ATE199909T1 - Derivate der phosphonsäure, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen die sie enthalten - Google Patents

Derivate der phosphonsäure, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen die sie enthalten

Info

Publication number: ATE199909T1
Authority: AT; Austria
Prior art keywords: group; alkyl; substituted; production; pharmaceutical compositions
Prior art date: 1993-06-30

Application number

AT94401268T

Other languages

English (en)

Inventor

Nanteuil Guillaume De

Georges Remond

Tony Verbeuren

Original Assignee

Adir

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-06-30

Filing date

1994-06-08

Publication date

2001-04-15

1994-06-08 Application filed by Adir filed Critical Adir

2001-04-15 Application granted granted Critical

2001-04-15 Publication of ATE199909T1 publication Critical patent/ATE199909T1/de

Links

229940042400 direct acting antivirals phosphonic acid derivative Drugs 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
150000003007 phosphonic acid derivatives Chemical class 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 3
-1 benzyloxy, benzyloxycarbonylamino, amino Chemical group 0.000 abstract 3
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
229940093817 Convertase inhibitor Drugs 0.000 abstract 1
102000002045 Endothelin Human genes 0.000 abstract 1
108050009340 Endothelin Proteins 0.000 abstract 1
125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004663 dialkyl amino group Chemical group 0.000 abstract 1
ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
229940126601 medicinal product Drugs 0.000 abstract 1
125000004923 naphthylmethyl group Chemical group C1(=CC=CC2=CC=CC=C12)C* 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000000547 substituted alkyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Animal Behavior & Ethology (AREA)
Biophysics (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT94401268T 1993-06-30 1994-06-08 Derivate der phosphonsäure, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen die sie enthalten ATE199909T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9307927A FR2707089B1 (fr)	1993-06-30	1993-06-30	Nouveaux dérivés d'acide phosphonique, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.

Publications (1)

Publication Number	Publication Date
ATE199909T1 true ATE199909T1 (de)	2001-04-15

Family

ID=9448690

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94401268T ATE199909T1 (de)	1993-06-30	1994-06-08	Derivate der phosphonsäure, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen die sie enthalten

Country Status (10)

Country	Link
US (3)	US5481030A (de)
EP (1)	EP0639586B1 (de)
JP (1)	JP2653976B2 (de)
AT (1)	ATE199909T1 (de)
AU (1)	AU677654B2 (de)
CA (1)	CA2127067C (de)
DE (1)	DE69426908D1 (de)
FR (1)	FR2707089B1 (de)
NZ (1)	NZ260873A (de)
ZA (1)	ZA944727B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5962490A (en)	1987-09-25	1999-10-05	Texas Biotechnology Corporation	Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US6342610B2 (en)	1993-05-20	2002-01-29	Texas Biotechnology Corp.	N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US6030991A (en) *	1993-05-20	2000-02-29	Texas Biotechnology Corp.	Benzenesulfonamides and the use thereof to modulate the activity of endothelin
US6376523B1 (en)	1994-05-20	2002-04-23	Texas Biotechnology Corporation	Benzenesulfonamides and the use thereof to modulate the activity of endothelin
US6541498B2 (en)	1993-05-20	2003-04-01	Texas Biotechnology	Benzenesulfonamides and the use thereof to modulate the activity of endothelin
US6613804B2 (en)	1993-05-20	2003-09-02	Encysive Pharmaceuticals, Inc.	Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin
US5958905A (en)	1996-03-26	1999-09-28	Texas Biotechnology Corporation	Phosphoramidates, phosphinic amides and related compounds and the use thereof to modulate the activity of endothelin
US5804585A (en)	1996-04-15	1998-09-08	Texas Biotechnology Corporation	Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin
US5783705A (en) *	1997-04-28	1998-07-21	Texas Biotechnology Corporation	Process of preparing alkali metal salys of hydrophobic sulfonamides
TR200202738T2 (tr)	1997-04-28	2003-03-21	Texas Biotechnology Corporation	Endotelin ile ilgili hastalıkların tedavisinde kullanılan sülfanoamidler
WO2007119214A2 (en) *	2006-04-13	2007-10-25	Actelion Pharmaceuticals Ltd	Endothelin receptor antagonists for early stage idiopathic pulmonary fibrosis

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4432971A (en) *	1981-08-03	1984-02-21	E. R. Squibb & Sons, Inc.	Phosphonamidate compounds
FR2543778A1 (fr) *	1983-04-01	1984-10-05	Soulier Joel	Dispositif de couplage d'une onde electromagnetique sur un materiau absorbant
US4853476A (en) *	1984-12-24	1989-08-01	Schering Corporation	Phosphorus containing compounds as inhibitors of enkephalinases
CA1337400C (en) *	1987-06-08	1995-10-24	Norma G. Delaney	Inhibitors of neutral endopeptidase
JPH05105698A (ja) *	1991-06-13	1993-04-27	Takeda Chem Ind Ltd	ホスホン酸誘導体、その製造法および用途
US5504070A (en) *	1991-12-05	1996-04-02	Berlex Laboratories, Inc.	Inhibitors of the conversion of big endothelin to endothelin

1993
- 1993-06-30 FR FR9307927A patent/FR2707089B1/fr not_active Expired - Lifetime
1994
- 1994-06-08 DE DE69426908T patent/DE69426908D1/de not_active Expired - Lifetime
- 1994-06-08 EP EP94401268A patent/EP0639586B1/de not_active Expired - Lifetime
- 1994-06-08 AT AT94401268T patent/ATE199909T1/de not_active IP Right Cessation
- 1994-06-28 AU AU66025/94A patent/AU677654B2/en not_active Ceased
- 1994-06-29 CA CA002127067A patent/CA2127067C/fr not_active Expired - Fee Related
- 1994-06-29 JP JP6147687A patent/JP2653976B2/ja not_active Expired - Lifetime
- 1994-06-29 US US08/267,971 patent/US5481030A/en not_active Expired - Fee Related
- 1994-06-29 NZ NZ260873A patent/NZ260873A/en unknown
- 1994-06-30 ZA ZA944727A patent/ZA944727B/xx unknown
1995
- 1995-07-03 US US08/497,811 patent/US5591728A/en not_active Expired - Fee Related
- 1995-07-03 US US08/497,812 patent/US5608045A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE69426908D1 (de)	2001-04-26
CA2127067C (fr)	2000-12-26
ZA944727B (en)	1995-07-13
FR2707089B1 (fr)	1995-08-18
EP0639586A1 (de)	1995-02-22
AU6602594A (en)	1995-01-12
AU677654B2 (en)	1997-05-01
US5608045A (en)	1997-03-04
US5591728A (en)	1997-01-07
NZ260873A (en)	1996-01-26
JP2653976B2 (ja)	1997-09-17
JPH07224091A (ja)	1995-08-22
US5481030A (en)	1996-01-02
CA2127067A1 (fr)	1994-12-31
EP0639586B1 (de)	2001-03-21
FR2707089A1 (fr)	1995-01-06

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Legal Events

Date	Code	Title	Description
2001-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties