ES2187483T3 - Procedimiento para la preparacion de acido a-lipoico esento de disolvente. - Google Patents

Procedimiento para la preparacion de acido a-lipoico esento de disolvente.

Info

Publication number
ES2187483T3
ES2187483T3 ES00954620T ES00954620T ES2187483T3 ES 2187483 T3 ES2187483 T3 ES 2187483T3 ES 00954620 T ES00954620 T ES 00954620T ES 00954620 T ES00954620 T ES 00954620T ES 2187483 T3 ES2187483 T3 ES 2187483T3
Authority
ES
Spain
Prior art keywords
lipoic acid
solvent
alpha
procedure
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES00954620T
Other languages
English (en)
Inventor
Hans Schuhbauer
Stefan Winkler
Ansgar Gruber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evonik Operations GmbH
Original Assignee
Degussa GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa GmbH filed Critical Degussa GmbH
Application granted granted Critical
Publication of ES2187483T3 publication Critical patent/ES2187483T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

Procedimiento para la preparación de ácido -lipoico exento de disolvente, caracterizado porque a) Se disuelve el ácido -lipoico a purificar en solución acuosa alcalina, o se disuelven sus sales en agua y se ajusta un valor pH alcalino, b) Se separan de la solución acuosa de la etapa a) las impurificaciones sólidas eventualmente presentes, c) Se ajusta la solución acuosa de la etapa a) o b) a un valor pH de -1,0 a 5,0 con ayuda de un ácido, y d) Se separa el ácido -lipoico precipitado.
ES00954620T 1999-08-14 2000-08-10 Procedimiento para la preparacion de acido a-lipoico esento de disolvente. Expired - Lifetime ES2187483T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19938621A DE19938621A1 (de) 1999-08-14 1999-08-14 Verfahren zur Herstellung von lösemittelfreier alpha-Liponsäure

Publications (1)

Publication Number Publication Date
ES2187483T3 true ES2187483T3 (es) 2003-06-16

Family

ID=7918432

Family Applications (1)

Application Number Title Priority Date Filing Date
ES00954620T Expired - Lifetime ES2187483T3 (es) 1999-08-14 2000-08-10 Procedimiento para la preparacion de acido a-lipoico esento de disolvente.

Country Status (11)

Country Link
US (1) US6462202B1 (es)
EP (1) EP1202983B1 (es)
CN (1) CN1131227C (es)
AT (1) ATE231854T1 (es)
AU (1) AU6701300A (es)
CA (1) CA2380495C (es)
DE (2) DE19938621A1 (es)
DK (1) DK1202983T3 (es)
ES (1) ES2187483T3 (es)
PT (1) PT1202983E (es)
WO (1) WO2001012620A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1319196B1 (it) * 2000-10-10 2003-09-26 Laboratorio Chimico Int Spa Sintesi dell'acido r(+)alfa-lipoico.
IT1319195B1 (it) * 2000-10-10 2003-09-26 Laboratorio Chimico Int Spa Processo per la produzione dell'acido r(+)alfa-lipoico.
DE10159245A1 (de) * 2001-12-03 2003-06-18 Degussa Stabile, saure, wässrige Lösung enthaltend alpha-Liponsäure(-Derivate), Verfahren zu deren Herstellung sowie ihre Verwendung
DE10201464B4 (de) * 2002-01-16 2005-06-16 Viatris Gmbh & Co. Kg Verfahren zur Herstellung reiner Thioctsäure
ITMI20050466A1 (it) * 2005-03-22 2006-09-23 Laboratorio Chimico Int Spa Processo di purificazione in acqua di acido tiottico
CN100375745C (zh) * 2005-12-21 2008-03-19 重庆药友制药有限责任公司 硫辛酸的精制方法
CN100387593C (zh) * 2006-01-26 2008-05-14 南京师范大学 连续逆流液液萃取分离二硫辛酸与乙醇及碱水溶液的方法
DE102007038849A1 (de) 2007-08-16 2009-02-19 Adscil Gmbh Verwendung von R(+)-alpha-Liponsäure zur Behandlung der kryptogenen Neuropathie
BRPI0916476A2 (pt) * 2008-12-01 2016-02-16 Invasc Therapeutics Inc composição, método de tratamento para um distúrbio relacionado ao sistema renina-angiotensina-aldosterona, método para reduzir a resistência à insulina, método para tratar um distúrbio relacionado à síndrome metabólica
CN102603709B (zh) * 2012-03-02 2013-09-25 海南灵康制药有限公司 一种硫辛酸化合物及其制法
CN105798322B (zh) * 2016-03-17 2018-04-24 湖北大学 银纳米簇的制备方法及其应用
CN114163418A (zh) * 2021-12-24 2022-03-11 山东龙辰药业有限公司 一种右旋硫辛酸的合成方法
CN115490861B (zh) * 2022-08-22 2023-11-17 北京化工大学 一种聚硫辛酸可再生高分子材料制备方法
CN116041318B (zh) * 2022-12-29 2025-04-18 江苏恒沛药物科技有限公司 一种制备硫辛酸的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19726519A1 (de) 1997-06-23 1998-12-24 Asta Medica Ag Verfahren zur Herstellung trockener Thioctsäure

Also Published As

Publication number Publication date
CA2380495C (en) 2006-10-17
PT1202983E (pt) 2003-06-30
DE50001184D1 (de) 2003-03-06
DE19938621A1 (de) 2001-02-22
EP1202983A1 (de) 2002-05-08
ATE231854T1 (de) 2003-02-15
AU6701300A (en) 2001-03-13
EP1202983B1 (de) 2003-01-29
DK1202983T3 (da) 2003-05-26
CA2380495A1 (en) 2001-02-22
CN1354748A (zh) 2002-06-19
WO2001012620A1 (de) 2001-02-22
US6462202B1 (en) 2002-10-08
CN1131227C (zh) 2003-12-17

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