ATE199159T1 - 17-difluormethylen-estratriene - Google Patents

17-difluormethylen-estratriene

Info

Publication number: ATE199159T1
Authority: AT; Austria
Prior art keywords: hydrogen atom; estratrienes; difluoromethylene; beta; alpha
Prior art date: 1995-03-13

Application number

AT96907453T

Other languages

English (en)

Inventor

Rolf Dr Bohlmann

Gabor Prof Dr Rubanyl

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-03-13

Filing date

1996-03-13

Publication date

2001-02-15

1996-03-13 Application filed by Schering Ag filed Critical Schering Ag

2001-02-15 Application granted granted Critical

2001-02-15 Publication of ATE199159T1 publication Critical patent/ATE199159T1/de

Links

125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 2
BSGPCYMUVXVZHZ-DCTDBFQOSA-N (9r,10s,13s)-17-(difluoromethylidene)-13-methyl-2,3,4,5,9,10,11,12-octahydro-1h-cyclopenta[a]phenanthrene Chemical class C([C@@H]1[C@H]2CC3)CCCC1C=CC2=C1[C@@]3(C)C(=C(F)F)C=C1 BSGPCYMUVXVZHZ-DCTDBFQOSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/02—Halogenated hydrocarbons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Biotechnology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Hematology (AREA)
Cardiology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Vehicle Body Suspensions (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Ceramic Products (AREA)
Electrical Control Of Air Or Fuel Supplied To Internal-Combustion Engine (AREA)
Photoreceptors In Electrophotography (AREA)
Exhaust-Gas Circulating Devices (AREA)

AT96907453T 1995-03-13 1996-03-13 17-difluormethylen-estratriene ATE199159T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19509729A DE19509729A1 (de)	1995-03-13	1995-03-13	17-Difluormethylen-Estratriene
PCT/EP1996/001069 WO1996028462A1 (de)	1995-03-13	1996-03-13	17-difluormethylen-estratriene

Publications (1)

Publication Number	Publication Date
ATE199159T1 true ATE199159T1 (de)	2001-02-15

Family

ID=7756963

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96907453T ATE199159T1 (de)	1995-03-13	1996-03-13	17-difluormethylen-estratriene

Country Status (21)

Country	Link
US (2)	US6018062A (de)
EP (1)	EP0815120B1 (de)
JP (1)	JPH11501644A (de)
KR (1)	KR19980703002A (de)
AT (1)	ATE199159T1 (de)
AU (1)	AU693335B2 (de)
BR (1)	BR9612787A (de)
CA (1)	CA2215201A1 (de)
CZ (1)	CZ281097A3 (de)
DE (2)	DE19509729A1 (de)
HU (1)	HUP9801846A3 (de)
IL (1)	IL117497A (de)
IS (1)	IS4556A (de)
NO (1)	NO308306B1 (de)
PL (1)	PL322199A1 (de)
RU (1)	RU2155770C2 (de)
SI (1)	SI9620030A (de)
SK (1)	SK121697A3 (de)
TR (1)	TR199700950T1 (de)
WO (1)	WO1996028462A1 (de)
ZA (1)	ZA962037B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU703814B2 (en) *	1995-12-04	1999-04-01	Wyeth	Antioxidant
US5773432A (en) *	1996-10-30	1998-06-30	Schering Aktiengesellschaft	Method for lowering plasma levels of lipoprotein(a)
US20070185275A1 (en) *	2003-08-11	2007-08-09	Industria Chimica Reggiana I.C.R. S.P.A.	Chemical composition and method of polymerisation thereof for use on vehicle bodywork repair
JP2008504329A (ja) *	2004-06-29	2008-02-14	ヤドテクノロジーズゲゼルシャフトミットベシュレンクテルハフツング	脂質ラフト内の病理プロセスに関係する障害を治療するためのステロイド由来の医薬組成物の使用
US8030298B2 (en)	2005-05-26	2011-10-04	Abbott Products Gmbh	17β-HSD1 and STS inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3741800A1 (de) *	1987-12-07	1989-06-15	Schering Ag	17-halogenmethylen-estratriene
US5883087A (en) *	1991-01-07	1999-03-16	Pherin Corporation	Androstane steroids as neurochemical initiators of change in human hypothalamic function and related pharmaceutical compositions and methods
US5969168A (en) *	1991-01-07	1999-10-19	Pherin Corporation	Androstanes for inducing hypothalamic effects
US5783571A (en) *	1991-01-07	1998-07-21	Pherin Corporation	Method of altering hypothalamic function by nasal administration of estrene steroids
US5773432A (en) *	1996-10-30	1998-06-30	Schering Aktiengesellschaft	Method for lowering plasma levels of lipoprotein(a)

1995
- 1995-03-13 DE DE19509729A patent/DE19509729A1/de not_active Withdrawn
1996
- 1996-03-13 WO PCT/EP1996/001069 patent/WO1996028462A1/de not_active Ceased
- 1996-03-13 AT AT96907453T patent/ATE199159T1/de not_active IP Right Cessation
- 1996-03-13 PL PL96322199A patent/PL322199A1/xx unknown
- 1996-03-13 CA CA002215201A patent/CA2215201A1/en not_active Abandoned
- 1996-03-13 ZA ZA962037A patent/ZA962037B/xx unknown
- 1996-03-13 TR TR97/00950T patent/TR199700950T1/xx unknown
- 1996-03-13 DE DE59606435T patent/DE59606435D1/de not_active Expired - Fee Related
- 1996-03-13 US US08/913,325 patent/US6018062A/en not_active Expired - Fee Related
- 1996-03-13 BR BR9612787-2A patent/BR9612787A/pt not_active Application Discontinuation
- 1996-03-13 JP JP8527276A patent/JPH11501644A/ja active Pending
- 1996-03-13 SI SI9620030A patent/SI9620030A/sl unknown
- 1996-03-13 EP EP96907453A patent/EP0815120B1/de not_active Expired - Lifetime
- 1996-03-13 CZ CZ972810A patent/CZ281097A3/cs unknown
- 1996-03-13 HU HU9801846A patent/HUP9801846A3/hu unknown
- 1996-03-13 RU RU97116513/04A patent/RU2155770C2/ru active
- 1996-03-13 KR KR1019970706410A patent/KR19980703002A/ko not_active Withdrawn
- 1996-03-13 SK SK1216-97A patent/SK121697A3/sk unknown
- 1996-03-13 AU AU51078/96A patent/AU693335B2/en not_active Ceased
- 1996-03-14 IL IL11749796A patent/IL117497A/xx not_active IP Right Cessation
1997
- 1997-09-08 IS IS4556A patent/IS4556A/is unknown
- 1997-09-12 NO NO974206A patent/NO308306B1/no unknown
1999
- 1999-03-08 US US09/263,062 patent/US6136800A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CZ281097A3 (cs)	1998-02-18
ZA962037B (en)	1996-09-25
EP0815120B1 (de)	2001-02-14
NO974206D0 (no)	1997-09-12
NO974206L (no)	1997-11-13
NO308306B1 (no)	2000-08-28
IL117497A (en)	1999-12-22
AU693335B2 (en)	1998-06-25
WO1996028462A1 (de)	1996-09-19
IS4556A (is)	1997-09-08
DE19509729A1 (de)	1996-09-19
HUP9801846A2 (hu)	1998-12-28
KR19980703002A (ko)	1998-09-05
HUP9801846A3 (en)	1999-03-01
EP0815120A1 (de)	1998-01-07
MX9707006A (es)	1997-11-29
SK121697A3 (en)	1998-02-04
SI9620030A (sl)	1998-02-28
DE59606435D1 (de)	2001-03-22
IL117497A0 (en)	1996-07-23
TR199700950T1 (xx)	1998-02-21
US6018062A (en)	2000-01-25
RU2155770C2 (ru)	2000-09-10
BR9612787A (pt)	1999-11-23
CA2215201A1 (en)	1996-09-19
JPH11501644A (ja)	1999-02-09
US6136800A (en)	2000-10-24
AU5107896A (en)	1996-10-02
PL322199A1 (en)	1998-01-19

Legal Events

Date	Code	Title	Description
2002-06-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
TR199801399T2 (xx)	1998-10-21	Yeni 19-nor-pregnen t�revleri.
HUP0001192A2 (hu)	2000-11-28	Topiramát és származékainak alkalmazása elhízás kezelésére használható gyógyszerkészítmények előállítására
DE60015795D1 (de)	2004-12-16	Geruchsneutralisierungsmittel
ATE342927T1 (de)	2006-11-15	Nicht-elastomere polyurethanzusammensetzungen
AR001440A1 (es)	1997-10-22	Nuevos taxoides, su preparación y composiciones farmacéuticas que los contienen.
TR199801255T2 (xx)	1998-10-21	Vitronektin resept�r antagonistleri.
YU11997A (sh)	1999-09-27	Laktamski derivati i njihove farmaceutske kompozicije
KR920021506A (ko)	1992-12-18	19-노르 비타민 d 화합물 합성용 중간체
DE69716292D1 (de)	2002-11-14	Benzopyranderivate
TR200201102T2 (tr)	2002-12-23	Yeni oligosakkaritler, bunların hazırlanması ve bunları içeren ilaç bileşimleri
BG102625A (en)	1999-04-30	Lactone derivatives of 17-beta-carboxy, carbothio and amide androstane derivatives
NO924857L (no)	1993-06-21	17-spirofuran-3'-yliden-steroider
MY128709A (en)	2007-02-28	Phosphonites
TR199701287T1 (xx)	1998-03-21	Azasikloalkan t�revleri, haz�rlan��lar� ve terapideki uygulamalar�.
CO4700298A1 (es)	1998-12-29	Derivados de 3-fenilisoquinoleina-1 (2h)-ona, su preparacion y su aplicacion en la terapeutica
DK0934080T3 (da)	2002-07-15	1,3-Bis-(N-lactamyl)propaner og deres farmaceutiske og kosmetiske anvendelse
ES2152563T3 (es)	2001-02-01	Procedimiento para preparar derivados de dihidroxipirimidina.
ATE199159T1 (de)	2001-02-15	17-difluormethylen-estratriene
ATE177293T1 (de)	1999-03-15	Ausziehführungsgarnitur für schubladen
BG101221A (bg)	1997-08-29	N-заместени азабициклохептанови производни, приложими като невролептици
TR199700802T2 (xx)	2002-04-22	Triazin t�revleri.
TR199701298T1 (xx)	1998-02-21	Tetralinler.
TR200003203T2 (tr)	2001-03-21	Karboksaldehitin saflaştırılması
DE59803066D1 (de)	2002-03-21	Substituierte benzyloxyimino-verbindungen
RO116856B1 (ro)	2001-07-30	Compoziţie erbicidă, lichidă, pe bază de n-(fosfonometil)glicină