ATE200183T1 - Reinigung von zein aus weizenglutenmehl - Google Patents
Reinigung von zein aus weizenglutenmehlInfo
- Publication number
- ATE200183T1 ATE200183T1 AT93901944T AT93901944T ATE200183T1 AT E200183 T1 ATE200183 T1 AT E200183T1 AT 93901944 T AT93901944 T AT 93901944T AT 93901944 T AT93901944 T AT 93901944T AT E200183 T1 ATE200183 T1 AT E200183T1
- Authority
- AT
- Austria
- Prior art keywords
- zein
- corn gluten
- bodies
- starch
- alcohol
- Prior art date
Links
- 108010068370 Glutens Proteins 0.000 title abstract 8
- 229920002494 Zein Polymers 0.000 title abstract 8
- 239000005019 zein Substances 0.000 title abstract 8
- 229940093612 zein Drugs 0.000 title abstract 8
- 235000021312 gluten Nutrition 0.000 title abstract 6
- 241000209140 Triticum Species 0.000 title 1
- 235000021307 Triticum Nutrition 0.000 title 1
- 238000004140 cleaning Methods 0.000 title 1
- 235000013312 flour Nutrition 0.000 title 1
- 235000013305 food Nutrition 0.000 abstract 6
- 240000008042 Zea mays Species 0.000 abstract 5
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 abstract 5
- 235000002017 Zea mays subsp mays Nutrition 0.000 abstract 5
- 235000005822 corn Nutrition 0.000 abstract 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 3
- 229920002472 Starch Polymers 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 235000019698 starch Nutrition 0.000 abstract 3
- 239000008107 starch Substances 0.000 abstract 3
- 235000012054 meals Nutrition 0.000 abstract 2
- 239000000049 pigment Substances 0.000 abstract 2
- 108010082495 Dietary Plant Proteins Proteins 0.000 abstract 1
- 108010009736 Protein Hydrolysates Proteins 0.000 abstract 1
- 239000006227 byproduct Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- 229940116540 protein supplement Drugs 0.000 abstract 1
- 235000005974 protein supplement Nutrition 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J3/00—Working-up of proteins for foodstuffs
- A23J3/14—Vegetable proteins
- A23J3/18—Vegetable proteins from wheat
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
- C07K14/425—Zeins
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Polymers & Plastics (AREA)
- Botany (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nutrition Science (AREA)
- Peptides Or Proteins (AREA)
- General Preparation And Processing Of Foods (AREA)
- Detergent Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/814,118 US5254673A (en) | 1991-12-26 | 1991-12-26 | Purification of zein from corn gluten meal |
| PCT/US1992/011134 WO1993012667A1 (en) | 1991-12-26 | 1992-12-18 | Purification of zein from corn gluten meal |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE200183T1 true ATE200183T1 (de) | 2001-04-15 |
Family
ID=25214214
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93901944T ATE200183T1 (de) | 1991-12-26 | 1992-12-18 | Reinigung von zein aus weizenglutenmehl |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US5254673A (de) |
| EP (1) | EP0648078B1 (de) |
| JP (1) | JPH07502416A (de) |
| AT (1) | ATE200183T1 (de) |
| CA (1) | CA2126668A1 (de) |
| DE (1) | DE69231771D1 (de) |
| WO (1) | WO1993012667A1 (de) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5254673A (en) * | 1991-12-26 | 1993-10-19 | Opta Food Ingredients, Inc. | Purification of zein from corn gluten meal |
| JP2772213B2 (ja) * | 1992-12-25 | 1998-07-02 | 昭和産業株式会社 | ツェインの製造方法 |
| US5736178A (en) * | 1995-05-02 | 1998-04-07 | Opta Food Ingredients, Inc. | Colloidal dispersions of gluten, method of making and use therefor |
| US5847238A (en) * | 1995-06-07 | 1998-12-08 | Cargill, Incorporated | Processes for recovering xanthophylls from corn gluten meal |
| US5602286A (en) * | 1995-06-07 | 1997-02-11 | Cargill, Incorporated | Process for recovering xanthophylls from corn gluten |
| US5916610A (en) * | 1997-09-03 | 1999-06-29 | Grain Processing Corporation | NPN delivery system and method for preparing same |
| US6174559B1 (en) | 1998-12-24 | 2001-01-16 | Opta Food Ingredients, Inc. | Gluten-derived colloidal dispersions and edible coatings therefrom and method of making |
| US6197353B1 (en) | 1998-12-24 | 2001-03-06 | Opta Food Ingredients, Inc. | Gluten-derived colloidal dispersions, edible coatings therefrom and method of making |
| CA2276066A1 (en) | 1999-03-11 | 2000-09-11 | Zycos Inc. | Microparticles for delivery of nucleic acid |
| US7045607B2 (en) * | 1999-05-18 | 2006-05-16 | The Board Of Trustees Of The University Of Illinois | Method and system for extraction of zein from corn |
| US6433146B1 (en) * | 1999-05-18 | 2002-08-13 | The Board Of Trustees Of The University Of Illinois | Corn oil and protein extraction method |
| US6610831B1 (en) | 1999-12-21 | 2003-08-26 | Lurgi Psi, Ltd. | Methods and apparatus for recovering zein from corn |
| US20040009263A1 (en) * | 2001-02-02 | 2004-01-15 | Jingping Liu | Methods for extracting corn proteins from corn gluten meal |
| AU2002255913B2 (en) * | 2001-03-27 | 2007-10-18 | Syngenta Seeds, Inc. | Uses of white corn hybrids |
| US6648978B2 (en) * | 2001-10-15 | 2003-11-18 | A. E. Staley Manufacturing Co. | Membrane filtration for thickening and starch washing in corn wet milling |
| US20030180415A1 (en) * | 2002-03-20 | 2003-09-25 | Stiefel Michael J. | High protein concentrate from cereal grain and methods of use thereof |
| JP4383345B2 (ja) * | 2002-06-21 | 2009-12-16 | バーコン ニュートラサイエンス (エムビー) コーポレイション | カノーラ油料種子粕からのタンパク質の抽出 |
| US20050106300A1 (en) * | 2003-06-30 | 2005-05-19 | Purdue Research Foundation | Method for producing a material having an increased solubility in alcohol |
| AR047658A1 (es) * | 2004-02-03 | 2006-02-01 | Cargill Inc | Concentrado de proteinas y corriente acuosa con carbohidratos hidrosolubles |
| US20100301254A1 (en) * | 2004-06-23 | 2010-12-02 | University Of Maine System Board Of Trustees | Barrier compositions and articles produced with the compositions |
| US7737200B2 (en) * | 2004-06-23 | 2010-06-15 | University Of Maine System Board Of Trustees | Barrier compositions and articles produced with the compositions |
| WO2006017712A2 (en) * | 2004-08-05 | 2006-02-16 | The Board Of Trustees Of The University Of Illinois | Corn oil and dextrose extraction apparatus and method |
| US7569671B2 (en) | 2005-01-06 | 2009-08-04 | The Board Of Trustees Of The University Of Illinois | Method and system for corn fractionation |
| US8344108B2 (en) * | 2005-01-06 | 2013-01-01 | The Board Of Trustees Of The University Of Illinois | Method and system for corn fractionation |
| US7854955B2 (en) * | 2005-03-21 | 2010-12-21 | Archer-Daniels-Midland Company | Corn fiber hulls as a food additive or animal feed |
| US20090148589A1 (en) | 2005-08-03 | 2009-06-11 | Fox Eugene J | Corn protein concentrates |
| US20090209423A1 (en) * | 2005-08-03 | 2009-08-20 | Johannis Slabbekoorn | Corn protein concentrates |
| EP2266420B1 (de) * | 2005-11-10 | 2016-10-19 | Cargill, Incorporated | Pflanzenproteinpellets |
| DE602007009045D1 (de) * | 2006-01-05 | 2010-10-21 | Med Inst Inc | Zein-beschichtete medizinische vorrichtung |
| WO2007133596A2 (en) * | 2006-05-08 | 2007-11-22 | The Board Of Trustees Of The University Of Illinois | Method and system for production of zein and/or xanthophylls using chromatography |
| US7939633B2 (en) * | 2007-03-27 | 2011-05-10 | The United States Of America As Represented By The Secretary Of Agriculture | Decolorization/deodorization of corn zein products |
| US20090069542A1 (en) * | 2007-09-12 | 2009-03-12 | Board Of Regents Of The University Of Nebraska | Process Of Extracting High Quality Proteins From Cereal Grains And Their ByProducts Using Acidic Medium And A Reducing Agent |
| EP2214747A2 (de) * | 2007-11-20 | 2010-08-11 | Cook Incorporated | Gesteuerte wirkstofffreisetzung mit anhand von lävulinsäure veränderter zeinschicht |
| KR101616771B1 (ko) | 2008-05-09 | 2016-04-29 | 사우스다코타주립대학 | 비면역원성의 소수성 단백질 나노입자의 형성방법 및 그 용도 |
| CA2725751C (en) * | 2008-06-12 | 2016-12-20 | Eduard Tearo | Isolation of protein products from defatted meal |
| EP2381760B1 (de) | 2008-12-31 | 2016-12-28 | POET Research, Inc. | Maiseiweisszusammensetzung |
| US9504274B2 (en) * | 2009-01-27 | 2016-11-29 | Frito-Lay North America, Inc. | Methods of flavor encapsulation and matrix-assisted concentration of aqueous foods and products produced therefrom |
| US9481737B2 (en) * | 2009-03-12 | 2016-11-01 | Industrias Nutrigrains, S.A., De C.V. | Hybrid vegetable protein and method for obtaining same |
| IT1400917B1 (it) * | 2010-07-02 | 2013-07-02 | Schar Gmbh Srl Dr | Procedimento per la produzione di proteine di mais ed uso di dette proteine per la produzione di prodotti da forno e pasta senza glutine |
| EP2678007A4 (de) | 2011-02-25 | 2015-08-12 | Univ South Dakota | Proteinnanoträger zur topischen verabreichung |
| WO2012155295A1 (zh) | 2011-05-17 | 2012-11-22 | 中国食品发酵工业研究院 | 一种工业化生产玉米降压活性肽的方法 |
| AU2012280966B2 (en) * | 2011-07-14 | 2017-03-16 | Poet Research, Inc. | Water-based prolamin compositions, methods of making water-based prolamin compositions, and applications thereof |
| US9883691B2 (en) | 2012-03-09 | 2018-02-06 | Kraft Foods Group Brands Llc | Food and beverage products containing 1,3-propanediol and methods of modifying flavor release using 1,3-propanediol |
| CN104203004B (zh) | 2012-03-09 | 2017-07-07 | 卡夫食品集团品牌有限责任公司 | 可食用组合物中氧化风味特征的抑制 |
| GB201303876D0 (en) * | 2013-01-29 | 2013-04-17 | Verenium Corp | Animal feed enzyme extraction |
| US9273227B2 (en) | 2013-03-06 | 2016-03-01 | Poet Research, Inc. | Waterborne aqueous-alcohol soluble protein compositions, applications, and methods |
| US9751260B2 (en) | 2013-07-24 | 2017-09-05 | The Boeing Company | Additive-manufacturing systems, apparatuses and methods |
| CN104774253A (zh) * | 2015-03-06 | 2015-07-15 | 广东省食品工业研究所 | 一种玉米醇溶蛋白的制备方法 |
| MX391223B (es) * | 2015-03-24 | 2025-03-21 | Cargill Inc | Aislado de proteina de maiz y metodos de manufacturacion del mismo. |
| US20160286840A1 (en) * | 2015-04-02 | 2016-10-06 | Prairie Gold, Inc. | Method for reducing prolamine content of cereal products |
| MX2018011370A (es) | 2016-03-24 | 2019-02-13 | Cargill Inc | Producto de proteina de maiz con menores niveles de sulfito libre y metodo para elaborarlo. |
| EP3432733A4 (de) * | 2016-03-24 | 2019-11-13 | Cargill, Incorporated | Maisproteinkonzentrat und verfahren zur herstellung davon |
| US20170295822A1 (en) * | 2016-04-15 | 2017-10-19 | Corn Products Development, Inc. | Natural, biodegradable beadlets and process to manufacture |
| US11985990B2 (en) | 2016-09-23 | 2024-05-21 | Cargill, Incorporated | Corn protein retention during extraction |
| EP3661368A4 (de) | 2017-08-02 | 2021-04-28 | Cargill, Incorporated | Extrudiertes maisproteinmaterial |
| US11667670B2 (en) | 2017-09-21 | 2023-06-06 | Cargill, Incorporated | Corn protein retention during extraction |
| CA3075418A1 (en) * | 2017-09-22 | 2019-03-28 | Cargill, Incorporated | Zein-enriched and depleted protein |
| CN107652361A (zh) * | 2017-11-28 | 2018-02-02 | 河南工业大学 | 利用蔗糖密度梯度离心法分离小麦醇溶蛋白的方法 |
| CN109984200A (zh) * | 2017-12-29 | 2019-07-09 | 中粮营养健康研究院有限公司 | 一种奶油组合物及其制备方法 |
| JP7053011B2 (ja) * | 2018-03-05 | 2022-04-12 | 国立大学法人広島大学 | ゲル添加剤の製造方法およびゲル添加剤の利用 |
| WO2021211995A1 (en) * | 2020-04-16 | 2021-10-21 | Akorn Technology, Inc. | Edible films and coatings employing water soluble corn prolamin and other functional ingredients |
| BR112022021894A2 (pt) * | 2020-04-30 | 2023-01-24 | Cargill Inc | Método de preparação de uma composição de hidrolisado de proteína enriquecida com zeína refinada e/ou uma composição de hidrolisado de proteína sem zeína refinada, composição de hidrolisado de proteína enriquecida com zeína refinada, composição de hidrolisado de proteína sem zeína refinada, composição de hidrolisado de proteína enriquecida com zeína refinada solúvel em água e insolúvel em água, composição de hidrolisado de proteína sem zeína refinada solúvel em água e insolúvel em água, bebida, e, produto alimentício não líquido e de suplemento nutricional |
| EP4161670A1 (de) | 2020-06-09 | 2023-04-12 | Traceless Materials GmbH | Verfahren zur herstellung von wasserfesten folien aus maisglutenmehl |
| CN112998128A (zh) * | 2021-03-18 | 2021-06-22 | 廊坊梅花生物技术开发有限公司 | 利用玉米糖渣生产饲料的方法 |
| CN113854397A (zh) * | 2021-10-09 | 2021-12-31 | 山东香驰健源生物科技有限公司 | 一种麸质水提取玉米浓缩蛋白的方法 |
| LU500976B1 (en) | 2021-12-09 | 2023-06-09 | Traceless Mat Gmbh | Process for producing a thermoplastic material for use as a powder or granulate for further processing such as injection moulding or coating |
| LU500975B1 (en) | 2021-12-09 | 2023-06-09 | Traceless Mat Gmbh | Process for producing a thermoplastic material for use as a film or as a flexible coating |
| CN114656548A (zh) * | 2022-04-13 | 2022-06-24 | 练文飞 | 一种降血压肽及其制备方法和应用 |
| CN117917219A (zh) * | 2022-10-21 | 2024-04-23 | 泰兴市东圣生物科技有限公司 | 一种高纯度螺旋藻蛋白质组合物及其制备方法 |
| WO2025045380A1 (en) * | 2023-09-01 | 2025-03-06 | Symrise Ag | Extraction process for plant-based proteins and cosmetic compositions based thereon |
| WO2025140303A1 (en) * | 2023-12-28 | 2025-07-03 | Novozymes A/S | Enzymatic treatment of a material comprising corn protein |
| CN117964729A (zh) * | 2024-02-08 | 2024-05-03 | 江苏科技大学 | 一种谷朊粉分离提纯醇溶蛋白的方法 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2238591A (en) * | 1941-04-15 | Process of precipitating zeinfkom | ||
| US2229870A (en) * | 1941-01-28 | Preparation and purification of zein | ||
| US2554750A (en) * | 1951-05-29 | Preparation of zein | ||
| US2287649A (en) * | 1942-06-23 | Process for the production of zein | ||
| GB536024A (de) * | ||||
| US2733234A (en) * | 1956-01-31 | Purification and recovery of zein | ||
| US2360381A (en) * | 1944-10-17 | Production and treatment of zein | ||
| CA480762A (en) * | 1952-01-29 | E. Coleman Roy | Method of preparing zein solutions directly from gluten | |
| US2133591A (en) * | 1938-10-18 | Isjjuwyjjji | ||
| US2272488A (en) * | 1942-02-10 | Process fok the production of zein | ||
| US1245818A (en) * | 1916-11-25 | 1917-11-06 | Jokichi Takamine | Process of obtaining proteid matter from corn. |
| US1280862A (en) * | 1916-12-30 | 1918-10-08 | Sadakichi Satow | Celluloid-like substance and process of making the same. |
| US2156928A (en) * | 1935-05-08 | 1939-05-02 | Corn Prod Refining Co | Process for the production of zein |
| US2105760A (en) * | 1935-05-08 | 1938-01-18 | Corn Prod Refining Co | Process for the production of zein |
| US2120946A (en) * | 1935-05-08 | 1938-06-14 | Corn Prod Refining Co | Process for the production of zein |
| US2044769A (en) * | 1935-08-07 | 1936-06-23 | Little Inc A | Process for preparing zein |
| US2221560A (en) * | 1937-07-26 | 1940-11-12 | Corn Prod Refining Co | Stabilization of a zein solution by clarification |
| US2206310A (en) * | 1937-08-02 | 1940-07-02 | Corn Prod Refining Co | Treatment of zein solutions |
| US2332356A (en) * | 1940-08-03 | 1943-10-19 | Corn Prod Refining Co | Production of zein |
| US2355056A (en) * | 1942-11-30 | 1944-08-08 | Time Inc | Preparation of zein solutions directly from gluten |
| US2479519A (en) * | 1947-02-24 | 1949-08-16 | American Maize Prod Co | Method for recovering corn oil and corn protein |
| GB651396A (en) * | 1947-06-24 | 1951-04-04 | Bx Plastics Ltd | Improvements in and relating to the purification of zein |
| US2676169A (en) * | 1951-09-26 | 1954-04-20 | Corn Prod Refining Co | Method of treating zein |
| US2882265A (en) * | 1957-01-14 | 1959-04-14 | Corn Products Co | Process for recovering whole zein |
| US3535305A (en) * | 1968-02-12 | 1970-10-20 | Nutrilite Products | Low temperature solvent extraction process for producing high purity zein |
| US3782964A (en) * | 1969-01-21 | 1974-01-01 | Cpc International Inc | Method of upgrading starch-containing crude gluten |
| US3840515A (en) * | 1972-02-07 | 1974-10-08 | Cpc International Inc | Method of treating gluten |
| US3802896A (en) * | 1972-05-15 | 1974-04-09 | Nutrilite Products | Color concentrated base dispersion used in tablet film coating |
| US3880665A (en) * | 1972-05-24 | 1975-04-29 | Agfa Gevaert Ag | Hardening with a heterocyclic carbamoyl ammonium compound of a photographic material containing a silver halide layer |
| US4018936A (en) * | 1975-10-16 | 1977-04-19 | Grain Processing Corporation | Gluten treatment |
| GB1572081A (en) * | 1976-01-12 | 1980-07-23 | Novo Industri As | Process for corn gluten by proteolytic treatment |
| US4624805A (en) * | 1984-09-27 | 1986-11-25 | The Texas A&M University System | Process for recovery of protein from agricultural commodities prior to alcohol production |
| US4645831A (en) * | 1984-12-10 | 1987-02-24 | The Texas A&M University System | Process for removing undesirable constituents from wheat gluten products |
| US4716218A (en) * | 1986-01-15 | 1987-12-29 | Purdue Research Foundation | Grain extraction milling |
| JPH0784477B2 (ja) * | 1987-01-26 | 1995-09-13 | 昭和産業株式会社 | ツエインの製造方法 |
| JPS63195999A (ja) * | 1987-02-10 | 1988-08-15 | 北川工業株式会社 | リストストラップ |
| US5021248A (en) * | 1988-09-19 | 1991-06-04 | Enzytech, Inc. | Hydrophobic protein microparticles and preparation thereof |
| EP0434760B1 (de) * | 1988-09-19 | 1994-01-12 | Opta Food Ingredients, Inc. | Hydrophobe proteinmikroteilchen und verfahren zur herstellung |
| JP2868818B2 (ja) * | 1990-01-08 | 1999-03-10 | 日本食品化工株式会社 | とうもろこし澱粉抽出残渣の処理法 |
| JP3091515B2 (ja) * | 1991-04-23 | 2000-09-25 | 昭和産業株式会社 | ツェインを含有する素材の処理方法 |
| JPH0523117A (ja) * | 1991-07-18 | 1993-02-02 | Sanei Touka Kk | コーテイング剤及びその製造方法 |
| US5254673A (en) * | 1991-12-26 | 1993-10-19 | Opta Food Ingredients, Inc. | Purification of zein from corn gluten meal |
-
1991
- 1991-12-26 US US07/814,118 patent/US5254673A/en not_active Expired - Fee Related
-
1992
- 1992-12-18 WO PCT/US1992/011134 patent/WO1993012667A1/en not_active Ceased
- 1992-12-18 EP EP93901944A patent/EP0648078B1/de not_active Expired - Lifetime
- 1992-12-18 CA CA002126668A patent/CA2126668A1/en not_active Abandoned
- 1992-12-18 JP JP51185093A patent/JPH07502416A/ja active Pending
- 1992-12-18 AT AT93901944T patent/ATE200183T1/de not_active IP Right Cessation
- 1992-12-18 DE DE69231771T patent/DE69231771D1/de not_active Expired - Lifetime
-
1995
- 1995-03-10 US US08/402,320 patent/US5580959A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0648078A4 (de) | 1994-07-20 |
| EP0648078A1 (de) | 1995-04-19 |
| US5580959A (en) | 1996-12-03 |
| JPH07502416A (ja) | 1995-03-16 |
| WO1993012667A1 (en) | 1993-07-08 |
| US5254673A (en) | 1993-10-19 |
| EP0648078B1 (de) | 2001-04-04 |
| DE69231771D1 (de) | 2001-05-10 |
| CA2126668A1 (en) | 1993-07-08 |
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