|
CA2001401A1
(en)
*
|
1988-10-25 |
1990-04-25 |
Claude Piantadosi |
Quaternary amine containing ether or ester lipid derivatives and therapeutic compositions
|
|
CA2164717C
(en)
*
|
1993-06-10 |
2009-10-20 |
Louis S. Kucera |
Method of combatting hepatitis b virus infection
|
|
US5798340A
(en)
|
1993-09-17 |
1998-08-25 |
Gilead Sciences, Inc. |
Nucleotide analogs
|
|
US5656745A
(en)
*
|
1993-09-17 |
1997-08-12 |
Gilead Sciences, Inc. |
Nucleotide analogs
|
|
CA2171868A1
(en)
*
|
1993-09-17 |
1995-03-23 |
Petr Alexander |
Method for dosing therapeutic compounds
|
|
JP4259611B2
(ja)
|
1994-08-29 |
2009-04-30 |
ウェイク フォレスト ユニバーシティ |
ウィルス感染を治療するための脂質アナログ
|
|
US7135584B2
(en)
|
1995-08-07 |
2006-11-14 |
Wake Forest University |
Lipid analogs for treating viral infections
|
|
CA2224710A1
(en)
*
|
1995-06-15 |
1997-01-03 |
Naoko Inoue |
Phosphonate nucleotide derivatives
|
|
KR970015804A
(ko)
*
|
1995-09-28 |
1997-04-28 |
이웅열 |
저수축 나일론 6 필라멘트사 및 그의 제조방법
|
|
DE19540798A1
(de)
*
|
1995-11-02 |
1997-05-07 |
Hoechst Ag |
Alkylxanthinphosphonate und Alkylxanthinphosphinoxide und deren Verwendung als Arzneimittel
|
|
CA2195262C
(en)
*
|
1996-01-18 |
2005-08-09 |
Masaru Ubasawa |
Phosphonate nucleotide compounds
|
|
US5922695A
(en)
*
|
1996-07-26 |
1999-07-13 |
Gilead Sciences, Inc. |
Antiviral phosphonomethyoxy nucleotide analogs having increased oral bioavarilability
|
|
US6194398B1
(en)
|
1996-08-13 |
2001-02-27 |
Mitsubishi Chemical Corporation |
Phosphonate nucleotide compound
|
|
US6284748B1
(en)
|
1997-03-07 |
2001-09-04 |
Metabasis Therapeutics, Inc. |
Purine inhibitors of fructose 1,6-bisphosphatase
|
|
ZA986614B
(en)
|
1997-07-25 |
1999-01-27 |
Gilead Sciences |
Nucleotide analog composition
|
|
US5935946A
(en)
*
|
1997-07-25 |
1999-08-10 |
Gilead Sciences, Inc. |
Nucleotide analog composition and synthesis method
|
|
ATE305009T1
(de)
*
|
1997-07-25 |
2005-10-15 |
Gilead Sciences Inc |
Nukleotid-analog zusamensetzung und synthese verfahren
|
|
CN1900091A
(zh)
*
|
1997-07-25 |
2007-01-24 |
吉尔利德科学股份有限公司 |
核苷酸类似物组合物
|
|
TR200000224T2
(tr)
*
|
1997-07-25 |
2000-07-21 |
Gilead Sciences, Inc. |
Nükleotid analog kompozisyonlar.
|
|
KR100818845B1
(ko)
|
1998-09-09 |
2008-04-01 |
메타베이시스 테라퓨틱스, 인크. |
신규한 프럭토스 1,6-비스포스파타제의 헤테로방향족 억제제
|
|
US7026469B2
(en)
|
2000-10-19 |
2006-04-11 |
Wake Forest University School Of Medicine |
Compositions and methods of double-targeting virus infections and cancer cells
|
|
CA2747954C
(en)
*
|
1999-12-03 |
2014-02-25 |
The Regents Of The University Of California |
Phosphonate compounds
|
|
EP1914237B1
(de)
|
1999-12-03 |
2014-06-18 |
The Regents of The University of California |
Antivirale Phosphonatesterverbindungen
|
|
AU784370B2
(en)
*
|
1999-12-22 |
2006-03-23 |
Metabasis Therapeutics, Inc. |
Novel bisamidate phosphonate prodrugs
|
|
CN1426418A
(zh)
|
2000-02-29 |
2003-06-25 |
三菱制药株式会社 |
膦酸酯核苷酸化合物
|
|
JP2003525944A
(ja)
|
2000-03-08 |
2003-09-02 |
メタバシス・セラピューティクス・インコーポレイテッド |
新規アリールフルクトース−1,6−ビスホスファターゼ阻害剤
|
|
US7563774B2
(en)
|
2000-06-29 |
2009-07-21 |
Metabasis Therapeutics, Inc. |
Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes
|
|
US7309696B2
(en)
|
2000-10-19 |
2007-12-18 |
Wake Forest University |
Compositions and methods for targeting cancer cells
|
|
MY141789A
(en)
*
|
2001-01-19 |
2010-06-30 |
Lg Chem Investment Ltd |
Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same.
|
|
WO2003000187A2
(en)
*
|
2001-06-21 |
2003-01-03 |
Ariad Pharmaceuticals, Inc. |
Novel pyrazolo-and pyrrolo-pyrimidines and uses thereof
|
|
WO2003028737A1
(en)
*
|
2001-08-30 |
2003-04-10 |
Mitsubishi Pharma Corporation |
Anti-viral agents and in-vitro method for the identification of candidates able to inhibit binding of polymerase to epsilon
|
|
KR100871648B1
(ko)
|
2001-08-31 |
2008-12-03 |
톰슨 라이센싱 |
조건부 액세스 시스템을 구현하는 방법, 컨텐트를 전송하는 방법 및 그 장치 및 컨텐트를 수신하고 처리하는 방법 및 그 장치
|
|
JP2005511749A
(ja)
*
|
2001-12-07 |
2005-04-28 |
三菱ウェルファーマ株式会社 |
B型肝炎ウィルス感染症を治療するためのホスホネートヌクレオチド類似体の使用
|
|
WO2003091264A2
(en)
|
2002-04-26 |
2003-11-06 |
Gilead Sciences, Inc. |
Non nucleoside reverse transcriptase inhibitors
|
|
EP2223927B1
(de)
|
2002-05-13 |
2014-10-15 |
Metabasis Therapeutics, Inc. |
Salze einer auf Phosphonsäure basierenden Prodrug von PMEA
|
|
WO2003095665A2
(en)
*
|
2002-05-13 |
2003-11-20 |
Metabasis Therapeutics, Inc. |
Pmea and pmpa cyclic producing synthesis
|
|
RU2005108601A
(ru)
*
|
2002-09-26 |
2006-01-20 |
Эл Джи Лайф Сайенсиз Лтд. (Kr) |
(+)-транс-изомеры(1-фосфонометокси-2-алкилциклопропил)метилнуклеозидные производные, способ получения их стереоизомеров и применение указанных соединений в качестве противовирусных средств
|
|
BR0315795A
(pt)
*
|
2002-10-31 |
2005-09-13 |
Metabasis Therapeutics Inc |
Pró-medicamentos de monofosfato de citarabina
|
|
DK1583542T3
(da)
|
2003-01-14 |
2008-09-22 |
Gilead Sciences Inc |
Sammensætninger og fremgangsmåder til antiviral kombinationsterapi
|
|
US7452901B2
(en)
|
2003-04-25 |
2008-11-18 |
Gilead Sciences, Inc. |
Anti-cancer phosphonate analogs
|
|
US7470724B2
(en)
|
2003-04-25 |
2008-12-30 |
Gilead Sciences, Inc. |
Phosphonate compounds having immuno-modulatory activity
|
|
EA014685B1
(ru)
|
2003-04-25 |
2010-12-30 |
Джилид Сайэнс, Инк. |
Фосфонатсодержащие антивирусные соединения (варианты) и фармацевтическая композиция на их основе
|
|
US7407965B2
(en)
|
2003-04-25 |
2008-08-05 |
Gilead Sciences, Inc. |
Phosphonate analogs for treating metabolic diseases
|
|
WO2005002626A2
(en)
|
2003-04-25 |
2005-01-13 |
Gilead Sciences, Inc. |
Therapeutic phosphonate compounds
|
|
US7432261B2
(en)
|
2003-04-25 |
2008-10-07 |
Gilead Sciences, Inc. |
Anti-inflammatory phosphonate compounds
|
|
KR20060022647A
(ko)
|
2003-04-25 |
2006-03-10 |
길리애드 사이언시즈, 인코포레이티드 |
키나아제 억제 포스포네이트 유사체
|
|
US7427636B2
(en)
|
2003-04-25 |
2008-09-23 |
Gilead Sciences, Inc. |
Inosine monophosphate dehydrogenase inhibitory phosphonate compounds
|
|
US7300924B2
(en)
|
2003-04-25 |
2007-11-27 |
Gilead Sciences, Inc. |
Anti-infective phosphonate analogs
|
|
US20050080053A1
(en)
*
|
2003-08-29 |
2005-04-14 |
Biocryst Pharmaceuticals, Inc. |
Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases
|
|
WO2005044279A1
(en)
|
2003-10-24 |
2005-05-19 |
Gilead Sciences, Inc. |
Purine nucleoside phosphonate conjugates
|
|
WO2005042773A1
(en)
|
2003-10-24 |
2005-05-12 |
Gilead Sciences, Inc. |
Methods and compositions for identifying therapeutic compounds
|
|
WO2005044308A1
(en)
|
2003-10-24 |
2005-05-19 |
Gilead Sciences, Inc. |
Phosphonate analogs of antimetabolites
|
|
GB0326168D0
(en)
*
|
2003-11-10 |
2003-12-17 |
Arrow Therapeutics Ltd |
Chemical compounds
|
|
CN1882327A
(zh)
|
2003-11-19 |
2006-12-20 |
症变治疗公司 |
含磷的新的拟甲状腺素药
|
|
BRPI0417988A
(pt)
|
2003-12-22 |
2007-04-27 |
Gilead Sciences Inc |
análogos de fosfonato antivirais
|
|
JP2007523180A
(ja)
*
|
2004-02-17 |
2007-08-16 |
エルジー・ライフ・サイエンシーズ・リミテッド |
Hiv感染治療に有用なヌクレオシドホスホネート誘導体
|
|
CA2565966A1
(en)
|
2004-06-08 |
2005-12-29 |
Metabasis Therapeutics, Inc. |
Lewis acid mediated synthesis of cyclic esters
|
|
AU2005330489B2
(en)
|
2004-07-27 |
2011-08-25 |
Gilead Sciences, Inc. |
Nucleoside phosphonate conjugates as anti HIV agents
|
|
JP2008510018A
(ja)
*
|
2004-08-18 |
2008-04-03 |
メタバシス・セラピューティクス・インコーポレイテッド |
フルクトース−1,6−ビスホスファターゼの新規チアゾール阻害物質
|
|
US8642577B2
(en)
|
2005-04-08 |
2014-02-04 |
Chimerix, Inc. |
Compounds, compositions and methods for the treatment of poxvirus infections
|
|
TWI471145B
(zh)
|
2005-06-13 |
2015-02-01 |
Bristol Myers Squibb & Gilead Sciences Llc |
單一式藥學劑量型
|
|
TWI375560B
(en)
|
2005-06-13 |
2012-11-01 |
Gilead Sciences Inc |
Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
|
|
WO2007014491A1
(fr)
*
|
2005-08-03 |
2007-02-08 |
Beijing Fu Kang Ren Bio-Pharm Tech.Co.Ltd. |
Phosphonates de nucléotides acycliques et leur utilisation dans des agents antiviraux
|
|
WO2007058927A1
(en)
|
2005-11-11 |
2007-05-24 |
The Scripps Research Institute |
Histone deacetylase inhibitors as therapeutics for neurological diseases
|
|
JP2009542698A
(ja)
|
2006-07-07 |
2009-12-03 |
ギリアード サイエンシーズ, インコーポレイテッド |
抗ウイルスホスフィナート化合物
|
|
US7842672B2
(en)
|
2006-07-07 |
2010-11-30 |
Gilead Sciences, Inc. |
Phosphonate inhibitors of HCV
|
|
KR20200123866A
(ko)
|
2007-02-09 |
2020-10-30 |
메타베이시스 테라퓨틱스, 인크. |
글루카곤 수용체의 길항제
|
|
CA2683316A1
(en)
|
2007-04-13 |
2009-02-19 |
Southern Research Institute |
Anti-angiogenic agents and methods of use
|
|
CN101821276B
(zh)
|
2007-08-13 |
2016-08-31 |
症变治疗公司 |
新颖的葡糖激酶活化剂
|
|
ES2572631T3
(es)
|
2008-01-25 |
2016-06-01 |
Chimerix, Inc. |
Métodos de tratamiento de infecciones virales
|
|
TWI444384B
(zh)
*
|
2008-02-20 |
2014-07-11 |
Gilead Sciences Inc |
核苷酸類似物及其在治療惡性腫瘤上的用途
|
|
US8658617B2
(en)
|
2008-07-08 |
2014-02-25 |
Gilead Sciences, Inc. |
Salts of HIV inhibitor compounds
|
|
PT2799428T
(pt)
|
2008-08-13 |
2017-02-17 |
Metabasis Therapeutics Inc |
Antagonistas de glicagina
|
|
US8273754B2
(en)
|
2008-12-30 |
2012-09-25 |
Arqule, Inc. |
Substituted 1H-pyrazolo[3,4-D]pyrimidine-6-amine compounds
|
|
US8343961B2
(en)
|
2009-03-31 |
2013-01-01 |
Arqule, Inc. |
Substituted heterocyclic compounds
|
|
WO2011011519A1
(en)
|
2009-07-21 |
2011-01-27 |
Chimerix, Inc. |
Compounds, compositions and methods for treating ocular conditions
|
|
US9006218B2
(en)
|
2010-02-12 |
2015-04-14 |
Chimerix Inc. |
Nucleoside phosphonate salts
|
|
US8940313B2
(en)
|
2010-04-23 |
2015-01-27 |
University Of Southern California |
Tyrosine-based prodrugs of antiviral agents
|
|
CA2797601A1
(en)
|
2010-04-26 |
2011-11-10 |
Chimerix, Inc. |
Methods of treating retroviral infections and related dosage regimes
|
|
WO2012079035A1
(en)
|
2010-12-10 |
2012-06-14 |
Sigmapharm Laboratories, Llc |
Highly stable compositions of orally active nucleotide analogues or orally active nucleotide analogue prodrugs
|
|
US9550803B2
(en)
|
2011-05-06 |
2017-01-24 |
University Of Southern California |
Method to improve antiviral activity of nucleotide analogue drugs
|
|
EP3578563B1
(de)
|
2011-12-22 |
2021-04-14 |
Geron Corporation |
Guanin-analoga als telomerasesubstrate und telomerlängenaffektoren
|
|
CN102786549B
(zh)
*
|
2012-08-13 |
2013-07-03 |
洛阳聚慧投资股份有限公司 |
一组具有抑制hiv-1病毒复制活性的替诺福韦双酯化合物、制备方法及其药物用途
|
|
SG10201800188SA
(en)
|
2013-03-15 |
2018-02-27 |
Univ California |
Acyclic nucleoside phosphonate diesters
|
|
AU2015217221A1
(en)
|
2014-02-13 |
2016-08-11 |
Ligand Pharmaceuticals, Inc. |
Prodrug compounds and their uses
|
|
CN103819472A
(zh)
*
|
2014-03-18 |
2014-05-28 |
福建天泉药业股份有限公司 |
缬恩替卡韦酸式加成盐及其制备方法
|
|
WO2015191900A1
(en)
|
2014-06-12 |
2015-12-17 |
Ligand Pharmaceuticals, Inc. |
Glucagon antagonists
|
|
CN106687118A
(zh)
|
2014-07-02 |
2017-05-17 |
配体药物公司 |
前药化合物及其用途
|
|
CN111808136B
(zh)
|
2014-09-15 |
2024-06-11 |
加利福尼亚大学董事会 |
核苷酸类似物
|
|
EP3350191B9
(de)
|
2015-09-15 |
2021-12-22 |
The Regents of the University of California |
Nukleotidanaloga
|
|
BR112018071559B1
(pt)
|
2016-04-22 |
2024-02-06 |
Viking Therapeutics, Inc |
Uso de um agonista de receptor beta de hormônios da tireoide para o tratamento de adrenoleucodistrofia ligada ao x
|
|
SI3661937T1
(sl)
|
2017-08-01 |
2021-11-30 |
Gilead Sciences, Inc. |
Kristalinične oblike etil((S)-((((2R,5R)-5-(6-amino-9H-purin-9-IL)-4- fluoro-2,5-dihidrofuran-2-IL)oksi)metil)(fenoksi)fosforil)-L-alaninata (GS-9131) za zdravljenje virusnih okužb
|
|
CA3087932A1
(en)
|
2018-01-09 |
2019-07-18 |
Ligand Pharmaceuticals, Inc. |
Acetal compounds and therapeutic uses thereof
|
|
WO2019160940A1
(en)
|
2018-02-13 |
2019-08-22 |
Ligand Pharmaceuticals Incorporated |
Glucagon receptor antagonists
|
|
KR20250052378A
(ko)
|
2022-07-21 |
2025-04-18 |
안티바 바이오사이언시즈, 인크. |
Hpv 감염 및 hpv-유도 신생물의 치료를 위한 조성물 및 투여 형태
|
|
CN119586613B
(zh)
*
|
2025-02-08 |
2025-04-29 |
浙江大学 |
多元醇乙二酸酯聚合物载药缓控释微球的制备方法
|