ATE202346T1 - Benzofuran derivate und ihre verwendung als inhibitoren der knochenresorption - Google Patents

Benzofuran derivate und ihre verwendung als inhibitoren der knochenresorption

Info

Publication number: ATE202346T1
Authority: AT; Austria
Prior art keywords: pct; inhibitors; bone resorption; sec; benzofuran derivatives
Prior art date: 1994-04-29

Application number

AT95916027T

Other languages

English (en)

Inventor

Yoshio Kawai

Hitoshi Yamazaki

Natsuko Kayakiri

Kousei Yoshihara

Takumi Yatabe

Teruo Oku

Original Assignee

Fujisawa Pharmaceutical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-04-29

Filing date

1995-04-21

Publication date

2001-07-15

1995-04-21 Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co

2001-07-15 Application granted granted Critical

2001-07-15 Publication of ATE202346T1 publication Critical patent/ATE202346T1/de

Links

208000006386 Bone Resorption Diseases 0.000 title abstract 2
230000024279 bone resorption Effects 0.000 title abstract 2
239000003112 inhibitor Substances 0.000 title abstract 2
IANQTJSKSUMEQM-UHFFFAOYSA-N 1-benzofuran Chemical class C1=CC=C2OC=CC2=C1 IANQTJSKSUMEQM-UHFFFAOYSA-N 0.000 title 1
230000004097 bone metabolism Effects 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
230000002159 abnormal effect Effects 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
150000002391 heterocyclic compounds Chemical class 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/76—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/32—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems containing carbocyclic rings other than six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/91—Dibenzofurans; Hydrogenated dibenzofurans
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
- C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/30—Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Nutrition Science (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Furan Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

AT95916027T 1994-04-29 1995-04-21 Benzofuran derivate und ihre verwendung als inhibitoren der knochenresorption ATE202346T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB9408577A GB9408577D0 (en)	1994-04-29	1994-04-29	New compound
PCT/JP1995/000787 WO1995029907A1 (en)	1994-04-29	1995-04-21	Benzofuran derivatives useful as inhibitors of bone resorption

Publications (1)

Publication Number	Publication Date
ATE202346T1 true ATE202346T1 (de)	2001-07-15

Family

ID=10754361

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95916027T ATE202346T1 (de)	1994-04-29	1995-04-21	Benzofuran derivate und ihre verwendung als inhibitoren der knochenresorption

Country Status (10)

Country	Link
US (1)	US5858995A (de)
EP (1)	EP0757682B1 (de)
JP (1)	JPH09512795A (de)
AT (1)	ATE202346T1 (de)
AU (1)	AU2267395A (de)
DE (1)	DE69521424T2 (de)
ES (1)	ES2158103T3 (de)
GB (1)	GB9408577D0 (de)
WO (1)	WO1995029907A1 (de)
ZA (1)	ZA953469B (de)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9614347D0 (en) *	1996-07-09	1996-09-04	Smithkline Beecham Spa	Novel compounds
EP0988289A2 (de)	1997-06-05	2000-03-29	Takeda Pharmaceutical Company Limited	Benzofurane und benzothiophene als unterdrücker der neurodegeneration
US6162930A (en) *	1998-03-06	2000-12-19	Baylor University	Anti-mitotic agents which inhibit tubulin polymerization
FR2786184B1 (fr) *	1998-11-24	2002-09-20	Hoechst Marion Roussel Inc	Nouveaux derives du benzofurane, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
US6479536B1 (en)	1998-12-04	2002-11-12	Takeda Chemical Industries, Ltd.	Benzofuran derivatives, process for the preparation of the same and uses thereof
CA2409096A1 (en)	2000-05-18	2002-11-15	Junji Nakamura	Novel benzofuran derivatives
PE20020506A1 (es) *	2000-08-22	2002-07-09	Glaxo Group Ltd	Derivados de pirazol fusionados como inhibidores de la proteina cinasa
KR100637564B1 (ko)	2001-01-26	2006-10-20	추가이 세이야쿠 가부시키가이샤	대사 조절자로서 유용한 말로닐-코에이 데카르복실라제억제제
US6969730B2 (en) *	2001-03-16	2005-11-29	Abbott Laboratories	Amines as histamine-3 receptor ligands and their therapeutic applications
GB0124938D0 (en)	2001-10-17	2001-12-05	Glaxo Group Ltd	Chemical compounds
GB0124936D0 (en)	2001-10-17	2001-12-05	Glaxo Group Ltd	Chemical compounds
GB0124941D0 (en) *	2001-10-17	2001-12-05	Glaxo Group Ltd	Chemical compounds
GB0124932D0 (en) *	2001-10-17	2001-12-05	Glaxo Group Ltd	Chemical compounds
GB0124934D0 (en)	2001-10-17	2001-12-05	Glaxo Group Ltd	Chemical compounds
GB0124933D0 (en) *	2001-10-17	2001-12-05	Glaxo Group Ltd	Chemical compounds
GB0124939D0 (en) *	2001-10-17	2001-12-05	Glaxo Group Ltd	Chemical compounds
GB0124931D0 (en) *	2001-10-17	2001-12-05	Glaxo Group Ltd	Chemical compounds
CA2467337A1 (en)	2001-12-21	2003-07-10	H. Lundbeck A/S	Aminoindane derivatives as serotonin and norepinephrine uptake inhibitors
ATE375980T1 (de)	2002-02-12	2007-11-15	Smithkline Beecham Corp	Nicotinamide und deren verwendung als p38 inhibitoren
GB0217757D0 (en)	2002-07-31	2002-09-11	Glaxo Group Ltd	Novel compounds
GB0308185D0 (en) *	2003-04-09	2003-05-14	Smithkline Beecham Corp	Novel compounds
GB0308186D0 (en)	2003-04-09	2003-05-14	Smithkline Beecham Corp	Novel compounds
GB0308201D0 (en) *	2003-04-09	2003-05-14	Smithkline Beecham Corp	Novel compounds
ITRM20030355A1 (it) *	2003-07-18	2005-01-19	Sigma Tau Ind Farmaceuti	Composti ad attivita' citotossica derivati della combretastatina.
GB0318814D0 (en) *	2003-08-11	2003-09-10	Smithkline Beecham Corp	Novel compounds
US7420083B2 (en)	2003-09-25	2008-09-02	Wyeth	Substituted aryloximes
US7342039B2 (en)	2003-09-25	2008-03-11	Wyeth	Substituted indole oximes
US7435837B2 (en) *	2003-10-24	2008-10-14	Wyeth	Dihydrobenzofuranyl alkanamine derivatives and methods for using same
US20050261347A1 (en) *	2003-10-24	2005-11-24	Wyeth	Dihydrobenzofuranyl alkanamine derivatives and methods for using same
SE0303480D0 (sv) *	2003-12-19	2003-12-19	Biovitrum Ab	Benzofuranes
GB0402143D0 (en) *	2004-01-30	2004-03-03	Smithkline Beecham Corp	Novel compounds
US20080051416A1 (en) *	2004-10-05	2008-02-28	Smithkline Beecham Corporation	Novel Compounds
EP1879875A1 (de) *	2005-04-22	2008-01-23	Wyeth	Kristallformen von {[(2r)-7-(2,6-dichlorophenyl)-5-fluoro-2,3-dihydro-1-benzofuran-2-yl]methyl}amin-hydrochlorid
GB0512429D0 (en) *	2005-06-17	2005-07-27	Smithkline Beecham Corp	Novel compound
US7662831B2 (en) *	2006-07-27	2010-02-16	Wyeth Llc	Tetracyclic indoles as potassium channel modulators
US7601856B2 (en) *	2006-07-27	2009-10-13	Wyeth	Benzofurans as potassium ion channel modulators
TW200819426A (en)	2006-08-31	2008-05-01	Lundbeck & Co As H	Novel indane compounds
WO2008063888A2 (en)	2006-11-22	2008-05-29	Plexxikon, Inc.	Compounds modulating c-fms and/or c-kit activity and uses therefor
MX2009013332A (es)	2007-06-08	2010-01-25	Mannkind Corp	Inhibidores de ire-1 alfa.
WO2009012283A1 (en)	2007-07-17	2009-01-22	Plexxikon Inc.	Compounds and methods for kinase modulation, and indications therefor
MY172424A (en)	2009-04-03	2019-11-25	Hoffmann La Roche	Propane- i-sulfonic acid {3- (4-chloro-phenyl)-1h-pyrrolo [2, 3-b] pyridine-3-carconyl] -2, 4-difluoro-phenyl} -amide compositions and uses thereof
WO2010144611A2 (en) *	2009-06-10	2010-12-16	3-V Biosciences, Inc.	Antivirals that target transporters, carriers, and ion channels
US8329724B2 (en)	2009-08-03	2012-12-11	Hoffmann-La Roche Inc.	Process for the manufacture of pharmaceutically active compounds
CN106220623A (zh)	2009-11-06	2016-12-14	普莱希科公司	用于激酶调节的化合物和方法及其适应症
CA2822357A1 (en)	2010-12-22	2012-06-28	Abbvie Inc.	Hepatitis c inhibitors and uses thereof
US9624213B2 (en)	2011-02-07	2017-04-18	Plexxikon Inc.	Compounds and methods for kinase modulation, and indications therefor
AR085279A1 (es)	2011-02-21	2013-09-18	Plexxikon Inc	Formas solidas de {3-[5-(4-cloro-fenil)-1h-pirrolo[2,3-b]piridina-3-carbonil]-2,4-difluor-fenil}-amida del acido propano-1-sulfonico
WO2012162291A1 (en) *	2011-05-24	2012-11-29	The Wistar Institute	Compositions and methods for modulating the activity of epstein-barr nuclear antigen 1
US9150570B2 (en)	2012-05-31	2015-10-06	Plexxikon Inc.	Synthesis of heterocyclic compounds
CN108623610B (zh) *	2018-06-04	2020-08-11	中国科学院化学研究所	一种氮杂*酮化合物及其制备方法
AU2019318046B2 (en) *	2018-08-06	2025-02-13	Dana-Farber Cancer Institute, Inc.	Histone demethylase 5 inhibitors and uses thereof
US20240300939A1 (en)	2021-06-14	2024-09-12	Scorpion Therapeutics, Inc.	Urea derivatives which can be used to treat cancer
AU2022303386A1 (en) *	2021-07-02	2023-12-14	Aldeyra Therapeutics, Inc.	Heterocyclic aldehyde trapping compounds and uses thereof
IL313455A (en)	2021-12-15	2024-08-01	Delix Therapeutics Inc	Phenoxy and benzyloxy modified psychroplastogens and their uses
WO2023114858A1 (en) *	2021-12-15	2023-06-22	Delix Therapeutics, Inc.	Benzofuran and benzothiophene psychoplastogens and uses thereof
JP7684660B2 (ja) *	2022-04-28	2025-05-28	国立大学法人富山大学	トランスサイレチンアミロイドーシス治療用医薬組成物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4212865A (en) *	1978-12-26	1980-07-15	Riker Laboratories, Inc.	Amine derivatives of 2-nitro-3-phenylbenzofuran
JPS58103380A (ja) *	1981-12-15	1983-06-20	Ota Seiyaku Kk	ベンゾフラン誘導体の製造法
JPS58170775A (ja) *	1982-03-30	1983-10-07	Kaken Pharmaceut Co Ltd	光学活性な（ｓ）−（−）−２−アセチル−７−（２−ヒドロキシ−３−イソプロピルアミノプロポキシ）ベンゾフラン塩酸塩の製造法
JPS6054379A (ja) *	1983-09-05	1985-03-28	Takeda Chem Ind Ltd	新規４ｈ−１−ベンゾピラン−４−オン誘導体，その製法および用途
IL87674A (en) *	1987-09-08	1993-08-18	Lilly Co Eli	Azabicycloalkyl esters and amides of heterocyclic acids, their preparation and pharmaceutical compositions containing them
US5006549A (en) *	1989-05-24	1991-04-09	Merck & Co., Inc.	Novel 7-aroyl-4-hydroxy-3-methyl-benzofurans as dual inhibitors of cyclooxygenase and 5-lipoxygenase
DE4117512A1 (de) *	1991-05-25	1992-11-26	Schering Ag	2-phenylbenzo(b)furane und -thiophene, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
JP3502403B2 (ja) *	1991-12-16	2004-03-02	アベンティスファーマ株式会社	骨吸収抑制剤
GB9203798D0 (en) *	1992-02-21	1992-04-08	Fujisawa Pharmaceutical Co	Quinolylbenzofuran derivatives,processes for preparation thereof and pharmaceutical composition comprising the same
JPH0744735B2 (ja) *	1992-08-03	1995-05-15	八重洲無線株式会社	無線通信機

1994
- 1994-04-29 GB GB9408577A patent/GB9408577D0/en active Pending
1995
- 1995-04-21 WO PCT/JP1995/000787 patent/WO1995029907A1/en not_active Ceased
- 1995-04-21 AT AT95916027T patent/ATE202346T1/de not_active IP Right Cessation
- 1995-04-21 ES ES95916027T patent/ES2158103T3/es not_active Expired - Lifetime
- 1995-04-21 JP JP7528110A patent/JPH09512795A/ja not_active Ceased
- 1995-04-21 AU AU22673/95A patent/AU2267395A/en not_active Abandoned
- 1995-04-21 US US08/727,627 patent/US5858995A/en not_active Expired - Fee Related
- 1995-04-21 DE DE69521424T patent/DE69521424T2/de not_active Expired - Fee Related
- 1995-04-21 EP EP95916027A patent/EP0757682B1/de not_active Expired - Lifetime
- 1995-04-28 ZA ZA953469A patent/ZA953469B/xx unknown

Also Published As

Publication number	Publication date
DE69521424D1 (de)	2001-07-26
JPH09512795A (ja)	1997-12-22
DE69521424T2 (de)	2001-10-18
EP0757682A1 (de)	1997-02-12
ZA953469B (en)	1996-01-17
AU2267395A (en)	1995-11-29
ES2158103T3 (es)	2001-09-01
WO1995029907A1 (en)	1995-11-09
GB9408577D0 (en)	1994-06-22
US5858995A (en)	1999-01-12
EP0757682B1 (de)	2001-06-20

Legal Events

Date	Code	Title	Description
2001-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69521424D1 (de)	2001-07-26	Benzofuran derivate und ihre verwendung als inhibitoren der knochenresorption
ATE273958T1 (de)	2004-09-15	Heterocyclische verbindungen als h+-atpasen
DE60226729D1 (de)	2008-07-03	Hydroxyalkylaminderivate als beta-secretase-inhibitoren und deren verwendung zur behandlung der alzheimerschen krankheit oder ähnlicher krankheiten
FI943948A0 (fi)	1994-08-26	Heterosykliset hiilihappojohdannaiset
NO20051010L (no)	2005-05-31	Triazolderivater som transformerende vekst faktor (TGF) inhibitorer
PT641328E (pt)	2002-04-29	Derivados aza-biciclicos em ponte como antagonistas da substancia p
NO20051008L (no)	2005-06-07	Nye imidazolforbindelser som transformerende vekst faktor (TGF) inhibitorer
DK0778834T3 (da)	2000-04-17	Bicykliske, heterocykliske diarylforbindelser som inhibitorer af cyclooxygenase-2
DE59409312D1 (de)	2000-05-31	Imidazopyridine und ihre anwendung zur behandlung von magen-darm krankheiten
DE59402222D1 (de)	1997-04-30	Substituierte heterocyclische Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel
UA44254C2 (uk)	2002-02-15	Похідні 4-(заміщеного феніламіно)хіназоліну, спосіб їх одержання, спосіб лікування і фармацевтична композиція
EA200500377A1 (ru)	2005-08-25	Пиразольные производные как ингибиторы трансформирующего фактора роста (tgf)
ES2098947T3 (es)	1997-05-01	Derivados de beta,beta-dimetil-4-piperidinoetanamina como inhibidores de la biosintesis del colesterol.
NO306345B1 (no)	1999-10-25	Piperidin-derivater med PAF antagonist-aktivitet, anvendelse derav og farmasöytisk blanding
DE60221283D1 (de)	2007-08-30	Verwendung von oxindolderivaten zur behandlung von mit demenz in zusammenhang stehenden krankheiten, alzheimer-krankheit und mit glycogensynthasekinase-3 assoziierten leiden
DE69725879D1 (de)	2003-12-04	VERWENDUNG VON p-AMINOPHENOLDERIVATEN ZUR HERSTELLUNG VON PHARMAZEUTISCHEN ZUSAMMENSETZUNGEN ZUR BEHANDLUNG VON NEURODEGENERATIVEN ERKRANKUNGEN
DE69511544D1 (de)	1999-09-23	Amidderivate und ihre therapeutische verwendung
DE69501359D1 (de)	1998-02-12	Verwendung von Phosphatdiestern zur Behandlung von Erkrankungen der Retina
BR9502072A (pt)	1996-04-09	Composto metodo para o tratamento de uma condiçao médica e composiçao farmaceutica
DK0720598T3 (da)	1999-06-21	Phenoxyphenylcyclopentenyl-hydroxyurinstoffer
NZ320522A (en)	1999-03-29	Piperazinylalkylthiopyrimidine derivatives, pharmaceutical compositions containing the same and a process for the preparation of the compounds
SG146685A1 (en)	2008-10-30	Dihydroporphine derivatives, processes for their preparation, and pharmaceutical compositions containing them
DK0769945T3 (da)	2003-06-10	Brug af 2-phenyl-3-aroylbenzothiophenderivater til fremstilling af et medikament til behandling af knogler og knoglebrud
ES2137665T3 (es)	1999-12-16	Nuevos derivados de piridina o piridazina, procedimientos para su preparacion, y medicamentos que contienen estos compuestos.
DE69421705D1 (de)	1999-12-23	Verwendung von Efaroxan und dessen Derivaten zur Herstellung eines Arzneimittels zur Behandlung neurogenerativer Erkrankungen