ATE198834T1 - Konjugate bestehend aus polysaccharid und protein - Google Patents

Konjugate bestehend aus polysaccharid und protein

Info

Publication number
ATE198834T1
ATE198834T1 AT92908970T AT92908970T ATE198834T1 AT E198834 T1 ATE198834 T1 AT E198834T1 AT 92908970 T AT92908970 T AT 92908970T AT 92908970 T AT92908970 T AT 92908970T AT E198834 T1 ATE198834 T1 AT E198834T1
Authority
AT
Austria
Prior art keywords
polysaccharide
protein
relates
conjugates consisting
conjugate
Prior art date
Application number
AT92908970T
Other languages
English (en)
Inventor
Rachel Schneerson
John B Robbins
Devi J N Sarvamangala
Original Assignee
Us Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Health filed Critical Us Health
Application granted granted Critical
Publication of ATE198834T1 publication Critical patent/ATE198834T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Gram-negative bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT92908970T 1991-03-12 1992-03-12 Konjugate bestehend aus polysaccharid und protein ATE198834T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66717091A 1991-03-12 1991-03-12
PCT/US1992/001796 WO1992016232A1 (en) 1991-03-12 1992-03-12 Polysaccharide-protein conjugates

Publications (1)

Publication Number Publication Date
ATE198834T1 true ATE198834T1 (de) 2001-02-15

Family

ID=24677105

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92908970T ATE198834T1 (de) 1991-03-12 1992-03-12 Konjugate bestehend aus polysaccharid und protein

Country Status (7)

Country Link
US (1) US6632437B1 (de)
EP (1) EP0630260B1 (de)
JP (1) JP2631035B2 (de)
AT (1) ATE198834T1 (de)
CA (1) CA2101648C (de)
DE (1) DE69231663T2 (de)
WO (1) WO1992016232A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1262896B (it) * 1992-03-06 1996-07-22 Composti coniugati formati da proteine heat shock (hsp) e oligo-poli- saccaridi, loro uso per la produzione di vaccini.
CU22420A1 (es) * 1993-12-29 1996-01-31 Centro Inmunologia Molecular Composicion vacunal para el desarrollo de una respuesta contra gangliosidos n glicolilados y su uso para el tratamiento del cancer
DE4435087A1 (de) * 1994-09-30 1996-04-04 Deutsches Krebsforsch Konjugat zur Behandlung von Infektions-, Autoimmun- und Hauterkrankungen
DE122009000055I1 (de) * 1995-03-22 2009-12-31 Jackson H M Found Military Med Herstellung von immunogenen konstrukten unter verwendung von löslichen kohlehydraten, die durch organische cyanylierungs-reagenzien aktiviert wurden
US5780606A (en) * 1995-06-07 1998-07-14 Connaught Laboratories Limited Neisseria meningitidis capsular polysaccharide conjugates
GB9713156D0 (en) * 1997-06-20 1997-08-27 Microbiological Res Authority Vaccines
WO1999010372A1 (en) * 1997-08-27 1999-03-04 Chiron Corporation Molecular mimetics of meningococcal b epitopes
US6858211B1 (en) * 1998-07-20 2005-02-22 The United States Of America As Represented By The Department Of Health And Human Services Vaccines against Escherichia coli O157 infection
NO20002828D0 (no) * 2000-06-02 2000-06-02 Statens Inst For Folkehelse Proteinholdig vaksine mot Neisseria meningtidis serogruppe samt fremgangsmÕte ved fremstilling derav
US7527797B1 (en) * 2000-09-01 2009-05-05 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Vibrio cholerae 0139 conjugate vaccines
NZ622900A (en) 2001-01-23 2015-11-27 Sanofi Pasteur Inc Multivalent meningococcal polysaccharide-protein conjugate vaccine
GB0115176D0 (en) 2001-06-20 2001-08-15 Chiron Spa Capular polysaccharide solubilisation and combination vaccines
EP1524999A1 (de) * 2002-04-25 2005-04-27 David R. Bundle Synthetische anti-candida albicans oligosaccharide basierender impfstoff
CN101926988B (zh) 2003-01-30 2014-06-04 诺华疫苗和诊断有限公司 抗多种脑膜炎球菌血清组的可注射性疫苗
WO2005117957A2 (en) * 2004-06-03 2005-12-15 The Regents Of The University Of California Compositions and methods involving o-acetylated group b streptococcus capsular polysaccharides
ES2640767T3 (es) * 2004-08-12 2017-11-06 Lipoxen Technologies Limited Fraccionamientodepolisacáridos cargados
CN103626884B (zh) * 2005-02-23 2016-05-18 利普生技术有限公司 用于蛋白质衍生和缀合的活化的唾液酸衍生物
US20080193481A1 (en) * 2005-03-14 2008-08-14 Governors Of The University Of Alberta Synthetic Anti-Candida Albicans Oligosaccharide Based Vaccines
ATE554788T1 (de) 2006-03-22 2012-05-15 Novartis Ag Schemata zur immunisierung mit meningokokken- konjugaten
US10828361B2 (en) 2006-03-22 2020-11-10 Glaxosmithkline Biologicals Sa Regimens for immunisation with meningococcal conjugates
CN103816870B (zh) 2008-12-03 2016-11-23 株式会社钟化 含有甲酰基的多孔性载体、使用该多孔性载体的吸附体以及它们的制造方法
JP5781542B2 (ja) 2009-12-30 2015-09-24 ノバルティス アーゲー Ｅ．ｃｏｌｉキャリアタンパク質に結合体化した多糖免疫原

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4356170A (en) * 1981-05-27 1982-10-26 Canadian Patents & Development Ltd. Immunogenic polysaccharide-protein conjugates
US4619828A (en) * 1982-07-06 1986-10-28 Connaught Laboratories, Inc. Polysaccharide exotoxoid conjugate vaccines
EP0109688A3 (de) * 1982-11-23 1986-12-03 The Wellcome Foundation Limited Komplexe, Verfahren zu deren Herstellung und diese Komplexe enthaltende Zusammensetzungen
US4695624A (en) * 1984-05-10 1987-09-22 Merck & Co., Inc. Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency
IT1187753B (it) * 1985-07-05 1987-12-23 Sclavo Spa Coniugati glicoproteici ad attivita' immunogenica trivalente
US4727136A (en) * 1985-10-01 1988-02-23 Canadian Patents And Development Ltd. Modified meningococcal group B polysaccharide for conjugate vaccine
WO1987006267A1 (en) * 1986-04-16 1987-10-22 The Brigham And Women's Hospital, Inc. Bacterial antigens, antibodies, vaccines, and methods of manufacture
US5034516A (en) * 1987-08-04 1991-07-23 University Of Ottawa Synthetic antigens of sialic acid and derivatives thereof

Also Published As

Publication number Publication date
EP0630260A4 (de) 1995-06-07
DE69231663T2 (de) 2001-08-23
EP0630260A1 (de) 1994-12-28
CA2101648C (en) 2003-09-09
JPH06504065A (ja) 1994-05-12
JP2631035B2 (ja) 1997-07-16
EP0630260B1 (de) 2001-01-24
DE69231663D1 (de) 2001-03-01
US6632437B1 (en) 2003-10-14
WO1992016232A1 (en) 1992-10-01
CA2101648A1 (en) 1992-09-13
AU1661792A (en) 1992-10-21
AU662141B2 (en) 1995-08-24

Similar Documents

Publication Publication Date Title
ATE198834T1 (de) Konjugate bestehend aus polysaccharid und protein
DE69637950D1 (de) Impfstoff bestehend aus auf Aluminium-Phosphat adsorbiertem, konjugiertem Polysaccharid Antigen
DK1242115T3 (da) Kemisk programmerbar immunitet
ATE296105T1 (de) Iminbildende polysaccharide, deren herstellung und verwendung als zusatzmittel und immunstimulierende mittel
DE69315993D1 (de) Konjugate aus hitzeshockproteinen und oligo- oder polysacchariden
TR199801861T2 (xx) Farmas�tik olarak yararl� bile�imler.
BR0009163A (pt) Vacina
LTIP888A (lt) Polietilenglikolio-interferono konjugatai
IT1292142B1 (it) Composizione farmaceutica in forma di microparticelle lipidiche solide atte alla somministrazione parenterale
KR930701456A (ko) 세팔로스포린 및 동족체, 제조 및 제약학적 조성물
BG103251A (bg) Оксадиазоли, методи за получаването им и приложението им като лекарствени средства
HUP0104365A3 (en) Hapten-carrier conjugates for treating and preventing nicotine addiction, vaccines and pharmaceutical compositions comprising thereof, antibody produced inresponse to the conjugate, and their use
LU90856I2 (fr) Uprima - apomorphine hydrochloride et ses d-riv-s pharmaceutiquement acceptables
DK0817847T4 (da) IL-17-receptor
FI943569A0 (fi) Hyviä liukenemisominaisuuksia omaavia farmaseuttisia koostumuksia
NO975547L (no) Vaksiner med modifiserte meningokokk/polysakkarid-konjugater
FR2671083B1 (fr) Nouvelles 4-(4-imidazolyl) piperidines substituees en 1, leur preparation ainsi que leurs applications therapeutiques.
BR0014355A (pt) Derivados de sapogenina e seu uso no tratamento de disfunção cognitiva
MEP20408A (en) Pharmaceutical dronedarone composition for parenteral administration
TR200001102T2 (tr) İkameli tetrahidropirimidinen türevleri, üretimleri ve kullanımları.
RU94038042A (ru) Производные гексагидроазепинов, фармацевтическая композиция на их основе и антипсихотропный агент
CA2337667A1 (en) Dextran-leptin conjugates, pharmaceutical compositions and related methods
GB9921592D0 (en) Preparation of highly pure toxin fragments
MD970269A (en) Clavulanates
FR2674755B1 (fr) Nouvelles compositions medicamenteuses immunostimulatrices.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties