ATE199159T1 - 17-difluormethylen-estratriene - Google Patents

17-difluormethylen-estratriene

Info

Publication number: ATE199159T1
Authority: AT; Austria
Prior art keywords: hydrogen atom; estratrienes; difluoromethylene; beta; alpha
Prior art date: 1995-03-13

Application number

AT96907453T

Other languages

English (en)

Inventor

Rolf Dr Bohlmann

Gabor Prof Dr Rubanyl

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-03-13

Filing date

1996-03-13

Publication date

2001-02-15

1996-03-13 Application filed by Schering Ag filed Critical Schering Ag

2001-02-15 Application granted granted Critical

2001-02-15 Publication of ATE199159T1 publication Critical patent/ATE199159T1/de

Links

125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 2
BSGPCYMUVXVZHZ-DCTDBFQOSA-N (9r,10s,13s)-17-(difluoromethylidene)-13-methyl-2,3,4,5,9,10,11,12-octahydro-1h-cyclopenta[a]phenanthrene Chemical class C([C@@H]1[C@H]2CC3)CCCC1C=CC2=C1[C@@]3(C)C(=C(F)F)C=C1 BSGPCYMUVXVZHZ-DCTDBFQOSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/02—Halogenated hydrocarbons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Biotechnology (AREA)
Cardiology (AREA)
Hematology (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Vehicle Body Suspensions (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Ceramic Products (AREA)
Saccharide Compounds (AREA)
Electrical Control Of Air Or Fuel Supplied To Internal-Combustion Engine (AREA)
Photoreceptors In Electrophotography (AREA)
Exhaust-Gas Circulating Devices (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT96907453T 1995-03-13 1996-03-13 17-difluormethylen-estratriene ATE199159T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19509729A DE19509729A1 (de)	1995-03-13	1995-03-13	17-Difluormethylen-Estratriene
PCT/EP1996/001069 WO1996028462A1 (de)	1995-03-13	1996-03-13	17-difluormethylen-estratriene

Publications (1)

Publication Number	Publication Date
ATE199159T1 true ATE199159T1 (de)	2001-02-15

Family

ID=7756963

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96907453T ATE199159T1 (de)	1995-03-13	1996-03-13	17-difluormethylen-estratriene

Country Status (21)

Country	Link
US (2)	US6018062A (de)
EP (1)	EP0815120B1 (de)
JP (1)	JPH11501644A (de)
KR (1)	KR19980703002A (de)
AT (1)	ATE199159T1 (de)
AU (1)	AU693335B2 (de)
BR (1)	BR9612787A (de)
CA (1)	CA2215201A1 (de)
CZ (1)	CZ281097A3 (de)
DE (2)	DE19509729A1 (de)
HU (1)	HUP9801846A3 (de)
IL (1)	IL117497A (de)
IS (1)	IS4556A (de)
NO (1)	NO308306B1 (de)
PL (1)	PL322199A1 (de)
RU (1)	RU2155770C2 (de)
SI (1)	SI9620030A (de)
SK (1)	SK121697A3 (de)
TR (1)	TR199700950T1 (de)
WO (1)	WO1996028462A1 (de)
ZA (1)	ZA962037B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU703814B2 (en) *	1995-12-04	1999-04-01	Wyeth	Antioxidant
US5773432A (en) *	1996-10-30	1998-06-30	Schering Aktiengesellschaft	Method for lowering plasma levels of lipoprotein(a)
EP1654325A1 (de) *	2003-08-11	2006-05-10	Industria Chimica Reggiana I.C.R. S.P.A.	Chemische zusammensetzung und polymerisationsverfahren dafür zur verwendung bei der fahrzeugkarosseriereparatur
EP1789056A1 (de) *	2004-06-29	2007-05-30	Jado Technologies GmbH	Verwendung von pharmazeutischen zusammensetzungen von steroiden zur behandlung von erkrankungen im zusammenhang mit pathologischen prozessen in lipid-rafts
US8030298B2 (en)	2005-05-26	2011-10-04	Abbott Products Gmbh	17β-HSD1 and STS inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3741800A1 (de) *	1987-12-07	1989-06-15	Schering Ag	17-halogenmethylen-estratriene
US5969168A (en) *	1991-01-07	1999-10-19	Pherin Corporation	Androstanes for inducing hypothalamic effects
US5783571A (en) *	1991-01-07	1998-07-21	Pherin Corporation	Method of altering hypothalamic function by nasal administration of estrene steroids
US5883087A (en) *	1991-01-07	1999-03-16	Pherin Corporation	Androstane steroids as neurochemical initiators of change in human hypothalamic function and related pharmaceutical compositions and methods
US5773432A (en) *	1996-10-30	1998-06-30	Schering Aktiengesellschaft	Method for lowering plasma levels of lipoprotein(a)

1995
- 1995-03-13 DE DE19509729A patent/DE19509729A1/de not_active Withdrawn
1996
- 1996-03-13 HU HU9801846A patent/HUP9801846A3/hu unknown
- 1996-03-13 ZA ZA962037A patent/ZA962037B/xx unknown
- 1996-03-13 SI SI9620030A patent/SI9620030A/sl unknown
- 1996-03-13 WO PCT/EP1996/001069 patent/WO1996028462A1/de not_active Ceased
- 1996-03-13 AU AU51078/96A patent/AU693335B2/en not_active Ceased
- 1996-03-13 TR TR97/00950T patent/TR199700950T1/xx unknown
- 1996-03-13 RU RU97116513/04A patent/RU2155770C2/ru active
- 1996-03-13 PL PL96322199A patent/PL322199A1/xx unknown
- 1996-03-13 AT AT96907453T patent/ATE199159T1/de not_active IP Right Cessation
- 1996-03-13 KR KR1019970706410A patent/KR19980703002A/ko not_active Withdrawn
- 1996-03-13 CZ CZ972810A patent/CZ281097A3/cs unknown
- 1996-03-13 CA CA002215201A patent/CA2215201A1/en not_active Abandoned
- 1996-03-13 SK SK1216-97A patent/SK121697A3/sk unknown
- 1996-03-13 US US08/913,325 patent/US6018062A/en not_active Expired - Fee Related
- 1996-03-13 DE DE59606435T patent/DE59606435D1/de not_active Expired - Fee Related
- 1996-03-13 JP JP8527276A patent/JPH11501644A/ja active Pending
- 1996-03-13 BR BR9612787-2A patent/BR9612787A/pt not_active Application Discontinuation
- 1996-03-13 EP EP96907453A patent/EP0815120B1/de not_active Expired - Lifetime
- 1996-03-14 IL IL11749796A patent/IL117497A/xx not_active IP Right Cessation
1997
- 1997-09-08 IS IS4556A patent/IS4556A/is unknown
- 1997-09-12 NO NO974206A patent/NO308306B1/no unknown
1999
- 1999-03-08 US US09/263,062 patent/US6136800A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
WO1996028462A1 (de)	1996-09-19
HUP9801846A3 (en)	1999-03-01
DE19509729A1 (de)	1996-09-19
KR19980703002A (ko)	1998-09-05
EP0815120A1 (de)	1998-01-07
NO974206D0 (no)	1997-09-12
BR9612787A (pt)	1999-11-23
IL117497A0 (en)	1996-07-23
US6018062A (en)	2000-01-25
JPH11501644A (ja)	1999-02-09
US6136800A (en)	2000-10-24
EP0815120B1 (de)	2001-02-14
IL117497A (en)	1999-12-22
PL322199A1 (en)	1998-01-19
NO308306B1 (no)	2000-08-28
RU2155770C2 (ru)	2000-09-10
TR199700950T1 (xx)	1998-02-21
AU693335B2 (en)	1998-06-25
ZA962037B (en)	1996-09-25
MX9707006A (es)	1997-11-29
HUP9801846A2 (hu)	1998-12-28
NO974206L (no)	1997-11-13
SK121697A3 (en)	1998-02-04
AU5107896A (en)	1996-10-02
IS4556A (is)	1997-09-08
SI9620030A (sl)	1998-02-28
CA2215201A1 (en)	1996-09-19
CZ281097A3 (cs)	1998-02-18
DE59606435D1 (de)	2001-03-22

Legal Events

Date	Code	Title	Description
2002-06-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
TR199801399T2 (xx)	1998-10-21	Yeni 19-nor-pregnen t�revleri.
HUP0001192A2 (hu)	2000-11-28	Topiramát és származékainak alkalmazása elhízás kezelésére használható gyógyszerkészítmények előállítására
DE60015795D1 (de)	2004-12-16	Geruchsneutralisierungsmittel
ATE342927T1 (de)	2006-11-15	Nicht-elastomere polyurethanzusammensetzungen
AR001440A1 (es)	1997-10-22	Nuevos taxoides, su preparación y composiciones farmacéuticas que los contienen.
MX9805181A (es)	1998-10-31	Derivados de lactona a partir de derivados de 17.beta- carboxi, carbotio y amida androstano.
TR199801255T2 (xx)	1998-10-21	Vitronektin resept�r antagonistleri.
KR920021506A (ko)	1992-12-18	19-노르 비타민 d 화합물 합성용 중간체
ATE225782T1 (de)	2002-10-15	Benzopyranderivate
DK0515544T3 (da)	1996-02-12	Steroidsulfataseinhibitorer
FI104178B1 (fi)	1999-11-30	17-spirofuran-3'-ylideenisteroidit
TR199701287T1 (xx)	1998-03-21	Azasikloalkan t�revleri, haz�rlan��lar� ve terapideki uygulamalar�.
CO4700298A1 (es)	1998-12-29	Derivados de 3-fenilisoquinoleina-1 (2h)-ona, su preparacion y su aplicacion en la terapeutica
TR199802384T2 (xx)	1999-03-22	N�rodejeneratif hastal�klar�n tedavisinde yararl� farmas�tik bile�imlerin haz�rlanmas� i�in P-Aminofenol t�revlerinin kullan�m�.
DK0934080T3 (da)	2002-07-15	1,3-Bis-(N-lactamyl)propaner og deres farmaceutiske og kosmetiske anvendelse
WO2002000638A8 (en)	2003-08-28	Substituted phthalides as anti-convulsive drugs
DK0852580T3 (da)	2000-11-20	Fremgangsmåde til fremstilling af dihydroxypyrimidin-derivater
DE59606435D1 (de)	2001-03-22	17-difluormethylen-estratriene
ATE177293T1 (de)	1999-03-15	Ausziehführungsgarnitur für schubladen
FR2688118B1 (fr)	2000-06-30	Nouvelles compositions fongicides a base d'inhibiteurs de la biosynthese des sterols.
BG101221A (bg)	1997-08-29	N-заместени азабициклохептанови производни, приложими като невролептици
TW350041B (en)	1999-01-11	Bis-depside tertiary alkyl ester derivatives and chemical positive photoresist material
TR199700802T2 (xx)	2002-04-22	Triazin t�revleri.
TW346483B (en)	1998-12-01	Benzene derivatives
RO116856B1 (ro)	2001-07-30	Compoziţie erbicidă, lichidă, pe bază de n-(fosfonometil)glicină