ATE198603T1 - Bivalente thrombininhibitore - Google Patents

Bivalente thrombininhibitore

Info

Publication number
ATE198603T1
ATE198603T1 AT94930133T AT94930133T ATE198603T1 AT E198603 T1 ATE198603 T1 AT E198603T1 AT 94930133 T AT94930133 T AT 94930133T AT 94930133 T AT94930133 T AT 94930133T AT E198603 T1 ATE198603 T1 AT E198603T1
Authority
AT
Austria
Prior art keywords
thrombin
glu
pct
inhibitors
active site
Prior art date
Application number
AT94930133T
Other languages
English (en)
Inventor
Yasuo Konishi
Zbigniew Szewczuk
Yuko Tsuda
Original Assignee
Ca Nat Research Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9321951A external-priority patent/GB9321951D0/en
Application filed by Ca Nat Research Council filed Critical Ca Nat Research Council
Application granted granted Critical
Publication of ATE198603T1 publication Critical patent/ATE198603T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT94930133T 1993-10-25 1994-10-25 Bivalente thrombininhibitore ATE198603T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9321951A GB9321951D0 (de) 1993-10-25 1993-10-25
GB9412707A GB9412707D0 (de) 1993-10-25 1994-06-24
PCT/CA1994/000585 WO1995011921A1 (en) 1993-10-25 1994-10-25 Bivalent thrombin inhibitors

Publications (1)

Publication Number Publication Date
ATE198603T1 true ATE198603T1 (de) 2001-01-15

Family

ID=26303742

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94930133T ATE198603T1 (de) 1993-10-25 1994-10-25 Bivalente thrombininhibitore

Country Status (8)

Country Link
US (1) US6127337A (de)
EP (1) EP0725797B1 (de)
AT (1) ATE198603T1 (de)
AU (1) AU7935494A (de)
CA (1) CA2175388A1 (de)
DE (1) DE69426569T2 (de)
ES (1) ES2153433T3 (de)
WO (1) WO1995011921A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999019356A1 (en) * 1997-10-15 1999-04-22 National Research Council Of Canada Trivalent thrombin inhibitor
US7829085B2 (en) * 1999-07-14 2010-11-09 Life Sciences Research Partners Vzw Methods of treating hemostasis disorders using antibodies binding the C1 domain of factor VIII
CA2726789A1 (en) 2000-02-05 2001-11-08 Theravance, Inc. Cyclodextrin containing glycopeptide antibiotic compositions
CA2535489C (en) 2003-08-14 2014-09-30 D. Collen Research Foundation Vzw Antibodies against factor viii with modified glycosylation in the variable region
WO2006000081A1 (en) * 2004-06-23 2006-01-05 National Research Council Of Canada Polypeptide ligands containing linkers
US7915223B2 (en) * 2004-09-27 2011-03-29 Technion Research & Development Foundation Ltd. Antimicrobial agents
US7504381B2 (en) * 2004-09-27 2009-03-17 Technion Research & Development Foundation Ltd. Antimicrobial agents
PT1737889E (pt) 2004-10-19 2010-12-13 Lonza Ag Método para síntese de péptidos em fase sólida
WO2008077621A1 (de) * 2006-12-23 2008-07-03 Aplagen Gmbh Verfahren zur ausbildung von disulfidbrücken
US20100173832A1 (en) * 2007-04-30 2010-07-08 Technion Research & Development Foundation Ltd. Anticancerous polymeric agents
US20080269065A1 (en) * 2007-04-30 2008-10-30 Syntrix Biosystems, Inc. Conformationally Constrained Analytical Probes
EP2152289A1 (de) * 2007-04-30 2010-02-17 Technion Research & Development Foundation Ltd. Neue antimikrobielle mittel
GB0711779D0 (en) 2007-06-18 2007-07-25 Univ Singapore Thrombin inhibitor
US9198952B2 (en) 2008-09-22 2015-12-01 The Brigham And Women's Hospital, Inc. Compositions of and methods of using ligand dimers
WO2011119836A1 (en) 2010-03-24 2011-09-29 Massachusetts Institute Of Technology Methods and compositions for cardioprotection and cardioregeneration

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3978045A (en) * 1973-08-13 1976-08-31 Mitsubishi Chemical Industries Ltd. N2 -dansyl-L-arginine derivatives, and the pharmaceutically acceptable acid addition salts thereof
US4173630A (en) * 1974-11-08 1979-11-06 Mitsubishi Chemical Industries Limited N2 Arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
ATE160356T1 (de) * 1990-06-15 1997-12-15 Ca Nat Research Council Thrombin-inhibitoren mit einer hirudin-ähnlichen sequenz
GB9209032D0 (en) * 1992-04-25 1992-06-10 Ciba Geigy Ag New peptide derivatives

Also Published As

Publication number Publication date
EP0725797A1 (de) 1996-08-14
CA2175388A1 (en) 1995-05-04
DE69426569T2 (de) 2001-05-10
WO1995011921A1 (en) 1995-05-04
ES2153433T3 (es) 2001-03-01
DE69426569D1 (de) 2001-02-15
EP0725797B1 (de) 2001-01-10
US6127337A (en) 2000-10-03
AU7935494A (en) 1995-05-22

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee