ATE202103T1 - 6-azaindole-hemmer der tromboxan-synthetase - Google Patents

6-azaindole-hemmer der tromboxan-synthetase

Info

Publication number: ATE202103T1
Authority: AT; Austria
Prior art keywords: tromboxane; synthetase; azaindole; integer; zero
Prior art date: 1994-01-31

Application number

AT95300551T

Other languages

English (en)

Inventor

Joseph Anthony Jakubowski

Alan David Palkowitz

Sandra Kay Sigmund

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-01-31

Filing date

1995-01-30

Publication date

2001-06-15

1995-01-30 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2001-06-15 Application granted granted Critical

2001-06-15 Publication of ATE202103T1 publication Critical patent/ATE202103T1/de

Links

XLKDJOPOOHHZAN-UHFFFAOYSA-N 1h-pyrrolo[2,3-c]pyridine Chemical compound C1=NC=C2NC=CC2=C1 XLKDJOPOOHHZAN-UHFFFAOYSA-N 0.000 title abstract 2
102000003960 Ligases Human genes 0.000 title 1
108090000364 Ligases Proteins 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
239000002253 acid Substances 0.000 abstract 1
230000002378 acidificating effect Effects 0.000 abstract 1
125000005647 linker group Chemical group 0.000 abstract 1
239000003768 thromboxane synthase inhibitor Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Urology & Nephrology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Diabetes (AREA)
Hematology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT95300551T 1994-01-31 1995-01-30 6-azaindole-hemmer der tromboxan-synthetase ATE202103T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/189,212 US5468757A (en)	1994-01-31	1994-01-31	6-azaindole thromboxane synthase inhibitors

Publications (1)

Publication Number	Publication Date
ATE202103T1 true ATE202103T1 (de)	2001-06-15

Family

ID=22696403

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95300551T ATE202103T1 (de)	1994-01-31	1995-01-30	6-azaindole-hemmer der tromboxan-synthetase

Country Status (11)

Country	Link
US (1)	US5468757A (de)
EP (1)	EP0668279B1 (de)
JP (1)	JPH0853448A (de)
AT (1)	ATE202103T1 (de)
CA (1)	CA2141231A1 (de)
DE (1)	DE69521223T2 (de)
DK (1)	DK0668279T3 (de)
ES (1)	ES2157292T3 (de)
GR (1)	GR3036570T3 (de)
PT (1)	PT668279E (de)
SI (1)	SI0668279T1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR100523112B1 (ko) *	1997-10-17	2005-10-19	유로진 리미티드	레닌-안지오텐신계 억제제의 사용
BR9812944A (pt)	1997-10-20	2000-08-08	Hoffmann La Roche	Inibidores bicìclicos da cinase
EP0997465B1 (de) *	1998-10-30	2004-02-04	Eli Lilly And Company	Azaindol derivate und ihre Verwendung als antithrombotische Wirkstoffe
CA2367121A1 (en) *	1999-03-10	2000-09-14	Merck & Co., Inc.	6-azaindole compounds as antagonists of gonadotropin releasing hormone
US20040235867A1 (en) *	2001-07-24	2004-11-25	Bilodeau Mark T.	Tyrosine kinase inhibitors
GB0330043D0 (en) *	2003-12-24	2004-01-28	Pharmacia Italia Spa	Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions comprising them
KR20070034049A (ko)	2004-06-09	2007-03-27	글락소 그룹 리미티드	피롤로피리딘 유도체
US20070155738A1 (en)	2005-05-20	2007-07-05	Alantos Pharmaceuticals, Inc.	Heterobicyclic metalloprotease inhibitors
WO2019126082A1 (en) *	2017-12-19	2019-06-27	Bristol-Myers Squibb Company	6-azaindole compounds
CN112839648B (zh) *	2018-06-07	2025-04-04	达萨玛治疗公司	Sarm1抑制剂
ES2960987T3 (es)	2019-04-12	2024-03-07	Riboscience Llc	Derivados de heteroarilo bicíclicos como inhibidores de la ectonucleótido pirofosfatasa fosfodiesterasa 1

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2101595B (en) *	1981-06-22	1985-05-30	Ciba Geigy Ag	Substituted imidazo(1,5-a)pyridines, process for their manufacture, pharmaceutical preparations containing these compounds and their therapeutic application
US4470986A (en) *	1982-12-21	1984-09-11	Ciba-Geigy Corporation	Certain imidazo (1,5-A) pyridine aliphatic carboxylic acid derivatives and their use as selective thromboxane inhibitors
US4588732A (en) *	1982-12-21	1986-05-13	Ciba-Geigy Corporation	Certain imidazo(1,5-a)pyridine derivatives and their use as thromboxane synthetase inhibitors
DE3302125A1 (de) *	1983-01-22	1984-07-26	Boehringer Ingelheim KG, 6507 Ingelheim	Aminosaeure-derivate, verfahren zu ihrer herstellung und verwendung
FR2658511B1 (fr) *	1990-02-16	1992-06-19	Union Pharma Scient Appl	Nouveaux derives de benzimidazole et d'azabenzimidazole, antagonistes des recepteurs au thromboxane; leurs procedes de preparation, compositions pharmaceutiques les contenant.
DE69227561T2 (de) *	1991-08-21	1999-06-02	Eisai Co., Ltd., Tokio/Tokyo	Kondensierte Pyrimidinderivate als Antitumorverbindungen

1994
- 1994-01-31 US US08/189,212 patent/US5468757A/en not_active Expired - Fee Related
1995
- 1995-01-27 CA CA002141231A patent/CA2141231A1/en not_active Abandoned
- 1995-01-30 SI SI9530517T patent/SI0668279T1/xx unknown
- 1995-01-30 DK DK95300551T patent/DK0668279T3/da active
- 1995-01-30 PT PT95300551T patent/PT668279E/pt unknown
- 1995-01-30 ES ES95300551T patent/ES2157292T3/es not_active Expired - Lifetime
- 1995-01-30 DE DE69521223T patent/DE69521223T2/de not_active Expired - Fee Related
- 1995-01-30 AT AT95300551T patent/ATE202103T1/de not_active IP Right Cessation
- 1995-01-30 EP EP95300551A patent/EP0668279B1/de not_active Expired - Lifetime
- 1995-01-31 JP JP7013686A patent/JPH0853448A/ja not_active Withdrawn
2001
- 2001-09-07 GR GR20010401424T patent/GR3036570T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0668279A2 (de)	1995-08-23
DK0668279T3 (da)	2001-08-27
CA2141231A1 (en)	1995-08-01
ES2157292T3 (es)	2001-08-16
PT668279E (pt)	2001-09-28
GR3036570T3 (en)	2001-12-31
EP0668279A3 (de)	1995-08-30
SI0668279T1 (en)	2001-12-31
EP0668279B1 (de)	2001-06-13
JPH0853448A (ja)	1996-02-27
DE69521223D1 (de)	2001-07-19
DE69521223T2 (de)	2001-11-08
US5468757A (en)	1995-11-21

Legal Events

Date	Code	Title	Description
2001-08-15	UEP	Publication of translation of european patent specification
2003-10-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
HUP9802859A2 (hu)	1999-03-29	Acil-amino-szalicilsav-amid-származékok és alkalmazásuk peszticidként
NO307255B1 (no)	2000-03-06	Nye forbindelser og antitumormidler
FI902555A0 (fi)	1990-05-23	Diarylstyrylkinolindisyror.
DE69728544D1 (de)	2004-05-13	Totalsynthese von acylfulvenen mit antitumorwirkung
ATE202103T1 (de)	2001-06-15	6-azaindole-hemmer der tromboxan-synthetase
ATE137220T1 (de)	1996-05-15	Benzen-, pyridin-, pyrimidinderivat
TR200001740T2 (tr)	2000-11-21	Mikrobisidal ve bitkiye bağışıklık kazandırıcı aktiviteleri olan tiyazol-türevleri
ATE232528T1 (de)	2003-02-15	Pyrimidinylpyrazolderivate
ES2188481T3 (es)	2003-07-01	Derivados de polinalbufina.
PT947504E (pt)	2003-12-31	Derivados de vitamina d 16-eno
ES2169220T3 (es)	2002-07-01	Derivados de vitamina d3 con sustituyentes en la posicion 2.
FI940731A0 (fi)	1994-02-16	Amiditetratsolit ACAT-inhibiitoreina
DK0601191T3 (da)	1999-04-26	Hidtil ukendt tetracyklisk forbindelse
ATE245147T1 (de)	2003-08-15	Substituierte aminochinazolinon (thion) derivate
NO900732D0 (no)	1990-02-15	Arylalkylaminforbindelser.
IT1197348B (it)	1988-11-30	Cinnamilammine, processo per la loro preparazione e composizioni farmaceutiche che le contengono
DE60221250D1 (de)	2007-08-30	Bis(5-aryl-2-pyridyl)derivate
PL321309A1 (en)	1998-02-02	Novel bis-imide compounds, method of obtaining them and pharmaceutic compositions containing such compounds
ATE217311T1 (de)	2002-05-15	Cyclopropancyclus enthaltende purinderivate
EP1219599A4 (de)	2002-09-11	Vitamin-d-derivate mit substituenten an der 2-alpha-position
EP1466900A4 (de)	2005-07-20	2-substituierte vitamin-d-derivate
EP0418655A3 (en)	1991-12-18	Conjugated gamma-hydroxybutenolide compounds and antiulcer agents containing the same as an effective ingredient
FI900796A0 (fi)	1990-02-16	Aralkylaminfoereningar.