLUYENDO HETEROCICLOS DE 5 MIEMBROS CON 1,2 O MAS HETEROATOMOS Y DE ANILLO FUNDIDO Y ANALOGOS DEL MISMO DE ANILLOS DE 6 MIEMBROS CON 1,2 O MAS HETEROATOMOS Y ANILLO FUNDIDO. AR{SUP, 2} ES PREFERIBLEMENTE TIOFENILO, FURILO, PIRROLILO, NAFTILO Y FENILO. LOS COMPUESTOS ENLOS CUALES AR{SUP, 1} ES UNA ISOXAZOLA 4-HALO-SUSTITUIDA SON MAS ACTIVOS QUE LOS COMPUESTOS SUSTITUIDOS CON ALQUILO CORRESPONDIENTES Y LOS COMPUESTOS EN LOS CUALES AR{SUP, 1} ESTA SUSTITUIDA EN ESTA POSICION CON UN ALQUILO MAYOR TIENDEN A EXHIBIR UNA ACTIVIDAD MAYOR PARA LOS RECEPTORES DE LA ET{SUB, B} QUE LOS COMPUESTOS SUSTITUIDOS CON ALQUILO INFERIOR CORRESPONDIENTES.
ES94918081T 1993-05-20 1994-05-20 Sulfonamidas y sus derivados que modulan la actividad de la endotelina. Expired - Lifetime ES2127397T3 (es)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US6520293A 1993-05-20 1993-05-20
US10012593A 1993-07-30 1993-07-30
US10056593A 1993-07-30 1993-07-30
US14263193A 1993-10-21 1993-10-21
US08/142,159 US5464853A (en) 1993-05-20 1993-10-21 N-(5-isoxazolyl)biphenylsulfonamides, N-(3-isoxazolyl)biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin
US08/142,552 US5514691A (en) 1993-05-20 1993-10-21 N-(4-halo-isoxazolyl)-sulfonamides and derivatives thereof that modulate the activity of endothelin
US08/222,287 US5591761A (en) 1993-05-20 1994-04-05 Thiophenyl-, furyl-and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin

Publications (1)

Publication Number Publication Date
ES2127397T3 true ES2127397T3 (es) 1999-04-16

Family

ID=27568241

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94918081T Expired - Lifetime ES2127397T3 (es) 1993-05-20 1994-05-20 Sulfonamidas y sus derivados que modulan la actividad de la endotelina.

Country Status (13)

Country Link
US (1) US5591761A (es)
EP (3) EP0870764A1 (es)
JP (1) JP3135922B2 (es)
AT (1) ATE174592T1 (es)
CA (1) CA2161346C (es)
CY (1) CY2124B1 (es)
DE (1) DE69415316T2 (es)
DK (1) DK0699191T3 (es)
ES (1) ES2127397T3 (es)
GB (1) GB2285625B (es)
RU (1) RU2151144C1 (es)
SG (1) SG48742A1 (es)
WO (1) WO1994027979A1 (es)

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DK0699191T3 (da) 1999-08-23
GB9503693D0 (en) 1995-04-12
EP1069114A2 (en) 2001-01-17
AU6964694A (en) 1994-12-20
RU2151144C1 (ru) 2000-06-20
US5591761A (en) 1997-01-07
JPH08510744A (ja) 1996-11-12
ATE174592T1 (de) 1999-01-15
DE69415316T2 (de) 1999-04-29
EP1069114A3 (en) 2001-01-31
EP0699191B1 (en) 1998-12-16
AU691813B2 (en) 1998-05-28
SG48742A1 (en) 1998-05-18
CY2124B1 (en) 2002-06-21
GB2285625A (en) 1995-07-19
JP3135922B2 (ja) 2001-02-19
CA2161346A1 (en) 1994-12-08
CA2161346C (en) 2004-11-23
EP0870764A1 (en) 1998-10-14
DE69415316D1 (de) 1999-01-28
WO1994027979A1 (en) 1994-12-08
GB2285625B (en) 1997-12-10
EP0699191A1 (en) 1996-03-06

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