IL117497A - 17-difluoromethylene estratriene derivatives and pharmaceutical compositions containing the same - Google Patents

17-difluoromethylene estratriene derivatives and pharmaceutical compositions containing the same

Info

Publication number: IL117497A
Authority: IL; Israel
Prior art keywords: difluoromethylene; hydrogen atom; same; pharmaceutical compositions; compositions containing
Prior art date: 1995-03-13

Application number

IL11749796A

Other languages

English (en)

Other versions

IL117497A0 (en

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-03-13

Filing date

1996-03-14

Publication date

1999-12-22

1996-03-14 Application filed by Schering Ag filed Critical Schering Ag

1996-07-23 Publication of IL117497A0 publication Critical patent/IL117497A0/xx

1999-12-22 Publication of IL117497A publication Critical patent/IL117497A/xx

Links

239000008194 pharmaceutical composition Substances 0.000 title 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 2
BSGPCYMUVXVZHZ-DCTDBFQOSA-N (9r,10s,13s)-17-(difluoromethylidene)-13-methyl-2,3,4,5,9,10,11,12-octahydro-1h-cyclopenta[a]phenanthrene Chemical class C([C@@H]1[C@H]2CC3)CCCC1C=CC2=C1[C@@]3(C)C(=C(F)F)C=C1 BSGPCYMUVXVZHZ-DCTDBFQOSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/02—Halogenated hydrocarbons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Biotechnology (AREA)
Cardiology (AREA)
Hematology (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Vehicle Body Suspensions (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Ceramic Products (AREA)
Saccharide Compounds (AREA)
Electrical Control Of Air Or Fuel Supplied To Internal-Combustion Engine (AREA)
Photoreceptors In Electrophotography (AREA)
Exhaust-Gas Circulating Devices (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

IL11749796A 1995-03-13 1996-03-14 17-difluoromethylene estratriene derivatives and pharmaceutical compositions containing the same IL117497A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19509729A DE19509729A1 (de)	1995-03-13	1995-03-13	17-Difluormethylen-Estratriene

Publications (2)

Publication Number	Publication Date
IL117497A0 IL117497A0 (en)	1996-07-23
IL117497A true IL117497A (en)	1999-12-22

Family

ID=7756963

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL11749796A IL117497A (en)	1995-03-13	1996-03-14	17-difluoromethylene estratriene derivatives and pharmaceutical compositions containing the same

Country Status (21)

Country	Link
US (2)	US6018062A (de)
EP (1)	EP0815120B1 (de)
JP (1)	JPH11501644A (de)
KR (1)	KR19980703002A (de)
AT (1)	ATE199159T1 (de)
AU (1)	AU693335B2 (de)
BR (1)	BR9612787A (de)
CA (1)	CA2215201A1 (de)
CZ (1)	CZ281097A3 (de)
DE (2)	DE19509729A1 (de)
HU (1)	HUP9801846A3 (de)
IL (1)	IL117497A (de)
IS (1)	IS4556A (de)
NO (1)	NO308306B1 (de)
PL (1)	PL322199A1 (de)
RU (1)	RU2155770C2 (de)
SI (1)	SI9620030A (de)
SK (1)	SK121697A3 (de)
TR (1)	TR199700950T1 (de)
WO (1)	WO1996028462A1 (de)
ZA (1)	ZA962037B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU703814B2 (en) *	1995-12-04	1999-04-01	Wyeth	Antioxidant
US5773432A (en) *	1996-10-30	1998-06-30	Schering Aktiengesellschaft	Method for lowering plasma levels of lipoprotein(a)
EP1654325A1 (de) *	2003-08-11	2006-05-10	Industria Chimica Reggiana I.C.R. S.P.A.	Chemische zusammensetzung und polymerisationsverfahren dafür zur verwendung bei der fahrzeugkarosseriereparatur
EP1789056A1 (de) *	2004-06-29	2007-05-30	Jado Technologies GmbH	Verwendung von pharmazeutischen zusammensetzungen von steroiden zur behandlung von erkrankungen im zusammenhang mit pathologischen prozessen in lipid-rafts
US8030298B2 (en)	2005-05-26	2011-10-04	Abbott Products Gmbh	17β-HSD1 and STS inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3741800A1 (de) *	1987-12-07	1989-06-15	Schering Ag	17-halogenmethylen-estratriene
US5969168A (en) *	1991-01-07	1999-10-19	Pherin Corporation	Androstanes for inducing hypothalamic effects
US5783571A (en) *	1991-01-07	1998-07-21	Pherin Corporation	Method of altering hypothalamic function by nasal administration of estrene steroids
US5883087A (en) *	1991-01-07	1999-03-16	Pherin Corporation	Androstane steroids as neurochemical initiators of change in human hypothalamic function and related pharmaceutical compositions and methods
US5773432A (en) *	1996-10-30	1998-06-30	Schering Aktiengesellschaft	Method for lowering plasma levels of lipoprotein(a)

1995
- 1995-03-13 DE DE19509729A patent/DE19509729A1/de not_active Withdrawn
1996
- 1996-03-13 HU HU9801846A patent/HUP9801846A3/hu unknown
- 1996-03-13 ZA ZA962037A patent/ZA962037B/xx unknown
- 1996-03-13 SI SI9620030A patent/SI9620030A/sl unknown
- 1996-03-13 WO PCT/EP1996/001069 patent/WO1996028462A1/de not_active Ceased
- 1996-03-13 AU AU51078/96A patent/AU693335B2/en not_active Ceased
- 1996-03-13 TR TR97/00950T patent/TR199700950T1/xx unknown
- 1996-03-13 RU RU97116513/04A patent/RU2155770C2/ru active
- 1996-03-13 PL PL96322199A patent/PL322199A1/xx unknown
- 1996-03-13 AT AT96907453T patent/ATE199159T1/de not_active IP Right Cessation
- 1996-03-13 KR KR1019970706410A patent/KR19980703002A/ko not_active Withdrawn
- 1996-03-13 CZ CZ972810A patent/CZ281097A3/cs unknown
- 1996-03-13 CA CA002215201A patent/CA2215201A1/en not_active Abandoned
- 1996-03-13 SK SK1216-97A patent/SK121697A3/sk unknown
- 1996-03-13 US US08/913,325 patent/US6018062A/en not_active Expired - Fee Related
- 1996-03-13 DE DE59606435T patent/DE59606435D1/de not_active Expired - Fee Related
- 1996-03-13 JP JP8527276A patent/JPH11501644A/ja active Pending
- 1996-03-13 BR BR9612787-2A patent/BR9612787A/pt not_active Application Discontinuation
- 1996-03-13 EP EP96907453A patent/EP0815120B1/de not_active Expired - Lifetime
- 1996-03-14 IL IL11749796A patent/IL117497A/xx not_active IP Right Cessation
1997
- 1997-09-08 IS IS4556A patent/IS4556A/is unknown
- 1997-09-12 NO NO974206A patent/NO308306B1/no unknown
1999
- 1999-03-08 US US09/263,062 patent/US6136800A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
WO1996028462A1 (de)	1996-09-19
HUP9801846A3 (en)	1999-03-01
DE19509729A1 (de)	1996-09-19
KR19980703002A (ko)	1998-09-05
EP0815120A1 (de)	1998-01-07
NO974206D0 (no)	1997-09-12
BR9612787A (pt)	1999-11-23
IL117497A0 (en)	1996-07-23
US6018062A (en)	2000-01-25
JPH11501644A (ja)	1999-02-09
US6136800A (en)	2000-10-24
EP0815120B1 (de)	2001-02-14
PL322199A1 (en)	1998-01-19
NO308306B1 (no)	2000-08-28
RU2155770C2 (ru)	2000-09-10
TR199700950T1 (xx)	1998-02-21
AU693335B2 (en)	1998-06-25
ZA962037B (en)	1996-09-25
MX9707006A (es)	1997-11-29
HUP9801846A2 (hu)	1998-12-28
NO974206L (no)	1997-11-13
SK121697A3 (en)	1998-02-04
AU5107896A (en)	1996-10-02
IS4556A (is)	1997-09-08
SI9620030A (sl)	1998-02-28
CA2215201A1 (en)	1996-09-19
CZ281097A3 (cs)	1998-02-18
DE59606435D1 (de)	2001-03-22
ATE199159T1 (de)	2001-02-15

Legal Events

Date	Code	Title	Description
2000-06-01	FF	Patent granted
2002-12-01	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
MY116845A (en)	2004-04-30	New 19-nor-pregnene derivatives
TW334418B (en)	1998-06-21	Stilbene derivatives and pharmaceutical compositions
TW325458B (en)	1998-01-21	Stilbene derivatives and pharmaceutical compositions comprising the same for anti-cancer
BG103485A (en)	2000-01-31	Ketobanzamides as calpain inhibitors
MX9805181A (es)	1998-10-31	Derivados de lactona a partir de derivados de 17.beta- carboxi, carbotio y amida androstano.
IL123293A (en)	2003-06-24	Piperidine derivatives, their preparation and pharmaceutical compositions containing them
TR199701040T1 (xx)	1998-01-21	Yeni taksoidler ve bunlar�n haz�rlanmas�.
LV12618A (en)	2001-02-20	Use of sulphamate derivatives as steroid sulphatase inhibitors
HUP0001192A2 (hu)	2000-11-28	Topiramát és származékainak alkalmazása elhízás kezelésére használható gyógyszerkészítmények előállítására
YU11997A (sh)	1999-09-27	Laktamski derivati i njihove farmaceutske kompozicije
TR199700727T1 (xx)	1998-02-21	Farnesil transferaz�n�n yeni inhibit�rleri.
MY125749A (en)	2006-08-30	Aralkyl and aralkylidene heterocyclic lactams and imides
ES8706717A1 (es)	1987-07-01	Metodo de preparar esteroides
TR200201102T2 (tr)	2002-12-23	Yeni oligosakkaritler, bunların hazırlanması ve bunları içeren ilaç bileşimleri
FI104178B1 (fi)	1999-11-30	17-spirofuran-3'-ylideenisteroidit
TR199802384T2 (xx)	1999-03-22	N�rodejeneratif hastal�klar�n tedavisinde yararl� farmas�tik bile�imlerin haz�rlanmas� i�in P-Aminofenol t�revlerinin kullan�m�.
BG102015A (en)	1998-08-31	Azacycloalkane derivatives, their preparation and application in therapy
IL117497A0 (en)	1996-07-23	17-Difluoromethylene estratriene derivatives and pharmaceutical compositions containing the same
GR3031118T3 (en)	1999-12-31	Novel seco-D steroids active in the cardiovascular system and pharmaceutical compositions containing same
DK1047664T3 (da)	2004-09-13	Tricykliske forbindelser, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende disse
ATE196910T1 (de)	2000-10-15	7-glykosyloxybenzopyranderivat und dieses enthaltendes antiallergisches mittel
ES8703872A1 (es)	1987-03-01	Procedimiento para preparar derivados de isoquinolina.
DE69614552D1 (de)	2001-09-20	MODIFIZIERTE ALPHA-D-GLCP-(1,2)-ALPHA-D-Glcp-(1,3)-ALPHA-D-Glcp-ANALOGE
NZ240882A (en)	1993-02-25	3-(2-chloro-4-trifluoromethylphenoxy)-1-azetidine carboxamide derivatives, pharmaceutical compositions, and intermediate compounds therefor
IL150082A (en)	2007-05-15	Unsaturated 14,15 - cyclopropane