ATE124410T1 - Antihypertensive 3-piperidinylindazol-derivate. - Google Patents

Antihypertensive 3-piperidinylindazol-derivate.

Info

Publication number: ATE124410T1
Authority: AT; Austria
Prior art keywords: 6alkyl; hydrogen; compounds; antihypertensive; chem
Prior art date: 1988-09-02

Application number

AT89202152T

Other languages

English (en)

Inventor

Jan Vandenberk

Ludo Edmond Josephine Kennis

Heertum Albertus H M T Van

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-09-02

Filing date

1989-08-25

Publication date

1995-07-15

1989-08-25 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

1995-07-15 Application granted granted Critical

1995-07-15 Publication of ATE124410T1 publication Critical patent/ATE124410T1/de

Links

KKXOXLSLPLCIQE-UHFFFAOYSA-N 3-piperidin-1-yl-1h-indazole Chemical class C1CCCCN1C1=NNC2=CC=CC=C12 KKXOXLSLPLCIQE-UHFFFAOYSA-N 0.000 title abstract 2
230000003276 anti-hypertensive effect Effects 0.000 title abstract 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
239000008194 pharmaceutical composition Substances 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
229940030600 antihypertensive agent Drugs 0.000 abstract 1
239000002220 antihypertensive agent Substances 0.000 abstract 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Pain & Pain Management (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Child & Adolescent Psychology (AREA)
Hematology (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT89202152T 1988-09-02 1989-08-25 Antihypertensive 3-piperidinylindazol-derivate. ATE124410T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US23991588A	1988-09-02	1988-09-02

Publications (1)

Publication Number	Publication Date
ATE124410T1 true ATE124410T1 (de)	1995-07-15

Family

ID=22904291

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89202152T ATE124410T1 (de)	1988-09-02	1989-08-25	Antihypertensive 3-piperidinylindazol-derivate.

Country Status (21)

Country	Link
EP (1)	EP0357134B1 (de)
JP (1)	JP2768992B2 (de)
KR (1)	KR0145705B1 (de)
CN (1)	CN1024346C (de)
AT (1)	ATE124410T1 (de)
AU (1)	AU614871B2 (de)
CA (1)	CA1331610C (de)
DE (1)	DE68923231T2 (de)
DK (1)	DK169547B1 (de)
ES (1)	ES2076201T3 (de)
FI (1)	FI91864C (de)
GR (1)	GR3017435T3 (de)
HU (1)	HU202232B (de)
IE (1)	IE66511B1 (de)
IL (1)	IL90879A0 (de)
NO (1)	NO176608C (de)
NZ (1)	NZ230367A (de)
PH (1)	PH26456A (de)
PT (1)	PT91613B (de)
SU (1)	SU1720489A3 (de)
ZA (1)	ZA896741B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5364866A (en)	1989-05-19	1994-11-15	Hoechst-Roussel Pharmaceuticals, Inc.	Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics
US5776963A (en)	1989-05-19	1998-07-07	Hoechst Marion Roussel, Inc.	3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility
DE4414113A1 (de) *	1994-04-22	1995-10-26	Merck Patent Gmbh	3-Indolylpiperidine
JPWO2004069828A1 (ja) *	2003-02-04	2006-05-25	三菱ウェルファーマ株式会社	ピペリジン化合物およびその医薬用途
JP7090639B2 (ja) *	2017-04-11	2022-06-24	サンシャイン・レイク・ファーマ・カンパニー・リミテッド	フッ素置換されたインダゾール化合物及びその使用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4335127A (en) *	1979-01-08	1982-06-15	Janssen Pharmaceutica, N.V.	Piperidinylalkyl quinazoline compounds, composition and method of use
US4342870A (en) *	1980-03-28	1982-08-03	Janssen Pharmaceutica N.V.	Novel 3-(1-piperidinylalkyl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives
US4443451A (en) *	1981-07-15	1984-04-17	Janssen Pharmaceutica N.V.	Bicyclic pyrimidin-5-one derivatives
JPS58159480A (ja) *	1982-03-17	1983-09-21	Chugai Pharmaceut Co Ltd	新規なフエニルピペラジン誘導体
US4485107A (en) *	1982-11-01	1984-11-27	Janssen Pharmaceutica N.V.	[[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones
US4670447A (en) *	1983-08-22	1987-06-02	Hoechst-Roussel Pharmaceuticals Inc.	Antipsychotic 3-(piperidinyl)- and 3-(pyrrolidinyl)-1H-indazoles
HU198036B (en) *	1983-08-22	1989-07-28	Hoechst Roussel Pharma	Process for production of derivatives of 3-piperidil-/1h/-indasole and medical preparatives containing them
US4716161A (en) *	1984-04-17	1987-12-29	Mitsubishi Chemical Industries Limited	Phenylpiperazine derivatives and their acid addition salts
CA1246074A (en) *	1984-12-05	1988-12-06	Albertus H.M.T. Van Heertum	Derivatives of hydroxy- or amino-substituted (piperidinylalkyl)quinazolines
ATE61054T1 (de) *	1985-01-23	1991-03-15	Hoechst Roussel Pharma	3-piperidinyl- 1h-indazole, verfahren zu deren herstellung und deren anwendung als arzneimittel.
US4804663A (en) *	1985-03-27	1989-02-14	Janssen Pharmaceutica N.V.	3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
US4711883A (en) *	1985-09-30	1987-12-08	Ortho Pharmaceutical Corporation	Substituted 3-(4-phenyl-1-piperazinyl)alkylquinazolin-2,4-(1H,3H) diones, methods of preparation, compositions and method of use
NZ223654A (en) *	1987-03-09	1990-03-27	Janssen Pharmaceutica Nv	1-alkyl-substituted-benzimidazole-4-piperidinamines and pharmaceutical compositions
CA1317939C (en) *	1987-07-01	1993-05-18	Janssen Pharmaceutica Naamloze Vennootschap	¬(bicyclic heterocyclyl)methyl and -hetero\| substituted hexahydro-1h-azepines and pyrrolidines

1989
- 1989-07-05 IL IL90879A patent/IL90879A0/xx not_active IP Right Cessation
- 1989-07-28 CA CA000606920A patent/CA1331610C/en not_active Expired - Fee Related
- 1989-08-18 NZ NZ230367A patent/NZ230367A/en unknown
- 1989-08-22 PH PH39128A patent/PH26456A/en unknown
- 1989-08-25 EP EP89202152A patent/EP0357134B1/de not_active Expired - Lifetime
- 1989-08-25 ES ES89202152T patent/ES2076201T3/es not_active Expired - Lifetime
- 1989-08-25 DE DE68923231T patent/DE68923231T2/de not_active Expired - Fee Related
- 1989-08-25 AT AT89202152T patent/ATE124410T1/de not_active IP Right Cessation
- 1989-08-28 AU AU40848/89A patent/AU614871B2/en not_active Ceased
- 1989-08-29 SU SU894742322A patent/SU1720489A3/ru active
- 1989-09-01 PT PT91613A patent/PT91613B/pt not_active IP Right Cessation
- 1989-09-01 DK DK434789A patent/DK169547B1/da not_active IP Right Cessation
- 1989-09-01 ZA ZA896741A patent/ZA896741B/xx unknown
- 1989-09-01 JP JP1224762A patent/JP2768992B2/ja not_active Expired - Fee Related
- 1989-09-01 FI FI894125A patent/FI91864C/fi active IP Right Grant
- 1989-09-01 IE IE282989A patent/IE66511B1/en not_active IP Right Cessation
- 1989-09-01 HU HU894541A patent/HU202232B/hu not_active IP Right Cessation
- 1989-09-01 NO NO893523A patent/NO176608C/no unknown
- 1989-09-02 KR KR1019890012700A patent/KR0145705B1/ko not_active Expired - Fee Related
- 1989-09-02 CN CN89106733A patent/CN1024346C/zh not_active Expired - Fee Related
1995
- 1995-09-18 GR GR950402560T patent/GR3017435T3/el unknown

Also Published As

Publication number	Publication date
ZA896741B (en)	1991-05-29
ES2076201T3 (es)	1995-11-01
EP0357134B1 (de)	1995-06-28
DE68923231D1 (de)	1995-08-03
IE66511B1 (en)	1996-01-10
PH26456A (en)	1992-07-27
NO893523L (no)	1990-03-05
CA1331610C (en)	1994-08-23
JP2768992B2 (ja)	1998-06-25
PT91613A (pt)	1990-03-30
GR3017435T3 (en)	1995-12-31
NO176608B (no)	1995-01-23
CN1040589A (zh)	1990-03-21
EP0357134A1 (de)	1990-03-07
HU202232B (en)	1991-02-28
KR900004721A (ko)	1990-04-12
DK434789D0 (da)	1989-09-01
AU4084889A (en)	1990-03-08
NZ230367A (en)	1991-03-26
JPH02160778A (ja)	1990-06-20
CN1024346C (zh)	1994-04-27
FI91864B (fi)	1994-05-13
FI894125A7 (fi)	1990-03-03
HUT51622A (en)	1990-05-28
FI894125A0 (fi)	1989-09-01
KR0145705B1 (ko)	1998-08-17
DE68923231T2 (de)	1995-11-09
DK434789A (da)	1990-03-03
IE892829L (en)	1990-03-02
FI91864C (fi)	1994-08-25
DK169547B1 (da)	1994-11-28
PT91613B (pt)	1995-05-04
IL90879A0 (en)	1990-02-09
NO893523D0 (no)	1989-09-01
AU614871B2 (en)	1991-09-12
NO176608C (no)	1995-05-03
SU1720489A3 (ru)	1992-03-15

Legal Events

Date	Code	Title	Description
1995-12-15	UEP	Publication of translation of european patent specification
2007-05-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE104971T1 (de)	1994-05-15	2-aminopyrimidinon-derivate.
ATE128132T1 (de)	1995-10-15	N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2h-benzopyran oder dihydrobenzodioxin)- carboxamid-derivate.
GR3004114T3 (de)	1993-03-31
ES549542A0 (es)	1986-04-16	Un procedimiento para preparar nuevos derivados de benzo- triazol- y benzoxazolamina
ATE122348T1 (de)	1995-05-15	Antipsychotische 3-piperazinylbenzazolderivate.
DE68923231D1 (de)	1995-08-03	Antihypertensive 3-Piperidinylindazol-Derivate.