ATE198889T1 - Apolipoprotein-b syntheseinhibitoren - Google Patents

Apolipoprotein-b syntheseinhibitoren

Info

Publication number: ATE198889T1
Authority: AT; Austria
Prior art keywords: apolipoprotein; synthesis inhibitors; inhibitors; synthesis
Prior art date: 1994-10-27

Application number

AT95937804T

Other languages

English (en)

Inventor

Jan Heeres

Leo Jacobus Jozef Backx

Robert Jozef Maria Hendrickx

Der Eycken Luc Alfons Leo Van

Chaffoy De Courcelles Didie De

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-10-27

Filing date

1995-10-19

Publication date

2001-02-15

1995-05-31 Priority claimed from US08/455,304 external-priority patent/US5521186A/en

1995-10-19 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2001-02-15 Application granted granted Critical

2001-02-15 Publication of ATE198889T1 publication Critical patent/ATE198889T1/de

Links

101710095342 Apolipoprotein B Proteins 0.000 title 1
102100040202 Apolipoprotein B-100 Human genes 0.000 title 1
230000015572 biosynthetic process Effects 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Diabetes (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Steroid Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT95937804T 1994-10-27 1995-10-19 Apolipoprotein-b syntheseinhibitoren ATE198889T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP94203120		1994-10-27
US08/455,304 US5521186A (en)	1994-10-27	1995-05-31	Apolipoprotein-β synthesis inhibitors
PCT/EP1995/004111 WO1996013499A1 (en)	1994-10-27	1995-10-19	Apolipoprotein-b synthesis inhibitors

Publications (1)

Publication Number	Publication Date
ATE198889T1 true ATE198889T1 (de)	2001-02-15

Family

ID=26136684

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95937804T ATE198889T1 (de)	1994-10-27	1995-10-19	Apolipoprotein-b syntheseinhibitoren

Country Status (30)

Country	Link
US (1)	US5929075A (de)
EP (1)	EP0788496B1 (de)
JP (1)	JP3025907B2 (de)
KR (1)	KR100227231B1 (de)
CN (1)	CN1068000C (de)
AP (1)	AP779A (de)
AT (1)	ATE198889T1 (de)
AU (1)	AU697744C (de)
BG (1)	BG63694B1 (de)
BR (1)	BR9509436A (de)
CA (1)	CA2203274C (de)
CY (1)	CY2256B1 (de)
CZ (1)	CZ286476B6 (de)
DE (3)	DE122007000005I2 (de)
DK (1)	DK0788496T3 (de)
ES (1)	ES2155535T3 (de)
FI (1)	FI119548B (de)
GR (1)	GR3035519T3 (de)
HR (1)	HRP950532B1 (de)
HU (1)	HU219862B (de)
IL (1)	IL115771A (de)
LU (1)	LU91306I2 (de)
NO (1)	NO311937B1 (de)
NZ (1)	NZ295353A (de)
OA (1)	OA10479A (de)
PT (1)	PT788496E (de)
RO (1)	RO118715B1 (de)
SK (1)	SK281908B6 (de)
TR (1)	TR199501295A2 (de)
WO (1)	WO1996013499A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR20010023729A (ko) *	1997-11-03	2001-03-26	디르크 반테	지질 저하제 조성물
PL358909A1 (en) *	1998-04-27	2004-08-23	Janssen Pharmaceutica N.V.	Pellets having a core coated with a lipid lowering agent and a polymer
NZ512891A (en)	1998-12-22	2003-01-31	Janssen Pharmaceutica Nv	S-oxide lipid lowering compounds
DE19945982A1 (de) *	1999-09-24	2001-03-29	Knoll Ag	Geschwindigkeitsbestimmte Partikel
US20050132022A1 (en) *	2003-12-12	2005-06-16	International Business Machines Corporation	Computer system with LAN-based I/O
JP4994043B2 (ja) *	2004-01-21	2012-08-08	エランコ・アニマル・ヘルス・アイルランド・リミテッド	ミトラタピデ経口用溶液
US7649002B2 (en)	2004-02-04	2010-01-19	Pfizer Inc	(3,5-dimethylpiperidin-1yl)(4-phenylpyrrolidin-3-yl)methanone derivatives as MCR4 agonists
US7262318B2 (en) *	2004-03-10	2007-08-28	Pfizer, Inc.	Substituted heteroaryl- and phenylsulfamoyl compounds
AU2005230397B2 (en) *	2004-04-09	2010-04-08	Elanco Animal Health Ireland Limited	Intermittent dosing regimen for the treatment of overweight with MTP-inhibitors
US20050288340A1 (en) *	2004-06-29	2005-12-29	Pfizer Inc	Substituted heteroaryl- and phenylsulfamoyl compounds
PA8660701A1 (es)	2005-02-04	2006-09-22	Pfizer Prod Inc	Agonistas de pyy y sus usos
EP1890767A2 (de) *	2005-05-27	2008-02-27	Pfizer Products Inc.	Kombinationstherapie zur behandlung von fettleibigkeit oder aufrechterhaltung des gewichtverlusts
CA2617654A1 (en) *	2005-08-04	2007-02-08	Pfizer Limited	Piperidinoyl-pyrrolidine and piperidinoyl-piperidine compounds
US7741317B2 (en)	2005-10-21	2010-06-22	Bristol-Myers Squibb Company	LXR modulators
US7888376B2 (en)	2005-11-23	2011-02-15	Bristol-Myers Squibb Company	Heterocyclic CETP inhibitors
WO2007096763A2 (en) *	2006-02-23	2007-08-30	Pfizer Limited	Melanocortin type 4 receptor agonist piperidinoylpyrrolidines
US8383660B2 (en)	2006-03-10	2013-02-26	Pfizer Inc.	Dibenzyl amine compounds and derivatives
CN101583593A (zh)	2006-11-13	2009-11-18	辉瑞产品公司	二芳基、二吡啶基和芳基-吡啶基衍生物及其用途
CN101663262B (zh)	2006-12-01	2014-03-26	百时美施贵宝公司	用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
ES2348530T3 (es)	2007-05-25	2010-12-09	Janssen Pharmaceutica, N.V.	Síntesis mejorada de metanosulfonato de (2s-cis)-2-(bromometil)-2-(4-clorofenil)-1,3 dioxolan-4-metanol (éster).
KR101280786B1 (ko) *	2008-08-06	2013-07-05	화이자 리미티드	멜라노코르틴 4 작용제로서 다이아제핀 및 다이아조칸 화합물
US9040539B2 (en) *	2010-05-19	2015-05-26	Sandoz Ag	Process for the preparation of chiral triazolones
BR112020018094A2 (pt)	2018-03-08	2020-12-22	Incyte Corporation	Compostos de aminopirazina diol como inibidores de pi3k-¿
US11046658B2 (en)	2018-07-02	2021-06-29	Incyte Corporation	Aminopyrazine derivatives as PI3K-γ inhibitors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4313953A (en) *	1978-06-23	1982-02-02	Janssen Pharmaceutica, N.V.	Heterocyclic derivatives of (4-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
US4218458A (en) *	1978-06-23	1980-08-19	Janssen Pharmaceutica, N.V.	Heterocyclic derivatives of (4-aryloxy-methyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
US4766125A (en) *	1981-06-23	1988-08-23	Janssen Pharmaceutica N.V.	N-aryl-piperazinealkanamides useful for protecting hearts from myocardial injury caused by ischaemia, anoxia or hypoxia
US4619931A (en) *	1983-02-28	1986-10-28	Janssen Pharmaceutica, N.V.	[[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles
CA1292472C (en) *	1985-12-03	1991-11-26	Alfonsus Guilielmus Knaeps	Derivatives of ¬¬4-¬4-(4-phenyl-1-piperazinyl)- phenoxymethyl\|-1,3-dioxolan-2-yl\|methyl\|-1h-imidazoles and 1h-1,2,4-triazoles
NZ223799A (en) *	1987-03-25	1989-12-21	Janssen Pharmaceutica Nv	Azolylmethyl-dioxolanylmethoxyphenyl-piperazinyl-phenyl-triazolones and antimicrobial compositions
CA1331757C (en) *	1988-02-29	1994-08-30	Janssen Pharmaceutica Naamloze Vennootschap	5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols
AU6359594A (en) *	1993-03-04	1994-09-26	Cytoven International N.V.	Pharmaceutical tryptophan containing dipeptide compositions and methods of use thereof
US5521186A (en) *	1994-10-27	1996-05-28	Janssen Pharmaceutica N.V.	Apolipoprotein-β synthesis inhibitors

1995
- 1995-10-19 DE DE122007000005C patent/DE122007000005I2/de active Active
- 1995-10-19 RO RO97-00812A patent/RO118715B1/ro unknown
- 1995-10-19 BR BR9509436A patent/BR9509436A/pt not_active IP Right Cessation
- 1995-10-19 NZ NZ295353A patent/NZ295353A/en not_active IP Right Cessation
- 1995-10-19 WO PCT/EP1995/004111 patent/WO1996013499A1/en not_active Ceased
- 1995-10-19 AP APAP/P/1997/000968A patent/AP779A/en active
- 1995-10-19 KR KR1019970702662A patent/KR100227231B1/ko not_active Expired - Fee Related
- 1995-10-19 ES ES95937804T patent/ES2155535T3/es not_active Expired - Lifetime
- 1995-10-19 EP EP95937804A patent/EP0788496B1/de not_active Expired - Lifetime
- 1995-10-19 CA CA002203274A patent/CA2203274C/en not_active Expired - Fee Related
- 1995-10-19 DK DK95937804T patent/DK0788496T3/da active
- 1995-10-19 US US08/817,247 patent/US5929075A/en not_active Expired - Lifetime
- 1995-10-19 CN CN95195885A patent/CN1068000C/zh not_active Expired - Fee Related
- 1995-10-19 DE DE1995619995 patent/DE122007000005I1/de active Pending
- 1995-10-19 AU AU38680/95A patent/AU697744C/en not_active Ceased
- 1995-10-19 DE DE69519995T patent/DE69519995T2/de not_active Expired - Lifetime
- 1995-10-19 PT PT95937804T patent/PT788496E/pt unknown
- 1995-10-19 AT AT95937804T patent/ATE198889T1/de active
- 1995-10-19 SK SK507-97A patent/SK281908B6/sk not_active IP Right Cessation
- 1995-10-19 JP JP8514288A patent/JP3025907B2/ja not_active Expired - Fee Related
- 1995-10-19 HU HU9701956A patent/HU219862B/hu not_active IP Right Cessation
- 1995-10-19 CZ CZ19971198A patent/CZ286476B6/cs not_active IP Right Cessation
- 1995-10-20 TR TR95/01295A patent/TR199501295A2/xx unknown
- 1995-10-26 IL IL11577195A patent/IL115771A/xx not_active IP Right Cessation
- 1995-10-27 HR HR950532A patent/HRP950532B1/xx not_active IP Right Cessation
1997
- 1997-04-10 BG BG101402A patent/BG63694B1/bg unknown
- 1997-04-24 NO NO19971895A patent/NO311937B1/no not_active IP Right Cessation
- 1997-04-25 FI FI971784A patent/FI119548B/fi not_active IP Right Cessation
- 1997-04-25 OA OA60997A patent/OA10479A/en unknown
2001
- 2001-03-05 GR GR20010400359T patent/GR3035519T3/el unknown
2002
- 2002-01-04 CY CY0200004A patent/CY2256B1/xx unknown
2007
- 2007-01-17 LU LU91306C patent/LU91306I2/fr unknown

Also Published As

Publication number	Publication date
DK0788496T3 (da)	2001-06-18
HUT77360A (hu)	1998-03-30
FI119548B (fi)	2008-12-31
FI971784A0 (fi)	1997-04-25
MX9703074A (es)	1997-07-31
AU697744C (en)	2002-08-22
HU219862B (hu)	2001-08-28
CA2203274C (en)	2002-02-19
CA2203274A1 (en)	1996-05-09
NO311937B1 (no)	2002-02-18
JP3025907B2 (ja)	2000-03-27
BR9509436A (pt)	1998-01-06
JPH09511759A (ja)	1997-11-25
DE69519995D1 (en)	2001-03-01
KR100227231B1 (ko)	1999-11-01
AU3868095A (en)	1996-05-23
CZ119897A3 (cs)	1998-03-18
EP0788496A1 (de)	1997-08-13
CN1068000C (zh)	2001-07-04
BG63694B1 (bg)	2002-09-30
EP0788496B1 (de)	2001-01-24
LU91306I2 (fr)	2007-03-19
PT788496E (pt)	2001-07-31
NZ295353A (en)	1998-08-26
TR199501295A2 (tr)	1996-06-21
DE122007000005I1 (de)	2007-04-26
NO971895L (no)	1997-04-24
FI971784L (fi)	1997-04-25
HRP950532B1 (en)	2001-06-30
IL115771A (en)	2000-02-29
DE122007000005I2 (de)	2008-04-24
HRP950532A2 (en)	1997-08-31
OA10479A (en)	2002-04-09
CZ286476B6 (en)	2000-04-12
DE69519995T2 (de)	2001-08-23
AP9700968A0 (en)	1997-04-30
AP779A (en)	1999-11-03
NO971895D0 (no)	1997-04-24
GR3035519T3 (en)	2001-06-29
RO118715B1 (ro)	2003-09-30
ES2155535T3 (es)	2001-05-16
WO1996013499A1 (en)	1996-05-09
US5929075A (en)	1999-07-27
CN1161695A (zh)	1997-10-08
AU697744B2 (en)	1998-10-15
CY2256B1 (en)	2003-07-04
BG101402A (en)	1997-10-31
SK50797A3 (en)	1998-04-08
IL115771A0 (en)	1996-01-19
SK281908B6 (sk)	2001-09-11

Publication	Publication Date	Title
ATE198889T1 (de)	2001-02-15	Apolipoprotein-b syntheseinhibitoren
FI963597L (fi)	1996-11-14	Isoprenyylitransferaasi-inhibiittoreita
NO972930D0 (no)	1997-06-23	Fibronectin-adhesjonsinhibitorer
FI972160A0 (fi)	1997-05-21	Matriisimetalloproteaasi-inhibiittorit
IS4771A (is)	1998-06-12	Interlevkín-1ß umbreytiensím tálmar
FI972970A7 (fi)	1997-09-11	Uusia yhdisteitä
BR9509760A (pt)	1998-06-30	Composto
BR9600534A (pt)	1997-05-13	Novos compostos
NO982850D0 (no)	1998-06-19	Ny syntese
FI963761L (fi)	1996-09-20	Kefalosporiinin synteesi
BR9600251A (pt)	1997-12-23	Composto
ZA959084B (en)	1997-04-29	Apolipoprotein-b synthesis inhibitors
EE9600011A (et)	1996-04-15	Uudsed dialkoksü-püridinüül-bensimidasooli derivaadid
BR9601295A (pt)	1998-01-13	Composto
BR9509740A (pt)	1997-10-21	Compostos 18-nor-vitamina d
BR9611576A (pt)	1999-03-30	Composto
BR9610514A (pt)	1999-03-30	Inibidores cicloantihelmínticos
ID18956A (id)	1998-05-28	Senyawa-senyawa herbisida
CY2007006I1 (el)	2009-11-04	Αναστολεις συνθεσης απολιποπρωτεινης-β
KR970011867U (ko)	1997-04-25	넥타이홀더
ITRC940003A0 (it)	1994-05-26	Campanello per appuntamenti
ITMI942305A0 (it)	1994-11-15	Ciclo-pentapeptidi antanonisti di tachichinine
SE9404416D0 (sv)	1994-12-20	Novel compounds
SE9503561D0 (sv)	1995-10-12	New Compounds
BR9500205A (pt)	1995-09-26	Composto