ATE201018T1 - Cryptophycinderivate und ihre verwendung als antimikrotubuli mittel - Google Patents

Cryptophycinderivate und ihre verwendung als antimikrotubuli mittel

Info

Publication number: ATE201018T1
Authority: AT; Austria
Prior art keywords: ring; lower alkyl; group; alkyl group; taken together
Prior art date: 1996-02-27

Application number

AT97301272T

Other languages

English (en)

Inventor

Bryan Hurst Norman

Chuan Shih

Julian Stanley Kroin

Original Assignee

Lilly Co Eli

Univ Hawaii

Univ Wayne State

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-02-27

Filing date

1997-02-26

Publication date

2001-05-15

1996-12-20 Priority claimed from PCT/US1996/020633 external-priority patent/WO1997023211A1/en

1997-02-26 Application filed by Lilly Co Eli, Univ Hawaii, Univ Wayne State filed Critical Lilly Co Eli

2001-05-15 Application granted granted Critical

2001-05-15 Publication of ATE201018T1 publication Critical patent/ATE201018T1/de

Links

PSNOPSMXOBPNNV-VVCTWANISA-N cryptophycin 1 Chemical class C1=C(Cl)C(OC)=CC=C1C[C@@H]1C(=O)NC[C@@H](C)C(=O)O[C@@H](CC(C)C)C(=O)O[C@H]([C@H](C)[C@@H]2[C@H](O2)C=2C=CC=CC=2)C/C=C/C(=O)N1 PSNOPSMXOBPNNV-VVCTWANISA-N 0.000 title abstract 3
230000001946 anti-microtubular Effects 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 6
125000003118 aryl group Chemical group 0.000 abstract 3
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 2
125000003282 alkyl amino group Chemical group 0.000 abstract 2
125000002877 alkyl aryl group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
229910052760 oxygen Inorganic materials 0.000 abstract 2
206010028980 Neoplasm Diseases 0.000 abstract 1
229910019142 PO4 Inorganic materials 0.000 abstract 1
125000006307 alkoxy benzyl group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
229940034982 antineoplastic agent Drugs 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
125000004069 aziridinyl group Chemical group 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
125000004663 dialkyl amino group Chemical group 0.000 abstract 1
150000002118 epoxides Chemical group 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
125000006498 halo alkoxy benzyl group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
125000006289 hydroxybenzyl group Chemical group 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
-1 monoalkylamino Chemical group 0.000 abstract 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
239000010452 phosphate Substances 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
150000003553 thiiranes Chemical group 0.000 abstract 1
125000005208 trialkylammonium group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
- C07D273/02—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Saccharide Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT97301272T 1996-02-27 1997-02-26 Cryptophycinderivate und ihre verwendung als antimikrotubuli mittel ATE201018T1 (de)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US1236596P	1996-02-27	1996-02-27
US1237596P	1996-02-27	1996-02-27
US2508096P	1996-08-30	1996-08-30
US2508196P	1996-08-30	1996-08-30
PCT/US1996/020633 WO1997023211A1 (en)	1995-12-22	1996-12-20	Pharmaceutical compounds

Publications (1)

Publication Number	Publication Date
ATE201018T1 true ATE201018T1 (de)	2001-05-15

Family

ID=27486177

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97301272T ATE201018T1 (de)	1996-02-27	1997-02-26	Cryptophycinderivate und ihre verwendung als antimikrotubuli mittel

Country Status (7)

Country	Link
EP (1)	EP0792875B1 (de)
AT (1)	ATE201018T1 (de)
AU (1)	AU2058197A (de)
DE (1)	DE69704731D1 (de)
DK (1)	DK0792875T3 (de)
ES (1)	ES2156338T3 (de)
WO (1)	WO1997031632A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0957912A1 (de) *	1996-08-30	1999-11-24	Eli Lilly And Company	Pharmazeutische zusammensetzungen
WO1998008505A1 (en) *	1996-08-30	1998-03-05	Eli Lilly And Company	Pharmaceutical compounds
EP0929535A4 (de) *	1996-09-06	2001-05-23	Lilly Co Eli	Verfahren und neue zwischenprodukte
IL131162A0 (en) *	1997-02-26	2001-01-28	Lilly Co Eli	Selective epoxidation process for preparing pharmaceutical compounds
JP2002527509A (ja) *	1998-10-16	2002-08-27	イーライ・リリー・アンド・カンパニー	抗腫瘍剤を製造するための立体選択的な方法
JP4776843B2 (ja)	1999-10-01	2011-09-21	イムノゲンインコーポレーティッド	免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法
MXPA03000905A (es) *	2000-08-02	2003-06-24	Slil Biomedical Corp	Compuestos de poliamina ciclicos como tratamiento contra el cancer.
US20050096324A1 (en) *	2003-11-05	2005-05-05	Zhi-Fu Tao	Macrocyclic kinase inhibitors
US7163939B2 (en)	2003-11-05	2007-01-16	Abbott Laboratories	Macrocyclic kinase inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5026703A (en) *	1990-06-11	1991-06-25	Merck & Co., Inc.	Peptide oxytocin antagonists
ATE203016T1 (de) *	1993-12-21	2001-07-15	Univ Hawaii	Cryptophycine

1997
- 1997-02-26 AT AT97301272T patent/ATE201018T1/de not_active IP Right Cessation
- 1997-02-26 ES ES97301272T patent/ES2156338T3/es not_active Expired - Lifetime
- 1997-02-26 AU AU20581/97A patent/AU2058197A/en not_active Abandoned
- 1997-02-26 DE DE69704731T patent/DE69704731D1/de not_active Expired - Lifetime
- 1997-02-26 EP EP97301272A patent/EP0792875B1/de not_active Expired - Lifetime
- 1997-02-26 DK DK97301272T patent/DK0792875T3/da active
- 1997-02-26 WO PCT/US1997/003029 patent/WO1997031632A1/en not_active Ceased

Also Published As

Publication number	Publication date
EP0792875A1 (de)	1997-09-03
AU2058197A (en)	1997-09-16
ES2156338T3 (es)	2001-06-16
WO1997031632A1 (en)	1997-09-04
DE69704731D1 (de)	2001-06-13
EP0792875B1 (de)	2001-05-09
DK0792875T3 (da)	2001-05-28

Legal Events

Date	Code	Title	Description
2001-07-15	UEP	Publication of translation of european patent specification
2003-11-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DK0622361T3 (da)	2001-12-03	Heterocykliske forbindelser som bradykininantagonister
ATE247654T1 (de)	2003-09-15	Neue heterozyklische verbindungen
CY1108256T1 (el)	2014-02-12	Νεα παραγωγα κουιναζολινης
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MA22895A1 (fr)	1993-12-31	7-(2-aminoethyl) benzothiazolones.
DK499385D0 (da)	1985-10-30	Piperazinforbindelser
ATE186301T1 (de)	1999-11-15	An den positionen 2 und 9 substituierte 4h-pyrido-(1,2-a)pyrimidin-4-one
DE69704731D1 (de)	2001-06-13	Cryptophycinderivate und ihre Verwendung als antimikrotubuli Mittel
NO905620D0 (no)	1990-12-28	Fremgangsmaate for fremstilling av terapeutisk aktive kinazolin-derivater.
ATE205209T1 (de)	2001-09-15	Chinolincarbonsäurederivate und ihre salze
EA200400758A1 (ru)	2005-06-30	Новые соединения бензотиазина и бензотиадиазина, способ их получения и фармацевтические композиции, которые их содержат
DE3472255D1 (en)	1988-07-28	Triazine derivatives, processes for preparation thereof and pharmaceutical compositions comprising the same
ATE186912T1 (de)	1999-12-15	Carbamoylpyrrolidon-derivate zur behandlung von depressionen und cerebrovasculären störungen
EA200400757A1 (ru)	2004-10-28	Новые соединения бензотиазина и бензотиадиазина, способ их получения и фармацевтические композиции, которые их содержат
SE8702697D0 (sv)	1987-06-30	Method of treating ischaemic vascular diseases
BRPI9917841B8 (pt)	2021-05-25	compostos 3-ciano quinolina substituídos e composições compreendendo os mesmos
FI903511A0 (fi)	1990-07-11	Pyrrolo (2,1-b) tiazolderivat.