ATE202143T1 - Chimere ribozym-snrna moleküle mit katalytischen aktivität nuklearer rnas - Google Patents
Chimere ribozym-snrna moleküle mit katalytischen aktivität nuklearer rnasInfo
- Publication number
- ATE202143T1 ATE202143T1 AT96830641T AT96830641T ATE202143T1 AT E202143 T1 ATE202143 T1 AT E202143T1 AT 96830641 T AT96830641 T AT 96830641T AT 96830641 T AT96830641 T AT 96830641T AT E202143 T1 ATE202143 T1 AT E202143T1
- Authority
- AT
- Austria
- Prior art keywords
- ribozyme
- catalytic activity
- chimeres
- molecules
- nuclear rnas
- Prior art date
Links
- 230000003197 catalytic effect Effects 0.000 title abstract 2
- 102000040650 (ribonucleotides)n+m Human genes 0.000 title 1
- 108091032973 (ribonucleotides)n+m Proteins 0.000 title 1
- 241000251204 Chimaeridae Species 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 2
- 230000036436 anti-hiv Effects 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
- C12N15/1132—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses against retroviridae, e.g. HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
- C12N2310/121—Hammerhead
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- AIDS & HIV (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT96RM000017A IT1283876B1 (it) | 1996-01-12 | 1996-01-12 | Molecole chimeriche ribozima-snrna ad attivita' catalitica per rna a localizzazione nucleare |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE202143T1 true ATE202143T1 (de) | 2001-06-15 |
Family
ID=11403768
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96830641T ATE202143T1 (de) | 1996-01-12 | 1996-12-20 | Chimere ribozym-snrna moleküle mit katalytischen aktivität nuklearer rnas |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US5994124A (de) |
| EP (1) | EP0784094B1 (de) |
| AT (1) | ATE202143T1 (de) |
| DE (1) | DE69613336T2 (de) |
| ES (1) | ES2160796T3 (de) |
| IT (1) | IT1283876B1 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6274369B1 (en) * | 1996-02-02 | 2001-08-14 | Invitrogen Corporation | Method capable of increasing competency of bacterial cell transformation |
| US6692910B2 (en) * | 1997-07-28 | 2004-02-17 | The University Of Connecticut | Inhibition of a target messenger RNA with a modified U1 small nuclear RNA |
| AUPP249298A0 (en) | 1998-03-20 | 1998-04-23 | Ag-Gene Australia Limited | Synthetic genes and genetic constructs comprising same I |
| BRPI9908967B1 (pt) | 1998-03-20 | 2017-05-30 | Benitec Australia Ltd | processos para reprimir, retardar ou de outro modo reduzir a expressão de um gene alvo em uma célula de planta |
| US20030036519A1 (en) * | 1998-04-21 | 2003-02-20 | Ryszard Kole | Stable alteration of pre-mrna splicing patterns by modified rnas |
| US6423885B1 (en) | 1999-08-13 | 2002-07-23 | Commonwealth Scientific And Industrial Research Organization (Csiro) | Methods for obtaining modified phenotypes in plant cells |
| AUPR621501A0 (en) | 2001-07-06 | 2001-08-02 | Commonwealth Scientific And Industrial Research Organisation | Delivery of ds rna |
| WO2004050674A2 (en) * | 2002-12-04 | 2004-06-17 | Algos Therapeutics, Inc. | Methods and materials for modulating trpm2 |
| JP4634371B2 (ja) * | 2003-03-27 | 2011-02-16 | ピーティーシー セラピューティクス，インコーポレーテッド | ｔＲＮＡスプライシングエンドヌクレアーゼに標的化する化合物の同定方法、および該化合物の抗増殖剤としての使用 |
| EP1613159A4 (de) * | 2003-03-27 | 2007-08-01 | Ptc Therapeutics Inc | Verfahren zur identifikation von verbindungen mit einer trna-splicenden endonuklease als angriffsort, sowie verwendungen für diese verbindungen als antifungale mittel |
| WO2004087884A2 (en) * | 2003-03-27 | 2004-10-14 | Ptc Therapeutics, Inc | TARGETING ENZYMES OF THE tRNA SPLICING PATHWAY FOR IDENTIFICATION OF ANTI-FUNGAL AND/OR ANTI-PROLIFERATIVE MOLECULES |
| CA2531321A1 (en) * | 2003-07-02 | 2005-01-13 | Ptc Therapeutics, Inc. | Rna processing protein complexes and uses thereof |
| AU2004272629A1 (en) * | 2003-09-12 | 2005-03-24 | Commonwealth Scientific And Industrial Research Organisation | Modified gene-silencing nucleic acid molecules and uses thereof |
| US9040491B2 (en) * | 2006-08-30 | 2015-05-26 | The Trustees Of The University Of Pennsylvania | Compositions, methods and kits based on small nuclear RNAs |
| WO2008113773A2 (en) * | 2007-03-16 | 2008-09-25 | Biorigen S.R.L. | Gene expression regulation technology and noncoding rnas for diagnosis and therapy |
| US9470350B2 (en) | 2013-07-23 | 2016-10-18 | Spencer Composites Corporation | Metal-to-composite interfaces |
| MX2020002872A (es) | 2017-09-15 | 2020-10-05 | Commw Scient Ind Res Org | Moléculas de arn. |
| EP4370680A4 (de) * | 2021-07-16 | 2025-08-13 | Aptah Bio Inc | Polynukleotidzusammensetzungen und verfahren zur genexpressionsregulierung |
| IL311101A (en) * | 2021-09-03 | 2024-04-01 | Tacit Therapeutics Inc | RNA editing through recruitment of SPLICEOSOME components |
| CN119137273A (zh) | 2022-03-04 | 2024-12-13 | 洛卡纳生物股份有限公司 | 包括工程化核内小RNA（snRNA）的组合物和方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2114312A1 (en) * | 1992-05-27 | 1993-12-09 | John J. Rossi | Chimeric trnalys-ribozyme molecules |
| WO1995000652A1 (en) * | 1993-06-18 | 1995-01-05 | Ciba-Geigy Ag | Chimeric plant genes possessing independent regulatory sequences |
| US5695938A (en) * | 1994-12-09 | 1997-12-09 | City Of Hope | Anti-HIV ribozymes |
-
1996
- 1996-01-12 IT IT96RM000017A patent/IT1283876B1/it active IP Right Grant
- 1996-12-20 DE DE69613336T patent/DE69613336T2/de not_active Expired - Lifetime
- 1996-12-20 EP EP96830641A patent/EP0784094B1/de not_active Expired - Lifetime
- 1996-12-20 ES ES96830641T patent/ES2160796T3/es not_active Expired - Lifetime
- 1996-12-20 AT AT96830641T patent/ATE202143T1/de active
-
1997
- 1997-01-09 US US08/781,620 patent/US5994124A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69613336T2 (de) | 2002-04-18 |
| EP0784094A1 (de) | 1997-07-16 |
| IT1283876B1 (it) | 1998-05-07 |
| US5994124A (en) | 1999-11-30 |
| ITRM960017A1 (it) | 1997-07-12 |
| EP0784094B1 (de) | 2001-06-13 |
| DE69613336D1 (de) | 2001-07-19 |
| ITRM960017A0 (it) | 1996-01-12 |
| ES2160796T3 (es) | 2001-11-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69613336D1 (de) | Chimere ribozym-snRNA Moleküle mit katalytischen Aktivität nuklearer RNAs | |
| ES2105698T3 (es) | Oligonucleotidos modificados con 7-deazapurina. | |
| DK0778842T3 (da) | Mammal telomerase | |
| NO900853L (no) | Slitebane for kjoeretoeydekk med midtre partier forsynt medskraa innsnitt. | |
| EP0623171A4 (de) | Enzymatische rna-moleküle. | |
| DE3789033D1 (de) | Motorbetriebene Servolenkung für Fahrzeuge. | |
| DE69514234D1 (de) | Oberflächenlokalisierte expression von enzymen in gengesteuerter prodrugtherapie | |
| DE69807507D1 (de) | Slurrykohlenwasserstoffsyntheseverfahren mit katalysatorwiederbelebung in auswendigem steigrohr | |
| IT209606Z2 (it) | Struttura di rivestimento, particolarmente per volanti di autoveicoli. | |
| EP0681643A1 (de) | Katalytischer konverter mit elektrischer beheizung. | |
| ITTO20000384A0 (it) | Ruota costipatrice con ramponi sostituibili. | |
| EP1250157A4 (de) | Antisens-modulation der expression der induzierbaren stickstoffmonoxid-synthase | |
| DE3787322D1 (de) | Motorbetriebene Servolenkung für Fahrzeuge. | |
| BR8803254A (pt) | Catalisador,processo para preparacao do mesmo bem como sua utilizacao em hidro-refinacao de fracoes de hidrocarbonetos | |
| DE3862466D1 (de) | Versorgungsfahrzeug, inbesondere fuer flugzeuge. | |
| DE69715457D1 (de) | Reformierungsverfahren mit katalysatorvorbehandlung | |
| DE68900790D1 (de) | Katalysator-traegerkoerper fuer katalytische reaktoren. | |
| DE68909839D1 (de) | Lenkvorrichtung für die Hinterräder. | |
| NO874119L (no) | Kjoeretoeydekk, spesielt til bruk for terrenggaaende kjoeretoeyer. | |
| DE58901721D1 (de) | Luftbereiftes fahrzeugrad. | |
| IT8748427A0 (it) | Autoveicolo con sterzatura sulle ruote anteriori e posteriori,in particolare sterzatura su quattro ruote | |
| BR9813347B1 (pt) | processo para preparar quinonadiiminas a partir de fenilenodiaminas com oxigênio na presença de catalisador de carbono ativado modificacado. | |
| ITRM930220V0 (it) | Vetro perfezionato per veicoli atto ad essere utilizzato come vetro resistente allo sfondamento. | |
| IT8520495A0 (it) | Ruota portante, in particolare per carrelli sospesi di gru. | |
| DE69010261D1 (de) | Lenkrad. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |