ATE197455T1 - 3-oxo-pyrido (1,2-a) benzimidazol-4-carboxyl und 4-oxo-azepino (1,2-a) benzimidazol-5-carboxyl derivate geeignet für die behandlung von zentralnervensystemerkrankungen - Google Patents

3-oxo-pyrido (1,2-a) benzimidazol-4-carboxyl und 4-oxo-azepino (1,2-a) benzimidazol-5-carboxyl derivate geeignet für die behandlung von zentralnervensystemerkrankungen

Info

Publication number
ATE197455T1
ATE197455T1 AT93920193T AT93920193T ATE197455T1 AT E197455 T1 ATE197455 T1 AT E197455T1 AT 93920193 T AT93920193 T AT 93920193T AT 93920193 T AT93920193 T AT 93920193T AT E197455 T1 ATE197455 T1 AT E197455T1
Authority
AT
Austria
Prior art keywords
benzimidazole
oxo
carboxyl
pct
nervous system
Prior art date
Application number
AT93920193T
Other languages
English (en)
Inventor
Bruce E Maryanoff
David F Mccomsey
Ho Winston
Original Assignee
Mcneilab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mcneilab Inc filed Critical Mcneilab Inc
Application granted granted Critical
Publication of ATE197455T1 publication Critical patent/ATE197455T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Toxicology (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT93920193T 1992-08-19 1993-08-18 3-oxo-pyrido (1,2-a) benzimidazol-4-carboxyl und 4-oxo-azepino (1,2-a) benzimidazol-5-carboxyl derivate geeignet für die behandlung von zentralnervensystemerkrankungen ATE197455T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93217692A 1992-08-19 1992-08-19
PCT/US1993/007794 WO1994004532A1 (en) 1992-08-19 1993-08-18 3-oxo-pyrido(1,2-a^_)benzimidazole-4-carboxyl and 4-oxo-azepino(1,2-a^_)benzimidazole-5-carboxyl derivatives useful in treating central nervous system disorders

Publications (1)

Publication Number Publication Date
ATE197455T1 true ATE197455T1 (de) 2000-11-11

Family

ID=25461897

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93920193T ATE197455T1 (de) 1992-08-19 1993-08-18 3-oxo-pyrido (1,2-a) benzimidazol-4-carboxyl und 4-oxo-azepino (1,2-a) benzimidazol-5-carboxyl derivate geeignet für die behandlung von zentralnervensystemerkrankungen

Country Status (16)

Country Link
US (2) US5639760A (de)
EP (1) EP0656002B1 (de)
JP (1) JP3463935B2 (de)
KR (1) KR100262762B1 (de)
AT (1) ATE197455T1 (de)
AU (1) AU679938B2 (de)
BR (1) BR9306929A (de)
CA (1) CA2142700C (de)
DE (1) DE69329654T2 (de)
DK (1) DK0656002T3 (de)
ES (1) ES2153842T3 (de)
GR (1) GR3035292T3 (de)
HU (1) HU221369B1 (de)
NZ (1) NZ255821A (de)
PT (1) PT656002E (de)
WO (1) WO1994004532A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI0935598T1 (en) * 1996-10-07 2004-04-30 Ortho-Mcneil Pharmaceutical, Inc. 5-HETEROATOM-CONTAINING ALKYL SUBSTITUTED-3-OXO-PYRIDO(1,2-a) BENZIMIDAZOLE-4-CARBOXAMIDE DERIVATIVES USEFUL IN TREATING CENTRAL NERVOUS SYSTEM DISORDERS
AU719333B2 (en) * 1996-10-07 2000-05-04 Ortho-Mcneil Pharmaceutical, Inc. 5-heteroatom-containing alkyl substituted-3-oxo-p yrido(1,2-a) benzimidazole-4-carboxamide derivatives useful in treating central nervous system disorders
US5922731A (en) * 1997-06-30 1999-07-13 Ortho Pharmaceutical Corporation 5- (heteroaryl)alkyl!-3-oxo-pyrido 1,2-a!benzimidazole-4-carboxamide derivatives useful in treating central nervous system disorders
DK1025101T3 (da) 1997-10-07 2003-04-07 Ortho Mcneil Pharm Inc Naphtho-imidazo[1,2-a]pyridinderivater, deres fremstilling og deres anvendelse ved behandlingen af sygdomme i centralnervesystemet
AU2003204221B2 (en) * 1997-10-07 2006-07-27 Ortho-Mcneil Pharmaceutical, Inc. Dipyridoimidazolderivatives useful in treating central nervous system disorders
EP1023291B1 (de) * 1997-10-07 2004-05-26 Ortho-McNeil Pharmaceutical, Inc. Dipyridoimidazolderivate zur behandlung von störungen des zentralen nervensystems
WO1999040092A1 (en) * 1998-02-04 1999-08-12 Neurogen Corporation Oxo-dipyridoimidazole-carboxamides: gaba brain receptor ligands
ATE300539T1 (de) * 1998-08-25 2005-08-15 Neurogen Corp Oxo-pyridoimidazol-carboxamide: gaba-rezeptor- liganden im gehirn
US6177569B1 (en) 1998-08-25 2001-01-23 Neurogen Corporation Oxo-pyridoimidazole-carboxamides: GABA brain receptor ligands
JP2002544197A (ja) * 1999-05-06 2002-12-24 ニューロゲン コーポレイション 置換４−オキソ−キノリン−３−カルボキサミド：ｇａｂａ脳受容体リガンド
ATE321044T1 (de) * 1999-08-02 2006-04-15 Ortho Mcneil Pharm Inc C-6 ringsubstituierte pyrido(1,2- a)benzimidazolderivate zur behandlung von störungen des zentralen nervensystems
GB0203058D0 (en) 2002-02-09 2002-03-27 Bp Chem Int Ltd Production of olefins

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2663934B1 (fr) * 1990-06-27 1994-06-03 Adir Nouveaux derives de l'acide 4 - amino butyrique, leur procede de preparation et les preparations pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
HUT72654A (en) 1996-05-28
PT656002E (pt) 2001-02-28
US6218384B1 (en) 2001-04-17
ES2153842T3 (es) 2001-03-16
KR100262762B1 (ko) 2000-08-01
WO1994004532A1 (en) 1994-03-03
HU221369B1 (en) 2002-09-28
CA2142700A1 (en) 1994-03-03
HU9500476D0 (en) 1995-04-28
GR3035292T3 (en) 2001-04-30
AU679938B2 (en) 1997-07-17
JP3463935B2 (ja) 2003-11-05
EP0656002B1 (de) 2000-11-08
DE69329654T2 (de) 2001-03-15
CA2142700C (en) 2007-01-09
US5639760A (en) 1997-06-17
AU5080893A (en) 1994-03-15
EP0656002A1 (de) 1995-06-07
DE69329654D1 (de) 2000-12-14
BR9306929A (pt) 1999-01-12
JPH08500594A (ja) 1996-01-23
NZ255821A (en) 1996-10-28
DK0656002T3 (da) 2000-11-27

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