DK0773794T3 - Nye rhodaminderivater til fotodynamisk cancerterapi og in vitro-rensning for leukæmier - Google Patents

Nye rhodaminderivater til fotodynamisk cancerterapi og in vitro-rensning for leukæmier

Info

Publication number
DK0773794T3
DK0773794T3 DK95928907T DK95928907T DK0773794T3 DK 0773794 T3 DK0773794 T3 DK 0773794T3 DK 95928907 T DK95928907 T DK 95928907T DK 95928907 T DK95928907 T DK 95928907T DK 0773794 T3 DK0773794 T3 DK 0773794T3
Authority
DK
Denmark
Prior art keywords
xanthen
imino
amino
benzoic acid
ester hydrochloride
Prior art date
Application number
DK95928907T
Other languages
Danish (da)
English (en)
Inventor
Louis Gaboury
Richard Giasson
Li Tiechao
Ajay Kumar Gupta
Luc Villeneuve
Original Assignee
Univ Montreal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Montreal filed Critical Univ Montreal
Application granted granted Critical
Publication of DK0773794T3 publication Critical patent/DK0773794T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Radiation-Therapy Devices (AREA)
DK95928907T 1994-09-02 1995-08-16 Nye rhodaminderivater til fotodynamisk cancerterapi og in vitro-rensning for leukæmier DK0773794T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/300,179 US5556992A (en) 1994-09-02 1994-09-02 Novel rhodamine derivatives for photodynamic therapy of cancer and in vitro purging of the leukemias
PCT/CA1995/000485 WO1996007431A1 (en) 1994-09-02 1995-08-16 Novel rhodamine derivatives for photodynamic therapy of cancer and in vitro purging of the leukemias

Publications (1)

Publication Number Publication Date
DK0773794T3 true DK0773794T3 (da) 2001-10-15

Family

ID=23158032

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95928907T DK0773794T3 (da) 1994-09-02 1995-08-16 Nye rhodaminderivater til fotodynamisk cancerterapi og in vitro-rensning for leukæmier

Country Status (14)

Country Link
US (2) US5556992A (de)
EP (1) EP0773794B1 (de)
JP (1) JP4222628B2 (de)
KR (1) KR970705413A (de)
AT (1) ATE202286T1 (de)
AU (1) AU688100B2 (de)
BR (1) BR9508779A (de)
CA (1) CA2197435C (de)
DE (1) DE69521430T2 (de)
DK (1) DK0773794T3 (de)
ES (1) ES2160173T3 (de)
GR (1) GR3036636T3 (de)
PT (1) PT773794E (de)
WO (1) WO1996007431A1 (de)

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JPH10279502A (ja) * 1997-03-31 1998-10-20 Katsuro Tachibana 光感受性物質の励起方法
IL121440A0 (en) 1997-07-31 1998-01-04 Yeda Res & Dev The use of 1,3,4,6-tetrahydroxy-helianthrone and its derivatives in photodynamic therapy and certain such novel derivatives
PL341661A1 (en) * 1997-10-10 2001-04-23 Cytovia Novel fluorescent reporter particles and their application in combination with testing capsizes
US6342611B1 (en) 1997-10-10 2002-01-29 Cytovia, Inc. Fluorogenic or fluorescent reporter molecules and their applications for whole-cell fluorescence screening assays for capsases and other enzymes and the use thereof
US8974363B2 (en) * 1997-12-11 2015-03-10 Provectus Pharmatech, Inc. Topical medicaments and methods for photodynamic treatment of disease
US7462605B2 (en) * 1998-01-23 2008-12-09 Celmed Oncology (Usa), Inc. Phosphoramidate compounds and methods of use
AU753155B2 (en) * 1998-01-23 2002-10-10 Kiadis Pharma Intellectual Property B.V. Enzyme catalyzed therapeutic agents
DE69920473T2 (de) * 1998-07-21 2006-02-23 Cytovia, Inc., San Diego Neue fluoreszenzfarbstoffe und ihre anwendung in fluoreszenznachweisverfahren ganzer zellen für kaspasen, peptidasen, proteasen und andere enzyme sowie deren verwendung
US20090117199A1 (en) * 1998-08-06 2009-05-07 Scott Timothy C Method of treatment of cancer
US7648695B2 (en) 1998-08-06 2010-01-19 Provectus Pharmatech, Inc. Medicaments for chemotherapeutic treatment of disease
US8557298B2 (en) * 1998-08-06 2013-10-15 Provectus Pharmatech, Inc. Medicaments for chemotherapeutic treatment of disease
US7384623B1 (en) 1998-12-21 2008-06-10 Provectus Pharmatech, Inc. High energy phototherapeutic agents
US8470296B2 (en) 1998-12-21 2013-06-25 Provectus Pharmatech, Inc. Intracorporeal medicaments for high energy phototherapeutic treatment of disease
AR022404A1 (es) * 1999-01-25 2002-09-04 Photogen Inc Metodo y agentes para la terapia de radiacion mejorada
US20040228871A1 (en) * 1999-06-03 2004-11-18 Tayyaba Hasan Treatment and analysis of proliferative disorders
US6683061B1 (en) * 1999-07-22 2004-01-27 Newbiotics, Inc. Enzyme catalyzed therapeutic activation
BR0012676A (pt) * 1999-07-22 2003-07-01 Newbiotics Inc Métodos para tratamento de tumores resistentes a terapia
CN1372467A (zh) 1999-08-13 2002-10-02 福托金公司 改进的局部用药物和疾病的光动力学治疗方法
MXPA02003522A (es) * 1999-10-05 2004-09-10 Univ Montreal Derivados de rodamina para diagnostico fotodinamico y tratamiento.
US8409564B2 (en) * 1999-10-05 2013-04-02 Universite De Montreal Rhodamine derivatives for photodynamic diagnosis and treatment
AU2001278135A1 (en) 2000-08-03 2002-02-18 Cytovia, Inc. Method of identifying immunosuppressive agents
US20020123530A1 (en) * 2001-01-03 2002-09-05 Indig Guilherme Luiz Use of crystal violet as photochemotherapeutic agent
US20040086453A1 (en) * 2001-01-22 2004-05-06 Howes Randolph M. Compositions, methods, apparatuses, and systems for singlet oxygen delivery
EP1276734A1 (de) * 2001-04-02 2003-01-22 Theratechnologies Inc. Halogenierte rhodamine derivate und deren verwendungen
CA2342675A1 (en) * 2001-04-02 2002-10-02 Abdelkrim Habi Halogenated rhodamine derivatives and applications thereof
AU2002243541A1 (en) * 2001-06-01 2002-12-16 Cytovia, Inc. Methods of identifying anti-cancer agents that are inducers of apoptosis
US7012100B1 (en) 2002-06-04 2006-03-14 Avolix Pharmaceuticals, Inc. Cell migration inhibiting compositions and methods and compositions for treating cancer
EP1701740A4 (de) * 2003-12-05 2010-03-31 Univ Montreal Immunologische verbindungen zur prävention, schutz, prophylaxe oder behandlung von immunologischen erkrankungen, infektionen und krebs
US8198328B2 (en) * 2004-01-21 2012-06-12 New York University Treatment of cancer using benzoic acid derivatives
GB0520436D0 (en) * 2005-10-07 2005-11-16 Photobiotics Ltd Biological materials and uses thereof
US20100144854A1 (en) * 2007-03-16 2010-06-10 Mikhail Kutushov Use of rhodamine 6g as a medicinal agent for treating malignant neoplasms and amiloidoses
WO2010085651A1 (en) * 2009-01-23 2010-07-29 The Penn State Research Foundation In vivo photodynamic therapy of cancer via a near infrared agent encapsulated in calcium phosphate nanoparticles
GB0904825D0 (en) 2009-03-20 2009-05-06 Photobiotics Ltd Biological materials and uses thereof
US9642687B2 (en) 2010-06-15 2017-05-09 The Procter & Gamble Company Methods for whitening teeth
RU2527519C2 (ru) * 2010-06-24 2014-09-10 Общество С Ограниченной Ответственностью "Митотех" Мягкие катионные митохондриальные разобщители
CN102304295A (zh) * 2011-07-12 2012-01-04 核工业理化工程研究院 一种适合532nm激光泵浦的罗丹明101酯激光染料的制备方法
CN103183657A (zh) * 2011-12-31 2013-07-03 中国科学院成都有机化学有限公司 一种罗丹明酯化衍生物的合成方法
EP3058957A1 (de) 2015-02-19 2016-08-24 Kiadis Pharma Intellectual Property BV Verbessertes fotodynamisches Verfahren und daraus hergestelltes Produkt
CN107118198B (zh) * 2017-06-08 2019-07-09 福州大学 兼有抗癌作用和荧光性能的罗丹明b衍生物及其制备方法
CN107880009A (zh) * 2017-11-28 2018-04-06 西安石油大学 一种具有表面活性的罗丹明b荧光探针制备方法
EP3700520B1 (de) * 2017-11-29 2024-05-01 The Rockefeller University Kombination aus lokalen und systemischen therapien für verbesserte behandlung von hautkrankheiten
US11474098B2 (en) 2017-12-22 2022-10-18 The Trustees Of Columbia University In The City Of New York Drug target for preventing pathologic calcium overload in cardiomyocytes and methods of screening for same
CN115960090B (zh) * 2022-12-30 2024-03-29 中山大学 一种罗丹明b修饰吡啶配体的制备方法及其光催化抗菌应用
CN119241495B (zh) * 2024-09-29 2025-10-14 山西大学 一种近红外硒罗丹明光动力光敏剂及其制备方法和应用

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US4612007A (en) * 1981-06-16 1986-09-16 Edelson Richard Leslie Method and system for externally treating the blood
DE3832739A1 (de) * 1988-09-27 1990-03-29 Basf Ag Verfahren zur herstellung von rhodamin-farbstoffen in granulatform
JP2811371B2 (ja) * 1991-06-21 1998-10-15 バクスター、インターナショナル、インコーポレイテッド 体液中の病原を不活性化する方法
US5459268A (en) * 1993-10-25 1995-10-17 Molecular Probes, Inc. Xanthylium dyes that are well retained in mitochondria

Also Published As

Publication number Publication date
US5556992A (en) 1996-09-17
BR9508779A (pt) 1997-12-23
KR970705413A (ko) 1997-10-09
CA2197435A1 (en) 1996-03-14
JPH10505349A (ja) 1998-05-26
JP4222628B2 (ja) 2009-02-12
ES2160173T3 (es) 2001-11-01
DE69521430T2 (de) 2002-05-02
DE69521430D1 (de) 2001-07-26
AU688100B2 (en) 1998-03-05
AU3248895A (en) 1996-03-27
EP0773794A1 (de) 1997-05-21
PT773794E (pt) 2001-12-28
GR3036636T3 (en) 2001-12-31
ATE202286T1 (de) 2001-07-15
WO1996007431A1 (en) 1996-03-14
EP0773794B1 (de) 2001-06-20
CA2197435C (en) 2010-01-12
US5773460A (en) 1998-06-30

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