ATE199563T1 - 4,7-dichlorrhodaminfarbstoffe - Google Patents

4,7-dichlorrhodaminfarbstoffe

Info

Publication number
ATE199563T1
ATE199563T1 AT97928653T AT97928653T ATE199563T1 AT E199563 T1 ATE199563 T1 AT E199563T1 AT 97928653 T AT97928653 T AT 97928653T AT 97928653 T AT97928653 T AT 97928653T AT E199563 T1 ATE199563 T1 AT E199563T1
Authority
AT
Austria
Prior art keywords
hydrogen
taken together
lower alkyl
benzo
chlorine
Prior art date
Application number
AT97928653T
Other languages
English (en)
Inventor
Linda Lee
Scott C Benson
Barnett B Rosenblum
Sandra L Spungeon
Original Assignee
Perkin Elmer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Perkin Elmer Corp filed Critical Perkin Elmer Corp
Application granted granted Critical
Publication of ATE199563T1 publication Critical patent/ATE199563T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B11/00Diaryl- or thriarylmethane dyes
    • C09B11/04Diaryl- or thriarylmethane dyes derived from triarylmethanes, i.e. central C-atom is substituted by amino, cyano, alkyl
    • C09B11/10Amino derivatives of triarylmethanes
    • C09B11/24Phthaleins containing amino groups ; Phthalanes; Fluoranes; Phthalides; Rhodamine dyes; Phthaleins having heterocyclic aryl rings; Lactone or lactame forms of triarylmethane dyes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pyrane Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Luminescent Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Dental Preparations (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Paints Or Removers (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)
  • Fats And Perfumes (AREA)
AT97928653T 1996-06-27 1997-05-21 4,7-dichlorrhodaminfarbstoffe ATE199563T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/672,196 US5847162A (en) 1996-06-27 1996-06-27 4, 7-Dichlororhodamine dyes
PCT/US1997/008797 WO1997049769A1 (en) 1996-06-27 1997-05-21 4,7-dichlororhodamine dyes

Publications (1)

Publication Number Publication Date
ATE199563T1 true ATE199563T1 (de) 2001-03-15

Family

ID=24697546

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97928653T ATE199563T1 (de) 1996-06-27 1997-05-21 4,7-dichlorrhodaminfarbstoffe

Country Status (8)

Country Link
US (2) US5847162A (de)
EP (1) EP0915935B1 (de)
JP (4) JP4140976B2 (de)
AT (1) ATE199563T1 (de)
AU (1) AU709209B2 (de)
CA (1) CA2258243C (de)
DE (1) DE69704205T2 (de)
WO (1) WO1997049769A1 (de)

Families Citing this family (221)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5847162A (en) * 1996-06-27 1998-12-08 The Perkin Elmer Corporation 4, 7-Dichlororhodamine dyes
US7825237B2 (en) * 1996-05-03 2010-11-02 Applied Biosystems, Llc Oligonucleotides and analogs labeled with energy transfer dyes
US7388092B2 (en) 1996-05-03 2008-06-17 Applera Corporation Oligonucleotides and analogs labeled with energy transfer dyes
US5945526A (en) * 1996-05-03 1999-08-31 Perkin-Elmer Corporation Energy transfer dyes with enhanced fluorescence
US7550570B2 (en) * 2000-05-25 2009-06-23 Applied Biosystems, Llc. 4,7-dichlororhodamine dyes labeled polynucleotides
US6080852A (en) * 1996-06-27 2000-06-27 The Perkin-Elmer Corporation 4,7-dichlororhodamine dyes
JP3489991B2 (ja) * 1997-07-07 2004-01-26 理化学研究所 3’−デオキシリボヌクレオチド誘導体
US5936087A (en) 1997-11-25 1999-08-10 The Perkin-Elmer Corporation Dibenzorhodamine dyes
US6080868A (en) 1998-01-23 2000-06-27 The Perkin-Elmer Corporation Nitro-substituted non-fluorescent asymmetric cyanine dye compounds
DE19824535A1 (de) * 1998-06-03 1999-12-09 Roche Diagnostics Gmbh Neue Rhodamin-Derivate und deren Verwendung
US20040121394A1 (en) * 1998-08-19 2004-06-24 Dawson Elliott P. Method for determining polynucleotide sequence variations
IL141329A (en) * 1998-08-19 2005-07-25 Bioventures Inc Method for detemining polynucleotides sequence variations
US20030138834A1 (en) * 1998-08-19 2003-07-24 Dawson Elliott P. Method for determining polynucleotide sequence variations
US6605434B1 (en) 1999-03-16 2003-08-12 Human Genome Sciences, Inc. Direct bacterial lysate sequencing
DE19923168A1 (de) * 1999-05-20 2000-11-23 Roche Diagnostics Gmbh Neue Fluoreszenzfarbstoffe und ihre Verwendung als Fluoreszenzmarker
US6248884B1 (en) 1999-06-03 2001-06-19 The Perkin-Elmer Corporation Extended rhodamine compounds useful as fluorescent labels
US6316230B1 (en) 1999-08-13 2001-11-13 Applera Corporation Polymerase extension at 3′ terminus of PNA-DNA chimera
US6372907B1 (en) * 1999-11-03 2002-04-16 Apptera Corporation Water-soluble rhodamine dye peptide conjugates
US6191278B1 (en) 1999-11-03 2001-02-20 Pe Corporation Water-soluble rhodamine dyes and conjugates thereof
US6232076B1 (en) 2000-02-04 2001-05-15 Genaissance Pharmaceuticals, Inc. Stabilizer of dye sequencing products
US6887664B2 (en) 2000-06-06 2005-05-03 Applera Corporation Asynchronous primed PCR
US7169922B2 (en) * 2000-08-04 2007-01-30 Invitrogen Corporation Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings
EP1317464B1 (de) * 2000-10-11 2009-05-13 Applera Corporation Fluoreszierende nukleobasekonjugate mit anionische linker
US6448407B1 (en) 2000-11-01 2002-09-10 Pe Corporation (Ny) Atropisomers of asymmetric xanthene fluorescent dyes and methods of DNA sequencing and fragment analysis
WO2002055512A1 (en) * 2001-01-12 2002-07-18 Northeastern University Xanthene derivatives
US7256275B2 (en) * 2001-03-09 2007-08-14 Boston Probes, Inc. Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation
US6887690B2 (en) * 2001-06-22 2005-05-03 Pe Corporation Dye-labeled ribonucleotide triphosphates
US6764710B2 (en) 2001-07-18 2004-07-20 Scimed Life Systems, Inc. Light emitting markers for use with substrates
US7052512B2 (en) * 2001-07-18 2006-05-30 Boston Scientific Scimed, Inc. Fluorescent dyed lubricant for medical devices
JP2004537053A (ja) * 2001-07-25 2004-12-09 アプレラ コーポレイション 電気泳動検出システムにおける時間遅延積分
US20030165935A1 (en) 2001-11-21 2003-09-04 Vann Charles S. Digital assay
US20040054195A1 (en) * 2002-01-10 2004-03-18 Jianxin Gao Xanthene derivatives
US20040171034A1 (en) * 2002-05-03 2004-09-02 Brian Agnew Compositions and methods for detection and isolation of phosphorylated molecules
CN1665790A (zh) 2002-05-03 2005-09-07 莫莱丘莱尔探针公司 用于检测和分离磷酸化分子的组合物及方法
US7445894B2 (en) 2002-05-03 2008-11-04 Molecular Probes, Inc. Compositions and methods for detection and isolation of phosphorylated molecules
DE60330182D1 (de) 2002-09-08 2009-12-31 Applera Corp Festphasengebundene PNA-Dimere und deren Synthese
US20050233307A1 (en) 2002-09-12 2005-10-20 Kyle Gee Site-specific labeling of affinity tags in fusion proteins
AU2003272704A1 (en) * 2002-09-25 2004-04-19 Amersham Biosciences Corp Energy transfer dyes, terminators and use thereof
US20050250214A1 (en) * 2004-05-05 2005-11-10 Gee Kyle R Zinc binding compounds and their method of use
WO2004101709A1 (en) 2003-05-09 2004-11-25 Applera Corporation Phenyl xanthene dyes
US7432298B2 (en) * 2003-05-09 2008-10-07 Applied Biosystems Inc. Fluorescent polymeric materials containing lipid soluble rhodamine dyes
US6860931B2 (en) * 2003-06-26 2005-03-01 Xerox Corporation Phase change inks containing colorant compounds
US6835238B1 (en) 2003-06-26 2004-12-28 Xerox Corporation Phase change inks containing colorant compounds
US6998493B2 (en) * 2003-06-26 2006-02-14 Xerox Corporation Colorant compounds
US7176317B2 (en) * 2003-06-26 2007-02-13 Xerox Corporation Colorant compounds
US7619059B2 (en) 2003-07-29 2009-11-17 Life Technologies Corporation Bimolecular optical probes
US7727752B2 (en) 2003-07-29 2010-06-01 Life Technologies Corporation Kinase and phosphatase assays
CA2445420A1 (en) 2003-07-29 2005-01-29 Invitrogen Corporation Kinase and phosphatase assays
US7271265B2 (en) * 2003-08-11 2007-09-18 Invitrogen Corporation Cyanine compounds and their application as quenching compounds
US20050064485A1 (en) * 2003-09-12 2005-03-24 Kurt Vogel Multiplex binding and activity assays
US7417726B2 (en) * 2003-09-19 2008-08-26 Applied Biosystems Inc. Normalization of data using controls
US7570443B2 (en) 2003-09-19 2009-08-04 Applied Biosystems, Llc Optical camera alignment
US7431915B2 (en) 2003-10-31 2008-10-07 The Regents Of The University Of California Peptides whose uptake by cells is controllable
US20050214807A1 (en) * 2003-11-19 2005-09-29 Iain Johnson Environmental sensitive fluorogenic compounds and their application for singlet oxygen and protein detection
PT1538154E (pt) * 2003-11-20 2009-03-23 Exiqon As Composições de agentes de extinção com porções de antraquinona
US7776529B2 (en) 2003-12-05 2010-08-17 Life Technologies Corporation Methine-substituted cyanine dye compounds
EP2607431B1 (de) 2003-12-05 2016-08-24 Life Technologies Corporation Cyanin Farbstoffverbindungen
JP4127204B2 (ja) * 2003-12-17 2008-07-30 セイコーエプソン株式会社 液晶表示装置の製造方法
WO2005071096A2 (en) 2004-01-21 2005-08-04 Molecular Probes, Inc. Derivatives of cephalosporin and clavulanic acid for detecting beta-lacamase in a sample
US20050255485A1 (en) * 2004-05-14 2005-11-17 Livak Kenneth J Detection of gene duplications
EP2290073A3 (de) 2004-05-28 2011-08-31 Asuragen, Inc. Verfahren und Zusammensetzungen mit MicroRNA
EP1766089A1 (de) * 2004-06-30 2007-03-28 Applera Corporation Analogsondenkomplexe
US7311767B2 (en) * 2004-07-23 2007-12-25 Xerox Corporation Processes for preparing phase change inks
US7732625B2 (en) * 2004-07-23 2010-06-08 Xerox Corporation Colorant compounds
US7033424B2 (en) 2004-07-23 2006-04-25 Xerox Corporation Phase change inks
WO2006023231A2 (en) 2004-07-27 2006-03-02 Molecular Probes, Inc. Fluorescent metal ion indicators with large stokes shift
EP2302055B1 (de) 2004-11-12 2014-08-27 Asuragen, Inc. Verfahren und Zusammensetzungen, die miRNAs und miRNAa-inhibitorischen Molekülen verbunden sind
US20060292586A1 (en) * 2004-12-17 2006-12-28 Schroth Gary P ID-tag complexes, arrays, and methods of use thereof
US20060166238A1 (en) * 2004-12-22 2006-07-27 Ramsing Niels B Probes, libraries and kits for analysis of mixtures of nucleic acids and methods for constructing the same
US20060228726A1 (en) * 2005-01-06 2006-10-12 Martin Patrick K Polypeptides having nucleic acid binding activity and compositions and methods for nucleic acid amplification
JP2008533167A (ja) 2005-03-15 2008-08-21 アプレラ コーポレイション 分析物の検出のための、抗体の代替抗原系の使用
JP2008541055A (ja) * 2005-05-03 2008-11-20 アプレラ コーポレイション 蛍光検出システムおよびそれとともに使用するための色素セット
JP5306811B2 (ja) 2005-05-11 2013-10-02 ライフ テクノロジーズ コーポレーション 2本鎖dnaへの高い選択性を有する蛍光化学物質及びそれらの使用
EP3257949A1 (de) 2005-06-15 2017-12-20 Complete Genomics Inc. Nukleinsäureanalyse durch zufällige mischungen von nichtüberlappenden fragmenten
US20070087360A1 (en) * 2005-06-20 2007-04-19 Boyd Victoria L Methods and compositions for detecting nucleotides
US20070134685A1 (en) * 2005-09-06 2007-06-14 Invitrogen Corporation Control of chemical modification
US20070059713A1 (en) * 2005-09-09 2007-03-15 Lee Jun E SSB-DNA polymerase fusion proteins
CA2624896C (en) 2005-10-07 2017-11-07 Callida Genomics, Inc. Self-assembled single molecule arrays and uses thereof
US7521577B2 (en) 2006-01-12 2009-04-21 Molecular Probes, Inc. Heavy metal binding compounds and their method of use
US20070196860A1 (en) * 2006-01-18 2007-08-23 Invitrogen Corporation Methods for Measuring Real Time Kinase Activity
SG170028A1 (en) 2006-02-24 2011-04-29 Callida Genomics Inc High throughput genome sequencing on dna arrays
CN101432439B (zh) 2006-02-24 2013-07-24 考利达基因组股份有限公司 Dna阵列上的高通量基因组测序
US9677123B2 (en) 2006-03-15 2017-06-13 Siemens Healthcare Diagnostics Inc. Degenerate nucleobase analogs
CA2653321A1 (en) 2006-05-26 2007-12-06 Althea Technologies, Inc. Biochemical analysis of partitioned cells
PT2062049E (pt) 2006-09-06 2014-07-28 Univ California Diagnóstico molecular e classificação de melanoma maligno
WO2008076524A2 (en) 2006-10-27 2008-06-26 Life Technologies Corporation Fluorogenic ph sensitive dyes and their method of use
US7910354B2 (en) 2006-10-27 2011-03-22 Complete Genomics, Inc. Efficient arrays of amplified polynucleotides
US20090111706A1 (en) 2006-11-09 2009-04-30 Complete Genomics, Inc. Selection of dna adaptor orientation by amplification
US8586743B2 (en) * 2007-01-30 2013-11-19 Life Technologies Corporation Labeling reagents and methods of their use
US7736426B2 (en) 2007-02-06 2010-06-15 Xerox Corporation Phase change inks containing colorant compounds
US8163074B2 (en) 2007-02-06 2012-04-24 Xerox Corporation Phase change inks containing colorant compounds
US7485728B2 (en) * 2007-02-06 2009-02-03 Xerox Corporation Colorant compounds
US7910754B2 (en) 2007-02-06 2011-03-22 Xerox Corporation Colorant compounds
US7485737B2 (en) 2007-02-06 2009-02-03 Xerox Corporation Colorant compounds
US20080187664A1 (en) 2007-02-06 2008-08-07 Xerox Corporation Phase change inks containing colorant compounds
CA2682761C (en) 2007-04-04 2015-10-13 Network Biosystems, Inc. Methods for rapid multiplexed amplification of target nucleic acids
US20080274458A1 (en) * 2007-05-01 2008-11-06 Latham Gary J Nucleic acid quantitation methods
US8513451B2 (en) * 2007-05-30 2013-08-20 Hee Chol Kang Fluorescent phospholipase A2 indicators
US7816135B2 (en) 2007-07-05 2010-10-19 Becton, Dickinson And Company Method of analyzing lymphocytes
WO2009036332A1 (en) 2007-09-14 2009-03-19 Asuragen, Inc. Micrornas differentially expressed in cervical cancer and uses thereof
US8017338B2 (en) * 2007-11-20 2011-09-13 Life Technologies Corporation Reversible di-nucleotide terminator sequencing
WO2009067632A1 (en) * 2007-11-20 2009-05-28 Applied Biosystems Inc. Method of sequencing nucleic acids using elaborated nucleotide phosphorothiolate compounds
WO2009070805A2 (en) 2007-12-01 2009-06-04 Asuragen, Inc. Mir-124 regulated genes and pathways as targets for therapeutic intervention
CA2716357A1 (en) 2008-03-05 2009-09-11 The Regents Of The University Of California Molecular diagnosis and classification of malignant melanoma
WO2009137807A2 (en) 2008-05-08 2009-11-12 Asuragen, Inc. Compositions and methods related to mirna modulation of neovascularization or angiogenesis
US20100159452A1 (en) * 2008-12-22 2010-06-24 Roche Molecular Systems, Inc. Method For Detecting a Target Nucleic Acid in a Sample
JP2012519170A (ja) 2009-02-26 2012-08-23 オーエスアイ・ファーマシューティカルズ,エルエルシー 生体内の腫瘍細胞のemtステータスをモニターするためのinsitu法
EP2432796B1 (de) 2009-05-21 2016-08-17 Siemens Healthcare Diagnostics Inc. Universaltags mit nicht-natürlichen nukleobasen
EP2634266B1 (de) 2009-05-22 2015-10-14 Asuragen, INC. miRNA-Biomarker für Erkrankungen der Prostata
EP2443254A2 (de) 2009-06-15 2012-04-25 NetBio, Inc. Verbesserte verfahren für forensische dna-quantifizierung
CN102725632A (zh) 2009-08-28 2012-10-10 奥斯瑞根公司 肺病的miRNA生物标志物
JP5451556B2 (ja) * 2009-09-18 2014-03-26 キヤノン株式会社 色素化合物
US20130261003A1 (en) 2010-08-06 2013-10-03 Ariosa Diagnostics, In. Ligation-based detection of genetic variants
US20120034603A1 (en) 2010-08-06 2012-02-09 Tandem Diagnostics, Inc. Ligation-based detection of genetic variants
JP5494351B2 (ja) * 2010-08-24 2014-05-14 ソニー株式会社 蛍光強度補正方法、蛍光強度算出方法及び蛍光強度算出装置並びに蛍光強度補正プログラム
BR112013010585B1 (pt) 2010-10-29 2020-12-01 Asuragen, Inc. método de caracterização de um locus de fmr1 ou um locus de frm2 em uma amostra de dna e método de análise de um locus fmr1 ou um locus fmr2 de uma amostra de dna humana
CN103597093A (zh) 2010-12-29 2014-02-19 生命技术公司 作为荧光参考标准品的ddao化合物
US20120190020A1 (en) 2011-01-25 2012-07-26 Aria Diagnostics, Inc. Detection of genetic abnormalities
US10131947B2 (en) 2011-01-25 2018-11-20 Ariosa Diagnostics, Inc. Noninvasive detection of fetal aneuploidy in egg donor pregnancies
WO2012118745A1 (en) 2011-02-28 2012-09-07 Arnold Oliphant Assay systems for detection of aneuploidy and sex determination
CA3106132C (en) 2011-05-12 2023-08-29 Ande Corporation Methods and compositions for rapid multiplex amplification of str loci
CN102337041A (zh) * 2011-07-19 2012-02-01 华东理工大学 一种制备罗丹明荧光染料的方法
WO2013039883A1 (en) 2011-09-12 2013-03-21 Abbvie Biotherapeutics Inc. Artificial nk cells and uses thereof
WO2013040251A2 (en) 2011-09-13 2013-03-21 Asurgen, Inc. Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease
EP3604555B1 (de) 2011-10-14 2024-12-25 President and Fellows of Harvard College Sequenzierung durch strukturanordnung
CN102516992A (zh) * 2011-12-07 2012-06-27 天津工业大学 一种检测Hg2+离子的荧光探针及其合成方法和用途
EP4148142B1 (de) 2012-05-21 2025-08-13 The Scripps Research Institute Verfahren zur probenvorbereitung
US9914967B2 (en) 2012-06-05 2018-03-13 President And Fellows Of Harvard College Spatial sequencing of nucleic acids using DNA origami probes
AU2013292266B2 (en) 2012-07-20 2019-01-03 President And Fellows Of Harvard College Cell based quality control bioassays for nutriceutical and medicinal products
US9476089B2 (en) 2012-10-18 2016-10-25 President And Fellows Of Harvard College Methods of making oligonucleotide probes
WO2014093291A1 (en) 2012-12-10 2014-06-19 Advandx, Inc. Use of probes for mass spectrometric identification of microorganisms or cells and associated conditions of interest
EA031930B1 (ru) 2013-01-30 2019-03-29 Авелас Байосайенсиз, Инк. Молекула селективной доставки для визуализации злокачественной ткани
US9540685B2 (en) 2013-03-15 2017-01-10 President And Fellows Of Harvard College Methods of identifying homologous genes using FISH
US10071990B2 (en) 2013-06-03 2018-09-11 The Research Foundation For The State University Of New York Site-specific orthogonal labeling of the carboxy terminus of α-tubulin in live cells
JP6692748B2 (ja) 2013-09-26 2020-05-13 ナショナル ユニヴァーシティー オブ シンガポール リゾホスファチジルコリンの足場を利用する組成物及び方法
JP6339787B2 (ja) * 2013-10-09 2018-06-06 株式会社日立ハイテクノロジーズ 核酸の分析方法
ES2686631T3 (es) 2014-01-05 2018-10-18 Biomirna Holdings Ltd. Determinaciones de cáncer de pulmón utilizando relaciones de miARN
WO2015120382A1 (en) 2014-02-07 2015-08-13 The Johns Hopkins University Predicting response to epigenetic drug therapy
EP3183358B1 (de) 2014-08-19 2020-10-07 President and Fellows of Harvard College Rna-geführte systeme zur sondierung und abbildung von nukleinsäuren
CN107109474B (zh) 2014-08-19 2021-03-19 豪夫迈·罗氏有限公司 用于核酸检测的方法和组合物
US10450562B2 (en) 2014-09-09 2019-10-22 Igenomx International Genomics Corporation Methods and compositions for rapid nucleic acid library preparation
US10385380B2 (en) 2014-10-02 2019-08-20 The Regents Of The University Of California Personalized protease assay to measure protease activity in neoplasms
WO2016081740A1 (en) 2014-11-21 2016-05-26 Nanostring Technologies, Inc. Enzyme- and amplification-free sequencing
WO2016094330A2 (en) 2014-12-08 2016-06-16 20/20 Genesystems, Inc Methods and machine learning systems for predicting the liklihood or risk of having cancer
US10383957B2 (en) 2015-01-06 2019-08-20 Anthony H. de Haas Near-infrared fluorescent surgical dye markers
EP3748002A1 (de) 2015-01-12 2020-12-09 Life Technologies Corporation Verfahren, systeme und zusammensetzungen daraus zur kontrolle und quantifizierung der nukleinsäurebibliotheksqualität
EP3292214A1 (de) 2015-05-04 2018-03-14 Academisch Medisch Centrum Verfahren zur quantifizierung von mirnas mittels normalisierung
AU2016297631B2 (en) 2015-07-23 2022-08-04 Asuragen, Inc. Methods, compositions, kits, and uses for analysis of nucleic acids comprising repeating A/T-rich segments
CN116200462B (zh) 2016-05-16 2025-10-03 布鲁克空间生物学公司 用于检测样品中目标核酸的方法
WO2018045162A1 (en) 2016-09-01 2018-03-08 Biogen Ma Inc. Biomarkers predictive of primary progressive multiple sclerosis and uses thereof
EP4556575A3 (de) 2016-11-21 2025-10-08 Bruker Spatial Biology, Inc. Verfahren zur sequenzierung von nukleinsäuren
WO2018223055A1 (en) 2017-06-02 2018-12-06 Affymetrix, Inc. Array-based methods for analysing mixed samples using differently labelled allele-specific probes
US11441174B2 (en) 2017-06-02 2022-09-13 Affymetrix, Inc. Array-based methods for analysing mixed samples using differently labelled allele-specific probes
AU2018310983B2 (en) 2017-08-02 2025-01-23 The Regents Of The University Of California Optimized peptides for targeting human nerves and their use in image guided surgery, diagnostics and therapeutic delivery
KR102133794B1 (ko) * 2017-08-24 2020-07-15 주식회사 셀투인 세포 소기관 내 글루타치온 측정용 실시간 형광 이미징 센서 및 이의 제조 방법
WO2019104070A1 (en) 2017-11-21 2019-05-31 Nanostring Technologies, Inc. O-nitrobenzyl photocleavable bifunctional linker
EP3794146B1 (de) 2018-05-14 2025-12-10 Bruker Spatial Biology, Inc. Verfahren zur erkennung einer zuvor bestimmten nukleotidesequenz
SG11202106124UA (en) 2018-12-20 2021-07-29 Life Technologies Corp Modified rhodamine dye and use thereof in biological assays
CN113195639A (zh) 2018-12-20 2021-07-30 生命技术公司 非对称罗丹明染料和其在生物测定中的用途
EP3719144A1 (de) 2019-04-05 2020-10-07 Fundación para la Investigación Biomédica del Hospital Universitario de la Paz (FIBHULP) Mir-151a-3p als universelle endogene steuerung zur exosomenladungsnormalisierung
EP3999664A1 (de) 2019-07-19 2022-05-25 Fundación para la Investigación Biomédica del Hospital Universitario de la Paz (FIBHULP) Verfahren zur bestimmung des ansprechens auf die behandlung eines patienten mit nicht-kleinzelligem lungenkarzinom (nsclc)
CA3153142A1 (en) 2019-10-10 2021-04-15 Brett J. Berman Methods and systems using peptides for targeting and mapping human nerves in image guided surgery, diagnostics and therapeutic delivery
IL292313A (en) 2019-10-18 2022-06-01 Univ Leland Stanford Junior Clinical- and industrial-scale intact-tissue sequencing
WO2021178893A2 (en) 2020-03-06 2021-09-10 Singular Genomics Systems, Inc. Linked paired strand sequencing
US12209273B2 (en) 2020-06-12 2025-01-28 10X Genomics, Inc. Nucleic acid assays using click chemistry bioconjugation
WO2022015600A2 (en) 2020-07-13 2022-01-20 Singular Genomics Systems, Inc. Methods of sequencing complementary polynucleotides
WO2022020731A2 (en) 2020-07-23 2022-01-27 Life Technologies Corporation Compositions, systems and methods for biological analysis involving energy transfer dye conjugates and analytes comprising the same
EP4185596A1 (de) 2020-07-23 2023-05-31 Life Technologies Corporation Energieübertragungsfarbstoffkonjugate zur verwendung in biologischen tests
CA3192943A1 (en) 2020-09-16 2022-03-24 Nanostring Technologies, Inc. Chemical compositions and methods of using the same
WO2022087485A1 (en) 2020-10-22 2022-04-28 Singular Genomics Systems, Inc. Nucleic acid circularization and amplification on a surface
US12071667B2 (en) 2020-11-04 2024-08-27 10X Genomics, Inc. Sequence analysis using meta-stable nucleic acid molecules
JP7721399B2 (ja) 2020-11-26 2025-08-12 キヤノン株式会社 新規化合物、及び硫化水素検出用の構造体
US20240207421A1 (en) 2020-12-04 2024-06-27 Alume Biosciences, Inc. Nerve targeting peptides and methods of use
CN116916971A (zh) 2021-01-14 2023-10-20 阿鲁莫生物科学公司 用于外科操作中输尿管可视化的方法和组合物
US12060603B2 (en) 2021-01-19 2024-08-13 10X Genomics, Inc. Methods for internally controlled in situ assays using padlock probes
EP4251770A4 (de) 2021-02-08 2024-05-29 Singular Genomics Systems, Inc. Verfahren und zusammensetzungen zur sequenzierung komplementärer polynukleotide
EP4263868A4 (de) 2021-03-12 2024-11-27 Singular Genomics Systems, Inc. Nanoarrays und verfahren zur verwendung davon
US11884977B2 (en) 2021-03-12 2024-01-30 Singular Genomics Systems, Inc. Nanoarrays and methods of use thereof
WO2022232308A1 (en) 2021-04-27 2022-11-03 Singular Genomics Systems, Inc. High density sequencing and multiplexed priming
EP4334706A4 (de) 2021-05-05 2025-08-06 Singular Genomics Systems Inc Multiomikanalysevorrichtung und verfahren zur verwendung davon
WO2022256324A1 (en) 2021-06-01 2022-12-08 10X Genomics, Inc. Methods and compositions for analyte detection and probe resolution
WO2022256422A1 (en) 2021-06-02 2022-12-08 10X Genomics, Inc. Sample analysis using asymmetric circularizable probes
WO2023288225A1 (en) 2021-07-13 2023-01-19 10X Genomics, Inc. Methods for preparing polymerized matrix with controllable thickness
US20250092261A1 (en) 2021-07-21 2025-03-20 Life Technologies Corporation Dibenzoxanthene Quenchers, Uses, and Methods of Preparation
US12139751B2 (en) 2021-07-30 2024-11-12 10X Genomics, Inc. Circularizable probes for in situ analysis
AU2022317053B2 (en) 2021-07-30 2025-01-02 10X Genomics, Inc. Methods and compositions for synchronizing reactions in situ
US12460251B2 (en) 2021-08-03 2025-11-04 10X Genomics, Inc. Stabilization and/or compaction of nucleic acid molecules
US12529096B2 (en) 2021-08-03 2026-01-20 10X Genomics, Inc. Stabilization and/or compaction of nucleic acid structures
US12391984B2 (en) 2021-08-03 2025-08-19 10X Genomics, Inc. Compositions and methods for rolling circle amplification
US12553079B2 (en) 2021-08-03 2026-02-17 10X Genomics, Inc. Nucleic acid concatemers and methods for stabilizing and/or compacting the same
EP4446426B1 (de) 2021-08-16 2026-03-04 10X Genomics, Inc. Sonden mit einem geteilten strichcodebereich und verfahren zur verwendung
WO2023023638A1 (en) 2021-08-20 2023-02-23 Singular Genomics Systems, Inc. Chemical and thermal assisted nucleic acid amplification methods
WO2023076832A1 (en) 2021-10-25 2023-05-04 Singular Genomics Systems, Inc. Manipulating and detecting biological samples
EP4422792A4 (de) 2021-10-26 2025-12-17 Singular Genomics Systems Inc Gezielte multiplex-amplifikation von polynukleotiden
EP4423296A2 (de) 2021-12-27 2024-09-04 10X Genomics, Inc. Verfahren und zusammensetzungen zur rolling-circle-amplifikation
EP4733410A2 (de) 2022-01-21 2026-04-29 10X Genomics, Inc. Mehrere auslesesignale zur analyse einer probe
IL315106A (en) 2022-02-23 2024-10-01 Insitro Inc Pooled optical screening and transcriptional measurements of cells comprising barcoded genetic perturbations
US20250188521A1 (en) 2022-03-10 2025-06-12 Singular Genomics Systems, Inc. Nucleic acid delivery scaffolds
EP4505177A1 (de) 2022-04-01 2025-02-12 10x Genomics, Inc. Zusammensetzungen und verfahren zur gezielten maskierung der autofluoreszenz
EP4519674A1 (de) 2022-05-06 2025-03-12 10X Genomics, Inc. Analyse von antigen- und antigenrezeptorinteraktionen
WO2023215603A1 (en) 2022-05-06 2023-11-09 10X Genomics, Inc. Methods and compositions for in situ analysis of v(d)j sequences
US20240084378A1 (en) 2022-05-11 2024-03-14 10X Genomics, Inc. Compositions and methods for in situ sequencing
EP4540607A1 (de) 2022-06-17 2025-04-23 10X Genomics, Inc. Katalytische entvernetzung von proben zur in-situ-analyse
US20240101978A1 (en) 2022-08-12 2024-03-28 10X Genomics, Inc. Puma1 polymerases and uses thereof
WO2024040060A1 (en) 2022-08-16 2024-02-22 10X Genomics, Inc. Ap50 polymerases and uses thereof
WO2024081869A1 (en) 2022-10-14 2024-04-18 10X Genomics, Inc. Methods for analysis of biological samples
WO2024102736A1 (en) 2022-11-08 2024-05-16 10X Genomics, Inc. Immobilization methods and compositions for in situ detection
EP4573210B1 (de) 2022-11-16 2026-05-06 10X Genomics, Inc. Verfahren zur analyse der genexprimierung in zellen in einem pellet
EP4634404A1 (de) 2022-12-16 2025-10-22 10X Genomics, Inc. Verfahren und zusammensetzungen zur beurteilung der leistung
US20240263219A1 (en) 2023-01-06 2024-08-08 10X Genomics, Inc. Methods and compositions for in situ analysis of variant sequences
US20240263220A1 (en) 2023-02-03 2024-08-08 10X Genomics, Inc. In situ analysis of variant sequences in biological samples
EP4680764A2 (de) 2023-03-17 2026-01-21 Bruker Spatial Biology, Inc. Assay für rekombinase-zugängliches chromatin sowie zugehörige zusammensetzungen und verfahren
WO2025029831A1 (en) 2023-07-31 2025-02-06 10X Genomics, Inc. Methods and systems for targeted rna cleavage and target rna-primed rolling circle amplification
WO2025059422A1 (en) 2023-09-14 2025-03-20 Bruker Spatial Biology, Inc. Methods for detecting target nucleic acids in a sample
US20250207203A1 (en) 2023-12-20 2025-06-26 10X Genomics, Inc. In situ detection of copy number variations in biological samples
WO2025147587A1 (en) 2024-01-05 2025-07-10 Glyphic Biotechnologies, Inc. Protein sequencing using super-resolution imaging
WO2025189030A1 (en) 2024-03-07 2025-09-12 Stellaromics, Inc. Methods and systems for volumetric imaging
WO2025240918A1 (en) 2024-05-17 2025-11-20 10X Genomics, Inc. Systems and methods for generating codebooks
WO2025264702A1 (en) 2024-06-18 2025-12-26 10X Genomics, Inc. 3d hydrogels for nucleic acid sequencing
WO2026030369A1 (en) 2024-07-31 2026-02-05 10X Genomics, Inc. Methods and compositions for in situ analyte detection
WO2026055487A1 (en) 2024-09-06 2026-03-12 10X Genomics, Inc. Modified nucleotides with oligomer spacers

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE108347C (de) *
DE47451C (de) * Badische Anilin- und Sodafabrik in Ludwigshafen a. Rh Neuerung in dem Verfahren zur Darstellung von Farbstoffen aus der Gruppe des Metaamidophenolpbtalelns. (4
DE45263C (de) * Badische Anilin- und Sodafabrik in Ludwigshafen a. Rh Neuerung in dem Verfahren zur Darstellung von Farbstoffen aus der Gruppe des m - Amidophenol - Phtalei'ns
JPS488725B1 (de) * 1969-10-08 1973-03-17
FR2065117A5 (de) * 1969-10-08 1971-07-23 Fuji Photo Film Co Ltd
US4318846A (en) * 1979-09-07 1982-03-09 Syva Company Novel ether substituted fluorescein polyamino acid compounds as fluorescers and quenchers
US4622400A (en) * 1983-12-29 1986-11-11 The United States Of America As Represented By The United States Department Of Energy Preparation of certain m-aminophenols and the use thereof for preparation of laser dyes
DE3425631A1 (de) * 1984-07-12 1986-01-16 Basf Ag, 6700 Ludwigshafen Rhodaminfarbstoffe
US4855225A (en) * 1986-02-07 1989-08-08 Applied Biosystems, Inc. Method of detecting electrophoretically separated oligonucleotides
CA1340806C (en) * 1986-07-02 1999-11-02 James Merrill Prober Method, system and reagents for dna sequencing
US4900686A (en) * 1987-04-02 1990-02-13 Polaroid Corporation Fluorescent conjugates and biological diagnostic assay
EP0333649B1 (de) * 1988-03-01 1994-06-08 Ciba-Geigy Ag 3-Basisch substituierte 2-Methylfluorane
WO1991003476A1 (en) * 1989-09-08 1991-03-21 Applied Biosystems, Inc. 5- and 6-succinimidylcarboxylate isomers of rhodamine dyes
US5366860A (en) * 1989-09-29 1994-11-22 Applied Biosystems, Inc. Spectrally resolvable rhodamine dyes for nucleic acid sequence determination
US5188934A (en) * 1989-11-14 1993-02-23 Applied Biosystems, Inc. 4,7-dichlorofluorescein dyes as molecular probes
US5750409A (en) * 1991-11-18 1998-05-12 Boehringer Mannheim Gmbh Pentacyclic compounds and their use as absorption or fluorescent dyes
US5256799A (en) * 1992-07-14 1993-10-26 The United States Of Americas As Represented By The United States Department Of Energy Preparation of 6-hydroxyindolines and their use for preparation of novel laser dyes
JPH08505121A (ja) * 1992-09-03 1996-06-04 アプライド バイオシステムズ,インコーポレイテッド 分子プローブとしての4,7−ジクロロフルオレセイン染料
US5283336A (en) * 1992-09-08 1994-02-01 The United States Of America As Represented By The United States Department Of Energy Method for preparation of 7-hydroxy-1,2,3,4-tetrahydroquinoline from 1,2,3,4-tetrahydroquinoline
WO1994006812A1 (en) * 1992-09-18 1994-03-31 Amoco Corporation Green fluorescent labeled nucleotides for use in probes
US6020481A (en) * 1996-04-01 2000-02-01 The Perkin-Elmer Corporation Asymmetric benzoxanthene dyes
US5847162A (en) * 1996-06-27 1998-12-08 The Perkin Elmer Corporation 4, 7-Dichlororhodamine dyes
US5800996A (en) * 1996-05-03 1998-09-01 The Perkin Elmer Corporation Energy transfer dyes with enchanced fluorescence

Also Published As

Publication number Publication date
JP4961410B2 (ja) 2012-06-27
JP2004305217A (ja) 2004-11-04
WO1997049769A1 (en) 1997-12-31
JP2003221515A (ja) 2003-08-08
EP0915935A1 (de) 1999-05-19
US6025505A (en) 2000-02-15
DE69704205T2 (de) 2001-10-25
CA2258243A1 (en) 1997-12-31
AU3285597A (en) 1998-01-14
EP0915935B1 (de) 2001-03-07
AU709209B2 (en) 1999-08-26
JP2000505503A (ja) 2000-05-09
US5847162A (en) 1998-12-08
JP2009073838A (ja) 2009-04-09
JP4140976B2 (ja) 2008-08-27
CA2258243C (en) 2007-11-13
DE69704205D1 (de) 2001-04-12

Similar Documents

Publication Publication Date Title
ATE199563T1 (de) 4,7-dichlorrhodaminfarbstoffe
CA2367868A1 (en) 4,7-dichlororhodamine dyes useful as molecular probes
CA2304645A1 (en) Aromatic-substituted xanthene dyes
DE69700303D1 (de) Asymmetrische benzoxanthenfarbstoffe
DK0942962T3 (da) Kemisk modificerede enzymer
ATE147067T1 (de) Selektive n-acylation von aminoalkoholen
DE59809639D1 (de) Verwendung von Carotinoid-Aggregaten als Färbemittel
ID21450A (id) S-oksida dan s,s-dioksida tetrahidrotiopiran pheniloksazolidinon
DE50012617D1 (de) Verwendung von methylchinolinium-verbindungen zum färben von keratinhaltigen fasern
DE69608347D1 (de) Zirkonverbindungen von Sulfonsäuren
DE69803171D1 (de) Herstellung von tertiär phophinen durch nickel-katalysierte cross coupling
AR246968A1 (es) Procedimiento y compuestos utiles como intermediarios,que no poseen actividad terapeutica en seres humanos y animales superiores,para la separacion de acidos oxoftalazinil-aceticos y sus analogos
ES2122149T3 (es) Procedimiento para la preparacion de 1-cloro-1-fluoroetano y/o 1,1-difluoroetano.
DE59900379D1 (de) Verwendung von detergensgemischen als lösungsvermittler
ES2188273T3 (es) Farmacos anticarcinogenos a base de antraquinona.
ATE304001T1 (de) Verfahren zur herstellung von 2-alkyl-3-aryl- und heteroaryloxaziridinen und neue 2-alkyl-3- aryloxaziridine
BR0311200A (pt) Artigo para uso em um processo enzimático de limpeza de tecido, kit de partes e método para limpeza de tecido
BR0213191A (pt) Processo para reciclagem de gás de processo em processos eletroquìmicos
BR9904902A (pt) Agente de tingimento e processo para a produção de tingimentos de cabelo temporários
ATE209636T1 (de) Verbessertes verfahren zur herstellung von unsymmetrischen 4,6- bis(aryloxy)pyrimidinverbindungen
SE9802939D0 (sv) New process
DE69931100D1 (de) Verfahren zu Fabrikation von Alpha 1l-Adrenorezeptor Antagonisten
CA2450501A1 (en) Asymmetric benzoxanthene dyes
DE69702171D1 (de) Verfahren zur Herstellung von Aminoalkynen
BR9807476A (pt) Processo para produção de uma mistura detergente particulada de escoamento livre contendo tensoativo não-iÈnico.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties