ATE198479T1 - Verfahren zur herstellung von purinderivaten - Google Patents

Verfahren zur herstellung von purinderivaten

Info

Publication number: ATE198479T1
Authority: AT; Austria
Prior art keywords: acyloxymethyl; hydroxymethyl; hydrogen; converting; group
Prior art date: 1988-07-23

Application number

AT89307271T

Other languages

English (en)

Inventor

Trevor John Grinter

Peter Markham Kincey

Original Assignee

Beecham Group Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-07-23

Filing date

1989-07-18

Publication date

2001-01-15

1989-07-18 Application filed by Beecham Group Plc filed Critical Beecham Group Plc

2001-01-15 Application granted granted Critical

2001-01-15 Publication of ATE198479T1 publication Critical patent/ATE198479T1/de

Links

238000004519 manufacturing process Methods 0.000 title 1
229940083251 peripheral vasodilators purine derivative Drugs 0.000 title 1
150000003212 purines Chemical class 0.000 title 1
125000005042 acyloxymethyl group Chemical group 0.000 abstract 5
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 5
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
-1 benzylthio Chemical group 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
230000007062 hydrolysis Effects 0.000 abstract 1
238000006460 hydrolysis reaction Methods 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000002346 iodo group Chemical group I* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/14—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with two methyl radicals in positions 1 and 3 and two methyl radicals in positions 7, 8, or 9

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Virology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Saccharide Compounds (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Catalysts (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Mechanical Operated Clutches (AREA)

AT89307271T 1988-07-23 1989-07-18 Verfahren zur herstellung von purinderivaten ATE198479T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB888817607A GB8817607D0 (en)	1988-07-23	1988-07-23	Novel process

Publications (1)

Publication Number	Publication Date
ATE198479T1 true ATE198479T1 (de)	2001-01-15

Family

ID=10641009

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89307271T ATE198479T1 (de)	1988-07-23	1989-07-18	Verfahren zur herstellung von purinderivaten

Country Status (18)

Country	Link
US (1)	US5017701A (de)
EP (1)	EP0352953B1 (de)
JP (1)	JP2856773B2 (de)
KR (1)	KR0137468B1 (de)
AT (1)	ATE198479T1 (de)
AU (1)	AU623667B2 (de)
DE (1)	DE68929277T2 (de)
DK (1)	DK171991B1 (de)
ES (1)	ES2153343T3 (de)
FI (1)	FI893535A7 (de)
GB (1)	GB8817607D0 (de)
HU (1)	HU204829B (de)
MA (1)	MA21601A1 (de)
NO (1)	NO169008C (de)
NZ (1)	NZ230026A (de)
PL (1)	PL161207B1 (de)
PT (1)	PT91247B (de)
ZA (1)	ZA895567B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5684153A (en)	1984-08-16	1997-11-04	Beecham Group Plc	Process for the preparation of purine derivatives
US5175288A (en) *	1987-08-01	1992-12-29	Beecham Group P.L.C.	Process for preparing purine derivatives and intermediates thereof
GB8822236D0 (en) *	1988-09-21	1988-10-26	Beecham Group Plc	Chemical process
GB8829571D0 (en) *	1988-12-19	1989-02-08	Wellcome Found	Antiviral compounds
GB8922076D0 (en) *	1989-09-28	1989-11-15	Beecham Group Plc	Novel process
DE4020481A1 (de) *	1990-06-27	1992-01-02	Hoechst Ag	Verfahren zur herstellung von substituierten acyclischen nukleosiden und dabei auftretende zwischenprodukte
CA2076886C (en) *	1991-11-22	2002-06-11	Masami Igi	Method for production of 2-amino-6-halogenopurine and synthesis intermediate therefor
US5874578A (en) *	1992-07-13	1999-02-23	Bristol-Myers Squibb	Process for preparing guanine-containing antiviral agents and purinyl salts useful in such process
GB9407698D0 (en) *	1994-04-19	1994-06-15	Smithkline Beecham Plc	Pharmaceuticals
JP3241994B2 (ja) *	1995-07-03	2001-12-25	株式会社荏原製作所	水中モータ及び防水コネクタ
GB9615275D0 (en) *	1996-07-20	1996-09-04	Smithkline Beecham Plc	Pharmaceuticals
GB9615276D0 (en) *	1996-07-20	1996-09-04	Smithkline Beecham Plc	Pharmaceuticals
AT412211B (de) *	1996-07-20	2004-11-25	Novartis Int Pharm Ltd	Verfahren zur herstellung von penciclovir und famciclovir
GB9615253D0 (en) *	1996-07-20	1996-09-04	Smithkline Beecham Plc	Pharmaceuticals
EP0827960A1 (de)	1996-09-10	1998-03-11	Ajinomoto Co., Inc.	Verfahren zur Herstellung von Purinderivaten
GB9807116D0 (en) *	1998-04-02	1998-06-03	Smithkline Beecham Plc	Novel process
GB9807114D0 (en) *	1998-04-02	1998-06-03	Smithkline Beecham Plc	Novel process
EP1352910A1 (de) *	2002-04-10	2003-10-15	Grünenthal GmbH	Neue Analoga von Nitrobenzylthioinosine
CA2496684A1 (en) *	2002-08-26	2004-03-04	Teva Pharmaceutical Industries Ltd	Crystalline solid famciclovir forms i, ii, iii and preparation thereof
JP4800216B2 (ja) *	2003-10-24	2011-10-26	エグゼリクシス，インコーポレイテッド	ｐ７０Ｓ６キナーゼモジュレーターおよび使用方法
EP1747223A1 (de) *	2004-05-18	2007-01-31	Teva Pharmaceutical Industries Ltd.	Trocknungsverfahren zur herstellung von kristallinem festen famciclovir
DE602004009166T2 (de) *	2004-06-29	2008-08-21	Grünenthal GmbH	Neue Analoga von Nitrobenzylthioinosin
KR100618232B1 (ko) *	2004-09-22	2006-09-04	한미약품 주식회사	팜시클로버의 제조방법
GB2426247A (en)	2005-05-20	2006-11-22	Arrow Int Ltd	Methods of preparing purine derivatives such as famciclovir

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4347187A (en) *	1980-10-20	1982-08-31	Syntex (U.S.A.) Inc.	Process for preparing 5-aroyl 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids and novel intermediates therein
US4347185A (en) *	1980-10-20	1982-08-31	Syntex (U.S.A.) Inc.	Processes for preparing 5-benzoyl-7-halo-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids
AU577303B2 (en) *	1983-08-18	1988-09-22	Novartis International Pharmaceutical Ltd	9-substituted-2-amino purines
EP0141927B1 (de) *	1983-08-18	1991-10-30	Beecham Group Plc	Antivirale Guanin-Derivate
IL73682A (en) *	1983-12-20	1991-08-16	Medivir Ab	Antiviral pharmaceutical compositions containing 9-hydroxy aliphatic derivatives of guanine,some new such derivatives and process for their preparation
US4845084A (en) *	1984-01-26	1989-07-04	Merck & Co., Inc.	Phosphate derivatives of substituted butyl guanines, antiviral compositions containing them, and methods of treating viral infections with them
DE3582399D1 (de) *	1984-09-20	1991-05-08	Beecham Group Plc	Purin-derivate und ihre pharmazeutische verwendung.
EP0302644B1 (de) *	1987-08-01	1997-01-29	Beecham Group Plc	Purinverbindungen und ihre Herstellung
GB8922076D0 (en) *	1989-09-28	1989-11-15	Beecham Group Plc	Novel process

1988
- 1988-07-23 GB GB888817607A patent/GB8817607D0/en active Pending
1989
- 1989-07-18 AT AT89307271T patent/ATE198479T1/de not_active IP Right Cessation
- 1989-07-18 ES ES89307271T patent/ES2153343T3/es not_active Expired - Lifetime
- 1989-07-18 EP EP89307271A patent/EP0352953B1/de not_active Expired - Lifetime
- 1989-07-18 DE DE68929277T patent/DE68929277T2/de not_active Expired - Lifetime
- 1989-07-21 US US07/383,859 patent/US5017701A/en not_active Expired - Lifetime
- 1989-07-21 PL PL1989280709A patent/PL161207B1/pl unknown
- 1989-07-21 NZ NZ230026A patent/NZ230026A/xx unknown
- 1989-07-21 DK DK362689A patent/DK171991B1/da not_active IP Right Cessation
- 1989-07-21 MA MA21853A patent/MA21601A1/fr unknown
- 1989-07-21 PT PT91247A patent/PT91247B/pt not_active IP Right Cessation
- 1989-07-21 AU AU38822/89A patent/AU623667B2/en not_active Expired
- 1989-07-21 JP JP1190386A patent/JP2856773B2/ja not_active Expired - Lifetime
- 1989-07-21 FI FI893535A patent/FI893535A7/fi not_active Application Discontinuation
- 1989-07-21 NO NO892998A patent/NO169008C/no not_active IP Right Cessation
- 1989-07-21 ZA ZA895567A patent/ZA895567B/xx unknown
- 1989-07-21 HU HU893709A patent/HU204829B/hu unknown
- 1989-07-22 KR KR1019890010404A patent/KR0137468B1/ko not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US5017701A (en)	1991-05-21
HK1012355A1 (en)	1999-07-30
NO169008B (no)	1992-01-20
EP0352953A3 (de)	1991-10-23
AU3882289A (en)	1990-01-25
ZA895567B (en)	1990-07-25
KR0137468B1 (ko)	1998-06-01
AU623667B2 (en)	1992-05-21
NZ230026A (en)	1992-11-25
PT91247A (pt)	1990-02-08
JP2856773B2 (ja)	1999-02-10
FI893535A0 (fi)	1989-07-21
EP0352953B1 (de)	2001-01-03
GB8817607D0 (en)	1988-09-01
HU204829B (en)	1992-02-28
HUT50820A (en)	1990-03-28
JPH0259583A (ja)	1990-02-28
EP0352953A2 (de)	1990-01-31
DK171991B1 (da)	1997-09-08
DK362689D0 (da)	1989-07-21
NO169008C (no)	1992-04-29
NO892998D0 (no)	1989-07-21
DK362689A (da)	1990-01-24
PL161207B1 (en)	1993-06-30
ES2153343T3 (es)	2001-03-01
NO892998L (no)	1990-01-24
FI893535A7 (fi)	1990-01-24
PT91247B (pt)	1995-05-04
DE68929277T2 (de)	2001-08-23
DE68929277D1 (de)	2001-02-08
MA21601A1 (fr)	1990-04-01
KR910002856A (ko)	1991-02-26

Legal Events

Date	Code	Title	Description
2009-10-15	EELA	Cancelled due to lapse of time

Publication	Publication Date	Title
DE68929277D1 (de)	2001-02-08	Verfahren zur Herstellung von Purinderivaten
DE69108014D1 (de)	1995-04-13	Verfahren zur herstellung von nucleosiden und ihre analogen.
EP0266182A3 (de)	1988-11-02	Gamma-Lactoncarbonsäure-Derivate und ihre Herstellung
AU6572896A (en)	1996-12-12	Enantiomerically enriched thiazolidine or oxazolidine compounds
DE3382761D1 (de)	1994-11-17	Verfahren zur Herstellung von Penem-Verbindungen.
ATE138379T1 (de)	1996-06-15	Verfahren zur herstellung von purinverbindungen
GB1467604A (en)	1977-03-16	Bis-type penicillins and process for producing the same
MX9803887A (es)	1998-09-30	Produccion de una sal de acido clavulanico.
ATE96796T1 (de)	1993-11-15	Verfahren zur herstellung von natriumpurinen.
AU8309591A (en)	1992-03-17	Process for producing aminomethanephosphonic acid and aminomethylphosphinic acids
ATE224393T1 (de)	2002-10-15	Verfahren zur herstellung von cephalosporinen und zwischenverbindungen in diesem verfahren
DE3851783D1 (de)	1994-11-17	Verfahren zur Herstellung von 6-[D(-)-alpha-(4-Äthyl-2,3-dioxo-1-piperazin-carboxamido)-phenylacetamido]penicillansäure.
ATE177737T1 (de)	1999-04-15	Verfahren zur herstellung von 5-arylhydantoin
ATE16706T1 (de)	1985-12-15	Verfahren zur herstellung von cephalosporinverbindungen.
DE69024114D1 (de)	1996-01-25	Verfahren zur Herstellung von Penemen
ES8609297A1 (es)	1986-09-01	Procedimiento de preparar aminolactonas
ES2138535A1 (es)	2000-01-01	Procedimiento para la preparacion de los compuestos antivirales penciclovir y famciclovir.
ATE244228T1 (de)	2003-07-15	Verfahren zur herstellung von chloroacetylaminothiazoleaceticsäure derivate
PT84870A (pt)	1988-05-27	Processo para a preparacao de derivados da cefalosporina
KR950701338A (ko)	1995-03-23	메탄디포스폰산 화합물의 제조방법(Process for producing methanediphosphonate compound)
DE69407742D1 (de)	1998-02-12	Verfahren zur herstellung von alpha-alkoxy-iminophenylacetonitril
ATE200283T1 (de)	2001-04-15	Verfahren zur herstellung eines carbonsäurederivates
DE69530064D1 (de)	2003-04-30	Verfahren zur herstellung einer methanphosphonsäureverbindung
KR960031464A (ko)	1996-09-17	세팔로스포린 유도체의 신규한 제조방법
ATE13535T1 (de)	1985-06-15	Verfahren zur herstellung von penamderivaten.