ATE197460T1 - Zyklische peptide mit antifungischer wirkung - Google Patents

Zyklische peptide mit antifungischer wirkung

Info

Publication number: ATE197460T1
Authority: AT; Austria
Prior art keywords: hydrogen; chem; alkyl; benzyl; independently
Prior art date: 1995-07-25

Application number

AT96305345T

Other languages

English (en)

Inventor

Michael John Rodriguez

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-07-25

Filing date

1996-07-22

Publication date

2000-11-11

1996-07-22 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2000-11-11 Application granted granted Critical

2000-11-11 Publication of ATE197460T1 publication Critical patent/ATE197460T1/de

Links

102000001189 Cyclic Peptides Human genes 0.000 title 1
108010069514 Cyclic Peptides Proteins 0.000 title 1
230000001716 anti-fugal effect Effects 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 9
239000001257 hydrogen Substances 0.000 abstract 9
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 5
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
150000002431 hydrogen Chemical class 0.000 abstract 4
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 4
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 3
-1 p-halo-phenyl Chemical group 0.000 abstract 3
125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 2
125000004642 (C1-C12) alkoxy group Chemical group 0.000 abstract 1
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
125000006711 (C2-C12) alkynyl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000002538 fungal effect Effects 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000006503 p-nitrobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1[N+]([O-])=O)C([H])([H])* 0.000 abstract 1
125000000636 p-nitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)[N+]([O-])=O 0.000 abstract 1
230000003071 parasitic effect Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Biochemistry (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Tropical Medicine & Parasitology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)

AT96305345T 1995-07-25 1996-07-22 Zyklische peptide mit antifungischer wirkung ATE197460T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/506,790 US5629289A (en)	1995-07-25	1995-07-25	Cyclic peptide antifungal agents

Publications (1)

Publication Number	Publication Date
ATE197460T1 true ATE197460T1 (de)	2000-11-11

Family

ID=24016022

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96305345T ATE197460T1 (de)	1995-07-25	1996-07-22	Zyklische peptide mit antifungischer wirkung

Country Status (13)

Country	Link
US (1)	US5629289A (de)
EP (1)	EP0757058B1 (de)
JP (1)	JPH11510165A (de)
AT (1)	ATE197460T1 (de)
AU (1)	AU6593896A (de)
CA (1)	CA2227364A1 (de)
DE (1)	DE69610880T2 (de)
DK (1)	DK0757058T3 (de)
ES (1)	ES2151638T3 (de)
GR (1)	GR3035351T3 (de)
PT (1)	PT757058E (de)
SI (1)	SI0757058T1 (de)
WO (1)	WO1997005163A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6743777B1 (en) *	1992-03-19	2004-06-01	Eli Lilly And Company	Cyclic peptide antifungal agents and process for preparation thereof
US6384013B1 (en) *	1992-03-19	2002-05-07	Eli Lilly And Company	Cyclic peptide antifungal agents and process for preparation thereof
JPH10508852A (ja) *	1994-11-15	1998-09-02	イーライ・リリー・アンド・カンパニー	レトロアルドール反応操作のための方法
EP1666587A1 (de)	1996-06-13	2006-06-07	Astellas Pharma Inc.	Zyclische lipopeptid acylase
JP3561917B2 (ja) *	1998-02-09	2004-09-08	藤沢薬品工業株式会社	新規化合物
US6323176B1 (en) *	1998-02-25	2001-11-27	Eli Lilly And Company	Cyclic peptide antifungal agents
ES2233070T3 (es)	1998-08-20	2005-06-01	ELI LILLY & COMPANY	Sintesis de analogos peptidicos ciclicos modificados en el anillo.
DE69933046T2 (de)	1998-12-09	2007-09-13	Eli Lilly And Co., Indianapolis	Reinigung von echinocandin cyclopeptiden
JP2002532513A (ja) *	1998-12-16	2002-10-02	イーライリリーアンドカンパニー	糖置換基を有する環式ペプチド抗真菌剤
WO2000051567A1 (en) *	1999-03-03	2000-09-08	Eli Lilly And Company	Processes for making pharmaceutical oral ecb formulations and compositions
AU767956B2 (en)	1999-03-03	2003-11-27	Eli Lilly And Company	Formation and anion-exchange of crystalline echinocandin ammonium salts
EP1582204B1 (de) *	1999-03-03	2013-09-25	Eli Lilly & Company	Echinocandin pharmazeutische Zusammensetzungen enthaltend Mizellen bildende Tenside
KR20020003864A (ko) *	1999-03-03	2002-01-15	피터 지. 스트링거	에키노칸딘/탄수화물 착물
US6991800B2 (en) *	2002-06-13	2006-01-31	Vicuron Pharmaceuticals Inc.	Antifungal parenteral products

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5260214A (en) *	1988-07-19	1993-11-09	Takara Shuzo Co.	Aureobasidium pullulans which produces antibiotic R106
US5057493A (en) *	1988-07-19	1991-10-15	Takara Shuzo Co., Ltd.	Novel antibiotics r106
US5166135A (en) *	1988-09-12	1992-11-24	Merck & Company, Inc.	Method for the control of pneumocystis carinii
JPH0826071B2 (ja) *	1989-07-11	1996-03-13	寶酒造株式会社	抗真菌抗生物質ｒ１０６誘導体
JP2639737B2 (ja) *	1990-01-23	1997-08-13	寳酒造株式会社	新規ｒ１０６類化合物
US5059540A (en) *	1990-08-13	1991-10-22	City Of Hope	Sequential C-terminal degradation of peptides and proteins using cleaving reagents such as sodium trimethylsilanolate or trimethylamine N-oxide
US5159059A (en) *	1990-05-29	1992-10-27	Merck & Co., Inc.	Process for reduction of certain cyclohexapeptide compounds
IE990233A1 (en) *	1990-06-18	2000-11-15	Fujisawa Pharmaceutical Co	New Polypeptide Compound and a Process for Preparation thereof
NZ247149A (en) *	1992-03-19	1996-10-28	Lilly Co Eli	Cyclic peptide antifungal agents and compositions thereof
JP3480848B2 (ja) *	1992-06-19	2003-12-22	タカラバイオ株式会社	環状ペプチドの合成方法
US6268338B1 (en) *	1993-04-30	2001-07-31	Merck & Co., Inc.	Cyclohexapeptidyl amine compounds
US5948753A (en) *	1993-05-04	1999-09-07	Merck & Co., Inc.	Cyclohexapeptidyl propanolamine compounds
CA2161149A1 (en) *	1993-05-04	1994-11-10	James M. Balkovec	Cyclohexapeptidyl aminoalkyl ethers
AU7874494A (en) *	1993-09-22	1995-04-10	Merck & Co., Inc.	Antifungal and anti-pneumocystis compounds, compositions containing such compounds, and methods of use
JPH10508852A (ja) *	1994-11-15	1998-09-02	イーライ・リリー・アンド・カンパニー	レトロアルドール反応操作のための方法

1995
- 1995-07-25 US US08/506,790 patent/US5629289A/en not_active Expired - Fee Related
1996
- 1996-07-22 ES ES96305345T patent/ES2151638T3/es not_active Expired - Lifetime
- 1996-07-22 DE DE69610880T patent/DE69610880T2/de not_active Expired - Fee Related
- 1996-07-22 EP EP96305345A patent/EP0757058B1/de not_active Expired - Lifetime
- 1996-07-22 DK DK96305345T patent/DK0757058T3/da active
- 1996-07-22 SI SI9630272T patent/SI0757058T1/xx unknown
- 1996-07-22 AT AT96305345T patent/ATE197460T1/de not_active IP Right Cessation
- 1996-07-22 PT PT96305345T patent/PT757058E/pt unknown
- 1996-07-23 CA CA002227364A patent/CA2227364A1/en not_active Abandoned
- 1996-07-23 AU AU65938/96A patent/AU6593896A/en not_active Abandoned
- 1996-07-23 JP JP9507687A patent/JPH11510165A/ja active Pending
- 1996-07-23 WO PCT/US1996/012111 patent/WO1997005163A1/en not_active Ceased
2001
- 2001-02-01 GR GR20010400176T patent/GR3035351T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
CA2227364A1 (en)	1997-02-13
JPH11510165A (ja)	1999-09-07
EP0757058B1 (de)	2000-11-08
ES2151638T3 (es)	2001-01-01
DE69610880T2 (de)	2001-05-10
WO1997005163A1 (en)	1997-02-13
DE69610880D1 (de)	2000-12-14
GR3035351T3 (en)	2001-05-31
AU6593896A (en)	1997-02-26
PT757058E (pt)	2001-04-30
DK0757058T3 (da)	2000-12-27
US5629289A (en)	1997-05-13
EP0757058A1 (de)	1997-02-05
SI0757058T1 (en)	2001-04-30

Legal Events

Date	Code	Title	Description
2001-04-15	UEP	Publication of translation of european patent specification
2003-04-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE197460T1 (de)	2000-11-11	Zyklische peptide mit antifungischer wirkung
EP0744405A3 (de)	1998-05-27	Zyklische Peptide mit fungizider Wirkung
WO2004032909A3 (en)	2004-07-01	Stabilized pharmaceutical composition containing basic excipients
WO2005056524A3 (en)	2005-09-22	Therapeutic agents useful for treating pain
FI950309A0 (fi)	1995-01-24	Proliiniamidijohdannaisia
UA26930C2 (uk)	1999-12-29	Засіб для іhгібуваhhя еhдометріозу
EP0744407A3 (de)	1998-05-20	Zyklische Peptide mit fungizider Wirkung
ATE223432T1 (de)	2002-09-15	Zyklische peptide mit fungizider wirkung
DK0659427T3 (da)	2002-09-02	2-Phenyl-3-azoylbenzothiophener til forøgelse af thrombomodulinekspression
ATE233786T1 (de)	2003-03-15	Zyklische peptide mit fungizider wirkung
DK0662325T3 (da)	2001-12-03	Inhibering af ovariedysgenese, forsinket pubertet eller sexuel infantilisme
YU44202A (sh)	2005-11-28	Kvaternerne soli n-substituisanih cikiličnih ili ne- cikličnih amina kao farmaceutski preparati
TNSN04077A1 (en)	2006-06-01	Linear basic compounds having nk-2 antagonist activity and formulations thereof
ATE263183T1 (de)	2004-04-15	A-500359-derivate
WO2000078793A3 (en)	2001-03-22	Antimicrobial agents
EP1433480A4 (de)	2005-10-05	Pyrimidinderivate enthaltendes medikament
ATE177106T1 (de)	1999-03-15	Ymidothiophosphat-derivat und insektizid, nematozid und akarizid enthalted dasselbe als aktiven bestandteil.