ATE198200T1 - Durch einen pyridinring substituierte thiazolidine und oxazolidine und ihre anwendung als hypoglykämische mittel - Google Patents

Durch einen pyridinring substituierte thiazolidine und oxazolidine und ihre anwendung als hypoglykämische mittel

Info

Publication number: ATE198200T1
Authority: AT; Austria
Prior art keywords: group; alkyl; cycloalkyl; thiazolidines; pyridine ring
Prior art date: 1994-03-28

Application number

AT95913343T

Other languages

English (en)

Inventor

Yoshio Ohara

Mikio Suzuki

Nobuhide Miyachi

Katsuhiro Kato

Keisuke Ohdoi

Tetsuya Kobayashi

Ken-Ichi Shikada

Takeshi Naito

Takashi Yotsumoto

Original Assignee

Nissan Chemical Ind Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-03-28

Filing date

1995-03-27

Publication date

2001-01-15

1995-03-27 Application filed by Nissan Chemical Ind Ltd filed Critical Nissan Chemical Ind Ltd

2001-01-15 Application granted granted Critical

2001-01-15 Publication of ATE198200T1 publication Critical patent/ATE198200T1/de

Links

JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 title abstract 3
OGYGFUAIIOPWQD-UHFFFAOYSA-N 1,3-thiazolidine Chemical group C1CSCN1 OGYGFUAIIOPWQD-UHFFFAOYSA-N 0.000 title 1
239000003472 antidiabetic agent Substances 0.000 title 1
229940126904 hypoglycaemic agent Drugs 0.000 title 1
150000002917 oxazolidines Chemical group 0.000 title 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 4
125000006701 (C1-C7) alkyl group Chemical group 0.000 abstract 3
125000000392 cycloalkenyl group Chemical group 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
125000006374 C2-C10 alkenyl group Chemical group 0.000 abstract 1
125000005865 C2-C10alkynyl group Chemical group 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
-1 alpha -naphthyl group Chemical group 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000006267 biphenyl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
230000002218 hypoglycaemic effect Effects 0.000 abstract 1
125000004043 oxo group Chemical group O=* 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
150000003548 thiazolidines Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Diabetes (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Hematology (AREA)
Obesity (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT95913343T 1994-03-28 1995-03-27 Durch einen pyridinring substituierte thiazolidine und oxazolidine und ihre anwendung als hypoglykämische mittel ATE198200T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP5719294		1994-03-28
JP29517794		1994-11-29
PCT/JP1995/000560 WO1995026347A1 (en)	1994-03-28	1995-03-27	Thiazolidines and oxazolidines substituted by a pyridine ring and their use as hypoglycemic agents

Publications (1)

Publication Number	Publication Date
ATE198200T1 true ATE198200T1 (de)	2001-01-15

Family

ID=26398213

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95913343T ATE198200T1 (de)	1994-03-28	1995-03-27	Durch einen pyridinring substituierte thiazolidine und oxazolidine und ihre anwendung als hypoglykämische mittel

Country Status (19)

Country	Link
EP (1)	EP0751944B1 (de)
KR (1)	KR100340615B1 (de)
CN (1)	CN1045776C (de)
AT (1)	ATE198200T1 (de)
AU (1)	AU683739B2 (de)
CA (1)	CA2186381A1 (de)
CZ (1)	CZ282096A3 (de)
DE (1)	DE69519666T2 (de)
DK (1)	DK0751944T3 (de)
ES (1)	ES2154727T3 (de)
GR (1)	GR3035277T3 (de)
HU (1)	HUT76062A (de)
IL (1)	IL113112A (de)
MX (1)	MX9604430A (de)
NZ (1)	NZ282893A (de)
PT (1)	PT751944E (de)
RU (1)	RU2125053C1 (de)
TW (1)	TW420669B (de)
WO (1)	WO1995026347A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU679626B2 (en) *	1994-03-08	1997-07-03	Wyeth	Thiazolidinedione derivatives as anti-hyperglycemic agents
US5919782A (en) *	1996-05-06	1999-07-06	Dr. Reddy's Research Foundation	Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
ZA973848B (en) *	1996-05-06	1997-12-02	Reddy Research Foundation	Novel heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them.
US5889025A (en) *	1996-05-06	1999-03-30	Reddy's Research Foundation	Antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
BR9711098B1 (pt)	1996-07-01	2011-10-04		compostos heterocìclicos, processo para sua preparação e composições farmacêuticas contendo os mesmos e seu uso no tratamento de diabetes e doenças relacionadas.
USRE39266E1 (en) *	1996-07-01	2006-09-05	Dr. Reddy's Laboratories, Limited	Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US6114526A (en) *	1996-07-01	2000-09-05	Dr. Reddy's Research Foundation	Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US6372750B2 (en)	1996-07-01	2002-04-16	Dr. Reddy's Research Foundation	Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases
US6011036A (en) *	1997-04-15	2000-01-04	Dr. Reddy's Research Foundation	Heterocyclic compounds having antidiabetic hypolipidemic antihypertensive properties process for their preparation and pharmaceutical compositions containing them
US6011031A (en) *	1997-05-30	2000-01-04	Dr. Reddy's Research Foundation	Azolidinediones useful for the treatment of diabetes, dyslipidemia and hypertension: process for their preparation and pharmaceutical compositions containing them
US6756360B1 (en)	1998-12-24	2004-06-29	Metabasis Therapeutics, Inc.	Combination of FBPase inhibitors and insulin sensitizers for the treatment of diabetes
US7563774B2 (en)	2000-06-29	2009-07-21	Metabasis Therapeutics, Inc.	Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes
NZ525164A (en)	2000-11-27	2005-04-29	Pfizer Prod Inc	EP4 receptor selective agonists in the treatment of osteoporosis
GB0122318D0 (en) *	2001-09-14	2001-11-07	Novartis Ag	Organic compounds
US7135488B2 (en) *	2003-01-02	2006-11-14	Hoffmann-La Roche Inc.	Pyrrolyl-thiazole derivatives
RU2403258C2 (ru) *	2004-10-07	2010-11-10	Бёрингер Ингельхайм Интернациональ Гмбх	Тиазолилдигидроиндазолы
EP2543667B1 (de) *	2006-03-24	2015-01-28	Array Biopharma, Inc.	Verfahren zur Herstellung von 2-Aminopyridin-Analoga als Glucokinase-Aktivatoren
CN101311167B (zh) *	2007-05-25	2011-04-06	天津药物研究院	1-苯基咪唑烷-2,4-二酮类衍生物及其用途
BR112012015248B1 (pt)	2009-12-23	2022-01-04	Jasco Pharmaceuticals, LLC	Composto
WO2012145617A2 (en)	2011-04-22	2012-10-26	Jasco Pharmaceuticals, LLC	Aminopyrimidine kinase inhibitors
EP2776432B1 (de)	2011-11-04	2017-03-29	Jasco Pharmaceuticals LLC	Aminopyrimidinkinasehemmer
KR20160004272U (ko)	2015-06-04	2016-12-14	심명보	걸이구가 구비된 케이블행거
KR200488728Y1 (ko)	2017-06-15	2019-03-11	심명보	걸이구가 구비된 케이블행거
IL272246B2 (en)	2017-07-28	2026-01-01	Applied Therapeutics Inc	History of 2-(4-oxo/thioketone/azo-3-((substituted)benzo[d]thiazol-2-yl)methyl)- 3,4-dihydrothieno[3,4-d]pyridazin-1-yl)acetic acid for use as an aldose reductase inhibitor for the treatment of galactosemia or prevention of galactosemia-related complications
AU2020254610A1 (en)	2019-04-01	2021-11-18	Applied Therapeutics Inc.	Inhibitors of aldose reductase
CN113966396A (zh)	2019-05-07	2022-01-21	迈阿密大学	遗传性神经病和相关障碍的治疗和检测
KR102433164B1 (ko) *	2020-06-29	2022-08-18	한국전력공사	길이와 각도 조절이 가능한 케이블 행거

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5564586A (en) *	1978-11-09	1980-05-15	Takeda Chem Ind Ltd	Thiazolidine derivative
MX15171A (es) *	1988-03-08	1993-05-01	Pfizer	Derivados de tiazolidinodiona hipoglicemicos
WO1989008650A1 (en) *	1988-03-08	1989-09-21	Pfizer Inc.	Thiazolidinedione hypoglycemic agents
JPH065228A (ja) *	1992-06-18	1994-01-14	Mitsubishi Electric Corp	偏向デバイス
TW245716B (de) *	1992-12-28	1995-04-21	Takeda Pharm Industry Co
KR960002625A (ko) *	1994-06-17	1996-01-26	제임스 조셉 드롱	다층 레지스트의 플라즈마 에칭을 위한 방법 및 장치

1995
- 1995-03-23 IL IL11311295A patent/IL113112A/xx not_active IP Right Cessation
- 1995-03-23 TW TW084102837A patent/TW420669B/zh not_active IP Right Cessation
- 1995-03-27 HU HU9602645A patent/HUT76062A/hu unknown
- 1995-03-27 RU RU96119770A patent/RU2125053C1/ru not_active IP Right Cessation
- 1995-03-27 DE DE69519666T patent/DE69519666T2/de not_active Expired - Fee Related
- 1995-03-27 DK DK95913343T patent/DK0751944T3/da active
- 1995-03-27 EP EP95913343A patent/EP0751944B1/de not_active Expired - Lifetime
- 1995-03-27 CA CA002186381A patent/CA2186381A1/en not_active Abandoned
- 1995-03-27 MX MX9604430A patent/MX9604430A/es unknown
- 1995-03-27 WO PCT/JP1995/000560 patent/WO1995026347A1/en not_active Ceased
- 1995-03-27 NZ NZ282893A patent/NZ282893A/en unknown
- 1995-03-27 ES ES95913343T patent/ES2154727T3/es not_active Expired - Lifetime
- 1995-03-27 CZ CZ962820A patent/CZ282096A3/cs unknown
- 1995-03-27 PT PT95913343T patent/PT751944E/pt unknown
- 1995-03-27 AU AU20833/95A patent/AU683739B2/en not_active Ceased
- 1995-03-27 CN CN95192264A patent/CN1045776C/zh not_active Expired - Fee Related
- 1995-03-27 KR KR1019960705283A patent/KR100340615B1/ko not_active Expired - Fee Related
- 1995-03-27 AT AT95913343T patent/ATE198200T1/de not_active IP Right Cessation
2001
- 2001-01-18 GR GR20010400094T patent/GR3035277T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
ES2154727T3 (es)	2001-04-16
DK0751944T3 (da)	2001-01-08
AU683739B2 (en)	1997-11-20
DE69519666D1 (de)	2001-01-25
NZ282893A (en)	1997-07-27
HUT76062A (en)	1997-06-30
MX9604430A (es)	1997-12-31
IL113112A (en)	2000-06-01
GR3035277T3 (en)	2001-04-30
AU2083395A (en)	1995-10-17
KR100340615B1 (ko)	2002-10-18
EP0751944B1 (de)	2000-12-20
TW420669B (en)	2001-02-01
CA2186381A1 (en)	1995-10-05
CN1144526A (zh)	1997-03-05
CZ282096A3 (en)	1997-03-12
IL113112A0 (en)	1995-06-29
WO1995026347A1 (en)	1995-10-05
KR970701716A (ko)	1997-04-12
DE69519666T2 (de)	2001-04-26
EP0751944A1 (de)	1997-01-08
HU9602645D0 (en)	1996-11-28
PT751944E (pt)	2001-03-30
RU2125053C1 (ru)	1999-01-20
CN1045776C (zh)	1999-10-20

Legal Events

Date	Code	Title	Description
2001-04-15	UEP	Publication of translation of european patent specification
2004-12-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69519666D1 (de)	2001-01-25	Durch einen pyridinring substituierte thiazolidine und oxazolidine und ihre anwendung als hypoglykämische mittel
TR200402512T4 (tr)	2004-12-21	Hipoglisemik ve hipolipidemik aktiviteye sahip 5-üyeli N-heterosiklik bileşikler
ATE195938T1 (de)	2000-09-15	2-(1',2',4'-triazol-3'yloxymethylen)-anilide und ihre verwendung als schädlingsbekämpfungsmittel
DE69032882D1 (de)	1999-02-18	Aminderivate
ATE152719T1 (de)	1997-05-15	Chinolylbenzofuran derivate als leukotrien- antagonisten
ES2103287T3 (es)	1997-09-16	Nuevos derivados de tiazolidina.
DE69327944D1 (de)	2000-04-06	Thiazolidindione-Derivate, ihre Herstellung und Verwendung
MX9604398A (es)	1997-09-30	Derivados de sulfonamida.
DE69104041D1 (de)	1994-10-20	Orthosubstituierte biphenylguanidinderivate sowie diese enthaltende antidiabetische oder hypoglykämische mittel.
ATE218329T1 (de)	2002-06-15	Anthracyclinon-derivate und ihre verwendung in amyloidose
DE3783754D1 (de)	1993-03-04	Prolin-derivate.
DK0690845T3 (da)	1999-02-22	Piperazinderivater som 5-HT1A-ligander
DE69119282D1 (de)	1996-06-13	Aminobenzolverbindungen, Herstellung und Verwendung
BR9508676A (pt)	1997-12-23	Carbamolicarboxamida composição processos para preparar compostos e a composição e para controlar fungos nocivos e uso compost e das composições
MX9302388A (es)	1993-10-01	Oxazolidinonas fungicidas y composicion fungicida que las contiene
ATE206050T1 (de)	2001-10-15	Okulares hypotensium
ATE122040T1 (de)	1995-05-15	Pestizide heterozyklische verbindungen.
NO179835C (no)	1996-12-27	Aminderivater med fungicid aktivitet og anvendelse som fungicider