ATE171712T1 - Neuartiger menschlicher proteaseinhibitor vom kunitz-typ und entsprechende varianten - Google Patents

Neuartiger menschlicher proteaseinhibitor vom kunitz-typ und entsprechende varianten

Info

Publication number: ATE171712T1
Authority: AT; Austria
Prior art keywords: phe; cys; gly; glu; asn
Prior art date: 1992-01-07

Application number

AT93902107T

Other languages

English (en)

Inventor

Fanny Norris

Kjeld Norris

Rn S Ren Erik Bj

Lars Christian Petersen

Ole Hvilsted Olsen

Donald Cameron Foster

Cindy Ann Sprecher

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-01-07

Filing date

1993-01-07

Publication date

1998-10-15

1993-01-07 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

1998-10-15 Application granted granted Critical

1998-10-15 Publication of ATE171712T1 publication Critical patent/ATE171712T1/de

Links

108091005804 Peptidases Proteins 0.000 title 1
239000004365 Protease Substances 0.000 title 1
102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 title 1
XVZCXCTYGHPNEM-IHRRRGAJSA-N (2s)-1-[(2s)-2-[[(2s)-2-amino-4-methylpentanoyl]amino]-4-methylpentanoyl]pyrrolidine-2-carboxylic acid Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(O)=O XVZCXCTYGHPNEM-IHRRRGAJSA-N 0.000 abstract 1
OSRZOHXQCUFIQG-FPMFFAJLSA-N Ala-Phe-Pro Chemical compound C([C@H](NC(=O)[C@@H]([NH3+])C)C(=O)N1[C@H](CCC1)C([O-])=O)C1=CC=CC=C1 OSRZOHXQCUFIQG-FPMFFAJLSA-N 0.000 abstract 1
RAUPFUCUDBQYHE-AVGNSLFASA-N Asn-Phe-Glu Chemical compound [H]N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(O)=O)C(O)=O RAUPFUCUDBQYHE-AVGNSLFASA-N 0.000 abstract 1
AECPDLSSUMDUAA-ZKWXMUAHSA-N Asn-Val-Cys Chemical compound CC(C)[C@@H](C(=O)N[C@@H](CS)C(=O)O)NC(=O)[C@H](CC(=O)N)N AECPDLSSUMDUAA-ZKWXMUAHSA-N 0.000 abstract 1
KABHAOSDMIYXTR-GUBZILKMSA-N Cys-Glu-Leu Chemical compound CC(C)C[C@@H](C(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CS)N KABHAOSDMIYXTR-GUBZILKMSA-N 0.000 abstract 1
NLDWTJBJFVWBDQ-KKUMJFAQSA-N Cys-Lys-Phe Chemical compound NCCCC[C@H](NC(=O)[C@@H](N)CS)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 NLDWTJBJFVWBDQ-KKUMJFAQSA-N 0.000 abstract 1
XKPACHRGOWQHFH-IRIUXVKKSA-N Gln-Thr-Tyr Chemical compound [H]N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O XKPACHRGOWQHFH-IRIUXVKKSA-N 0.000 abstract 1
OHWJUIXZHVIXJJ-GUBZILKMSA-N Glu-Lys-Cys Chemical compound C(CCN)C[C@@H](C(=O)N[C@@H](CS)C(=O)O)NC(=O)[C@H](CCC(=O)O)N OHWJUIXZHVIXJJ-GUBZILKMSA-N 0.000 abstract 1
MFNUFCFRAZPJFW-JYJNAYRXSA-N Glu-Lys-Phe Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 MFNUFCFRAZPJFW-JYJNAYRXSA-N 0.000 abstract 1
KMSGYZQRXPUKGI-BYPYZUCNSA-N Gly-Gly-Asn Chemical compound NCC(=O)NCC(=O)N[C@H](C(O)=O)CC(N)=O KMSGYZQRXPUKGI-BYPYZUCNSA-N 0.000 abstract 1
IDOGEHIWMJMAHT-BYPYZUCNSA-N Gly-Gly-Cys Chemical compound NCC(=O)NCC(=O)N[C@@H](CS)C(O)=O IDOGEHIWMJMAHT-BYPYZUCNSA-N 0.000 abstract 1
QSQXZZCGPXQBPP-BQBZGAKWSA-N Gly-Pro-Cys Chemical compound C1C[C@H](N(C1)C(=O)CN)C(=O)N[C@@H](CS)C(=O)O QSQXZZCGPXQBPP-BQBZGAKWSA-N 0.000 abstract 1
YOZCKMXHBYKOMQ-IHRRRGAJSA-N Leu-Arg-Lys Chemical compound CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)O)N YOZCKMXHBYKOMQ-IHRRRGAJSA-N 0.000 abstract 1
XVZCXCTYGHPNEM-UHFFFAOYSA-N Leu-Leu-Pro Natural products CC(C)CC(N)C(=O)NC(CC(C)C)C(=O)N1CCCC1C(O)=O XVZCXCTYGHPNEM-UHFFFAOYSA-N 0.000 abstract 1
VZBXCMCHIHEPBL-SRVKXCTJSA-N Met-Glu-Lys Chemical compound CSCC[C@H](N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@H](C(O)=O)CCCCN VZBXCMCHIHEPBL-SRVKXCTJSA-N 0.000 abstract 1
KSIPKXNIQOWMIC-RCWTZXSCSA-N Met-Thr-Arg Chemical compound CSCC[C@H](N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H](C(O)=O)CCCNC(N)=N KSIPKXNIQOWMIC-RCWTZXSCSA-N 0.000 abstract 1
NOFBJKKOPKJDCO-KKXDTOCCSA-N Phe-Ala-Tyr Chemical compound [H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O NOFBJKKOPKJDCO-KKXDTOCCSA-N 0.000 abstract 1
229940124158 Protease/peptidase inhibitor Drugs 0.000 abstract 1
OOKCGAYXSNJBGQ-ZLUOBGJFSA-N Ser-Asn-Asn Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O OOKCGAYXSNJBGQ-ZLUOBGJFSA-N 0.000 abstract 1
AQAMPXBRJJWPNI-JHEQGTHGSA-N Thr-Gly-Glu Chemical compound [H]N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(O)=O AQAMPXBRJJWPNI-JHEQGTHGSA-N 0.000 abstract 1
BOMYCJXTWRMKJA-RNXOBYDBSA-N Trp-Phe-Phe Chemical compound C1=CC=C(C=C1)C[C@@H](C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)O)NC(=O)[C@H](CC3=CNC4=CC=CC=C43)N BOMYCJXTWRMKJA-RNXOBYDBSA-N 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
108010016616 cysteinylglycine Proteins 0.000 abstract 1
108010044056 leucyl-phenylalanine Proteins 0.000 abstract 1
108010064235 lysylglycine Proteins 0.000 abstract 1
239000000137 peptide hydrolase inhibitor Substances 0.000 abstract 1
239000003001 serine protease inhibitor Substances 0.000 abstract 1
108010005652 splenotritin Proteins 0.000 abstract 1
108010017949 tyrosyl-glycyl-glycine Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/16—Animal cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Wood Science & Technology (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Cell Biology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Saccharide Compounds (AREA)
Detergent Compositions (AREA)

AT93902107T 1992-01-07 1993-01-07 Neuartiger menschlicher proteaseinhibitor vom kunitz-typ und entsprechende varianten ATE171712T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DK9200003		1992-01-07

Publications (1)

Publication Number	Publication Date
ATE171712T1 true ATE171712T1 (de)	1998-10-15

Family

ID=8153772

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93902107T ATE171712T1 (de)	1992-01-07	1993-01-07	Neuartiger menschlicher proteaseinhibitor vom kunitz-typ und entsprechende varianten

Country Status (17)

Country	Link
US (1)	US5618696A (de)
EP (1)	EP0621873B1 (de)
JP (1)	JP3345420B2 (de)
KR (1)	KR940703860A (de)
AT (1)	ATE171712T1 (de)
AU (1)	AU670059B2 (de)
CA (1)	CA2127247A1 (de)
CZ (1)	CZ164894A3 (de)
DE (1)	DE69321342T2 (de)
ES (1)	ES2123635T3 (de)
FI (1)	FI943235A0 (de)
HU (1)	HUT70291A (de)
IL (1)	IL104314A0 (de)
NO (1)	NO942553L (de)
NZ (1)	NZ246571A (de)
WO (1)	WO1993014123A1 (de)
ZA (1)	ZA9394B (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5663143A (en) *	1988-09-02	1997-09-02	Dyax Corp.	Engineered human-derived kunitz domains that inhibit human neutrophil elastase
US20060134087A1 (en) *	1988-09-02	2006-06-22	Dyax Corp.	ITI-D1 Kunitz domain mutants as hNE inhibitors
US6057287A (en)	1994-01-11	2000-05-02	Dyax Corp.	Kallikrein-binding "Kunitz domain" proteins and analogues thereof
US5795954A (en) *	1994-03-04	1998-08-18	Genentech, Inc.	Factor VIIa inhibitors from Kunitz domain proteins
US5780265A (en) *	1995-06-05	1998-07-14	Genentech, Inc.	Kunitz type plasma kallikrein inhibitors
US5786328A (en) *	1995-06-05	1998-07-28	Genentech, Inc.	Use of kunitz type plasma kallikrein inhibitors
US6242414B1 (en)	1995-06-07	2001-06-05	Chiron Corporation	Regulation of cytokine synthesis and release
US7153829B2 (en)	2002-06-07	2006-12-26	Dyax Corp.	Kallikrein-inhibitor therapies
WO2003103475A2 (en)	2002-06-07	2003-12-18	Dyax Corp.	Prevention and reduction of blood loss
DK1587907T3 (da) *	2003-01-07	2011-04-04	Dyax Corp	Kunitz-domænebibliotek
MX2007000473A (es) *	2004-07-13	2007-03-29	Bayer Pharmaceuticals Corp	Variantes mejoradas de la aprotinina.
US7235530B2 (en)	2004-09-27	2007-06-26	Dyax Corporation	Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
SI1981519T1 (en)	2005-12-29	2018-05-31	Dyax Corp.	INHIBITION PROTEAZE
CA2696208A1 (en) *	2007-08-21	2009-02-26	Genzyme Corporation	Treatment with kallikrein inhibitors
CN101952309A (zh) *	2007-12-21	2011-01-19	Ifxa有限公司	蛋白酶抑制剂
WO2010071894A2 (en)	2008-12-19	2010-06-24	Baxter International Inc.	Tfpi inhibitors and methods of use
CA2744235A1 (en) *	2009-01-06	2010-07-15	Dyax Corp.	Treatment of mucositis with kallikrein inhibitors
EP3459564B1 (de)	2010-01-06	2021-10-27	Takeda Pharmaceutical Company Limited	Plasmakallikreinbindende proteine
AU2011227714B2 (en)	2010-03-19	2014-09-04	Takeda Pharmaceutical Company Limited	TFPI inhibitors and methods of use
CA2823776A1 (en)	2011-01-06	2012-07-12	Dyax Corp.	Plasma kallikrein binding proteins
WO2013141965A1 (en)	2012-03-21	2013-09-26	Baxter International Inc.	Tfpi inhibitors and methods of use
IL295414B2 (en)	2014-03-27	2026-02-01	Takeda Pharmaceuticals Co	Compositions and methods for treating macular edema due to diabetes
AU2016366557B2 (en)	2015-12-11	2024-01-25	Takeda Pharmaceutical Company Limited	Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack
US11339396B2 (en)	2016-06-08	2022-05-24	President And Fellows Of Harvard College	Engineered viral vector reduces induction of inflammatory and immune responses
AU2018364542A1 (en)	2017-11-08	2020-04-16	President And Fellows Of Harvard College	Compositions and methods for inhibiting viral vector-induced inflammatory responses
US12528880B2 (en)	2020-01-13	2026-01-20	Takeda Pharmaceutical Company Limited	Plasma kallikrein inhibitors and uses thereof for treating pediatric hereditary angioedema attack

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2199582A (en) *	1987-01-07	1988-07-13	Bayer Ag	Analogues of pancreatic secretory trypsin inhibitor
DE3724570A1 (de) *	1987-06-27	1989-01-05	Bayer Ag	Human-aprotinin, dessen lys-rest in position 15 gegen einen anderen protogenen aminosaeurerest ausgetauscht ist
US4966852A (en) *	1987-07-23	1990-10-30	Monsanto Company	DNA clone of human tissue factor inhibitor
US5106833A (en) *	1987-07-23	1992-04-21	Washington University	Coagulation inhibitors
DK225488D0 (da)	1988-04-26	1988-04-26	Novo Industri As	Polypeptid
JPH07102137B2 (ja) *	1988-07-19	1995-11-08	塩野義製薬株式会社	修飾ヒトｐｓｔｉ

1993
- 1993-01-06 IL IL104314A patent/IL104314A0/xx unknown
- 1993-01-07 AT AT93902107T patent/ATE171712T1/de not_active IP Right Cessation
- 1993-01-07 ZA ZA9394A patent/ZA9394B/xx unknown
- 1993-01-07 AU AU33461/93A patent/AU670059B2/en not_active Ceased
- 1993-01-07 CA CA002127247A patent/CA2127247A1/en not_active Abandoned
- 1993-01-07 FI FI943235A patent/FI943235A0/fi unknown
- 1993-01-07 JP JP51208493A patent/JP3345420B2/ja not_active Expired - Fee Related
- 1993-01-07 NZ NZ246571A patent/NZ246571A/en unknown
- 1993-01-07 EP EP93902107A patent/EP0621873B1/de not_active Expired - Lifetime
- 1993-01-07 KR KR1019940702349A patent/KR940703860A/ko not_active Withdrawn
- 1993-01-07 DE DE69321342T patent/DE69321342T2/de not_active Expired - Fee Related
- 1993-01-07 ES ES93902107T patent/ES2123635T3/es not_active Expired - Lifetime
- 1993-01-07 HU HU9401989A patent/HUT70291A/hu unknown
- 1993-01-07 CZ CZ941648A patent/CZ164894A3/cs unknown
- 1993-01-07 WO PCT/DK1993/000006 patent/WO1993014123A1/en not_active Ceased
1994
- 1994-07-06 NO NO942553A patent/NO942553L/no unknown
1995
- 1995-02-06 US US08/384,489 patent/US5618696A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE69321342T2 (de)	1999-04-01
FI943235L (fi)	1994-07-06
DE69321342D1 (de)	1998-11-05
AU670059B2 (en)	1996-07-04
JP3345420B2 (ja)	2002-11-18
CZ164894A3 (en)	1994-12-15
NO942553D0 (no)	1994-07-06
FI943235A7 (fi)	1994-07-06
EP0621873A1 (de)	1994-11-02
WO1993014123A1 (en)	1993-07-22
ZA9394B (en)	1993-08-10
US5618696A (en)	1997-04-08
HU9401989D0 (en)	1994-09-28
NO942553L (no)	1994-09-07
FI943235A0 (fi)	1994-07-06
KR940703860A (ko)	1994-12-12
EP0621873B1 (de)	1998-09-30
JPH07504652A (ja)	1995-05-25
HUT70291A (en)	1995-09-28
ES2123635T3 (es)	1999-01-16
IL104314A0 (en)	1993-05-13
CA2127247A1 (en)	1993-07-22
NZ246571A (en)	1996-09-25
AU3346193A (en)	1993-08-03

Legal Events

Date	Code	Title	Description
1999-03-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE171712T1 (de)	1998-10-15	Neuartiger menschlicher proteaseinhibitor vom kunitz-typ und entsprechende varianten
PT2298278E (pt)	2016-02-25	Prevenção e redução da perda de sangue e resposta inflamatória
NL300013I1 (nl)	2000-10-02	Nieuwe protein met TNF-remmende werking en hun ber
DE3875538D1 (de)	1992-12-03	Aminoluciferine, verfahren zu deren herstellung und ihre verwendung.
NO942551L (no)	1994-09-07	Humanproteaseinhibitorvariant av Kunitz-type
DE69128664D1 (de)	1998-02-19	CNP-Gen und Vorläuferprotein aus Schwein
ATE106449T1 (de)	1994-06-15	Hemmung des reaktionswegs für die n-ende-regel in lebenden zellen.
YU29596A (sh)	1998-07-10	Genski proizvodi koji regulišu gojaznost
NZ334714A (en)	2000-08-25	Liver proteins as agents against autoimmune diseases
ATE124955T1 (de)	1995-07-15	Substrat-peptide.
ES2171157T3 (es)	2002-09-01	Gen recombinante codificante para una proteina con actividad endoquitinasa.
RU94036002A (ru)	1996-09-27	Ингибитор протеазы, днк, вектор, клетка, способ получения ингибитора, фармацевтическая композиция
DE60038310D1 (de)	2008-04-24	Menschliche antithrombin-varianten
PT100299A (pt)	1993-09-30	Analogo de hirudina, metodo para a sua producao e anti-coagulante contendo-o, e vector de secrecao , microorganismos transformados com o referido vector e metodo para a producao de produtos a partir dos referidos microorganismos
ECSP972344A (es)	1998-12-22	Proteinas antiobesidad
ATE305478T1 (de)	2005-10-15	Topoisomerase-ii inhibitoren
RU94036770A (ru)	1996-09-27	Домен ингибитора протеазы, днк, вектор, клетка, способ получения домена, фармацевтическая композиция, применение домена