ATE201026T1 - Verfahren zur herstellung von salzen von erythromicyn, roxithromicyn, clarythromicyn und azithromycin - Google Patents

Verfahren zur herstellung von salzen von erythromicyn, roxithromicyn, clarythromicyn und azithromycin

Info

Publication number: ATE201026T1
Authority: AT; Austria
Prior art keywords: erythromycin; azithromycin; under nitrogen; roxithromicyn; erythromicyn
Prior art date: 1996-08-07

Application number

AT97935730T

Other languages

English (en)

Inventor

Helmut Schickaneder

Aggelos Nikolopoulos

Original Assignee

Russinsky Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-08-07

Filing date

1997-08-07

Publication date

2001-05-15

1997-08-07 Application filed by Russinsky Ltd filed Critical Russinsky Ltd

2001-05-15 Application granted granted Critical

2001-05-15 Publication of ATE201026T1 publication Critical patent/ATE201026T1/de

Links

229960004099 azithromycin Drugs 0.000 title abstract 2
MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 6
229910052757 nitrogen Inorganic materials 0.000 abstract 3
150000003839 salts Chemical class 0.000 abstract 3
JJVXHDTWVIPRBZ-VKHMYHEASA-N (2r)-2-[carboxy(methyl)amino]-3-sulfanylpropanoic acid Chemical compound OC(=O)N(C)[C@@H](CS)C(O)=O JJVXHDTWVIPRBZ-VKHMYHEASA-N 0.000 abstract 2
ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 abstract 2
PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 abstract 2
229960004308 acetylcysteine Drugs 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
239000000725 suspension Substances 0.000 abstract 2
RXZBMPWDPOLZGW-XMRMVWPWSA-N (E)-roxithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=N/OCOCCOC)/[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 RXZBMPWDPOLZGW-XMRMVWPWSA-N 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
239000005864 Sulphur Substances 0.000 abstract 1
229960002626 clarithromycin Drugs 0.000 abstract 1
AGOYDEPGAOXOCK-KCBOHYOISA-N clarithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@](C)([C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)OC)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 AGOYDEPGAOXOCK-KCBOHYOISA-N 0.000 abstract 1
229960003276 erythromycin Drugs 0.000 abstract 1
239000008213 purified water Substances 0.000 abstract 1
239000000376 reactant Substances 0.000 abstract 1
229960005224 roxithromycin Drugs 0.000 abstract 1
ULSZVNJBVJWEJE-UHFFFAOYSA-N thiazolidine-2-carboxylic acid Chemical class OC(=O)C1NCCS1 ULSZVNJBVJWEJE-UHFFFAOYSA-N 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT97935730T 1996-08-07 1997-08-07 Verfahren zur herstellung von salzen von erythromicyn, roxithromicyn, clarythromicyn und azithromycin ATE201026T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IE960568		1996-08-07
PCT/IE1997/000056 WO1998005674A1 (en)	1996-08-07	1997-08-07	Process for the production of salts of erythromycin, roxithromycin, clarithromycin and azithromycin

Publications (1)

Publication Number	Publication Date
ATE201026T1 true ATE201026T1 (de)	2001-05-15

Family

ID=11041234

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97935730T ATE201026T1 (de)	1996-08-07	1997-08-07	Verfahren zur herstellung von salzen von erythromicyn, roxithromicyn, clarythromicyn und azithromycin

Country Status (7)

Country	Link
EP (1)	EP0922051B1 (de)
AT (1)	ATE201026T1 (de)
AU (1)	AU3861497A (de)
CA (1)	CA2255124A1 (de)
DE (1)	DE69704778T2 (de)
IE (1)	IE970584A1 (de)
WO (1)	WO1998005674A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA966601B (en) *	1995-08-03	1997-02-19	Chugai Pharmaceutical Co Ltd	Process for producing erythromycin derivatives.
WO2000023081A1 (en) *	1998-10-20	2000-04-27	Lauteral Limited	Derivatives of erythromycin, clarithromycin, roxithromycin or azithromycin with antibiotic and mucolytic activity
US7468428B2 (en)	2004-03-17	2008-12-23	App Pharmaceuticals, Llc	Lyophilized azithromycin formulation
KR20120107989A (ko) *	2009-12-18	2012-10-04	노스-웨스트 유니버시티	아지트로마이신의 무정형 비결정성 글래스 형태를 포함하는 조성물
CN103232506B (zh) *	2013-04-11	2016-02-03	宜昌东阳光药业股份有限公司	克拉霉素杂质o及其相类似化合物的制备工艺

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2502627A1 (fr) *	1981-02-02	1982-10-01	Refarmed Sa	Derives thioliques de l'erythromycine a activite therapeutique, procede de preparation et produits pharmaceutiques dans lesquels ils apparaissent
IT1189285B (it) *	1982-05-28	1988-02-04	Nuovo Consor Sanitar Nazionale	Sali dell'antibiotico eritromicina e del suo estere propionico con acidi ad attivita' terapeutica coadiuvante
IT1190987B (it) *	1982-09-07	1988-02-24	Pharma Edmond Srl	Tioesteri dell'acido acetilsalicilico,procedimento per la loro preparazione e composizioni farmaceutiche che li conttengono
IT1173441B (it) *	1984-03-14	1987-06-24	Edmond Pharma Srl	Sali di eritromicina con derivati dell'acido acetico,procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
GB8521402D0 (en) *	1985-08-28	1985-10-02	Beecham Group Plc	Chemical compounds
AU4399396A (en) *	1994-12-19	1996-07-10	Russinsky Limited	Compounds

1997
- 1997-08-07 AT AT97935730T patent/ATE201026T1/de not_active IP Right Cessation
- 1997-08-07 IE IE19970584A patent/IE970584A1/en not_active IP Right Cessation
- 1997-08-07 CA CA002255124A patent/CA2255124A1/en not_active Abandoned
- 1997-08-07 WO PCT/IE1997/000056 patent/WO1998005674A1/en not_active Ceased
- 1997-08-07 EP EP97935730A patent/EP0922051B1/de not_active Expired - Lifetime
- 1997-08-07 DE DE69704778T patent/DE69704778T2/de not_active Expired - Fee Related
- 1997-08-07 AU AU38614/97A patent/AU3861497A/en not_active Abandoned

Also Published As

Publication number	Publication date
WO1998005674A1 (en)	1998-02-12
DE69704778D1 (de)	2001-06-13
EP0922051A1 (de)	1999-06-16
IE970584A1 (en)	2000-02-09
DE69704778T2 (de)	2001-09-20
AU3861497A (en)	1998-02-25
EP0922051B1 (de)	2001-05-09
CA2255124A1 (en)	1998-02-12

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Legal Events

Date	Code	Title	Description
2001-11-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties