ATE198880T1 - Therapeutische verbindung - fettsäurekonjugate - Google Patents
Therapeutische verbindung - fettsäurekonjugateInfo
- Publication number
- ATE198880T1 ATE198880T1 AT94922189T AT94922189T ATE198880T1 AT E198880 T1 ATE198880 T1 AT E198880T1 AT 94922189 T AT94922189 T AT 94922189T AT 94922189 T AT94922189 T AT 94922189T AT E198880 T1 ATE198880 T1 AT E198880T1
- Authority
- AT
- Austria
- Prior art keywords
- therapeutic compound
- fatty acid
- therapeutic
- acid conjugates
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
- C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Steroid Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPM032593 | 1993-08-02 | ||
| PCT/AU1994/000440 WO1995004030A1 (en) | 1993-08-02 | 1994-08-02 | Therapeutic compound - fatty acid conjugates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE198880T1 true ATE198880T1 (de) | 2001-02-15 |
Family
ID=3777106
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94922189T ATE198880T1 (de) | 1993-08-02 | 1994-08-02 | Therapeutische verbindung - fettsäurekonjugate |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US5792786A (de) |
| EP (1) | EP0712389B1 (de) |
| JP (1) | JPH09501655A (de) |
| CN (1) | CN1125040C (de) |
| AT (1) | ATE198880T1 (de) |
| CA (1) | CA2167818A1 (de) |
| DE (1) | DE69426629T2 (de) |
| DK (1) | DK0712389T3 (de) |
| ES (1) | ES2156156T3 (de) |
| FI (1) | FI960504L (de) |
| NO (1) | NO313227B1 (de) |
| NZ (1) | NZ269773A (de) |
| RU (1) | RU2137755C1 (de) |
| WO (1) | WO1995004030A1 (de) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPM747694A0 (en) * | 1994-08-16 | 1994-09-08 | Commonwealth Scientific And Industrial Research Organisation | Delivery of nucleic acids and peptides |
| RU2166512C2 (ru) * | 1995-01-16 | 2001-05-10 | Коммонвелт Сайентифик Энд Индастриал Рисерч Организейшн | Конъюгаты терапевтического соединения с жирной кислотой |
| USRE40546E1 (en) * | 1996-05-01 | 2008-10-21 | Scarista, Ltd. | 1,3-Propane diol esters and ethers and methods for their use in drug delivery |
| US6015821A (en) * | 1995-05-01 | 2000-01-18 | Horrobin; David Frederick | Nicotinic acid esters and pharmaceutical compositions containing them |
| MY118354A (en) * | 1995-05-01 | 2004-10-30 | Scarista Ltd | 1,3-propane diol derivatives as bioactive compounds |
| AUPN741696A0 (en) * | 1996-01-05 | 1996-01-25 | Commonwealth Scientific And Industrial Research Organisation | Delivery of nucleic acids ii |
| DE19631189A1 (de) * | 1996-08-02 | 1998-02-05 | Max Delbrueck Centrum | Neuartige kationische Amphiphile für den liposomalen Gentransfer |
| AUPP751398A0 (en) * | 1998-12-04 | 1999-01-07 | Commonwealth Scientific And Industrial Research Organisation | Methotrexate derivatives |
| US6762182B1 (en) | 1999-01-07 | 2004-07-13 | Vanderbilt University | Converting cox inhibition compounds that are not COX-2 selective inhibitors to derivatives that are COX-2 selective inhibitors |
| US6207700B1 (en) | 1999-01-07 | 2001-03-27 | Vanderbilt University | Amide derivatives for antiangiogenic and/or antitumorigenic use |
| US6716452B1 (en) * | 2000-08-22 | 2004-04-06 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
| US6306890B1 (en) | 1999-08-30 | 2001-10-23 | Vanderbilt University | Esters derived from indolealkanols and novel amides derived from indolealkylamides that are selective COX-2 inhibitors |
| US8394813B2 (en) | 2000-11-14 | 2013-03-12 | Shire Llc | Active agent delivery systems and methods for protecting and administering active agents |
| IL158882A0 (en) * | 2001-06-05 | 2004-05-12 | Control Delivery Sys Inc | Sustained-release analgesic compounds |
| US7169752B2 (en) | 2003-09-30 | 2007-01-30 | New River Pharmaceuticals Inc. | Compounds and compositions for prevention of overdose of oxycodone |
| US20060014697A1 (en) | 2001-08-22 | 2006-01-19 | Travis Mickle | Pharmaceutical compositions for prevention of overdose or abuse |
| US20030148379A1 (en) * | 2002-02-06 | 2003-08-07 | Roitman Daniel B. | Methods for making microbar encoders for bioprobes |
| WO2004032824A2 (en) * | 2002-10-10 | 2004-04-22 | Yeda Research And Development Co. Ltd. | Basic esters of fatty alcohols and their use as anti-inflammatory or immunomodulatory agents |
| KR101159477B1 (ko) * | 2003-05-29 | 2012-07-02 | 샤이어 엘엘씨 | 남용 방지성 암페타민 화합물 |
| JP2007534702A (ja) | 2004-04-26 | 2007-11-29 | バンダービルト・ユニバーシティ | 胃腸毒性の低い治療薬としてのインドール酢酸、及びインデン酢酸誘導体 |
| EP2111881A1 (de) | 2004-07-05 | 2009-10-28 | Ziscoat N.V. | biokompatible Beschichtungen für medizinische vorrichtungen mit Molekularsieben |
| US7691364B2 (en) * | 2005-01-28 | 2010-04-06 | Bezwada Biomedical, Llc | Functionalized drugs and polymers derived therefrom |
| EP2322183B1 (de) * | 2006-06-01 | 2014-10-22 | Santen SAS | Verwendung von Arzneimittelpräkursor für okuläre intravitrealen Verabreichung |
| WO2007149456A2 (en) | 2006-06-19 | 2007-12-27 | Vanderbilt University | Methods and compositions for diagnostic and therapeutic targeting of cox-2 |
| CN108250090B (zh) * | 2006-07-27 | 2021-08-20 | 于崇曦 | 具有快速皮肤穿透速度的带正电荷的水溶性酮洛芬及相关化合物的前药 |
| US9085527B2 (en) | 2008-07-08 | 2015-07-21 | Catabasis Pharmaceuticals, Inc. | Fatty acid acylated salicylates and their uses |
| SI2315740T1 (en) | 2008-07-08 | 2018-03-30 | Catabasis Pharmaceuticals, Inc. | Fatty acids acetylated salicylates and their uses |
| US9346803B2 (en) | 2011-10-17 | 2016-05-24 | Vanderbilt University | Indomethacin analogs for the treatment of castrate-resistant prostate cancer |
| PL2863921T3 (pl) | 2012-06-26 | 2018-11-30 | Polyactiva Pty Ltd | Koniugat polimer-nlpz |
| CA2972871A1 (en) * | 2015-01-23 | 2016-07-28 | Novartis Ag | Synthetic apelin fatty acid conjugates with improved half-life |
| WO2024018762A1 (ja) * | 2022-07-19 | 2024-01-25 | 国立大学法人北海道大学 | ｐＨ感受性カチオン性脂質及び脂質ナノ粒子 |
| CN116496193B (zh) * | 2023-03-10 | 2026-01-02 | 圣诺生物医药技术(苏州)有限公司 | 一种氨基酸脂质形成的纳米递送系统及其应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3686238A (en) * | 1970-01-19 | 1972-08-22 | Syntex Corp | Glycerol esterified with 2-naphthyl-acetic acids and fatty acids |
| BE871709A (fr) * | 1978-10-31 | 1979-02-15 | Abbott Lab | Procede de preparation de composes doues d'une activite anti-inflammatoire |
| DE3904119A1 (de) | 1989-02-11 | 1990-08-16 | Hoechst Ag | Polymerfixiertes methotrexat, verfahren zur herstellung und verwendung |
| ATE131471T1 (de) * | 1989-12-22 | 1995-12-15 | Commw Scient Ind Res Org | An fette gebundene aminosäuren, peptide oder deren derivate |
| WO1992016236A1 (en) | 1991-03-19 | 1992-10-01 | Rajadhyaksha Vithal J | Compositions and method comprising aminoalcohol derivatives as membrane penetration enhancers |
| EP0596959B1 (de) * | 1991-07-26 | 2000-03-29 | Commonwealth Scientific And Industrial Research Organisation | System der bereitstellung eines impfstoffes auf peptidbasis, das sein eigenes adjuvans bildet, und seine herstellung |
| DE4311987A1 (de) | 1993-04-07 | 1994-10-13 | Schering Ag | Neue Glucocorticoide |
-
1994
- 1994-08-02 WO PCT/AU1994/000440 patent/WO1995004030A1/en not_active Ceased
- 1994-08-02 EP EP94922189A patent/EP0712389B1/de not_active Expired - Lifetime
- 1994-08-02 AT AT94922189T patent/ATE198880T1/de not_active IP Right Cessation
- 1994-08-02 FI FI960504A patent/FI960504L/fi not_active IP Right Cessation
- 1994-08-02 CN CN94192985A patent/CN1125040C/zh not_active Expired - Fee Related
- 1994-08-02 RU RU96104379A patent/RU2137755C1/ru not_active IP Right Cessation
- 1994-08-02 JP JP7505456A patent/JPH09501655A/ja active Pending
- 1994-08-02 US US08/592,399 patent/US5792786A/en not_active Expired - Fee Related
- 1994-08-02 DE DE69426629T patent/DE69426629T2/de not_active Expired - Fee Related
- 1994-08-02 NZ NZ269773A patent/NZ269773A/en unknown
- 1994-08-02 CA CA002167818A patent/CA2167818A1/en not_active Abandoned
- 1994-08-02 DK DK94922189T patent/DK0712389T3/da active
- 1994-08-02 ES ES94922189T patent/ES2156156T3/es not_active Expired - Lifetime
-
1996
- 1996-01-30 NO NO19960389A patent/NO313227B1/no not_active IP Right Cessation
-
1998
- 1998-01-30 US US09/016,633 patent/US6353124B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DK0712389T3 (da) | 2001-06-05 |
| NZ269773A (en) | 1997-11-24 |
| CN1125040C (zh) | 2003-10-22 |
| JPH09501655A (ja) | 1997-02-18 |
| FI960504A7 (fi) | 1996-02-02 |
| NO313227B1 (no) | 2002-09-02 |
| NO960389L (no) | 1996-01-30 |
| FI960504A0 (fi) | 1996-02-02 |
| ES2156156T3 (es) | 2001-06-16 |
| DE69426629D1 (de) | 2001-03-01 |
| CA2167818A1 (en) | 1995-02-09 |
| EP0712389A1 (de) | 1996-05-22 |
| FI960504L (fi) | 1996-02-02 |
| CN1128531A (zh) | 1996-08-07 |
| WO1995004030A1 (en) | 1995-02-09 |
| DE69426629T2 (de) | 2001-08-02 |
| RU2137755C1 (ru) | 1999-09-20 |
| EP0712389B1 (de) | 2001-01-24 |
| US6353124B1 (en) | 2002-03-05 |
| EP0712389A4 (de) | 1997-04-09 |
| US5792786A (en) | 1998-08-11 |
| NO960389D0 (no) | 1996-01-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee |