ATE198881T1 - Trennung von 4-cyano-4-(3,4-dimethoxyphenyl)-5- methylexancarbonsäure - Google Patents

Trennung von 4-cyano-4-(3,4-dimethoxyphenyl)-5- methylexancarbonsäure

Info

Publication number: ATE198881T1
Authority: AT; Austria
Prior art keywords: acid; dimethoxyphenyl; cyano; methylexanecarbonyl; separation
Prior art date: 1996-02-08

Application number

AT97904517T

Other languages

English (en)

Inventor

Robin Mark Bannister

Graham Robert Evans

Benjamin Mark Skead

Original Assignee

Darwin Discovery Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-02-08

Filing date

1997-02-10

Publication date

2001-02-15

1996-02-08 Priority claimed from GBGB9602515.0A external-priority patent/GB9602515D0/en

1996-02-08 Priority claimed from GBGB9602514.3A external-priority patent/GB9602514D0/en

1997-02-10 Application filed by Darwin Discovery Ltd filed Critical Darwin Discovery Ltd

2001-02-15 Application granted granted Critical

2001-02-15 Publication of ATE198881T1 publication Critical patent/ATE198881T1/de

Links

239000002253 acid Substances 0.000 title abstract 2
238000000926 separation method Methods 0.000 title 1
150000003839 salts Chemical class 0.000 abstract 2
SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 abstract 1
BSHCLIANLKRGLY-UHFFFAOYSA-N 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexanoic acid Chemical compound COC1=CC=C(C(CCC(O)=O)(C#N)C(C)C)C=C1OC BSHCLIANLKRGLY-UHFFFAOYSA-N 0.000 abstract 1
LOUPRKONTZGTKE-WZBLMQSHSA-N Quinine Chemical compound C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-WZBLMQSHSA-N 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
LOUPRKONTZGTKE-UHFFFAOYSA-N cinchonine Natural products C1C(C(C2)C=C)CCN2C1C(O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-UHFFFAOYSA-N 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
229960001722 verapamil Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/32—Separation; Purification; Stabilisation; Use of additives
- C07C253/34—Separation; Purification
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/41—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by carboxyl groups, other than cyano groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT97904517T 1996-02-08 1997-02-10 Trennung von 4-cyano-4-(3,4-dimethoxyphenyl)-5- methylexancarbonsäure ATE198881T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9602515.0A GB9602515D0 (en)	1996-02-08	1996-02-08	Resolution
GBGB9602514.3A GB9602514D0 (en)	1996-02-08	1996-02-08	Resolution
PCT/GB1997/000370 WO1997029081A1 (en)	1996-02-08	1997-02-10	Resolution of 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexanoic acid

Publications (1)

Publication Number	Publication Date
ATE198881T1 true ATE198881T1 (de)	2001-02-15

Family

ID=26308631

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97904517T ATE198881T1 (de)	1996-02-08	1997-02-10	Trennung von 4-cyano-4-(3,4-dimethoxyphenyl)-5- methylexancarbonsäure

Country Status (6)

Country	Link
EP (1)	EP0879225B1 (de)
JP (1)	JP2000504683A (de)
AT (1)	ATE198881T1 (de)
AU (1)	AU705865B2 (de)
DE (1)	DE69707318T2 (de)
WO (1)	WO1997029081A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR100341256B1 (ko) *	1999-09-11	2002-06-21	박호군	리파제를 이용한 베라파밀 중간체의 분할 및 (ｒ)- 및 (ｓ)-베라파밀의 제조 방법
DE602005024964D1 (de) *	2004-05-31	2011-01-05	Sysmex Corp	Verfahren zur beurteilung der malignität einer säuger-krebszelle
CA2964177A1 (en) *	2014-10-29	2016-05-06	Center Laboratories, Inc.	Crystal forms of verapamil hydrochloride

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2059923C3 (de) *	1970-12-05	1979-01-25	Knoll Ag, 6700 Ludwigshafen	l-a-Isopropyl-o-[(N-methyl-N-homoveratryl)v-aminopropyl] -3,4-dimethoxyphenylacetonitril, Verfahren zu dessen Herstellung und dieses enthaltende Arzneimittel
GB9319918D0 (en) *	1993-09-27	1993-11-10	Chiros Ltd	Chiral compounds and their preparation

1997
- 1997-02-10 AU AU17295/97A patent/AU705865B2/en not_active Ceased
- 1997-02-10 WO PCT/GB1997/000370 patent/WO1997029081A1/en not_active Ceased
- 1997-02-10 DE DE69707318T patent/DE69707318T2/de not_active Expired - Fee Related
- 1997-02-10 AT AT97904517T patent/ATE198881T1/de active
- 1997-02-10 JP JP9528308A patent/JP2000504683A/ja active Pending
- 1997-02-10 EP EP97904517A patent/EP0879225B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JP2000504683A (ja)	2000-04-18
AU705865B2 (en)	1999-06-03
AU1729597A (en)	1997-08-28
DE69707318T2 (de)	2002-02-21
WO1997029081A1 (en)	1997-08-14
EP0879225A1 (de)	1998-11-25
DE69707318D1 (de)	2001-11-15
EP0879225B1 (de)	2001-01-24

Similar Documents

Publication	Publication Date	Title
DE3786794D1 (de)	1993-09-02	Verahren zur vermehrung von knollen.
DE69022540D1 (de)	1995-10-26	Verfahren zur 1,2 Dehydrogenierung der Azasteroiden.
ATE149160T1 (de)	1997-03-15	Verfahren zu reinigung von taxol derivate
DK0879228T3 (da)	2003-03-03	Fremgangsmåde til fremstilling af d-threo-(R,R)-methylphenidat og recirkulering af uønskede enantiomerer ved epimerisering
DE3667167D1 (de)	1990-01-04	Verfahren zur herstellung von 1,5-diazido-3-nitrazapentan.
DE3680454D1 (de)	1991-08-29	Verfahren zur herstellung von halogenhaltigen (2,2)-paracyclophanen.
DE69710051D1 (de)	2002-03-14	Auflösungsverfahren von threo-methylphenidate
DE69912474D1 (de)	2003-12-04	Verfahren zur racematspaltung von tramadol
DE69800901D1 (de)	2001-07-19	Verfahren zur Herstellung von Trans 1,4-Cyclohexan-bis-(methylamin)
ATE198881T1 (de)	2001-02-15	Trennung von 4-cyano-4-(3,4-dimethoxyphenyl)-5- methylexancarbonsäure
DE69006789D1 (de)	1994-03-31	Verfahren zur Herstellung von sulfoalkyl-substituierten Hydroxylaminen.
DE68911257D1 (de)	1994-01-20	Verfahren zur Herstellung von 2,6-Dimethylnaphthalin.
AT349662B (de)	1979-04-25	Verfahren zur herstellung von neuen l-3-(3,4- dihydroxy-phenyl)-2-methyl-alanin-peptiden
DE58901165D1 (de)	1992-05-21	Verfahren zur herstellung von 2,4-dihydroxybenzoesaeure.
DE59601601D1 (de)	1999-05-12	Verfahren zur Reindarstellung von trans- und cis-4-Hydroxy-2,2,6-trimethyl-cyclohexan-1-on aus Isomerengemischen
DE68912809D1 (de)	1994-03-17	Verfahren zur Herstellung von Bis(2,2,6,6-tetramethyl-4-piperidyl)amin.
DE3767052D1 (de)	1991-02-07	Verfahren zur trennung von monohydraten von l-cysteine-hydrochloriden.
NO883444L (no)	1989-02-06	Fremgangsmaate til fremstilling av nye, umettede aminosyreforbindelser.
DE69009394D1 (de)	1994-07-07	Verfahren zur Herstellung von 3-Cyano-3,5,5-trimethyl-1-cyclohexanon.
DE69004542D1 (de)	1993-12-16	Verfahren zur Herstellung von 2,6-Dimethylnaphthalin.
DE3667965D1 (de)	1990-02-08	Verfahren zur herstellung von hydroxycarbonyl-verbindungen aus 1,2-diolen.
DE3869633D1 (de)	1992-05-07	Verfahren zur herstellung von n,n-(dibenzohexatrienylen)harnstoffen.
DE69802329D1 (de)	2001-12-13	Verfahren zur Herstellung von 3,4 disubstituirten Dinitroanilinen
DE68902240D1 (de)	1992-09-03	Verfahren zur destillation von 2,2,3,3-tetrafluoroxetan.
DE68909118D1 (de)	1993-10-21	Verfahren zur Ausscheidung von 2,6-Dimethylnaphthalin.