ES2087247T3 - Inhibidor de aldosa reductasa. - Google Patents

Inhibidor de aldosa reductasa.

Info

Publication number
ES2087247T3
ES2087247T3 ES91307304T ES91307304T ES2087247T3 ES 2087247 T3 ES2087247 T3 ES 2087247T3 ES 91307304 T ES91307304 T ES 91307304T ES 91307304 T ES91307304 T ES 91307304T ES 2087247 T3 ES2087247 T3 ES 2087247T3
Authority
ES
Spain
Prior art keywords
aldosa
reductasa
inhibitor
different
chem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91307304T
Other languages
English (en)
Inventor
Yukio Suzuki
Kouichi Kuno
Motoshi Shoda
Masao Yaso
Satoshi Yaginuma
Akira Asahi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Kasei Corp
Asahi Chemical Industry Co Ltd
Original Assignee
Asahi Chemical Industry Co Ltd
Asahi Kasei Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Chemical Industry Co Ltd, Asahi Kasei Kogyo KK filed Critical Asahi Chemical Industry Co Ltd
Application granted granted Critical
Publication of ES2087247T3 publication Critical patent/ES2087247T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/72—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings and other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

UNA COMPOSICION INHIBIDORA DE LA REDUCTOSA ALDOSA QUE CONSTA DE UN COMPUESTO DE FORMULA (I): EN LA QUE CADA R, PUEDE SER IDENTICO O DIFERENTE, ES UN GRUPO ALQUILO BAJO O UN GRUPO CICLOHEXILMETILO Y CADA N, QUE PUEDE SER IDENTICO O DIFERENTE, ES 2 O 3 O UNA SAL FISIOLOGICAMENTE ACEPTABLE DEL MISMO, Y UN TRANSPORTADOR.
ES91307304T 1990-08-08 1991-08-08 Inhibidor de aldosa reductasa. Expired - Lifetime ES2087247T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2208128A JPH0495025A (ja) 1990-08-08 1990-08-08 アルドースリダクターゼ阻害剤

Publications (1)

Publication Number Publication Date
ES2087247T3 true ES2087247T3 (es) 1996-07-16

Family

ID=16551106

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91307304T Expired - Lifetime ES2087247T3 (es) 1990-08-08 1991-08-08 Inhibidor de aldosa reductasa.

Country Status (6)

Country Link
US (1) US5155259A (es)
EP (1) EP0473308B1 (es)
JP (1) JPH0495025A (es)
AT (1) ATE138364T1 (es)
DE (1) DE69119668T2 (es)
ES (1) ES2087247T3 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994010206A1 (en) * 1992-10-26 1994-05-11 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE DEPARTMENT OFHEALTH AND HUMAN SERVICES Intrinsic inhibitors of aldose reductase
WO1999019291A1 (en) 1997-10-14 1999-04-22 Asahi Kasei Kogyo Kabushiki Kaisha Biphenyl-5-alkanoic acid derivatives and use thereof
US6867320B2 (en) * 2002-02-21 2005-03-15 Asahi Kasei Pharma Corporation Substituted phenylalkanoic acid derivatives and use thereof
US7470807B2 (en) * 2003-08-14 2008-12-30 Asahi Kasei Pharma Corporation Substituted arylalkanoic acid derivatives and use thereof
CA2820931C (en) 2006-07-20 2015-08-18 Asahi Kasei Pharma Corporation Novel crystals of substituted phenylalkanoic acid and method of producing the same
US8273746B2 (en) * 2007-03-23 2012-09-25 The Board Of Regents Of The University Of Texas System Methods involving aldose reductase inhibitors
US8916563B2 (en) 2010-07-16 2014-12-23 The Trustees Of Columbia University In The City Of New York Aldose reductase inhibitors and uses thereof
EP3192796B1 (en) 2010-07-16 2019-09-04 The Trustees of Columbia University in the City of New York Aldose reductase inhibitors and uses thereof
DK3352754T3 (da) 2016-06-21 2020-12-07 Univ Columbia Aldosereduktaseinhibitorer og fremgangsmåder til anvendelse deraf
IL272246B2 (en) 2017-07-28 2026-01-01 Applied Therapeutics Inc History of 2-(4-oxo/thioketone/azo-3-((substituted)benzo[d]thiazol-2-yl)methyl)- 3,4-dihydrothieno[3,4-d]pyridazin-1-yl)acetic acid for use as an aldose reductase inhibitor for the treatment of galactosemia or prevention of galactosemia-related complications
CN113840825A (zh) 2019-04-01 2021-12-24 应用治疗公司 醛糖还原酶抑制剂
WO2020227430A1 (en) 2019-05-07 2020-11-12 University Of Miami Treatment and detection of inherited neuropathies and associated disorders
IL297779A (en) 2020-05-01 2022-12-01 Applied Therapeutics Inc Aldose reductase inhibitors for treating sorbitol dehydrogenase deficiency

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62205095A (ja) * 1986-03-04 1987-09-09 Toyo Jozo Co Ltd 新生理活性物質アルドスタチンおよびその製造法

Also Published As

Publication number Publication date
DE69119668D1 (de) 1996-06-27
ATE138364T1 (de) 1996-06-15
EP0473308A1 (en) 1992-03-04
DE69119668T2 (de) 1997-01-02
JPH0495025A (ja) 1992-03-27
EP0473308B1 (en) 1996-05-22
US5155259A (en) 1992-10-13

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