ATE201195T1 - Tricyclische verbindungen - Google Patents

Tricyclische verbindungen

Info

Publication number
ATE201195T1
ATE201195T1 AT96935342T AT96935342T ATE201195T1 AT E201195 T1 ATE201195 T1 AT E201195T1 AT 96935342 T AT96935342 T AT 96935342T AT 96935342 T AT96935342 T AT 96935342T AT E201195 T1 ATE201195 T1 AT E201195T1
Authority
AT
Austria
Prior art keywords
tricyclic compounds
hydrogen
ch2o
chem
useful
Prior art date
Application number
AT96935342T
Other languages
English (en)
Inventor
Makoto Yoshida
Shin-Ichi Sasaki
Shigeru Aono
Shigeki Fujiwara
Haruki Takai
Tsuyoshi Yamagata
Ken Nagasahima
Akira Karasawa
Original Assignee
Kyowa Hakko Kogyo Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Kk filed Critical Kyowa Hakko Kogyo Kk
Application granted granted Critical
Publication of ATE201195T1 publication Critical patent/ATE201195T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/16—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/12—[b,e]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • C07D333/80—Seven-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D337/12—[b,e]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/16—Benz[e]indenes; Hydrogenated benz[e]indenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/30—Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings
    • C07C2603/32—Dibenzocycloheptenes; Hydrogenated dibenzocycloheptenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Surgical Instruments (AREA)
  • Eye Examination Apparatus (AREA)
  • Led Devices (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Dental Preparations (AREA)
AT96935342T 1995-10-16 1996-10-16 Tricyclische verbindungen ATE201195T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP26723295 1995-10-16
JP32429895 1995-12-13
PCT/JP1996/002997 WO1997014672A1 (en) 1995-10-16 1996-10-16 Triciclic compounds

Publications (1)

Publication Number Publication Date
ATE201195T1 true ATE201195T1 (de) 2001-06-15

Family

ID=26547771

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96935342T ATE201195T1 (de) 1995-10-16 1996-10-16 Tricyclische verbindungen

Country Status (12)

Country Link
US (1) US5726325A (de)
EP (1) EP0798288B1 (de)
JP (1) JP3847786B2 (de)
CN (1) CN1168133A (de)
AT (1) ATE201195T1 (de)
AU (1) AU700386B2 (de)
DE (1) DE69612835T2 (de)
ES (1) ES2159047T3 (de)
HU (1) HUP9801356A3 (de)
NO (1) NO972726L (de)
NZ (1) NZ320580A (de)
WO (1) WO1997014672A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5840749A (en) * 1989-08-25 1998-11-24 Hoechst Marion Roussel, Inc. N-hydroxy-dibenz b,e!oxepinalkylamines, N-hydroxy-dibenz b,e!oxepinalkanoic acid amides and related heterocyclic analogues
EP0842179A1 (de) * 1995-07-24 1998-05-20 Takeda Chemical Industries, Ltd. Verfahren zur herstellung von optisch aktivenbezothiepin salzen
ES2273413T3 (es) * 1997-04-15 2007-05-01 Kyowa Hakko Kogyo Co., Ltd. Compuestos triciclicos.
EP1074539B1 (de) * 1999-08-04 2007-10-17 Sumitomo Chemical Company, Limited Verfahren zur Herstellung von optisch aktiver 3,3,3-Trifluor-2-hydroxy-2-methylpropionsäure und deren Salze
EA007069B1 (ru) * 2001-03-30 2006-06-30 Киова Хакко Когио Ко., Лтд. Терапевтическое средство по поводу повышенной чувствительности мочевого пузыря
JP4104986B2 (ja) * 2001-03-30 2008-06-18 協和醗酵工業株式会社 前立腺肥大症に伴う膀胱刺激症状治療剤
BR0208420A (pt) * 2001-03-30 2004-03-30 Kyowa Hakko Kogyo Kk Agente terapêutico para bexiga hiperativa, uso do composto tricìclico ou do sal farmaceuticamente aceitável do mesmo, e, método para o tratamento de bexiga hiperativa
EP1444980A1 (de) * 2001-11-13 2004-08-11 Kyowa Hakko Kogyo Co., Ltd. Mittel zur prävention oder behandlung von pruritus
TW200400816A (en) * 2002-06-26 2004-01-16 Lilly Co Eli Tricyclic steroid hormone nuclear receptor modulators
CA2520680A1 (en) * 2003-03-31 2004-10-14 Kyowa Hakko Kogyo Co., Ltd. Antitussives
AR044870A1 (es) * 2003-06-27 2005-10-05 Kyowa Hakko Kogyo Kk Compuesto azufrado triciclico y su uso como agente terapeutico para la vejiga hiperactiva
WO2005007154A1 (ja) * 2003-07-16 2005-01-27 Kyowa Hakko Kogyo Co., Ltd. 疼痛の予防及び／または治療剤
WO2005011674A1 (ja) * 2003-08-05 2005-02-10 Kyowa Hakko Kogyo Co., Ltd. 気管支喘息の予防及び／または治療剤
FR2872159B1 (fr) * 2004-06-28 2007-10-05 Merck Sante Soc Par Actions Si Nouveaux derives acides carboxyliques phenyliques et leur utilisation dans le traitement du diabete
TW200606133A (en) * 2004-06-30 2006-02-16 Sankyo Co Substituted benzene compounds
DE102005022020A1 (de) * 2005-05-12 2006-11-23 Merckle Gmbh Dibenzocycloheptanverbindungen und pharmazeutische Mittel, welche diese Verbindungen enthalten
RU2408584C2 (ru) * 2005-06-23 2011-01-10 Мерк Шарп Энд Домэ Корп. Ингибиторы тирозинкиназы
EP1951249A2 (de) * 2005-10-21 2008-08-06 Merck and Co., Inc. Tyrosin-kinase-hemmer
US7790739B2 (en) * 2005-10-21 2010-09-07 Merck & Co., Inc. and Merck Sharp & Dohme Corp. Tyrosine kinase inhibitors
JP2009513580A (ja) * 2005-10-21 2009-04-02 メルク エンド カムパニー インコーポレーテッド チロシンキナーゼ阻害剤
TW200813021A (en) * 2006-07-10 2008-03-16 Merck & Co Inc Tyrosine kinase inhibitors
TW200827367A (en) * 2006-10-26 2008-07-01 Kyowa Hakko Kogyo Kk A therapeutic agent for irritable bowel syndrome
AU2018354418B2 (en) * 2017-10-27 2025-09-11 Immunebridge Inc. Compositions and methods of making expanded hematopoietic stem cells using derivatives of fluorene

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3458578A (en) * 1965-03-22 1969-07-29 Sandoz Ag Aminodibenzocycloalkenones
US4477465A (en) * 1983-03-10 1984-10-16 Hoechst-Roussel Pharmaceuticals Inc. Substituted 4,10-dihydro-10-oxothieno benzoxepins
JPS6310784A (ja) * 1986-03-03 1988-01-18 Kyowa Hakko Kogyo Co Ltd 抗アレルギー剤
GB9214120D0 (en) * 1991-07-25 1992-08-12 Ici Plc Therapeutic amides

Also Published As

Publication number Publication date
ES2159047T3 (es) 2001-09-16
AU7332696A (en) 1997-05-07
DE69612835D1 (de) 2001-06-21
MX9704411A (es) 1998-07-31
EP0798288A4 (de) 1999-06-16
NZ320580A (en) 1998-12-23
HUP9801356A2 (hu) 1998-10-28
EP0798288A1 (de) 1997-10-01
DE69612835T2 (de) 2001-10-04
EP0798288B1 (de) 2001-05-16
HUP9801356A3 (en) 2000-07-28
JP3847786B2 (ja) 2006-11-22
CN1168133A (zh) 1997-12-17
NO972726L (no) 1997-08-05
WO1997014672A1 (en) 1997-04-24
NO972726D0 (no) 1997-06-13
US5726325A (en) 1998-03-10
AU700386B2 (en) 1999-01-07

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