BRPI0417988A - análogos de fosfonato antivirais - Google Patents

análogos de fosfonato antivirais

Info

Publication number
BRPI0417988A
BRPI0417988A BRPI0417988-9A BRPI0417988A BRPI0417988A BR PI0417988 A BRPI0417988 A BR PI0417988A BR PI0417988 A BRPI0417988 A BR PI0417988A BR PI0417988 A BRPI0417988 A BR PI0417988A
Authority
BR
Brazil
Prior art keywords
compounds
phosphonate analogs
antiviral phosphonate
antiviral
methods
Prior art date
Application number
BRPI0417988-9A
Other languages
English (en)
Inventor
Maria Fardis
Choung U Kim
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of BRPI0417988A publication Critical patent/BRPI0417988A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"ANáLOGOS DE FOSFONATO ANTIVIRAIS". A presente invenção refere-se a derivados de nucleosídeo 4<39>-substituídos de fórmula I: onde B e R¬ 1¬ têm qualquer um dos valores descritos no pedido, assim como a composições compreendendo tais compostos, métodos e intermediários úteis para preparar tais compostos, e métodos terapêuticos compreendendo administrar tais compostos a animais com necessidades dos mesmos.
BRPI0417988-9A 2003-12-22 2004-12-22 análogos de fosfonato antivirais BRPI0417988A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53225603P 2003-12-22 2003-12-22
PCT/US2004/043571 WO2005063751A1 (en) 2003-12-22 2004-12-22 4’-substituted carbovir-and abacavir-derivatives as well as related compounds with hiv and hcv antiviral activity

Publications (1)

Publication Number Publication Date
BRPI0417988A true BRPI0417988A (pt) 2007-04-27

Family

ID=34738778

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0417988-9A BRPI0417988A (pt) 2003-12-22 2004-12-22 análogos de fosfonato antivirais

Country Status (13)

Country Link
US (2) US7432272B2 (pt)
EP (1) EP1706405B1 (pt)
JP (1) JP2007515495A (pt)
KR (1) KR20060127906A (pt)
CN (1) CN1906196A (pt)
AT (1) ATE424400T1 (pt)
AU (1) AU2004309418B2 (pt)
BR (1) BRPI0417988A (pt)
CA (1) CA2548753A1 (pt)
DE (1) DE602004019815D1 (pt)
MX (1) MXPA06006899A (pt)
NZ (1) NZ547907A (pt)
WO (1) WO2005063751A1 (pt)

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DE10204821A1 (de) * 2002-02-01 2003-08-14 Obe Ohnmacht & Baumgaertner Federscharnier
PL1628685T3 (pl) 2003-04-25 2011-05-31 Gilead Sciences Inc Przeciwwirusowe analogi fosfonianowe
DE602004019815D1 (de) * 2003-12-22 2009-04-16 Gilead Sciences Inc 4'-substituierte carbovir- und abacavir-derivate sowie verwandte verbindungen mit hiv- und hcv-antiviraler wirkung
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EP2085397A1 (en) * 2008-01-21 2009-08-05 Esteve Quimica, S.A. Crystalline form of abacavir
AU2009268681B2 (en) 2008-07-08 2014-10-02 Gilead Sciences, Inc. Salts of HIV inhibitor compounds
US8760000B2 (en) 2010-11-19 2014-06-24 Honeywell International Inc. Mixed signal conversion, isolation, and transmission for aerospace multi-channel data and power interface systems
GEP201706656B (en) 2011-11-11 2017-04-25 Pfizer 2-thiopyrimidinones
IL296496B2 (en) 2014-12-26 2024-10-01 Univ Emory N4-hydroxycytidine and derivatives and anti-viral uses related thereto
MA42035A (fr) 2015-05-05 2018-03-14 Pfizer 2-thiopyrimidinones
EP3661937B1 (en) 2017-08-01 2021-07-28 Gilead Sciences, Inc. Crystalline forms of ethyl ((s)-((((2r,5r)-5-(6-amino-9h-purin-9-yl)-4-fluoro-2,5-dihydrofuran-2-yl)oxy)methyl)(phenoxy)phosphoryl)-l-alaninate (gs-9131) for treating viral infections
KR102626210B1 (ko) 2017-12-07 2024-01-18 에모리 유니버시티 N4-하이드록시사이티딘 및 유도체 및 이와 관련된 항-바이러스 용도

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Also Published As

Publication number Publication date
CN1906196A (zh) 2007-01-31
DE602004019815D1 (de) 2009-04-16
US20050222180A1 (en) 2005-10-06
EP1706405A1 (en) 2006-10-04
US20080287471A1 (en) 2008-11-20
AU2004309418B2 (en) 2012-01-19
EP1706405B1 (en) 2009-03-04
JP2007515495A (ja) 2007-06-14
WO2005063751A1 (en) 2005-07-14
MXPA06006899A (es) 2006-09-04
AU2004309418A1 (en) 2005-07-14
US7432272B2 (en) 2008-10-07
NZ547907A (en) 2010-07-30
KR20060127906A (ko) 2006-12-13
CA2548753A1 (en) 2005-07-14
HK1094892A1 (en) 2007-04-13
ATE424400T1 (de) 2009-03-15

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2260 DE 29/04/2014.