ES2155535T3 - Inhibidores de sintesis de apoliproteina b. - Google Patents

Inhibidores de sintesis de apoliproteina b.

Info

Publication number
ES2155535T3
ES2155535T3 ES95937804T ES95937804T ES2155535T3 ES 2155535 T3 ES2155535 T3 ES 2155535T3 ES 95937804 T ES95937804 T ES 95937804T ES 95937804 T ES95937804 T ES 95937804T ES 2155535 T3 ES2155535 T3 ES 2155535T3
Authority
ES
Spain
Prior art keywords
sub
rent
sup
hydrogen
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95937804T
Other languages
English (en)
Inventor
Jan Heeres
Leo Jacobus Jozef Backx
Robert Jozef Maria Hendrickx
Der Eycken Luc Alfons Leo Van
Chaffoy De Courcelles Didie De
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/455,304 external-priority patent/US5521186A/en
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Application granted granted Critical
Publication of ES2155535T3 publication Critical patent/ES2155535T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LA PRESENTE INVENCION, PROPORCIONA NUEVOS COMPUESTOS DE FORMULA (I), N-OXIDOS, FORMAS ESTEREOQUIMICAMENTE ISOMERICAS, Y SALES DE ADICION ACIDAS, FARMACEUTICAMENTE ACEPTABLES, DE LOS MISMOS. EN LA FORMULA (I), A Y B, UNIDOS, FORMAN UN RADICAL BIVALENTE DE FORMULA: -N=CH- (A), -CH=N- (B), CH{SUB,2}-CH{SUB,2}- (C), CH=CH- (D), -C(=O)-CH{SUB,2}- (E), -CH{SUB,2}-C(=O)- (F); R{SUP,1} ES HIDROGENO, ALQUILO C{SUB,1-6}, O HALO; R{SUP,2} ES HIDROGENO O HALO; R{SUP,3} ES HIDROGENO; ALQUILO C{SUB,1-8}, CICLOALQUILO C{SUB,3-6} O ALQUILO C{SUB,1-8} SUSTITUIDO CON HIDROXI, OXO, CICLOALQUILO C{SUB,3-6} O ARILO. HET ES UN ANILLO HETEROCICLICO DE CINCO O SEIS MIEMBROS, OPCIONALMENTE SUSTITUIDO. SE DESCRIBE ASIMISMO SU UTILIZACION COMO MEDICINA, ESPECIALMENTE COMO AGENTE REDUCTOR DE LIPIDOS, ASI COMO LAS COMPOSICIONES FARMACEUTICAS Y PROCEDIMIENTOS DE PREPARACION DE DICHOS COMPUESTOS Y COMPOSICIONES.
ES95937804T 1994-10-27 1995-10-19 Inhibidores de sintesis de apoliproteina b. Expired - Lifetime ES2155535T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP94203120 1994-10-27
US08/455,304 US5521186A (en) 1994-10-27 1995-05-31 Apolipoprotein-β synthesis inhibitors

Publications (1)

Publication Number Publication Date
ES2155535T3 true ES2155535T3 (es) 2001-05-16

Family

ID=26136684

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95937804T Expired - Lifetime ES2155535T3 (es) 1994-10-27 1995-10-19 Inhibidores de sintesis de apoliproteina b.

Country Status (30)

Country Link
US (1) US5929075A (es)
EP (1) EP0788496B1 (es)
JP (1) JP3025907B2 (es)
KR (1) KR100227231B1 (es)
CN (1) CN1068000C (es)
AP (1) AP779A (es)
AT (1) ATE198889T1 (es)
AU (1) AU697744C (es)
BG (1) BG63694B1 (es)
BR (1) BR9509436A (es)
CA (1) CA2203274C (es)
CY (1) CY2256B1 (es)
CZ (1) CZ286476B6 (es)
DE (3) DE69519995T2 (es)
DK (1) DK0788496T3 (es)
ES (1) ES2155535T3 (es)
FI (1) FI119548B (es)
GR (1) GR3035519T3 (es)
HR (1) HRP950532B1 (es)
HU (1) HU219862B (es)
IL (1) IL115771A (es)
LU (1) LU91306I2 (es)
NO (1) NO311937B1 (es)
NZ (1) NZ295353A (es)
OA (1) OA10479A (es)
PT (1) PT788496E (es)
RO (1) RO118715B1 (es)
SK (1) SK281908B6 (es)
TR (1) TR199501295A2 (es)
WO (1) WO1996013499A1 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EE200000186A (et) * 1997-11-03 2001-04-16 Janssen Pharmaceutica N.V. Osake, selliste osakeste valmistamismeetod ja kasutamine, farmatseutiline doosivorm ja selle valmistamismeetod, tahke dispersioon ja farmatseutiline pakend
WO1999055313A1 (en) * 1998-04-27 1999-11-04 Janssen Pharmaceutica N.V. Pellets having a core coated with a lipid lowering agent and a polymer
US6451802B1 (en) 1998-12-22 2002-09-17 Janssen Pharmaceutica N.V. S-oxide lipid lowering compounds
DE19945982A1 (de) * 1999-09-24 2001-03-29 Knoll Ag Geschwindigkeitsbestimmte Partikel
US20050132022A1 (en) * 2003-12-12 2005-06-16 International Business Machines Corporation Computer system with LAN-based I/O
AU2005205933B2 (en) * 2004-01-21 2010-02-18 Elanco Animal Health Ireland Limited Mitratapide oral solution
US7649002B2 (en) 2004-02-04 2010-01-19 Pfizer Inc (3,5-dimethylpiperidin-1yl)(4-phenylpyrrolidin-3-yl)methanone derivatives as MCR4 agonists
US7262318B2 (en) * 2004-03-10 2007-08-28 Pfizer, Inc. Substituted heteroaryl- and phenylsulfamoyl compounds
US20080280922A1 (en) * 2004-04-09 2008-11-13 Marc Alois Celine Maria Engelen Intermittent Dosing Regimen For Overweight and Obese Subjects
US20050288340A1 (en) * 2004-06-29 2005-12-29 Pfizer Inc Substituted heteroaryl- and phenylsulfamoyl compounds
PA8660701A1 (es) 2005-02-04 2006-09-22 Pfizer Prod Inc Agonistas de pyy y sus usos
JP2008542255A (ja) * 2005-05-27 2008-11-27 ファイザー・プロダクツ・インク 肥満症の治療または体重減量の維持のためのカンナビノイド−１受容体アンタゴニストおよびミクロソームトリグリセリド輸送タンパク質阻害物質の併用
WO2007015162A1 (en) * 2005-08-04 2007-02-08 Pfizer Limited Piperidinoyl-pyrrolidine and piperidinoyl-piperidine compounds
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
AP2008004602A0 (en) * 2006-02-23 2008-10-31 Pfizer Ltd Melanocortin type 4 receptor agonist piperidinoylpyrrolidines
US8383660B2 (en) 2006-03-10 2013-02-26 Pfizer Inc. Dibenzyl amine compounds and derivatives
CA2669311C (en) 2006-11-13 2011-09-20 Pfizer Products Inc. Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof
JP5498168B2 (ja) 2006-12-01 2014-05-21 ブリストル−マイヤーズ スクイブ カンパニー アテローム性動脈硬化および循環器疾患の治療のためのｃｅｔｐ阻害剤としてのｎ−（（３−ベンジル）−２，２−（ビス−フェニル）−プロパン−１−アミン誘導体
BRPI0811902B1 (pt) 2007-05-25 2020-03-24 Janssen Pharmaceutica N.V. Síntese aprimorada do (2s-cis)-2-(bromometil)-2-(-4-clorofenil)-1,3-dioxolano-4-metanol metanosulfonato (éster)
CA2731897C (en) * 2008-08-06 2013-07-02 Pfizer Limited Diazepine and diazocane compounds as mc4 agonists
EP2571871B1 (en) * 2010-05-19 2017-06-21 Sandoz AG Process for the preparation of chiral triazolones
MD3762368T2 (ro) 2018-03-08 2022-07-31 Incyte Corp Compuși diol aminopirazină ca inhibitori ai PI3K-Y
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4313953A (en) * 1978-06-23 1982-02-02 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of (4-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
US4267179A (en) * 1978-06-23 1981-05-12 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
US4766125A (en) * 1981-06-23 1988-08-23 Janssen Pharmaceutica N.V. N-aryl-piperazinealkanamides useful for protecting hearts from myocardial injury caused by ischaemia, anoxia or hypoxia
US4619931A (en) * 1983-02-28 1986-10-28 Janssen Pharmaceutica, N.V. [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles
CA1292472C (en) * 1985-12-03 1991-11-26 Alfonsus Guilielmus Knaeps Derivatives of ¬¬4-¬4-(4-phenyl-1-piperazinyl)- phenoxymethyl|-1,3-dioxolan-2-yl|methyl|-1h-imidazoles and 1h-1,2,4-triazoles
NZ223799A (en) * 1987-03-25 1989-12-21 Janssen Pharmaceutica Nv Azolylmethyl-dioxolanylmethoxyphenyl-piperazinyl-phenyl-triazolones and antimicrobial compositions
CA1331757C (en) * 1988-02-29 1994-08-30 Janssen Pharmaceutica Naamloze Vennootschap 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols
WO1994020063A2 (en) * 1993-03-04 1994-09-15 Cytoven International N.V. Pharmaceutical tryptophan containing dipeptide compositions and methods of use thereof
US5521186A (en) * 1994-10-27 1996-05-28 Janssen Pharmaceutica N.V. Apolipoprotein-β synthesis inhibitors

Also Published As

Publication number Publication date
HRP950532B1 (en) 2001-06-30
FI119548B (fi) 2008-12-31
AP9700968A0 (en) 1997-04-30
AU697744B2 (en) 1998-10-15
DE69519995D1 (en) 2001-03-01
HRP950532A2 (en) 1997-08-31
CZ286476B6 (en) 2000-04-12
RO118715B1 (ro) 2003-09-30
SK281908B6 (sk) 2001-09-11
DE122007000005I2 (de) 2008-04-24
CY2256B1 (en) 2003-07-04
JPH09511759A (ja) 1997-11-25
CA2203274C (en) 2002-02-19
EP0788496A1 (en) 1997-08-13
SK50797A3 (en) 1998-04-08
HUT77360A (hu) 1998-03-30
TR199501295A2 (tr) 1996-06-21
US5929075A (en) 1999-07-27
IL115771A (en) 2000-02-29
CN1068000C (zh) 2001-07-04
CZ119897A3 (cs) 1998-03-18
CN1161695A (zh) 1997-10-08
AU697744C (en) 2002-08-22
ATE198889T1 (de) 2001-02-15
FI971784L (fi) 1997-04-25
KR100227231B1 (ko) 1999-11-01
BG63694B1 (bg) 2002-09-30
NO971895D0 (no) 1997-04-24
EP0788496B1 (en) 2001-01-24
WO1996013499A1 (en) 1996-05-09
BG101402A (en) 1997-10-31
GR3035519T3 (en) 2001-06-29
DE122007000005I1 (de) 2007-04-26
AU3868095A (en) 1996-05-23
OA10479A (en) 2002-04-09
JP3025907B2 (ja) 2000-03-27
AP779A (en) 1999-11-03
HU219862B (hu) 2001-08-28
CA2203274A1 (en) 1996-05-09
BR9509436A (pt) 1998-01-06
DK0788496T3 (da) 2001-06-18
NO311937B1 (no) 2002-02-18
PT788496E (pt) 2001-07-31
NZ295353A (en) 1998-08-26
LU91306I2 (fr) 2007-03-19
NO971895L (no) 1997-04-24
DE69519995T2 (de) 2001-08-23
MX9703074A (es) 1997-07-31
FI971784A0 (fi) 1997-04-25
IL115771A0 (en) 1996-01-19

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