ATE202286T1 - Rhodamin-derivate für die photodynamische therapie von krebs und in-vitro reinigung von leukämien - Google Patents

Rhodamin-derivate für die photodynamische therapie von krebs und in-vitro reinigung von leukämien

Info

Publication number: ATE202286T1
Authority: AT; Austria
Prior art keywords: xanthen; imino; amino; benzoic acid; ester hydrochloride
Prior art date: 1994-09-02

Application number

AT95928907T

Other languages

English (en)

Inventor

Louis Gaboury

Richard Giasson

Li Tiechao

Ajay Kumar Gupta

Luc Villeneuve

Original Assignee

Univ Montreal

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-09-02

Filing date

1995-08-16

Publication date

2001-07-15

1995-08-16 Application filed by Univ Montreal filed Critical Univ Montreal

2001-07-15 Application granted granted Critical

2001-07-15 Publication of ATE202286T1 publication Critical patent/ATE202286T1/de

Links

PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical class [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 title abstract 3
206010028980 Neoplasm Diseases 0.000 title abstract 2
201000011510 cancer Diseases 0.000 title abstract 2
238000000338 in vitro Methods 0.000 title 1
208000032839 leukemia Diseases 0.000 title 1
238000002428 photodynamic therapy Methods 0.000 title 1
238000000746 purification Methods 0.000 title 1
MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
GJDFFYWUIWJIMO-UHFFFAOYSA-N [9-(2-butoxycarbonylphenyl)-6-(ethylamino)xanthen-3-ylidene]-ethylazanium;chloride Chemical compound Cl.CCCCOC(=O)C1=CC=CC=C1C1=C2C=CC(=NCC)C=C2OC2=CC(NCC)=CC=C21 GJDFFYWUIWJIMO-UHFFFAOYSA-N 0.000 abstract 1
YFSICBRXHDFNIR-UHFFFAOYSA-N butyl 2-(3-amino-4,5-dibromo-6-iminoxanthen-9-yl)benzoate;hydrochloride Chemical compound Cl.CCCCOC(=O)C1=CC=CC=C1C1=C2C=CC(=N)C(Br)=C2OC2=C(Br)C(N)=CC=C21 YFSICBRXHDFNIR-UHFFFAOYSA-N 0.000 abstract 1
230000022534 cell killing Effects 0.000 abstract 1
230000002708 enhancing effect Effects 0.000 abstract 1
GETYPKQGOHYZCU-UHFFFAOYSA-N ethyl 2-(3-amino-4,5-dibromo-6-iminoxanthen-9-yl)benzoate;hydrochloride Chemical compound Cl.CCOC(=O)C1=CC=CC=C1C1=C2C=CC(=N)C(Br)=C2OC2=C(Br)C(N)=CC=C21 GETYPKQGOHYZCU-UHFFFAOYSA-N 0.000 abstract 1
230000037041 intracellular level Effects 0.000 abstract 1
230000014759 maintenance of location Effects 0.000 abstract 1
MUDCDMMNYVJLEB-UHFFFAOYSA-N methyl 2-(3-amino-4,5-dibromo-6-iminoxanthen-9-yl)benzoate;hydrochloride Chemical compound Cl.COC(=O)C1=CC=CC=C1C1=C2C=CC(=N)C(Br)=C2OC2=C(Br)C(N)=CC=C21 MUDCDMMNYVJLEB-UHFFFAOYSA-N 0.000 abstract 1
PBCZJGUPXWPWCW-UHFFFAOYSA-N octyl 2-(3-amino-4,5-dibromo-6-iminoxanthen-9-yl)benzoate;hydrochloride Chemical compound Cl.CCCCCCCCOC(=O)C1=CC=CC=C1C1=C2C=CC(=N)C(Br)=C2OC2=C(Br)C(N)=CC=C21 PBCZJGUPXWPWCW-UHFFFAOYSA-N 0.000 abstract 1
238000006862 quantum yield reaction Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
- C07D311/82—Xanthenes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Radiation-Therapy Devices (AREA)

AT95928907T 1994-09-02 1995-08-16 Rhodamin-derivate für die photodynamische therapie von krebs und in-vitro reinigung von leukämien ATE202286T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/300,179 US5556992A (en)	1994-09-02	1994-09-02	Novel rhodamine derivatives for photodynamic therapy of cancer and in vitro purging of the leukemias
PCT/CA1995/000485 WO1996007431A1 (en)	1994-09-02	1995-08-16	Novel rhodamine derivatives for photodynamic therapy of cancer and in vitro purging of the leukemias

Publications (1)

Publication Number	Publication Date
ATE202286T1 true ATE202286T1 (de)	2001-07-15

Family

ID=23158032

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95928907T ATE202286T1 (de)	1994-09-02	1995-08-16	Rhodamin-derivate für die photodynamische therapie von krebs und in-vitro reinigung von leukämien

Country Status (14)

Country	Link
US (2)	US5556992A (de)
EP (1)	EP0773794B1 (de)
JP (1)	JP4222628B2 (de)
KR (1)	KR970705413A (de)
AT (1)	ATE202286T1 (de)
AU (1)	AU688100B2 (de)
BR (1)	BR9508779A (de)
CA (1)	CA2197435C (de)
DE (1)	DE69521430T2 (de)
DK (1)	DK0773794T3 (de)
ES (1)	ES2160173T3 (de)
GR (1)	GR3036636T3 (de)
PT (1)	PT773794E (de)
WO (1)	WO1996007431A1 (de)

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ATE285793T1 (de) *	1999-10-05	2005-01-15	Univ Montreal	Rhodaminderivate für die photodynamische diagnose und behandlung
US8409564B2 (en)	1999-10-05	2013-04-02	Universite De Montreal	Rhodamine derivatives for photodynamic diagnosis and treatment
US6828091B2 (en)	2000-08-03	2004-12-07	Cytovia, Inc.	Method of identifying immunosuppressive agents
US20020123530A1 (en) *	2001-01-03	2002-09-05	Indig Guilherme Luiz	Use of crystal violet as photochemotherapeutic agent
US20040086453A1 (en) *	2001-01-22	2004-05-06	Howes Randolph M.	Compositions, methods, apparatuses, and systems for singlet oxygen delivery
EP1276734A1 (de) *	2001-04-02	2003-01-22	Theratechnologies Inc.	Halogenierte rhodamine derivate und deren verwendungen
CA2342675A1 (en) *	2001-04-02	2002-10-02	Abdelkrim Habi	Halogenated rhodamine derivatives and applications thereof
US20030027229A1 (en) *	2001-06-01	2003-02-06	Cytovia, Inc.	Methods of identifying potentially therapeutically selective and effective anti-cancer agents that are inducers of apoptosis
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WO2005053743A1 (en) *	2003-12-05	2005-06-16	Université de Montréal	Immunologic compounds for prevention, protection, prophylaxis or treatment of immunological disorders, infections and cancer
US8198328B2 (en)	2004-01-21	2012-06-12	New York University	Treatment of cancer using benzoic acid derivatives
GB0520436D0 (en) *	2005-10-07	2005-11-16	Photobiotics Ltd	Biological materials and uses thereof
WO2008115088A1 (fr) *	2007-03-16	2008-09-25	Evgeny Pavlovich Germanov	Utilisation de rhodamine 6g en tant que médicament destiné au traitement de néoplasies malignes et d'amyloïdoses
WO2010085651A1 (en) *	2009-01-23	2010-07-29	The Penn State Research Foundation	In vivo photodynamic therapy of cancer via a near infrared agent encapsulated in calcium phosphate nanoparticles
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US9642687B2 (en)	2010-06-15	2017-05-09	The Procter & Gamble Company	Methods for whitening teeth
RU2527519C2 (ru) *	2010-06-24	2014-09-10	Общество С Ограниченной Ответственностью "Митотех"	Мягкие катионные митохондриальные разобщители
CN102304295A (zh) *	2011-07-12	2012-01-04	核工业理化工程研究院	一种适合532nm激光泵浦的罗丹明101酯激光染料的制备方法
CN103183657A (zh) *	2011-12-31	2013-07-03	中国科学院成都有机化学有限公司	一种罗丹明酯化衍生物的合成方法
EP3058957A1 (de)	2015-02-19	2016-08-24	Kiadis Pharma Intellectual Property BV	Verbessertes fotodynamisches Verfahren und daraus hergestelltes Produkt
CN107118198B (zh) *	2017-06-08	2019-07-09	福州大学	兼有抗癌作用和荧光性能的罗丹明b衍生物及其制备方法
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1994
- 1994-09-02 US US08/300,179 patent/US5556992A/en not_active Expired - Lifetime
1995
- 1995-08-16 BR BR9508779A patent/BR9508779A/pt not_active IP Right Cessation
- 1995-08-16 ES ES95928907T patent/ES2160173T3/es not_active Expired - Lifetime
- 1995-08-16 WO PCT/CA1995/000485 patent/WO1996007431A1/en not_active Ceased
- 1995-08-16 AT AT95928907T patent/ATE202286T1/de active
- 1995-08-16 KR KR1019970701111A patent/KR970705413A/ko not_active Withdrawn
- 1995-08-16 DK DK95928907T patent/DK0773794T3/da active
- 1995-08-16 DE DE69521430T patent/DE69521430T2/de not_active Expired - Lifetime
- 1995-08-16 PT PT95928907T patent/PT773794E/pt unknown
- 1995-08-16 CA CA002197435A patent/CA2197435C/en not_active Expired - Lifetime
- 1995-08-16 AU AU32488/95A patent/AU688100B2/en not_active Ceased
- 1995-08-16 EP EP95928907A patent/EP0773794B1/de not_active Expired - Lifetime
- 1995-08-16 JP JP50905796A patent/JP4222628B2/ja not_active Expired - Lifetime
1996
- 1996-07-01 US US08/674,247 patent/US5773460A/en not_active Expired - Lifetime
2001
- 2001-09-17 GR GR20010401494T patent/GR3036636T3/el unknown

Also Published As

Publication number	Publication date
KR970705413A (ko)	1997-10-09
US5773460A (en)	1998-06-30
ES2160173T3 (es)	2001-11-01
EP0773794A1 (de)	1997-05-21
JPH10505349A (ja)	1998-05-26
AU3248895A (en)	1996-03-27
DK0773794T3 (da)	2001-10-15
CA2197435A1 (en)	1996-03-14
US5556992A (en)	1996-09-17
EP0773794B1 (de)	2001-06-20
BR9508779A (pt)	1997-12-23
JP4222628B2 (ja)	2009-02-12
DE69521430T2 (de)	2002-05-02
DE69521430D1 (de)	2001-07-26
WO1996007431A1 (en)	1996-03-14
CA2197435C (en)	2010-01-12
GR3036636T3 (en)	2001-12-31
PT773794E (pt)	2001-12-28
AU688100B2 (en)	1998-03-05

Publication	Publication Date	Title
ATE202286T1 (de)	2001-07-15	Rhodamin-derivate für die photodynamische therapie von krebs und in-vitro reinigung von leukämien
US7066941B2 (en)	2006-06-27	Apparatus for skin treatment
Grossweiner	1984	Photochemistry of proteins: a review
CA2209167A1 (en)	1997-05-09	Hydroxylamine derivatives useful for enhancing the molecular chaperon production and the preparation thereof
ES2100452T3 (es)	1997-06-16	Composiciones de liposomas de fotosensibilizadores de porfirina.
MY119483A (en)	2005-06-30	1-(2-oxo-acetyl)-piperidine-2-carboxylic acid derivatives as multi-drug-resistant cancer cell sensitizers
JP2004506005A5 (de)	2011-07-07
ATE277515T1 (de)	2004-10-15	Verfahren zur behandlung von pigmentierten krebszellen durch photodynamische therapie
DE68925505D1 (de)	1996-03-07	Zusammensetzungen zum Erreichen eines Lasereffektes und Methoden zu deren Gebrauch
CA2284879A1 (en)	1998-11-12	Ethylene glycol esters of monohydrobenzoporphyrin derivatives as photoactive agents
CA2273010A1 (en)	1998-06-18	Use of green porphyrins for the manufacture of a medicament for the treatment of secondary cataracts
DK0553890T3 (da)	1996-11-18	Diphenylheteroalkylderivater, deres fremstilling og lægemidler og kosmetisk fremstillet derudfra
ATE336488T1 (de)	2006-09-15	Neue ortho-naphthochinonderivate, neue synthesen zu ihrer herstellung und ihre anwendung in der inhibierung von neoplastischem zellwachstum
ES2166470T3 (es)	2002-04-16	Derivados de indolalquilo de la benzodioxanmetilamina como ligandos de los receptores 5-ht1a.
ATE62400T1 (de)	1991-04-15	Kosmetisches mittel zum schutz gegen uvstrahlung, das einen kupferkomplex des 3,5diisopropyl-salicyls\|ure enthaelt sowie dessen verwendung in kosmetika.
NO995440D0 (no)	1999-11-05	Ny klasse fotoaktive benzoporfyrinderivat-forbindelser
ATE278698T1 (de)	2004-10-15	Phospholipid-derivate von phosphonocarbonsäuren, deren herstellung sowie deren verwendung als antivirale arzneimittel
CA2270558A1 (en)	1998-05-14	Treatment of autoimmune diseases by photochemotherapy
TR199700694T1 (xx)	1998-02-21	D vitamini t�revlerinin dermotolojik kullan�m�.
AU8355598A (en)	1999-02-22	The use of 1,3,4,6-tetrahydroxy-helianthrone and its derivatives in phot odynamictherapy and certain such novel derivatives
Radakovic-Fijan et al.	1999	Ultrastructural changes in PAM cells after photodynamic treatment with delta-aminolevulinic acid-induced porphyrins or photosan
AR020923A1 (es)	2002-06-05	Una composicion de filtro solar
CA2223522A1 (en)	1996-12-12	Use of 5-aminolevulinic acid for treating or detecting rapidly growing cells of exogenous origin
ES2105973B1 (es)	1998-05-01	Composicion liposomal para la regeneracion celular de la piel.