ES2103287T3 - Nuevos derivados de tiazolidina. - Google Patents
Nuevos derivados de tiazolidina.Info
- Publication number
- ES2103287T3 ES2103287T3 ES91111866T ES91111866T ES2103287T3 ES 2103287 T3 ES2103287 T3 ES 2103287T3 ES 91111866 T ES91111866 T ES 91111866T ES 91111866 T ES91111866 T ES 91111866T ES 2103287 T3 ES2103287 T3 ES 2103287T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- carbon atom
- general formula
- atom
- single bond
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- OGYGFUAIIOPWQD-UHFFFAOYSA-N 1,3-thiazolidine Chemical class C1CSCN1 OGYGFUAIIOPWQD-UHFFFAOYSA-N 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 11
- 229910052799 carbon Inorganic materials 0.000 abstract 8
- 125000002947 alkylene group Chemical group 0.000 abstract 5
- 125000004450 alkenylene group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 208000000044 Amnesia Diseases 0.000 abstract 1
- 208000031091 Amnestic disease Diseases 0.000 abstract 1
- 102000056251 Prolyl Oligopeptidases Human genes 0.000 abstract 1
- 101710178372 Prolyl endopeptidase Proteins 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000006986 amnesia Effects 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 229930195734 saturated hydrocarbon Natural products 0.000 abstract 1
- 150000003548 thiazolidines Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
UN NUEVO DERIVADO DE TIAZOLIDINA DE LA FORMULA GENERAL: DONDE R REPRESENTA UN GRUPO DE LA FORMULA GENERAL: G-E-D-B-ADONDE A REPRESENTA UN GRUPO ALCALINO DE UNION SIMPLE DE 1 A 6 ATOMO(S) DE CARBONO, UN GRUPO ALKENILENO DE 2 A 6 ATOMOS DE CARBONO, UN GRUPO DE LA FORMULA GENERAL: O DE ANILLO DE HIDROCARBURO SATURADO DE 4 A 7 ATOMOS DE CARBONO O DE UN ANILLO HETEROCICLICO MONOAROMATICO QUE CONTIENE DE 4 A 7 MIEMBROS DE ANILLO QUE INCLUYEN UN ATOMO DE NITROGENO Y/O UN ATOMO DE AZUFRE QUE PUEDEN SER TOTAL O PARCIALMENTE SATURADOS, Y REPRESENTA UN GRUPO ALKILENO DE 1 A 4 ATOMO(S) DE CARBONO O UN GRUPO ALKENILENO DE 2 A 4 ATOMOS DE CARBONO, B REPRESENTA UN GRUPO ALCALINO DE UNION SIMPLE DE 1 A 6 ATOMO(S) DE CARBONO, D REPRESENTA UN ATOMO DE OXIGENO DE UNION SIMPLE, UN GRUPO CARBONILO U OTRO DE LA FORMULA GENERAL: R ELEVADO 1 REPRESENTA UN ATOMO DE HIDROGENO, UN GRUPO ALCALINO DE 1 A 4 ATOMO(S) DE CARBONO, UN GRUPO FENILO O BENCILO, E REPRESENTA UN GRUPO ALCALINO DE UNION SIMPLE DE 1 A 8 ATOMO(S) DE CARBONO O UN GRUPO ALCALINO DE 1 A 8 ATOMO(S) DE CARBONO SUSTITUIDOS POR UN GRUPO FENILO O BENCILO, G REPRESENTA ANILLO(S) CARBONCICLICOS MONO, BI O TRIAROMATICOS QUE CONTIENEN NO MAS DE 15 ATOMOS DE CARBONO QUE PUEDEN SER PARCIAL O COMPLETAMENTE SATURADOS, O G REPRESENTA ANILLO(S) HETEROCICLICOS MONO, BI O TRIAROMATICOS QUE CONTIENEN NO MAS DE 15 MIEMBROS DE ANILLOS QUE INCLUYEN UN ATOMO DE NITROGENO QUE PUEDE SER PARCIAL O COMPLETAMENTE SATURADO DONDE DICHO ANILLO CARBOCICLICO O HETEROCICLICO REPRESENTADO POR G PUEDE SUSTITUIRSE O NO, POR UNO A TRES GRUPOS ALCALINOS DE 1 A 6 ATOMO(S) DE CARBONO, POR UN GRUPO ALKOXI DE 1 A 6 ATOMO(S) DE CARBONO, POR ATOMO HALOGENO, POR UN GRUPO TRIFLUOROMETILO O NITRO, CON LA CONDICION DE QUE A Y B NO REPRESENTEN UNIONES SIMPLES AL MISMO TIEMPO POSEE ACTIVIDAD INHIBITORIA EN LA PROLIL ENDOPEPTIDASA Y, POR LO TANTO, ES UTIL COMO AGENTE PARA EL TRATAMIENTO Y/O PREVENCION DE LA AMNESIA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3784487 | 1987-02-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2103287T3 true ES2103287T3 (es) | 1997-09-16 |
Family
ID=12508841
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES91111866T Expired - Lifetime ES2103287T3 (es) | 1987-02-23 | 1988-02-16 | Nuevos derivados de tiazolidina. |
| ES88102243T Expired - Lifetime ES2052619T3 (es) | 1987-02-23 | 1988-02-16 | Un procedimiento para la preparacion de los nuevos derivados de tiazolidina. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES88102243T Expired - Lifetime ES2052619T3 (es) | 1987-02-23 | 1988-02-16 | Un procedimiento para la preparacion de los nuevos derivados de tiazolidina. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4857537A (es) |
| EP (2) | EP0461677B1 (es) |
| KR (1) | KR960001205B1 (es) |
| AT (1) | ATE151760T1 (es) |
| DE (2) | DE3875361T2 (es) |
| ES (2) | ES2103287T3 (es) |
| GR (1) | GR3006406T3 (es) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01250370A (ja) * | 1987-12-23 | 1989-10-05 | Zeria Pharmaceut Co Ltd | 新規アミノ酸イミド誘導体、製法ならびに用途 |
| JP2515568B2 (ja) * | 1987-12-25 | 1996-07-10 | 株式会社ヤクルト本社 | 新規なチアゾリジン誘導体 |
| US5212191A (en) * | 1988-04-08 | 1993-05-18 | Ono Pharmaceutical Co., Ltd. | Heterocyclic compounds |
| US5053414A (en) * | 1988-04-08 | 1991-10-01 | Ono Pharmaceutical Co., Ltd. | Heterocyclic compounds |
| CA2004028C (en) * | 1988-12-08 | 1998-09-22 | Motoki Torizuka | Condensed benzene derivative |
| EP0419683A4 (en) * | 1989-04-13 | 1992-03-11 | Japan Tobacco Inc. | New amino acid derivatives having prolylendopeptidase inhibitor activity |
| US5073549A (en) * | 1990-03-22 | 1991-12-17 | Bristol-Myers Squibb Company | BU-4164E - A and B, prolyl endopeptidase inhibitors and their methods of use |
| US4999349A (en) * | 1990-03-22 | 1991-03-12 | Bristol-Myers Squibb Co. | BU-4164E - A and B, prolyl endopeptidase inhibitors |
| FI925500A7 (fi) * | 1990-06-04 | 1992-12-03 | Pfizer | Aromaattisia pyrrolidiini- ja tiatsolidiiniamideja |
| US5506256A (en) * | 1990-07-27 | 1996-04-09 | Yoshitomi Pharmaceutical Industries, Ltd. | Proline derivatives possessing prolyl endopeptidase-inhibitory activity |
| IT1283782B1 (it) * | 1996-08-09 | 1998-04-30 | Ct Lab Farm Srl | Uso di ammidi dell'acido gamma-idrossibutirrico nel trattamento di tossicodipendenze,ed in particolare sell'alcolismo |
| US6419857B1 (en) * | 1999-12-06 | 2002-07-16 | Baker Hughes Incorporated | Thiazolidines and use thereof for corrosion inhibition |
| WO2004098591A2 (en) | 2003-05-05 | 2004-11-18 | Probiodrug Ag | Inhibitors of glutaminyl cyclase and their use in the treatment of neurological diseases |
| AU2004290499C1 (en) | 2003-11-03 | 2011-02-24 | Probiodrug Ag | Combinations useful for the treatment of neuronal disorders |
| CA2554809C (en) | 2004-02-05 | 2014-04-29 | Probiodrug Ag | Novel n-alkyl thiourea- and thioamide-substituted imidazolyl inhibitors of glutaminyl cyclase |
| EP1760076A1 (en) | 2005-09-02 | 2007-03-07 | Ferring B.V. | FAP Inhibitors |
| US8278345B2 (en) | 2006-11-09 | 2012-10-02 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| ATE554085T1 (de) | 2006-11-30 | 2012-05-15 | Probiodrug Ag | Neue inhibitoren von glutaminylcyclase |
| JP5930573B2 (ja) | 2007-03-01 | 2016-06-15 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤の新規使用 |
| EP2142514B1 (en) | 2007-04-18 | 2014-12-24 | Probiodrug AG | Thiourea derivatives as glutaminyl cyclase inhibitors |
| JP5934645B2 (ja) | 2009-09-11 | 2016-06-15 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体 |
| JP6026284B2 (ja) | 2010-03-03 | 2016-11-16 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤 |
| NZ602312A (en) | 2010-03-10 | 2014-02-28 | Probiodrug Ag | Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5) |
| WO2011131748A2 (en) | 2010-04-21 | 2011-10-27 | Probiodrug Ag | Novel inhibitors |
| EP2686313B1 (en) | 2011-03-16 | 2016-02-03 | Probiodrug AG | Benzimidazole derivatives as inhibitors of glutaminyl cyclase |
| ES2812698T3 (es) | 2017-09-29 | 2021-03-18 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60188317A (ja) * | 1984-03-09 | 1985-09-25 | Yakult Honsha Co Ltd | 抗健忘症剤 |
| JPS6137764A (ja) * | 1984-07-31 | 1986-02-22 | Suntory Ltd | 抗プロリルエンドペプチダ−ゼ活性を有する新規生理活性化合物 |
| JPH0623190B2 (ja) * | 1985-04-16 | 1994-03-30 | サントリー株式会社 | インヒビタ−活性を有するｎ−アシルピロリジン誘導体及びその製法並びに用途 |
| CA1309805C (en) * | 1985-04-16 | 1992-11-03 | Naoki Higuchi | Dipeptide derivative and synthesis and use thereof |
| EP0201743B1 (en) * | 1985-04-16 | 1992-04-01 | Suntory Limited | Dipeptide derivatives of fatty acids, process for preparing them, pharmaceutical composition and use |
-
1988
- 1988-02-16 DE DE8888102243T patent/DE3875361T2/de not_active Expired - Fee Related
- 1988-02-16 EP EP91111866A patent/EP0461677B1/en not_active Expired - Lifetime
- 1988-02-16 EP EP88102243A patent/EP0280956B1/en not_active Expired - Lifetime
- 1988-02-16 ES ES91111866T patent/ES2103287T3/es not_active Expired - Lifetime
- 1988-02-16 DE DE3855875T patent/DE3855875T2/de not_active Expired - Fee Related
- 1988-02-16 AT AT91111866T patent/ATE151760T1/de not_active IP Right Cessation
- 1988-02-16 ES ES88102243T patent/ES2052619T3/es not_active Expired - Lifetime
- 1988-02-23 US US07/159,073 patent/US4857537A/en not_active Expired - Lifetime
- 1988-02-23 KR KR1019880001849A patent/KR960001205B1/ko not_active Expired - Fee Related
-
1992
- 1992-12-02 GR GR920402770T patent/GR3006406T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0461677B1 (en) | 1997-04-16 |
| EP0461677A1 (en) | 1991-12-18 |
| KR960001205B1 (ko) | 1996-01-24 |
| KR880009949A (ko) | 1988-10-06 |
| GR3006406T3 (es) | 1993-06-21 |
| ATE151760T1 (de) | 1997-05-15 |
| DE3855875T2 (de) | 1997-08-28 |
| EP0280956B1 (en) | 1992-10-21 |
| DE3855875D1 (de) | 1997-05-22 |
| DE3875361D1 (de) | 1992-11-26 |
| US4857537A (en) | 1989-08-15 |
| DE3875361T2 (de) | 1993-03-25 |
| ES2052619T3 (es) | 1994-07-16 |
| EP0280956A1 (en) | 1988-09-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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