ATE199724T1 - Verfahren zur herstellung von 1-(2'-desoxy-2',2'- difluoro-d-ribo-pentofuranosyl)-cytosin aus 2- desoxy-2,2-difluoro-beta-d-ribo-pentopyranose - Google Patents

Verfahren zur herstellung von 1-(2'-desoxy-2',2'- difluoro-d-ribo-pentofuranosyl)-cytosin aus 2- desoxy-2,2-difluoro-beta-d-ribo-pentopyranose

Info

Publication number: ATE199724T1
Authority: AT; Austria
Prior art keywords: ribo; difluoro; deoxy; pentofuranosyl; cytosine
Prior art date: 1995-02-03

Application number

AT96300419T

Other languages

English (en)

Inventor

David D Wirth

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-02-03

Filing date

1996-01-22

Publication date

2001-03-15

1996-01-22 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2001-03-15 Application granted granted Critical

2001-03-15 Publication of ATE199724T1 publication Critical patent/ATE199724T1/de

Links

229940104302 cytosine Drugs 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title 1
238000000034 method Methods 0.000 abstract 2
230000000840 anti-viral effect Effects 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
239000003443 antiviral agent Substances 0.000 abstract 1
238000005866 tritylation reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/18—Acyclic radicals, substituted by carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT96300419T 1995-02-03 1996-01-22 Verfahren zur herstellung von 1-(2'-desoxy-2',2'- difluoro-d-ribo-pentofuranosyl)-cytosin aus 2- desoxy-2,2-difluoro-beta-d-ribo-pentopyranose ATE199724T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/383,165 US5559222A (en)	1995-02-03	1995-02-03	Preparation of 1-(2'-deoxy-2',2'-difluoro-D-ribo-pentofuranosyl)-cytosine from 2-deoxy-2,2-difluoro-β-D-ribo-pentopyranose

Publications (1)

Publication Number	Publication Date
ATE199724T1 true ATE199724T1 (de)	2001-03-15

Family

ID=23511995

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96300419T ATE199724T1 (de)	1995-02-03	1996-01-22	Verfahren zur herstellung von 1-(2'-desoxy-2',2'- difluoro-d-ribo-pentofuranosyl)-cytosin aus 2- desoxy-2,2-difluoro-beta-d-ribo-pentopyranose

Country Status (10)

Country	Link
US (2)	US5559222A (de)
EP (1)	EP0727433B1 (de)
JP (1)	JPH08245685A (de)
AT (1)	ATE199724T1 (de)
CA (1)	CA2168080C (de)
DE (1)	DE69612024T2 (de)
DK (1)	DK0727433T3 (de)
ES (1)	ES2154788T3 (de)
GR (1)	GR3035931T3 (de)
PT (1)	PT727433E (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19741715A1 (de) *	1997-09-22	1999-03-25	Hoechst Ag	Pentopyranosyl-Nucleosid, seine Herstellung und Verwendung
CN1438981A (zh) *	2000-04-21	2003-08-27	罗迪亚/奇莱克斯公司	制备r－1－(芳氧基)丙－2－醇的方法
US7214791B2 (en) *	2004-07-01	2007-05-08	Shenzhen Hande Technology Co., Ltd.	Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material
JP2008531680A (ja) *	2005-03-04	2008-08-14	ダブール・ファーマ・リミテッド	βアノマーが富化された２１−デオキシ−２１，２１−ジフルオロ−Ｄ−リボフラノシルヌクレオシドの調製のための中間体と方法
CA2610283C (en) *	2005-06-03	2011-08-30	Scinopharm Taiwan, Ltd.	Process of making an alpha-anomer enriched 2-deoxy-2,2-diflouro-d-ribofuranosyl sulfonate and use thereof for making a beta nucleoside
AU2011202539B2 (en) *	2005-06-03	2012-07-05	Scinopharm Taiwan, Ltd.	Process of making an alpha-anomer enriched 2-deoxy-2,2-difluoro-d-ribofuranosyl sulfonate and use thereof for making a beta nucleoside
JP2009526782A (ja) *	2006-02-07	2009-07-23	ケマジス・リミテッド	ゲムシタビンおよび関連中間体の製造方法
US20070249823A1 (en) *	2006-04-20	2007-10-25	Chemagis Ltd.	Process for preparing gemcitabine and associated intermediates
CN101024667B (zh) *	2007-03-30	2011-01-26	湖北益泰药业有限公司	盐酸吉西他宾的合成方法
US20080262215A1 (en) *	2007-04-23	2008-10-23	Chemagis Ltd.	Gemcitabine production process

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4526988A (en) *	1983-03-10	1985-07-02	Eli Lilly And Company	Difluoro antivirals and intermediate therefor
ATE92499T1 (de) *	1984-12-04	1993-08-15	Lilly Co Eli	Tumorbehandlung bei saeugetieren.
US4965374A (en) *	1987-08-28	1990-10-23	Eli Lilly And Company	Process for and intermediates of 2',2'-difluoronucleosides
CA1324128C (en) *	1987-08-28	1993-11-09	Ta-Sen Chou	2', 2'-difluoronucleosides
US5223608A (en) *	1987-08-28	1993-06-29	Eli Lilly And Company	Process for and intermediates of 2',2'-difluoronucleosides
US4954623A (en) *	1989-03-20	1990-09-04	Eli Lilly And Company	Recovery of difluoro sugar
US5401838A (en) *	1992-06-22	1995-03-28	Eli Lilly And Company	Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5426183A (en) *	1992-06-22	1995-06-20	Eli Lilly And Company	Catalytic stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5371210A (en) *	1992-06-22	1994-12-06	Eli Lilly And Company	Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
YU43193A (sh) *	1992-06-22	1997-01-08	Eli Lilly And Company	2'-deoksi-2',2'-difluoro(4-supstituisani)pirimidinski nukleozidi antivirusnog i antikancerogenog dejstva i međuproizvodi
UA41261C2 (uk) *	1992-06-22	2001-09-17	Елі Ліллі Енд Компані	Спосіб одержання збагачених бета-аномером нуклеозидів

1995
- 1995-02-03 US US08/383,165 patent/US5559222A/en not_active Expired - Lifetime
1996
- 1996-01-22 DK DK96300419T patent/DK0727433T3/da active
- 1996-01-22 PT PT96300419T patent/PT727433E/pt unknown
- 1996-01-22 EP EP96300419A patent/EP0727433B1/de not_active Expired - Lifetime
- 1996-01-22 DE DE69612024T patent/DE69612024T2/de not_active Expired - Lifetime
- 1996-01-22 AT AT96300419T patent/ATE199724T1/de active
- 1996-01-22 ES ES96300419T patent/ES2154788T3/es not_active Expired - Lifetime
- 1996-01-25 CA CA002168080A patent/CA2168080C/en not_active Expired - Fee Related
- 1996-02-02 JP JP8017511A patent/JPH08245685A/ja active Pending
- 1996-05-16 US US08/649,934 patent/US5608043A/en not_active Expired - Lifetime
2001
- 2001-05-25 GR GR20010400784T patent/GR3035931T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE69612024T2 (de)	2001-09-06
CA2168080C (en)	2007-05-29
US5608043A (en)	1997-03-04
PT727433E (pt)	2001-06-29
EP0727433A1 (de)	1996-08-21
EP0727433B1 (de)	2001-03-14
JPH08245685A (ja)	1996-09-24
GR3035931T3 (en)	2001-08-31
DK0727433T3 (da)	2001-04-17
DE69612024D1 (de)	2001-04-19
ES2154788T3 (es)	2001-04-16
US5559222A (en)	1996-09-24
CA2168080A1 (en)	1996-08-04

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Legal Events

Date	Code	Title	Description
2001-06-15	UEP	Publication of translation of european patent specification